Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HMK7_LEIBR

TriTrypDb:

LbrM.34.1770 , LBRM2903_340024000

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.490
CLV_C14_Caspase3-7	566	570	PF00656	0.729
CLV_NRD_NRD_1	168	170	PF00675	0.640
CLV_NRD_NRD_1	314	316	PF00675	0.478
CLV_NRD_NRD_1	43	45	PF00675	0.590
CLV_NRD_NRD_1	481	483	PF00675	0.383
CLV_PCSK_KEX2_1	168	170	PF00082	0.649
CLV_PCSK_KEX2_1	43	45	PF00082	0.590
CLV_PCSK_KEX2_1	481	483	PF00082	0.383
CLV_PCSK_KEX2_1	499	501	PF00082	0.383
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.383
CLV_PCSK_SKI1_1	184	188	PF00082	0.620
CLV_PCSK_SKI1_1	272	276	PF00082	0.350
CLV_PCSK_SKI1_1	408	412	PF00082	0.383
CLV_Separin_Metazoa	244	248	PF03568	0.231
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DEG_SCF_FBW7_1	146	151	PF00400	0.798
DOC_CKS1_1	162	167	PF01111	0.695
DOC_CYCLIN_RxL_1	528	536	PF00134	0.431
DOC_MAPK_DCC_7	195	203	PF00069	0.493
DOC_MAPK_gen_1	264	273	PF00069	0.392
DOC_MAPK_gen_1	315	322	PF00069	0.481
DOC_MAPK_gen_1	417	426	PF00069	0.383
DOC_MAPK_gen_1	43	49	PF00069	0.520
DOC_MAPK_HePTP_8	261	273	PF00069	0.481
DOC_MAPK_HePTP_8	414	426	PF00069	0.383
DOC_MAPK_MEF2A_6	195	203	PF00069	0.493
DOC_MAPK_MEF2A_6	264	273	PF00069	0.329
DOC_MAPK_MEF2A_6	417	426	PF00069	0.383
DOC_PP1_RVXF_1	394	401	PF00149	0.383
DOC_PP2B_LxvP_1	426	429	PF13499	0.383
DOC_PP2B_PxIxI_1	86	92	PF00149	0.527
DOC_USP7_MATH_1	48	52	PF00917	0.656
DOC_USP7_MATH_1	67	71	PF00917	0.747
DOC_WW_Pin1_4	144	149	PF00397	0.800
DOC_WW_Pin1_4	161	166	PF00397	0.543
DOC_WW_Pin1_4	174	179	PF00397	0.671
DOC_WW_Pin1_4	539	544	PF00397	0.383
DOC_WW_Pin1_4	83	88	PF00397	0.523
LIG_14-3-3_CanoR_1	184	190	PF00244	0.469
LIG_14-3-3_CanoR_1	408	414	PF00244	0.383
LIG_14-3-3_CanoR_1	43	49	PF00244	0.520
LIG_BRCT_BRCA1_1	181	185	PF00533	0.663
LIG_BRCT_BRCA1_1	199	203	PF00533	0.291
LIG_BRCT_BRCA1_1	310	314	PF00533	0.383
LIG_BRCT_BRCA1_1	341	345	PF00533	0.383
LIG_BRCT_BRCA1_1	389	393	PF00533	0.431
LIG_BRCT_BRCA1_2	310	316	PF00533	0.431
LIG_CtBP_PxDLS_1	180	184	PF00389	0.672
LIG_deltaCOP1_diTrp_1	435	439	PF00928	0.383
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.383
LIG_EVH1_1	81	85	PF00568	0.526
LIG_FHA_1	127	133	PF00498	0.620
LIG_FHA_1	145	151	PF00498	0.781
LIG_FHA_1	162	168	PF00498	0.546
LIG_FHA_1	251	257	PF00498	0.383
LIG_FHA_1	288	294	PF00498	0.383
LIG_FHA_1	353	359	PF00498	0.383
LIG_FHA_1	429	435	PF00498	0.383
LIG_FHA_1	469	475	PF00498	0.231
LIG_FHA_1	562	568	PF00498	0.721
LIG_FHA_1	58	64	PF00498	0.753
LIG_FHA_2	137	143	PF00498	0.534
LIG_FHA_2	185	191	PF00498	0.600
LIG_FHA_2	430	436	PF00498	0.481
LIG_FHA_2	543	549	PF00498	0.377
LIG_HCF-1_HBM_1	262	265	PF13415	0.281
LIG_Integrin_RGD_1	169	171	PF01839	0.556
LIG_LIR_Apic_2	416	422	PF02991	0.383
LIG_LIR_Apic_2	78	84	PF02991	0.785
LIG_LIR_Gen_1	262	273	PF02991	0.445
LIG_LIR_Gen_1	327	338	PF02991	0.383
LIG_LIR_Gen_1	522	533	PF02991	0.383
LIG_LIR_Nem_3	103	109	PF02991	0.740
LIG_LIR_Nem_3	253	257	PF02991	0.383
LIG_LIR_Nem_3	262	268	PF02991	0.364
LIG_LIR_Nem_3	327	333	PF02991	0.383
LIG_LIR_Nem_3	438	442	PF02991	0.383
LIG_LIR_Nem_3	467	472	PF02991	0.387
