rRNA processing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic rRNA processing protein EBP2, putative

Species:

Leishmania braziliensis

UniProt:

A4HMK3_LEIBR

TriTrypDb:

LbrM.34.1730 , LBRM2903_340023600

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0034399	nuclear periphery	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HMK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.639
CLV_NRD_NRD_1	16	18	PF00675	0.465
CLV_NRD_NRD_1	185	187	PF00675	0.239
CLV_NRD_NRD_1	220	222	PF00675	0.257
CLV_NRD_NRD_1	224	226	PF00675	0.232
CLV_NRD_NRD_1	270	272	PF00675	0.517
CLV_NRD_NRD_1	8	10	PF00675	0.453
CLV_PCSK_FUR_1	221	225	PF00082	0.235
CLV_PCSK_KEX2_1	10	12	PF00082	0.450
CLV_PCSK_KEX2_1	121	123	PF00082	0.239
CLV_PCSK_KEX2_1	149	151	PF00082	0.239
CLV_PCSK_KEX2_1	16	18	PF00082	0.474
CLV_PCSK_KEX2_1	185	187	PF00082	0.239
CLV_PCSK_KEX2_1	210	212	PF00082	0.281
CLV_PCSK_KEX2_1	223	225	PF00082	0.251
CLV_PCSK_KEX2_1	244	246	PF00082	0.372
CLV_PCSK_KEX2_1	263	265	PF00082	0.246
CLV_PCSK_KEX2_1	270	272	PF00082	0.552
CLV_PCSK_KEX2_1	70	72	PF00082	0.479
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.450
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.239
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.257
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.239
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.239
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.301
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.259
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.479
CLV_PCSK_PC7_1	206	212	PF00082	0.239
CLV_PCSK_SKI1_1	101	105	PF00082	0.267
CLV_PCSK_SKI1_1	12	16	PF00082	0.505
CLV_PCSK_SKI1_1	186	190	PF00082	0.285
CLV_PCSK_SKI1_1	241	245	PF00082	0.372
CLV_Separin_Metazoa	201	205	PF03568	0.239
DEG_SPOP_SBC_1	103	107	PF00917	0.257
DOC_CKS1_1	249	254	PF01111	0.372
DOC_PP1_RVXF_1	87	93	PF00149	0.372
DOC_PP4_FxxP_1	92	95	PF00568	0.239
DOC_USP7_MATH_1	103	107	PF00917	0.241
DOC_USP7_MATH_1	63	67	PF00917	0.710
DOC_USP7_MATH_1	77	81	PF00917	0.568
DOC_USP7_UBL2_3	189	193	PF12436	0.239
DOC_USP7_UBL2_3	263	267	PF12436	0.317
DOC_WW_Pin1_4	248	253	PF00397	0.352
LIG_14-3-3_CanoR_1	101	111	PF00244	0.252
LIG_14-3-3_CanoR_1	136	141	PF00244	0.282
LIG_14-3-3_CanoR_1	185	189	PF00244	0.392
LIG_FHA_1	105	111	PF00498	0.257
LIG_FHA_2	185	191	PF00498	0.317
LIG_FHA_2	86	92	PF00498	0.336
LIG_LIR_Apic_2	91	95	PF02991	0.259
LIG_LIR_Gen_1	152	163	PF02991	0.290
LIG_NRP_CendR_1	270	273	PF00754	0.607
LIG_PCNA_yPIPBox_3	121	135	PF02747	0.205
LIG_PCNA_yPIPBox_3	221	234	PF02747	0.301
LIG_SH2_NCK_1	4	8	PF00017	0.474
LIG_SH2_SRC	4	7	PF00017	0.571
LIG_SH2_SRC	48	51	PF00017	0.596
LIG_SH2_STAP1	155	159	PF00017	0.251
LIG_SH2_STAT5	48	51	PF00017	0.596
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.257
LIG_TRAF2_1	51	54	PF00917	0.744
MOD_CDK_SPK_2	248	253	PF00069	0.317
MOD_CDK_SPxxK_3	248	255	PF00069	0.317
MOD_CK1_1	106	112	PF00069	0.260
MOD_CK1_1	66	72	PF00069	0.679
MOD_CK2_1	136	142	PF00069	0.257
MOD_CK2_1	184	190	PF00069	0.341
MOD_CK2_1	232	238	PF00069	0.193
MOD_CK2_1	29	35	PF00069	0.687
MOD_CK2_1	48	54	PF00069	0.477
MOD_CK2_1	85	91	PF00069	0.313
MOD_GlcNHglycan	65	68	PF01048	0.500
MOD_GlcNHglycan	79	82	PF01048	0.455
MOD_GSK3_1	102	109	PF00069	0.284
MOD_GSK3_1	77	84	PF00069	0.542
MOD_N-GLC_1	226	231	PF02516	0.439
MOD_NEK2_1	102	107	PF00069	0.239
MOD_NEK2_1	172	177	PF00069	0.282
MOD_NEK2_1	213	218	PF00069	0.372
MOD_PIKK_1	29	35	PF00454	0.591
MOD_PKA_2	184	190	PF00069	0.372
MOD_Plk_2-3	232	238	PF00069	0.165
MOD_Plk_4	127	133	PF00069	0.260
MOD_ProDKin_1	248	254	PF00069	0.352
MOD_SUMO_for_1	120	123	PF00179	0.239
MOD_SUMO_rev_2	236	246	PF00179	0.294
TRG_ENDOCYTIC_2	155	158	PF00928	0.251
TRG_ER_diArg_1	15	17	PF00400	0.598
TRG_ER_diArg_1	203	206	PF00400	0.269
TRG_ER_diArg_1	252	255	PF00400	0.372
TRG_ER_diArg_1	270	273	PF00400	0.576
TRG_NLS_Bipartite_1	210	227	PF00514	0.239
TRG_NLS_MonoCore_2	220	225	PF00514	0.241
TRG_NLS_MonoCore_2	8	13	PF00514	0.432
TRG_NLS_MonoExtC_3	220	225	PF00514	0.261
TRG_NLS_MonoExtN_4	221	227	PF00514	0.239
TRG_NLS_MonoExtN_4	241	248	PF00514	0.301
TRG_NLS_MonoExtN_4	9	14	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I326	Leptomonas seymouri	71%	100%
A0A0S4IQU9	Bodo saltans	58%	100%
A0A1X0P5U9	Trypanosomatidae	74%	100%
A0A3Q8IPE1	Leishmania donovani	88%	100%
A0A3R7KIH6	Trypanosoma rangeli	68%	100%
A4IB82	Leishmania infantum	88%	100%
C9ZZK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AF03	Leishmania major	86%	100%
E9B659	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q09958	Caenorhabditis elegans	30%	80%
Q9D903	Mus musculus	31%	89%