Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMK8_LEIBR

TriTrypDb:

LbrM.34.1780 , LBRM2903_340024100 , LBRM2903_340024200

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.704
CLV_NRD_NRD_1	181	183	PF00675	0.530
CLV_NRD_NRD_1	292	294	PF00675	0.634
CLV_NRD_NRD_1	441	443	PF00675	0.654
CLV_NRD_NRD_1	559	561	PF00675	0.774
CLV_NRD_NRD_1	636	638	PF00675	0.684
CLV_NRD_NRD_1	680	682	PF00675	0.511
CLV_NRD_NRD_1	726	728	PF00675	0.585
CLV_PCSK_FUR_1	557	561	PF00082	0.673
CLV_PCSK_KEX2_1	181	183	PF00082	0.530
CLV_PCSK_KEX2_1	292	294	PF00082	0.634
CLV_PCSK_KEX2_1	441	443	PF00082	0.650
CLV_PCSK_KEX2_1	559	561	PF00082	0.774
CLV_PCSK_KEX2_1	569	571	PF00082	0.604
CLV_PCSK_KEX2_1	636	638	PF00082	0.684
CLV_PCSK_KEX2_1	680	682	PF00082	0.511
CLV_PCSK_KEX2_1	726	728	PF00082	0.585
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.619
CLV_PCSK_PC7_1	177	183	PF00082	0.533
CLV_PCSK_PC7_1	565	571	PF00082	0.668
CLV_PCSK_SKI1_1	17	21	PF00082	0.409
CLV_PCSK_SKI1_1	514	518	PF00082	0.509
CLV_PCSK_SKI1_1	569	573	PF00082	0.534
CLV_PCSK_SKI1_1	606	610	PF00082	0.736
CLV_PCSK_SKI1_1	91	95	PF00082	0.676
DEG_APCC_KENBOX_2	84	88	PF00400	0.537
DEG_COP1_1	641	650	PF00400	0.524
DEG_Nend_Nbox_1	1	3	PF02207	0.655
DEG_SCF_TRCP1_1	421	426	PF00400	0.543
DEG_SPOP_SBC_1	279	283	PF00917	0.530
DOC_CYCLIN_RxL_1	510	521	PF00134	0.359
DOC_CYCLIN_RxL_1	565	576	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.663
DOC_MAPK_DCC_7	181	189	PF00069	0.525
DOC_MAPK_gen_1	181	189	PF00069	0.525
DOC_MAPK_HePTP_8	179	191	PF00069	0.526
DOC_MAPK_MEF2A_6	182	191	PF00069	0.525
DOC_MAPK_MEF2A_6	249	257	PF00069	0.520
DOC_MAPK_MEF2A_6	713	721	PF00069	0.504
DOC_PP1_RVXF_1	111	118	PF00149	0.434
DOC_PP2B_LxvP_1	98	101	PF13499	0.683
DOC_PP4_FxxP_1	343	346	PF00568	0.537
DOC_SPAK_OSR1_1	489	493	PF12202	0.540
DOC_USP7_MATH_1	150	154	PF00917	0.523
DOC_USP7_MATH_1	162	166	PF00917	0.513
DOC_USP7_MATH_1	235	239	PF00917	0.688
DOC_USP7_MATH_1	256	260	PF00917	0.526
DOC_USP7_MATH_1	299	303	PF00917	0.533
DOC_USP7_MATH_1	351	355	PF00917	0.629
DOC_USP7_MATH_1	417	421	PF00917	0.625
DOC_USP7_MATH_1	539	543	PF00917	0.664
DOC_USP7_MATH_1	590	594	PF00917	0.647
DOC_USP7_MATH_1	628	632	PF00917	0.683
DOC_USP7_MATH_1	650	654	PF00917	0.663
DOC_WW_Pin1_4	169	174	PF00397	0.607
DOC_WW_Pin1_4	239	244	PF00397	0.747
DOC_WW_Pin1_4	249	254	PF00397	0.686
DOC_WW_Pin1_4	484	489	PF00397	0.425
DOC_WW_Pin1_4	520	525	PF00397	0.528
LIG_14-3-3_CanoR_1	142	150	PF00244	0.485
LIG_14-3-3_CanoR_1	158	162	PF00244	0.644
LIG_14-3-3_CanoR_1	169	173	PF00244	0.646
LIG_14-3-3_CanoR_1	278	285	PF00244	0.576
LIG_14-3-3_CanoR_1	298	308	PF00244	0.575
LIG_14-3-3_CanoR_1	424	428	PF00244	0.620
LIG_14-3-3_CanoR_1	519	523	PF00244	0.442
LIG_14-3-3_CanoR_1	565	572	PF00244	0.602
LIG_14-3-3_CanoR_1	606	611	PF00244	0.568
LIG_14-3-3_CanoR_1	637	643	PF00244	0.602
LIG_14-3-3_CanoR_1	680	689	PF00244	0.529
LIG_Actin_WH2_2	303	319	PF00022	0.481
LIG_APCC_ABBA_1	490	495	PF00400	0.517
