UBX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubx domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HML7_LEIBR

TriTrypDb:

LbrM.34.1880 , LBRM2903_340025300

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HML7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HML7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.425
CLV_C14_Caspase3-7	74	78	PF00656	0.290
CLV_NRD_NRD_1	170	172	PF00675	0.480
CLV_NRD_NRD_1	265	267	PF00675	0.313
CLV_NRD_NRD_1	330	332	PF00675	0.526
CLV_PCSK_KEX2_1	25	27	PF00082	0.449
CLV_PCSK_KEX2_1	265	267	PF00082	0.319
CLV_PCSK_KEX2_1	330	332	PF00082	0.526
CLV_PCSK_KEX2_1	8	10	PF00082	0.417
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.554
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.439
CLV_PCSK_SKI1_1	163	167	PF00082	0.512
CLV_PCSK_SKI1_1	265	269	PF00082	0.386
CLV_PCSK_SKI1_1	296	300	PF00082	0.414
CLV_PCSK_SKI1_1	52	56	PF00082	0.447
DEG_APCC_DBOX_1	162	170	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DOC_MAPK_gen_1	8	16	PF00069	0.476
DOC_MAPK_MEF2A_6	8	16	PF00069	0.476
DOC_PP2B_LxvP_1	12	15	PF13499	0.500
DOC_USP7_MATH_1	232	236	PF00917	0.578
DOC_USP7_UBL2_3	168	172	PF12436	0.459
DOC_USP7_UBL2_3	230	234	PF12436	0.611
DOC_WW_Pin1_4	38	43	PF00397	0.405
LIG_14-3-3_CanoR_1	266	276	PF00244	0.313
LIG_14-3-3_CterR_2	330	332	PF00244	0.515
LIG_Actin_WH2_2	314	332	PF00022	0.189
LIG_APCC_ABBAyCdc20_2	234	240	PF00400	0.642
LIG_BIR_III_4	77	81	PF00653	0.303
LIG_BRCT_BRCA1_1	67	71	PF00533	0.500
LIG_deltaCOP1_diTrp_1	119	127	PF00928	0.469
LIG_deltaCOP1_diTrp_1	307	315	PF00928	0.332
LIG_EVH1_1	301	305	PF00568	0.425
LIG_FHA_1	100	106	PF00498	0.469
LIG_FHA_1	248	254	PF00498	0.344
LIG_FHA_1	275	281	PF00498	0.423
LIG_FHA_1	55	61	PF00498	0.406
LIG_FHA_2	18	24	PF00498	0.439
LIG_FHA_2	280	286	PF00498	0.332
LIG_LIR_Gen_1	31	42	PF02991	0.473
LIG_LIR_Nem_3	31	37	PF02991	0.478
LIG_NRBOX	165	171	PF00104	0.594
LIG_Pex14_2	116	120	PF04695	0.422
LIG_Pex14_2	297	301	PF04695	0.425
LIG_SH2_SRC	38	41	PF00017	0.426
LIG_SH2_STAP1	263	267	PF00017	0.404
LIG_SH2_STAT5	34	37	PF00017	0.353
LIG_SH2_STAT5	38	41	PF00017	0.349
LIG_SH2_STAT5	50	53	PF00017	0.371
LIG_SH3_3	252	258	PF00018	0.400
LIG_SH3_3	299	305	PF00018	0.341
LIG_SUMO_SIM_anti_2	57	68	PF11976	0.491
LIG_TRAF2_1	190	193	PF00917	0.566
LIG_TRAF2_1	20	23	PF00917	0.476
LIG_TRAF2_1	209	212	PF00917	0.386
LIG_TRAF2_1	217	220	PF00917	0.569
LIG_UBA3_1	165	172	PF00899	0.556
MOD_CK1_1	112	118	PF00069	0.522
MOD_CK2_1	153	159	PF00069	0.513
MOD_CK2_1	17	23	PF00069	0.443
MOD_CK2_1	279	285	PF00069	0.393
MOD_GlcNHglycan	155	158	PF01048	0.586
MOD_GlcNHglycan	227	230	PF01048	0.590
MOD_GlcNHglycan	258	261	PF01048	0.386
MOD_GSK3_1	240	247	PF00069	0.581
MOD_GSK3_1	287	294	PF00069	0.408
MOD_NEK2_1	64	69	PF00069	0.422
MOD_NEK2_1	71	76	PF00069	0.368
MOD_PIKK_1	232	238	PF00454	0.506
MOD_PKA_2	112	118	PF00069	0.481
MOD_PKA_2	225	231	PF00069	0.641
MOD_Plk_1	290	296	PF00069	0.425
MOD_Plk_1	65	71	PF00069	0.517
MOD_Plk_4	274	280	PF00069	0.332
MOD_Plk_4	65	71	PF00069	0.458
MOD_Plk_4	78	84	PF00069	0.366
MOD_Plk_4	99	105	PF00069	0.416
MOD_ProDKin_1	38	44	PF00069	0.407
MOD_SUMO_rev_2	312	321	PF00179	0.370
TRG_DiLeu_BaEn_1	59	64	PF01217	0.448
TRG_ENDOCYTIC_2	34	37	PF00928	0.369
TRG_ER_diArg_1	265	267	PF00400	0.313
TRG_ER_diArg_1	329	331	PF00400	0.386
TRG_NES_CRM1_1	271	285	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ2	Leptomonas seymouri	65%	100%
A0A0S4JEV1	Bodo saltans	31%	100%
A0A1X0P6W3	Trypanosomatidae	34%	100%
A0A3R7KII9	Trypanosoma rangeli	34%	100%
A0A3S7X998	Leishmania donovani	91%	100%
A4IB95	Leishmania infantum	91%	100%
C9ZZL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AF19	Leishmania major	92%	100%
E9B675	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q28BP9	Xenopus tropicalis	24%	75%
Q2HJD0	Bos taurus	25%	75%
Q3TDN2	Mus musculus	28%	75%
Q5BK32	Rattus norvegicus	27%	96%
Q6AZH6	Xenopus laevis	22%	75%
Q6GQ69	Xenopus laevis	25%	75%
Q96CS3	Homo sapiens	28%	75%
Q9M0N1	Arabidopsis thaliana	27%	69%