Serine protease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Serine protease

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HML8_LEIBR

TriTrypDb:

LbrM.34.1890 , LBRM2903_340025400

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HML8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HML8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.613
CLV_C14_Caspase3-7	508	512	PF00656	0.535
CLV_NRD_NRD_1	303	305	PF00675	0.593
CLV_NRD_NRD_1	34	36	PF00675	0.431
CLV_NRD_NRD_1	4	6	PF00675	0.705
CLV_NRD_NRD_1	401	403	PF00675	0.652
CLV_NRD_NRD_1	450	452	PF00675	0.599
CLV_NRD_NRD_1	551	553	PF00675	0.606
CLV_NRD_NRD_1	557	559	PF00675	0.542
CLV_NRD_NRD_1	570	572	PF00675	0.564
CLV_PCSK_FUR_1	32	36	PF00082	0.454
CLV_PCSK_FUR_1	552	556	PF00082	0.622
CLV_PCSK_KEX2_1	142	144	PF00082	0.535
CLV_PCSK_KEX2_1	302	304	PF00082	0.602
CLV_PCSK_KEX2_1	34	36	PF00082	0.431
CLV_PCSK_KEX2_1	4	6	PF00082	0.705
CLV_PCSK_KEX2_1	554	556	PF00082	0.568
CLV_PCSK_KEX2_1	557	559	PF00082	0.561
CLV_PCSK_KEX2_1	569	571	PF00082	0.508
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.554
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.591
CLV_PCSK_PC7_1	298	304	PF00082	0.734
CLV_PCSK_SKI1_1	114	118	PF00082	0.504
CLV_PCSK_SKI1_1	283	287	PF00082	0.512
CLV_PCSK_SKI1_1	339	343	PF00082	0.529
CLV_PCSK_SKI1_1	432	436	PF00082	0.586
DEG_APCC_DBOX_1	128	136	PF00400	0.426
DEG_APCC_DBOX_1	450	458	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DOC_ANK_TNKS_1	301	308	PF00023	0.689
DOC_CKS1_1	71	76	PF01111	0.502
DOC_MAPK_DCC_7	325	333	PF00069	0.584
DOC_MAPK_gen_1	168	177	PF00069	0.314
DOC_MAPK_gen_1	322	331	PF00069	0.593
DOC_MAPK_MEF2A_6	322	331	PF00069	0.602
DOC_PP2B_LxvP_1	196	199	PF13499	0.496
DOC_USP7_MATH_1	182	186	PF00917	0.478
DOC_USP7_MATH_1	305	309	PF00917	0.722
DOC_USP7_MATH_1	505	509	PF00917	0.631
DOC_USP7_MATH_1	534	538	PF00917	0.822
DOC_USP7_MATH_1	545	549	PF00917	0.734
DOC_USP7_UBL2_3	24	28	PF12436	0.462
DOC_WW_Pin1_4	221	226	PF00397	0.400
DOC_WW_Pin1_4	403	408	PF00397	0.643
DOC_WW_Pin1_4	532	537	PF00397	0.821
DOC_WW_Pin1_4	70	75	PF00397	0.483
LIG_14-3-3_CanoR_1	103	108	PF00244	0.462
LIG_14-3-3_CanoR_1	451	455	PF00244	0.593
LIG_14-3-3_CanoR_1	473	481	PF00244	0.513
LIG_14-3-3_CanoR_1	88	95	PF00244	0.511
LIG_Actin_WH2_2	127	144	PF00022	0.504
LIG_BRCT_BRCA1_1	271	275	PF00533	0.430