LIG_APCC_ABBAyCdc20_2	489	495	PF00400	0.524
LIG_BIR_III_2	330	334	PF00653	0.460
LIG_BIR_III_4	437	441	PF00653	0.540
LIG_BRCT_BRCA1_1	411	415	PF00533	0.513
LIG_BRCT_BRCA1_1	486	490	PF00533	0.488
LIG_BRCT_BRCA1_1	593	597	PF00533	0.486
LIG_CtBP_PxDLS_1	623	627	PF00389	0.661
LIG_eIF4E_1	401	407	PF01652	0.640
LIG_eIF4E_1	512	518	PF01652	0.517
LIG_FHA_1	121	127	PF00498	0.411
LIG_FHA_1	169	175	PF00498	0.560
LIG_FHA_1	212	218	PF00498	0.694
LIG_FHA_1	240	246	PF00498	0.755
LIG_FHA_1	33	39	PF00498	0.675
LIG_FHA_1	345	351	PF00498	0.586
LIG_FHA_1	381	387	PF00498	0.574
LIG_FHA_1	390	396	PF00498	0.547
LIG_FHA_1	58	64	PF00498	0.501
LIG_FHA_1	686	692	PF00498	0.502
LIG_FHA_1	704	710	PF00498	0.512
LIG_FHA_2	149	155	PF00498	0.524
LIG_FHA_2	432	438	PF00498	0.703
LIG_FHA_2	671	677	PF00498	0.518
LIG_FHA_2	680	686	PF00498	0.540
LIG_LIR_Apic_2	341	346	PF02991	0.535
LIG_LIR_Gen_1	136	145	PF02991	0.582
LIG_LIR_Gen_1	306	316	PF02991	0.469
LIG_LIR_Gen_1	487	498	PF02991	0.358
LIG_LIR_Nem_3	136	141	PF02991	0.572
LIG_LIR_Nem_3	251	257	PF02991	0.517
LIG_LIR_Nem_3	306	311	PF02991	0.476
LIG_LIR_Nem_3	457	462	PF02991	0.573
LIG_LIR_Nem_3	487	493	PF02991	0.383
LIG_NRBOX	114	120	PF00104	0.425
LIG_PDZ_Class_1	731	736	PF00595	0.515
LIG_SH2_CRK	459	463	PF00017	0.527
LIG_SH2_GRB2like	73	76	PF00017	0.522
LIG_SH2_STAP1	512	516	PF00017	0.523
LIG_SH2_STAT3	512	515	PF00017	0.527
LIG_SH2_STAT5	533	536	PF00017	0.679
LIG_SH2_STAT5	671	674	PF00017	0.637
LIG_SH2_STAT5	73	76	PF00017	0.522
LIG_SH3_3	180	186	PF00018	0.521
LIG_SH3_3	250	256	PF00018	0.693
LIG_SH3_3	459	465	PF00018	0.420
LIG_SH3_3	482	488	PF00018	0.607
LIG_SH3_3	50	56	PF00018	0.687
LIG_SH3_3	593	599	PF00018	0.651
LIG_Sin3_3	308	315	PF02671	0.454
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.408
LIG_SUMO_SIM_anti_2	500	506	PF11976	0.312
LIG_SUMO_SIM_anti_2	704	711	PF11976	0.528
LIG_SUMO_SIM_par_1	256	262	PF11976	0.528
LIG_SUMO_SIM_par_1	704	711	PF11976	0.535
LIG_WRC_WIRS_1	304	309	PF05994	0.471
MOD_CDK_SPK_2	484	489	PF00069	0.425
MOD_CK1_1	108	114	PF00069	0.528
MOD_CK1_1	208	214	PF00069	0.531
MOD_CK1_1	229	235	PF00069	0.542
MOD_CK1_1	259	265	PF00069	0.661
MOD_CK1_1	277	283	PF00069	0.536
MOD_CK1_1	306	312	PF00069	0.471
MOD_CK1_1	319	325	PF00069	0.320
MOD_CK1_1	32	38	PF00069	0.719
MOD_CK1_1	377	383	PF00069	0.589
MOD_CK1_1	402	408	PF00069	0.645
MOD_CK1_1	426	432	PF00069	0.539
MOD_CK1_1	483	489	PF00069	0.432
MOD_CK1_1	564	570	PF00069	0.638
MOD_CK1_1	630	636	PF00069	0.654
MOD_CK1_1	653	659	PF00069	0.527
MOD_CK2_1	148	154	PF00069	0.532
MOD_CK2_1	670	676	PF00069	0.551
MOD_CK2_1	679	685	PF00069	0.543
MOD_Cter_Amidation	439	442	PF01082	0.565
MOD_GlcNHglycan	145	148	PF01048	0.624
MOD_GlcNHglycan	207	210	PF01048	0.693
MOD_GlcNHglycan	237	240	PF01048	0.564
MOD_GlcNHglycan	282	285	PF01048	0.682
MOD_GlcNHglycan	318	321	PF01048	0.452
MOD_GlcNHglycan	353	356	PF01048	0.698
MOD_GlcNHglycan	358	361	PF01048	0.620
MOD_GlcNHglycan	411	414	PF01048	0.656
MOD_GlcNHglycan	421	424	PF01048	0.632