LIG_LIR_Nem_3	522	528	PF02991	0.383
LIG_LIR_Nem_3	548	554	PF02991	0.383
LIG_MAD2	364	372	PF02301	0.431
LIG_MLH1_MIPbox_1	199	203	PF16413	0.584
LIG_PDZ_Class_2	571	576	PF00595	0.477
LIG_SH2_CRK	106	110	PF00017	0.724
LIG_SH2_CRK	231	235	PF00017	0.421
LIG_SH2_CRK	265	269	PF00017	0.445
LIG_SH2_CRK	330	334	PF00017	0.383
LIG_SH2_NCK_1	330	334	PF00017	0.383
LIG_SH2_PTP2	318	321	PF00017	0.481
LIG_SH2_SRC	197	200	PF00017	0.546
LIG_SH2_SRC	330	333	PF00017	0.481
LIG_SH2_STAP1	280	284	PF00017	0.324
LIG_SH2_STAP1	430	434	PF00017	0.383
LIG_SH2_STAT3	280	283	PF00017	0.383
LIG_SH2_STAT5	197	200	PF00017	0.502
LIG_SH2_STAT5	202	205	PF00017	0.416
LIG_SH2_STAT5	280	283	PF00017	0.383
LIG_SH2_STAT5	318	321	PF00017	0.383
LIG_SH2_STAT5	413	416	PF00017	0.383
LIG_SH2_STAT5	430	433	PF00017	0.383
LIG_SH2_STAT5	468	471	PF00017	0.383
LIG_SH2_STAT5	475	478	PF00017	0.383
LIG_SH3_1	499	505	PF00018	0.387
LIG_SH3_1	81	87	PF00018	0.774
LIG_SH3_3	159	165	PF00018	0.696
LIG_SH3_3	175	181	PF00018	0.589
LIG_SH3_3	448	454	PF00018	0.383
LIG_SH3_3	499	505	PF00018	0.387
LIG_SH3_3	61	67	PF00018	0.789
LIG_SH3_3	79	85	PF00018	0.490
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.537
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.481
LIG_TRAF2_1	188	191	PF00917	0.478
LIG_TRAF2_1	284	287	PF00917	0.383
LIG_TRAF2_1	403	406	PF00917	0.383
LIG_TRFH_1	322	326	PF08558	0.383
LIG_WRC_WIRS_1	436	441	PF05994	0.383
MOD_CDK_SPxxK_3	161	168	PF00069	0.544
MOD_CK1_1	51	57	PF00069	0.530
MOD_CK1_1	558	564	PF00069	0.584
MOD_CK1_1	568	574	PF00069	0.653
MOD_CK1_1	69	75	PF00069	0.476
MOD_CK2_1	184	190	PF00069	0.596
MOD_CK2_1	399	405	PF00069	0.488
MOD_CK2_1	542	548	PF00069	0.231
MOD_Cter_Amidation	479	482	PF01082	0.370
MOD_Cter_Amidation	496	499	PF01082	0.370
MOD_GlcNHglycan	102	105	PF01048	0.765
MOD_GlcNHglycan	379	382	PF01048	0.231
MOD_GlcNHglycan	389	392	PF01048	0.388
MOD_GlcNHglycan	401	404	PF01048	0.371
MOD_GlcNHglycan	53	56	PF01048	0.746
MOD_GlcNHglycan	557	560	PF01048	0.537
MOD_GlcNHglycan	69	72	PF01048	0.495
MOD_GSK3_1	142	149	PF00069	0.801
MOD_GSK3_1	17	24	PF00069	0.611
MOD_GSK3_1	377	384	PF00069	0.416
MOD_GSK3_1	387	394	PF00069	0.383
MOD_GSK3_1	409	416	PF00069	0.383
MOD_GSK3_1	5	12	PF00069	0.784
MOD_GSK3_1	557	564	PF00069	0.665
MOD_GSK3_1	568	575	PF00069	0.539
MOD_GSK3_1	62	69	PF00069	0.792
MOD_GSK3_1	89	96	PF00069	0.584
MOD_N-GLC_1	17	22	PF02516	0.664
MOD_N-GLC_1	278	283	PF02516	0.383
MOD_N-GLC_2	158	160	PF02516	0.698
MOD_NEK2_1	308	313	PF00069	0.383
MOD_NEK2_1	567	572	PF00069	0.731
MOD_NEK2_1	93	98	PF00069	0.627
MOD_NEK2_2	21	26	PF00069	0.531
MOD_NEK2_2	391	396	PF00069	0.261
MOD_PKA_2	215	221	PF00069	0.521
MOD_PKA_2	42	48	PF00069	0.519
MOD_PKA_2	5	11	PF00069	0.530
MOD_PKA_2	555	561	PF00069	0.625
MOD_PKA_2	67	73	PF00069	0.649
MOD_Plk_1	391	397	PF00069	0.383
MOD_Plk_2-3	136	142	PF00069	0.533
MOD_Plk_2-3	287	293	PF00069	0.481
MOD_Plk_4	128	134	PF00069	0.536
MOD_Plk_4	197	203	PF00069	0.585
MOD_Plk_4	93	99	PF00069	0.540
MOD_ProDKin_1	144	150	PF00069	0.800
MOD_ProDKin_1	161	167	PF00069	0.544
MOD_ProDKin_1	174	180	PF00069	0.659
MOD_ProDKin_1	539	545	PF00069	0.383
