Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HML3_LEIBR

TriTrypDb:

LbrM.34.1830 , LBRM2903_340024800

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HML3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HML3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.611
CLV_NRD_NRD_1	246	248	PF00675	0.411
CLV_NRD_NRD_1	315	317	PF00675	0.576
CLV_NRD_NRD_1	93	95	PF00675	0.439
CLV_PCSK_KEX2_1	245	247	PF00082	0.429
CLV_PCSK_KEX2_1	93	95	PF00082	0.476
CLV_PCSK_SKI1_1	301	305	PF00082	0.611
CLV_PCSK_SKI1_1	68	72	PF00082	0.545
CLV_PCSK_SKI1_1	81	85	PF00082	0.474
CLV_PCSK_SKI1_1	93	97	PF00082	0.487
DEG_APCC_KENBOX_2	64	68	PF00400	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SPOP_SBC_1	198	202	PF00917	0.611
DOC_CKS1_1	172	177	PF01111	0.630
DOC_PP2B_LxvP_1	135	138	PF13499	0.650
DOC_USP7_MATH_1	129	133	PF00917	0.661
DOC_USP7_MATH_1	193	197	PF00917	0.702
DOC_USP7_MATH_1	198	202	PF00917	0.569
DOC_USP7_MATH_1	218	222	PF00917	0.554
DOC_USP7_MATH_2	129	135	PF00917	0.617
DOC_USP7_UBL2_3	73	77	PF12436	0.573
DOC_WW_Pin1_4	171	176	PF00397	0.628
DOC_WW_Pin1_4	220	225	PF00397	0.635
DOC_WW_Pin1_4	295	300	PF00397	0.337
DOC_WW_Pin1_4	44	49	PF00397	0.804
LIG_14-3-3_CanoR_1	249	259	PF00244	0.546
LIG_14-3-3_CanoR_1	81	89	PF00244	0.625
LIG_14-3-3_CanoR_1	93	102	PF00244	0.583
LIG_deltaCOP1_diTrp_1	97	108	PF00928	0.607
LIG_FHA_1	167	173	PF00498	0.630
LIG_FHA_1	237	243	PF00498	0.626
LIG_FHA_1	45	51	PF00498	0.623
LIG_FHA_1	82	88	PF00498	0.599
LIG_FHA_2	125	131	PF00498	0.607
LIG_HCF-1_HBM_1	36	39	PF13415	0.590
LIG_LIR_Gen_1	149	160	PF02991	0.588
LIG_LIR_Gen_1	174	180	PF02991	0.630
LIG_LIR_Gen_1	21	31	PF02991	0.593
LIG_LIR_Nem_3	149	155	PF02991	0.592
LIG_LIR_Nem_3	174	179	PF02991	0.627
LIG_LIR_Nem_3	21	27	PF02991	0.591
LIG_LIR_Nem_3	29	34	PF02991	0.600
LIG_LIR_Nem_3	76	82	PF02991	0.665
LIG_NRBOX	310	316	PF00104	0.382
LIG_PDZ_Class_1	319	324	PF00595	0.412
LIG_Pex14_1	108	112	PF04695	0.596
LIG_Pex14_1	257	261	PF04695	0.310
LIG_PTB_Apo_2	170	177	PF02174	0.602
LIG_SH2_CRK	156	160	PF00017	0.579
LIG_SH2_CRK	31	35	PF00017	0.608
LIG_SH2_PTP2	24	27	PF00017	0.548
LIG_SH2_STAP1	156	160	PF00017	0.579
LIG_SH2_STAP1	186	190	PF00017	0.577
LIG_SH2_STAP1	292	296	PF00017	0.416
LIG_SH2_STAT3	39	42	PF00017	0.605
LIG_SH2_STAT5	24	27	PF00017	0.592
LIG_SH2_STAT5	39	42	PF00017	0.649
LIG_SH2_STAT5	79	82	PF00017	0.608
LIG_SH3_3	169	175	PF00018	0.628
LIG_TRFH_1	164	168	PF08558	0.559