LIG_BRCT_BRCA1_1	348	352	PF00533	0.588
LIG_BRCT_BRCA1_1	354	358	PF00533	0.646
LIG_BRCT_BRCA1_1	494	498	PF00533	0.516
LIG_Clathr_ClatBox_1	278	282	PF01394	0.425
LIG_FHA_1	216	222	PF00498	0.458
LIG_FHA_1	248	254	PF00498	0.437
LIG_FHA_1	61	67	PF00498	0.427
LIG_FHA_1	85	91	PF00498	0.526
LIG_FHA_2	217	223	PF00498	0.512
LIG_FHA_2	250	256	PF00498	0.471
LIG_FHA_2	295	301	PF00498	0.668
LIG_FHA_2	340	346	PF00498	0.521
LIG_FHA_2	374	380	PF00498	0.678
LIG_FHA_2	472	478	PF00498	0.639
LIG_FHA_2	71	77	PF00498	0.479
LIG_FHA_2	92	98	PF00498	0.468
LIG_LIR_Apic_2	408	414	PF02991	0.584
LIG_LIR_Apic_2	73	78	PF02991	0.536
LIG_LIR_Gen_1	272	281	PF02991	0.408
LIG_LIR_Gen_1	59	69	PF02991	0.467
LIG_LIR_Nem_3	272	278	PF02991	0.405
LIG_LIR_Nem_3	30	36	PF02991	0.485
LIG_LIR_Nem_3	59	65	PF02991	0.475
LIG_LIR_Nem_3	76	80	PF02991	0.504
LIG_Pex14_2	42	46	PF04695	0.495
LIG_PTB_Apo_2	151	158	PF02174	0.517
LIG_PTB_Apo_2	496	503	PF02174	0.727
LIG_PTB_Phospho_1	151	157	PF10480	0.543
LIG_PTB_Phospho_1	496	502	PF10480	0.620
LIG_SH2_GRB2like	346	349	PF00017	0.683
LIG_SH2_GRB2like	411	414	PF00017	0.772
LIG_SH2_NCK_1	411	415	PF00017	0.697
LIG_SH2_NCK_1	502	506	PF00017	0.653
LIG_SH2_SRC	411	414	PF00017	0.647
LIG_SH2_STAP1	15	19	PF00017	0.509
LIG_SH2_STAP1	270	274	PF00017	0.403
LIG_SH2_STAP1	502	506	PF00017	0.637
LIG_SH2_STAP1	518	522	PF00017	0.694
LIG_SH2_STAT3	81	84	PF00017	0.698
LIG_SH2_STAT5	157	160	PF00017	0.510
LIG_SH3_3	131	137	PF00018	0.434
LIG_SH3_3	537	543	PF00018	0.747
LIG_SH3_3	68	74	PF00018	0.397
LIG_SH3_4	395	402	PF00018	0.677
LIG_SUMO_SIM_par_1	194	200	PF11976	0.481
LIG_SUMO_SIM_par_1	276	282	PF11976	0.427
LIG_UBA3_1	274	283	PF00899	0.477
LIG_WRC_WIRS_1	384	389	PF05994	0.797
MOD_CDC14_SPxK_1	224	227	PF00782	0.412
MOD_CDK_SPxK_1	221	227	PF00069	0.402
MOD_CK1_1	386	392	PF00069	0.743
MOD_CK1_1	504	510	PF00069	0.604
MOD_CK1_1	535	541	PF00069	0.761
MOD_CK1_1	91	97	PF00069	0.483
MOD_CK2_1	178	184	PF00069	0.418
MOD_CK2_1	216	222	PF00069	0.491
MOD_CK2_1	249	255	PF00069	0.447
MOD_CK2_1	294	300	PF00069	0.660
MOD_GlcNHglycan	143	146	PF01048	0.518
MOD_GlcNHglycan	180	183	PF01048	0.591
MOD_GlcNHglycan	348	351	PF01048	0.598
MOD_GlcNHglycan	354	357	PF01048	0.641
MOD_GlcNHglycan	364	367	PF01048	0.548
MOD_GlcNHglycan	503	506	PF01048	0.647
MOD_GlcNHglycan	58	61	PF01048	0.569
MOD_GSK3_1	178	185	PF00069	0.438
MOD_GSK3_1	262	269	PF00069	0.428