MOD_ProDKin_1	83	89	PF00069	0.525
MOD_SUMO_for_1	370	373	PF00179	0.383
TRG_DiLeu_BaEn_4	286	292	PF01217	0.383
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.481
TRG_ENDOCYTIC_2	106	109	PF00928	0.746
TRG_ENDOCYTIC_2	231	234	PF00928	0.415
TRG_ENDOCYTIC_2	243	246	PF00928	0.270
TRG_ENDOCYTIC_2	265	268	PF00928	0.445
TRG_ENDOCYTIC_2	318	321	PF00928	0.383
TRG_ENDOCYTIC_2	330	333	PF00928	0.383
TRG_ENDOCYTIC_2	450	453	PF00928	0.383
TRG_ER_diArg_1	167	169	PF00400	0.553
TRG_ER_diArg_1	538	541	PF00400	0.481
TRG_NLS_Bipartite_1	481	502	PF00514	0.383
TRG_NLS_MonoExtC_3	497	502	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	74%	80%
A0A0S4IIU2	Bodo saltans	36%	100%
A0A0S4IL53	Bodo saltans	26%	85%
A0A3Q8IB74	Leishmania donovani	28%	100%
A0A3Q8IC55	Leishmania donovani	30%	100%
A0A3Q8IVR8	Leishmania donovani	34%	100%
A0A3S5H6C8	Leishmania donovani	27%	100%
A0A3S5H7N7	Leishmania donovani	27%	100%
A0A3S7WQK7	Leishmania donovani	27%	100%
A0A3S7WR45	Leishmania donovani	26%	100%
A0A3S7X2Z6	Leishmania donovani	25%	100%
A0A3S7X9D1	Leishmania donovani	83%	100%
A0A3S7XA45	Leishmania donovani	31%	100%
A4H5L7	Leishmania braziliensis	27%	100%
A4H641	Leishmania braziliensis	25%	100%
A4H7F4	Leishmania braziliensis	26%	100%
A4H9X5	Leishmania braziliensis	28%	100%
A4HC27	Leishmania braziliensis	31%	100%
A4HIM5	Leishmania braziliensis	28%	100%
A4HLJ9	Leishmania braziliensis	27%	100%
A4HNG3	Leishmania braziliensis	31%	100%
A4HNT2	Leishmania braziliensis	33%	100%
A4HTV4	Leishmania infantum	27%	100%
A4HTV5	Leishmania infantum	27%	100%
A4HUG1	Leishmania infantum	26%	100%
A4HZH0	Leishmania infantum	30%	100%
A4I564	Leishmania infantum	25%	100%
A4I5X0	Leishmania infantum	27%	100%
A4IB86	Leishmania infantum	83%	100%
A4IC54	Leishmania infantum	31%	100%
A4ICR2	Leishmania infantum	34%	100%
A8WJR8	Caenorhabditis briggsae	40%	71%
C9ZRX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	68%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ACB1	Leishmania major	27%	100%
E9AF07	Leishmania major	82%	100%
E9AFX4	Leishmania major	31%	100%
E9AGS0	Leishmania infantum	28%	100%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B164	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O43781	Homo sapiens	38%	98%
P14680	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	71%
P83102	Drosophila melanogaster	38%	70%
Q45FA5	Physarum polycephalum	27%	100%
Q4Q204	Leishmania major	33%	100%
Q4Q701	Leishmania major	27%	100%
Q4Q7S2	Leishmania major	25%	100%
Q4QC19	Leishmania major	32%	100%
Q4QDK3	Leishmania major	28%	100%
Q4QFG6	Leishmania major	35%	100%
Q4QH69	Leishmania major	26%	100%
Q4QHG6	Leishmania major	26%	100%
Q4QHY3	Leishmania major	27%	100%
Q4QHY4	Leishmania major	27%	100%
Q4R6S5	Macaca fascicularis	40%	100%
Q4V8A3	Rattus norvegicus	42%	98%
Q5U4C9	Mus musculus	41%	96%
Q5ZIU3	Gallus gallus	41%	100%
Q922Y0	Mus musculus	42%	98%
Q92630	Homo sapiens	41%	96%
Q9V3D5	Drosophila melanogaster	39%	80%
Q9XTF3	Caenorhabditis elegans	39%	71%
V5AZ01	Trypanosoma cruzi	28%	74%
V5B8S3	Trypanosoma cruzi	38%	100%
V5DIC3	Trypanosoma cruzi	33%	95%