ATP synthase mitochondrial F1 complex assembly factor 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP11 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HML6_LEIBR

TriTrypDb:

LbrM.34.1860 , LBRM2903_340025100

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HML6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HML6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1
GO:0043461	proton-transporting ATP synthase complex assembly	7	1
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.300
CLV_PCSK_FUR_1	125	129	PF00082	0.205
CLV_PCSK_KEX2_1	127	129	PF00082	0.221
CLV_PCSK_KEX2_1	13	15	PF00082	0.417
CLV_PCSK_KEX2_1	142	144	PF00082	0.303
CLV_PCSK_KEX2_1	172	174	PF00082	0.274
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.221
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.417
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.303
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.274
CLV_PCSK_SKI1_1	128	132	PF00082	0.221
CLV_PCSK_SKI1_1	184	188	PF00082	0.362
CLV_PCSK_SKI1_1	82	86	PF00082	0.284
DEG_APCC_DBOX_1	16	24	PF00400	0.274
DEG_MDM2_SWIB_1	48	56	PF02201	0.289
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DOC_CKS1_1	213	218	PF01111	0.495
DOC_CKS1_1	31	36	PF01111	0.487
DOC_CYCLIN_RxL_1	124	135	PF00134	0.334
DOC_MAPK_gen_1	125	132	PF00069	0.274
DOC_MAPK_gen_1	142	149	PF00069	0.274
DOC_PP4_FxxP_1	12	15	PF00568	0.631
DOC_PP4_FxxP_1	74	77	PF00568	0.274
DOC_USP7_UBL2_3	192	196	PF12436	0.431
DOC_WW_Pin1_4	212	217	PF00397	0.500
DOC_WW_Pin1_4	30	35	PF00397	0.292
DOC_WW_Pin1_4	68	73	PF00397	0.399
LIG_14-3-3_CanoR_1	17	21	PF00244	0.331
LIG_14-3-3_CanoR_1	222	230	PF00244	0.434
LIG_14-3-3_CanoR_1	54	64	PF00244	0.298
LIG_14-3-3_CanoR_1	6	10	PF00244	0.513
LIG_APCC_ABBA_1	76	81	PF00400	0.368
LIG_BIR_III_4	207	211	PF00653	0.547
LIG_BRCT_BRCA1_1	70	74	PF00533	0.368
LIG_deltaCOP1_diTrp_1	164	170	PF00928	0.289
LIG_FHA_1	148	154	PF00498	0.274
LIG_FHA_1	225	231	PF00498	0.573
LIG_FHA_2	163	169	PF00498	0.220
LIG_FHA_2	213	219	PF00498	0.490
LIG_GBD_Chelix_1	220	228	PF00786	0.589
LIG_LIR_Apic_2	71	77	PF02991	0.311
LIG_LIR_Gen_1	178	186	PF02991	0.425
LIG_LIR_Nem_3	138	144	PF02991	0.425
LIG_LIR_Nem_3	158	162	PF02991	0.293
LIG_LIR_Nem_3	178	182	PF02991	0.290
LIG_LIR_Nem_3	207	212	PF02991	0.535
LIG_LIR_Nem_3	58	64	PF02991	0.307
LIG_LIR_Nem_3	71	76	PF02991	0.248
LIG_MLH1_MIPbox_1	70	74	PF16413	0.368
LIG_Pex14_1	166	170	PF04695	0.289
LIG_Pex14_2	48	52	PF04695	0.274
LIG_SH2_CRK	157	161	PF00017	0.289
LIG_SH2_STAP1	163	167	PF00017	0.289
LIG_SH2_STAT5	11	14	PF00017	0.644
LIG_SH2_STAT5	157	160	PF00017	0.289
LIG_SH2_STAT5	73	76	PF00017	0.274
LIG_SH3_3	28	34	PF00018	0.193
LIG_TRFH_1	62	66	PF08558	0.368
LIG_WRC_WIRS_1	167	172	PF05994	0.368
MOD_CK1_1	5	11	PF00069	0.592
MOD_CK2_1	16	22	PF00069	0.289
MOD_CK2_1	162	168	PF00069	0.225
MOD_CK2_1	24	30	PF00069	0.289
MOD_Cter_Amidation	15	18	PF01082	0.274
MOD_GSK3_1	162	169	PF00069	0.255
MOD_NEK2_1	123	128	PF00069	0.314
MOD_NEK2_1	162	167	PF00069	0.216
MOD_NEK2_1	2	7	PF00069	0.568
MOD_NEK2_1	29	34	PF00069	0.428
MOD_NEK2_2	24	29	PF00069	0.417
MOD_PIKK_1	147	153	PF00454	0.274
MOD_PKA_2	16	22	PF00069	0.215
MOD_PKA_2	2	8	PF00069	0.578
MOD_Plk_4	162	168	PF00069	0.225
MOD_Plk_4	24	30	PF00069	0.333
MOD_ProDKin_1	212	218	PF00069	0.498
MOD_ProDKin_1	30	36	PF00069	0.292
MOD_ProDKin_1	68	74	PF00069	0.399
MOD_SUMO_for_1	136	139	PF00179	0.417
MOD_SUMO_for_1	186	189	PF00179	0.362
MOD_SUMO_for_1	195	198	PF00179	0.498
MOD_SUMO_rev_2	188	197	PF00179	0.458
MOD_SUMO_rev_2	198	202	PF00179	0.526
TRG_ENDOCYTIC_2	156	159	PF00928	0.289
TRG_ENDOCYTIC_2	179	182	PF00928	0.350
TRG_ENDOCYTIC_2	61	64	PF00928	0.314
TRG_ENDOCYTIC_2	73	76	PF00928	0.314
TRG_ER_diArg_1	66	69	PF00400	0.227
TRG_NES_CRM1_1	21	35	PF08389	0.193
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P324	Leptomonas seymouri	86%	100%
A0A0S4JHC0	Bodo saltans	71%	99%
A0A1X0P5W7	Trypanosomatidae	72%	100%
A0A3Q8IPF8	Leishmania donovani	91%	100%
A0A3R7RMJ9	Trypanosoma rangeli	70%	98%
A4IB93	Leishmania infantum	91%	100%
C9ZZL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	95%
E9AF17	Leishmania major	92%	100%
E9B673	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B8Y3	Trypanosoma cruzi	69%	98%