MOD_GSK3_1	386	393	PF00069	0.758
MOD_GSK3_1	426	433	PF00069	0.578
MOD_GSK3_1	501	508	PF00069	0.609
MOD_GSK3_1	532	539	PF00069	0.795
MOD_GSK3_1	56	63	PF00069	0.538
MOD_GSK3_1	80	87	PF00069	0.579
MOD_GSK3_1	91	98	PF00069	0.480
MOD_N-GLC_1	425	430	PF02516	0.587
MOD_N-GLC_1	435	440	PF02516	0.610
MOD_N-GLC_1	471	476	PF02516	0.734
MOD_N-GLC_1	53	58	PF02516	0.496
MOD_N-GLC_1	545	550	PF02516	0.761
MOD_NEK2_1	123	128	PF00069	0.514
MOD_NEK2_1	215	220	PF00069	0.445
MOD_NEK2_1	234	239	PF00069	0.406
MOD_NEK2_1	249	254	PF00069	0.434
MOD_NEK2_1	262	267	PF00069	0.390
MOD_NEK2_1	318	323	PF00069	0.584
MOD_NEK2_1	352	357	PF00069	0.648
MOD_NEK2_1	37	42	PF00069	0.395
MOD_NEK2_1	466	471	PF00069	0.614
MOD_NEK2_1	47	52	PF00069	0.517
MOD_NEK2_1	95	100	PF00069	0.461
MOD_NEK2_2	182	187	PF00069	0.482
MOD_PIKK_1	359	365	PF00454	0.588
MOD_PIKK_1	53	59	PF00454	0.455
MOD_PIKK_1	80	86	PF00454	0.602
MOD_PIKK_1	97	103	PF00454	0.409
MOD_PKA_2	450	456	PF00069	0.593
MOD_Plk_1	294	300	PF00069	0.620
MOD_Plk_1	37	43	PF00069	0.415
MOD_Plk_1	435	441	PF00069	0.634
MOD_Plk_1	53	59	PF00069	0.530
MOD_Plk_1	545	551	PF00069	0.757
MOD_Plk_4	182	188	PF00069	0.487
MOD_Plk_4	234	240	PF00069	0.424
MOD_Plk_4	305	311	PF00069	0.551
MOD_Plk_4	329	335	PF00069	0.562
MOD_Plk_4	466	472	PF00069	0.648
MOD_Plk_4	545	551	PF00069	0.729
MOD_ProDKin_1	221	227	PF00069	0.402
MOD_ProDKin_1	403	409	PF00069	0.639
MOD_ProDKin_1	532	538	PF00069	0.819
MOD_ProDKin_1	70	76	PF00069	0.498
MOD_SUMO_rev_2	144	150	PF00179	0.491
MOD_SUMO_rev_2	184	193	PF00179	0.546
MOD_SUMO_rev_2	255	262	PF00179	0.564
MOD_SUMO_rev_2	332	341	PF00179	0.493
MOD_SUMO_rev_2	437	444	PF00179	0.600
TRG_ENDOCYTIC_2	113	116	PF00928	0.509
TRG_ER_diArg_1	159	162	PF00400	0.473
TRG_ER_diArg_1	202	205	PF00400	0.476
TRG_ER_diArg_1	227	230	PF00400	0.594
TRG_ER_diArg_1	302	304	PF00400	0.624
TRG_ER_diArg_1	33	35	PF00400	0.448
TRG_ER_diArg_1	568	571	PF00400	0.596
TRG_NES_CRM1_1	97	108	PF08389	0.503
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P326	Leptomonas seymouri	80%	98%
A0A0S4JIC7	Bodo saltans	55%	100%
A0A1X0P7C6	Trypanosomatidae	68%	100%
A0A3Q8IM74	Leishmania donovani	90%	100%
A4IB96	Leishmania infantum	90%	100%
C9ZZM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AF20	Leishmania major	91%	99%
E9B676	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5ATF8	Trypanosoma cruzi	68%	100%