MOD_GlcNHglycan	542	545	PF01048	0.706
MOD_GlcNHglycan	575	578	PF01048	0.641
MOD_GlcNHglycan	582	585	PF01048	0.722
MOD_GlcNHglycan	642	645	PF01048	0.683
MOD_GlcNHglycan	652	655	PF01048	0.593
MOD_GlcNHglycan	733	736	PF01048	0.523
MOD_GlcNHglycan	78	82	PF01048	0.716
MOD_GSK3_1	169	176	PF00069	0.625
MOD_GSK3_1	235	242	PF00069	0.679
MOD_GSK3_1	25	32	PF00069	0.708
MOD_GSK3_1	274	281	PF00069	0.713
MOD_GSK3_1	299	306	PF00069	0.496
MOD_GSK3_1	377	384	PF00069	0.597
MOD_GSK3_1	385	392	PF00069	0.515
MOD_GSK3_1	419	426	PF00069	0.681
MOD_GSK3_1	429	436	PF00069	0.592
MOD_GSK3_1	44	51	PF00069	0.520
MOD_GSK3_1	480	487	PF00069	0.449
MOD_GSK3_1	518	525	PF00069	0.364
MOD_GSK3_1	561	568	PF00069	0.686
MOD_GSK3_1	602	609	PF00069	0.747
MOD_GSK3_1	627	634	PF00069	0.684
MOD_GSK3_1	649	656	PF00069	0.513
MOD_GSK3_1	670	677	PF00069	0.520
MOD_GSK3_1	679	686	PF00069	0.642
MOD_GSK3_1	73	80	PF00069	0.609
MOD_N-GLC_1	229	234	PF02516	0.545
MOD_N-GLC_1	444	449	PF02516	0.528
MOD_N-GLC_1	728	733	PF02516	0.477
MOD_N-GLC_1	81	86	PF02516	0.538
MOD_NEK2_1	316	321	PF00069	0.492
MOD_NEK2_1	409	414	PF00069	0.510
MOD_NEK2_1	518	523	PF00069	0.367
MOD_NEK2_1	604	609	PF00069	0.681
MOD_NEK2_2	339	344	PF00069	0.532
MOD_NEK2_2	488	493	PF00069	0.541
MOD_PIKK_1	120	126	PF00454	0.412
MOD_PKA_2	157	163	PF00069	0.566
MOD_PKA_2	168	174	PF00069	0.622
MOD_PKA_2	277	283	PF00069	0.555
MOD_PKA_2	316	322	PF00069	0.587
MOD_PKA_2	423	429	PF00069	0.604
MOD_PKA_2	488	494	PF00069	0.531
MOD_PKA_2	518	524	PF00069	0.361
MOD_PKA_2	564	570	PF00069	0.608
MOD_PKA_2	679	685	PF00069	0.624
MOD_Plk_1	105	111	PF00069	0.511
MOD_Plk_1	402	408	PF00069	0.645
MOD_Plk_1	703	709	PF00069	0.536
MOD_Plk_4	191	197	PF00069	0.528
MOD_Plk_4	303	309	PF00069	0.600
MOD_Plk_4	339	345	PF00069	0.532
MOD_Plk_4	386	392	PF00069	0.595
MOD_Plk_4	402	408	PF00069	0.479
MOD_Plk_4	423	429	PF00069	0.540
MOD_Plk_4	48	54	PF00069	0.531
MOD_Plk_4	551	557	PF00069	0.538
MOD_Plk_4	591	597	PF00069	0.517
MOD_Plk_4	606	612	PF00069	0.657
MOD_Plk_4	674	680	PF00069	0.525
MOD_ProDKin_1	169	175	PF00069	0.608
MOD_ProDKin_1	239	245	PF00069	0.748
MOD_ProDKin_1	249	255	PF00069	0.684
MOD_ProDKin_1	484	490	PF00069	0.411
MOD_ProDKin_1	520	526	PF00069	0.526
MOD_SUMO_rev_2	194	202	PF00179	0.535
MOD_SUMO_rev_2	705	714	PF00179	0.465
TRG_DiLeu_BaEn_1	513	518	PF01217	0.436
TRG_DiLeu_BaEn_1	705	710	PF01217	0.470
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.624
TRG_ENDOCYTIC_2	138	141	PF00928	0.572
TRG_ENDOCYTIC_2	459	462	PF00928	0.533
TRG_ER_diArg_1	181	183	PF00400	0.530
TRG_ER_diArg_1	292	294	PF00400	0.571
TRG_ER_diArg_1	441	443	PF00400	0.699
TRG_ER_diArg_1	679	681	PF00400	0.535
TRG_NES_CRM1_1	303	313	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	681	685	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II80	Leishmania donovani	70%	100%
A4IB87	Leishmania infantum	70%	100%
E9AF08	Leishmania major	68%	100%
E9B664	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%