Putative 60S ribosomal protein L5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L5, putative

Species:

Leishmania braziliensis

UniProt:

A4HMK9_LEIBR

TriTrypDb:

LbrM.34.1790 , LBRM2903_340024400

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005737	cytoplasm	2	12
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A4HMK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK9

PDB structure(s): 6az3_O

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0000027	ribosomal large subunit assembly	7	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0008097	5S rRNA binding	6	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.587
CLV_NRD_NRD_1	107	109	PF00675	0.303
CLV_NRD_NRD_1	23	25	PF00675	0.334
CLV_NRD_NRD_1	33	35	PF00675	0.334
CLV_PCSK_FUR_1	21	25	PF00082	0.334
CLV_PCSK_KEX2_1	107	109	PF00082	0.303
CLV_PCSK_KEX2_1	14	16	PF00082	0.334
CLV_PCSK_KEX2_1	21	23	PF00082	0.334
CLV_PCSK_KEX2_1	288	290	PF00082	0.390
CLV_PCSK_KEX2_1	33	35	PF00082	0.334
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.334
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.401
CLV_PCSK_SKI1_1	149	153	PF00082	0.293
CLV_PCSK_SKI1_1	193	197	PF00082	0.449
CLV_PCSK_SKI1_1	215	219	PF00082	0.541
CLV_PCSK_SKI1_1	266	270	PF00082	0.324
CLV_PCSK_SKI1_1	5	9	PF00082	0.496
DEG_APCC_DBOX_1	106	114	PF00400	0.503
DEG_SPOP_SBC_1	157	161	PF00917	0.503
DOC_MAPK_gen_1	107	115	PF00069	0.503
DOC_MAPK_MEF2A_6	149	156	PF00069	0.503
DOC_PP1_RVXF_1	226	233	PF00149	0.596
DOC_PP4_FxxP_1	44	47	PF00568	0.517
DOC_SPAK_OSR1_1	15	19	PF12202	0.534
DOC_USP7_MATH_1	125	129	PF00917	0.556
DOC_USP7_MATH_1	258	262	PF00917	0.588
DOC_USP7_UBL2_3	10	14	PF12436	0.487
DOC_USP7_UBL2_3	262	266	PF12436	0.517
DOC_USP7_UBL2_3	270	274	PF12436	0.517
DOC_WW_Pin1_4	43	48	PF00397	0.517
LIG_14-3-3_CanoR_1	107	111	PF00244	0.556
LIG_14-3-3_CanoR_1	158	166	PF00244	0.501
LIG_eIF4E_1	99	105	PF01652	0.503
LIG_FHA_1	99	105	PF00498	0.500
LIG_FHA_2	132	138	PF00498	0.503
LIG_FHA_2	54	60	PF00498	0.517
LIG_LIR_Apic_2	42	47	PF02991	0.517
LIG_LIR_Nem_3	126	132	PF02991	0.511
LIG_LIR_Nem_3	46	52	PF02991	0.517
LIG_PTB_Apo_2	6	13	PF02174	0.486
LIG_PTB_Phospho_1	6	12	PF10480	0.486
LIG_SH2_CRK	129	133	PF00017	0.503
LIG_SH2_CRK	49	53	PF00017	0.517
LIG_SH2_NCK_1	95	99	PF00017	0.503
LIG_SH2_STAP1	79	83	PF00017	0.491
LIG_SH2_STAP1	95	99	PF00017	0.503
LIG_SH2_STAT3	213	216	PF00017	0.468
LIG_SH2_STAT5	12	15	PF00017	0.529
LIG_SH2_STAT5	213	216	PF00017	0.468
LIG_SH3_2	180	185	PF14604	0.606
LIG_SH3_3	177	183	PF00018	0.517
LIG_UBA3_1	60	68	PF00899	0.482
MOD_CDK_SPK_2	43	48	PF00069	0.374
MOD_CDK_SPxxK_3	43	50	PF00069	0.374
MOD_CK1_1	277	283	PF00069	0.466
MOD_CK2_1	281	287	PF00069	0.392
MOD_GlcNHglycan	129	132	PF01048	0.468
MOD_GlcNHglycan	192	196	PF01048	0.492
MOD_GlcNHglycan	283	286	PF01048	0.482
MOD_GSK3_1	127	134	PF00069	0.409
MOD_GSK3_1	187	194	PF00069	0.368
MOD_GSK3_1	277	284	PF00069	0.354
MOD_GSK3_1	39	46	PF00069	0.374
MOD_NEK2_1	156	161	PF00069	0.342
MOD_PKA_1	281	287	PF00069	0.465
MOD_PKA_2	106	112	PF00069	0.428
MOD_PKA_2	157	163	PF00069	0.352
MOD_PKA_2	53	59	PF00069	0.374