LIG_TYR_ITIM	290	295	PF00017	0.374
LIG_TYR_ITSM	27	34	PF00017	0.555
LIG_WRC_WIRS_1	140	145	PF05994	0.600
MOD_CDC14_SPxK_1	223	226	PF00782	0.638
MOD_CDC14_SPxK_1	298	301	PF00782	0.336
MOD_CDK_SPxK_1	220	226	PF00069	0.638
MOD_CDK_SPxK_1	295	301	PF00069	0.338
MOD_CK1_1	271	277	PF00069	0.310
MOD_CK1_1	69	75	PF00069	0.584
MOD_CK2_1	139	145	PF00069	0.570
MOD_CK2_1	238	244	PF00069	0.617
MOD_CK2_1	50	56	PF00069	0.746
MOD_CMANNOS	141	144	PF00535	0.383
MOD_GlcNHglycan	149	152	PF01048	0.442
MOD_GlcNHglycan	274	277	PF01048	0.302
MOD_GlcNHglycan	52	55	PF01048	0.467
MOD_GlcNHglycan	61	64	PF01048	0.455
MOD_GlcNHglycan	68	71	PF01048	0.440
MOD_GSK3_1	193	200	PF00069	0.606
MOD_GSK3_1	218	225	PF00069	0.633
MOD_GSK3_1	267	274	PF00069	0.277
MOD_GSK3_1	291	298	PF00069	0.347
MOD_N-GLC_1	59	64	PF02516	0.433
MOD_N-GLC_1	66	71	PF02516	0.401
MOD_NEK2_1	111	116	PF00069	0.592
MOD_NEK2_1	179	184	PF00069	0.567
MOD_NEK2_1	211	216	PF00069	0.585
MOD_NEK2_1	250	255	PF00069	0.606
MOD_NEK2_1	26	31	PF00069	0.597
MOD_NEK2_1	291	296	PF00069	0.359
MOD_NEK2_1	303	308	PF00069	0.381
MOD_PIKK_1	199	205	PF00454	0.644
MOD_PIKK_1	212	218	PF00454	0.582
MOD_PIKK_1	303	309	PF00454	0.382
MOD_PKA_1	245	251	PF00069	0.576
MOD_PKA_1	93	99	PF00069	0.640
MOD_PKA_2	245	251	PF00069	0.610
MOD_PKA_2	93	99	PF00069	0.640
MOD_Plk_1	129	135	PF00069	0.595
MOD_Plk_1	237	243	PF00069	0.646
MOD_Plk_1	75	81	PF00069	0.571
MOD_Plk_2-3	238	244	PF00069	0.611
MOD_Plk_4	26	32	PF00069	0.599
MOD_Plk_4	291	297	PF00069	0.365
MOD_Plk_4	310	316	PF00069	0.508
MOD_Plk_4	75	81	PF00069	0.568
MOD_ProDKin_1	171	177	PF00069	0.625
MOD_ProDKin_1	220	226	PF00069	0.636
MOD_ProDKin_1	295	301	PF00069	0.338
MOD_ProDKin_1	44	50	PF00069	0.803
MOD_SUMO_rev_2	62	70	PF00179	0.621
MOD_SUMO_rev_2	72	78	PF00179	0.559
TRG_DiLeu_BaEn_1	22	27	PF01217	0.587
TRG_DiLeu_BaEn_4	97	103	PF01217	0.633
TRG_ENDOCYTIC_2	156	159	PF00928	0.582
TRG_ENDOCYTIC_2	24	27	PF00928	0.592
TRG_ENDOCYTIC_2	292	295	PF00928	0.369
TRG_ENDOCYTIC_2	31	34	PF00928	0.602
TRG_ER_diArg_1	245	247	PF00400	0.643
TRG_ER_diArg_1	87	90	PF00400	0.660
TRG_ER_diArg_1	93	95	PF00400	0.620
TRG_NES_CRM1_1	8	22	PF08389	0.604
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K1	Leptomonas seymouri	38%	97%
A0A3Q8IG78	Leishmania donovani	70%	99%
A4IB90	Leishmania infantum	70%	99%
E9AF14	Leishmania major	70%	100%
E9B670	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%