MOD_Plk_1	191	197	PF00069	0.613
MOD_ProDKin_1	43	49	PF00069	0.374
MOD_SUMO_for_1	217	220	PF00179	0.537
MOD_SUMO_for_1	268	271	PF00179	0.417
MOD_SUMO_rev_2	192	200	PF00179	0.605
MOD_SUMO_rev_2	220	230	PF00179	0.545
MOD_SUMO_rev_2	233	241	PF00179	0.482
TRG_ENDOCYTIC_2	129	132	PF00928	0.354
TRG_ENDOCYTIC_2	49	52	PF00928	0.374
TRG_ER_diArg_1	20	23	PF00400	0.397
TRG_NLS_Bipartite_1	250	270	PF00514	0.374
TRG_NLS_MonoExtC_3	265	270	PF00514	0.387
TRG_NLS_MonoExtN_4	265	270	PF00514	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P958	Leptomonas seymouri	91%	100%
A0A0S4JJ00	Bodo saltans	80%	100%
A0A1X0P669	Trypanosomatidae	82%	99%
A0A3Q8IJC5	Leishmania donovani	95%	100%
A1RVN4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	35%	100%
A2BMD8	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	34%	100%
A2WXX3	Oryza sativa subsp. indica	51%	100%
A3MSJ3	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	36%	100%
A4IB88	Leishmania infantum	95%	100%
A4WMD6	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	36%	100%
A8AC01	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	31%	100%
A8M9I3	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	37%	100%
B1Y8V2	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	36%	100%
C9ZZL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	99%
E9AF09	Leishmania major	95%	100%
E9AF10	Leishmania major	95%	100%
E9B665	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O22608	Dunaliella salina	49%	100%
O44248	Anopheles gambiae	54%	94%
O59953	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	100%
O65353	Helianthus annuus	51%	100%
O74306	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O76190	Bombyx mori	51%	100%
P09895	Rattus norvegicus	55%	100%
P15125	Xenopus laevis	55%	100%
P15126	Xenopus laevis	55%	100%
P22451	Gallus gallus	56%	100%
P26321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P46777	Homo sapiens	56%	100%
P47962	Mus musculus	55%	100%
P49227	Arabidopsis thaliana	53%	100%
P49405	Caenorhabditis elegans	52%	100%
P52822	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q0JGY1	Oryza sativa subsp. japonica	51%	100%
Q18GG8	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	30%	100%
Q1HQU2	Aedes aegypti	54%	100%
Q231U7	Tetrahymena thermophila (strain SB210)	49%	100%
Q26481	Styela clava	54%	100%
Q4KTI3	Suberites domuncula	54%	100%
Q4N655	Theileria parva	52%	100%
Q4R5M0	Macaca fascicularis	55%	100%
Q4UDE7	Theileria annulata	52%	100%
Q54XX3	Dictyostelium discoideum	55%	100%
Q56FG6	Lysiphlebus testaceipes	50%	100%
Q58DW5	Bos taurus	56%	100%
Q5AGZ7	Candida albicans (strain SC5314 / ATCC MYA-2876)	52%	100%
Q5EY89	Eimeria tenella	52%	98%
Q5XUC7	Toxoptera citricida	50%	100%
Q627R7	Caenorhabditis briggsae	53%	100%
Q6JWW5	Oikopleura dioica	50%	100%
Q6UNT2	Cucumis sativus	51%	100%
Q8L4L4	Oryza sativa subsp. japonica	52%	100%
Q8LBI1	Arabidopsis thaliana	53%	100%
Q8ZVV7	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	39%	100%
Q9W5R8	Drosophila melanogaster	51%	100%
Q9YF94	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%
V5BHY0	Trypanosoma cruzi	76%	100%