Trypanin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nexin-dynein regulatory complex 4

Species:

Leishmania braziliensis

UniProt:

A4HMK2_LEIBR

TriTrypDb:

LbrM.34.1720 , LBRM2903_340023500

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	11
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005794	Golgi apparatus	5	1
GO:0005874	microtubule	6	1
GO:0005930	axoneme	2	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1

Expansion

Sequence features

A4HMK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0048870	cell motility	2	12
GO:0051179	localization	1	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0008104	protein localization	4	1
GO:0033036	macromolecule localization	2	1
GO:0043393	regulation of protein binding	4	1
GO:0051098	regulation of binding	3	1
GO:0051641	cellular localization	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:1904526	regulation of microtubule binding	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.440
CLV_NRD_NRD_1	192	194	PF00675	0.450
CLV_NRD_NRD_1	202	204	PF00675	0.401
CLV_NRD_NRD_1	246	248	PF00675	0.206
CLV_NRD_NRD_1	346	348	PF00675	0.232
CLV_NRD_NRD_1	352	354	PF00675	0.212
CLV_PCSK_FUR_1	264	268	PF00082	0.293
CLV_PCSK_KEX2_1	248	250	PF00082	0.206
CLV_PCSK_KEX2_1	266	268	PF00082	0.206
CLV_PCSK_KEX2_1	300	302	PF00082	0.309
CLV_PCSK_KEX2_1	352	354	PF00082	0.219
CLV_PCSK_KEX2_1	379	381	PF00082	0.213
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.206
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.206
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.309
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.230
CLV_PCSK_SKI1_1	111	115	PF00082	0.442
CLV_PCSK_SKI1_1	150	154	PF00082	0.484
CLV_PCSK_SKI1_1	169	173	PF00082	0.268
CLV_PCSK_SKI1_1	217	221	PF00082	0.222
CLV_PCSK_SKI1_1	238	242	PF00082	0.242
CLV_PCSK_SKI1_1	266	270	PF00082	0.211
CLV_PCSK_SKI1_1	293	297	PF00082	0.169
CLV_PCSK_SKI1_1	301	305	PF00082	0.191
CLV_PCSK_SKI1_1	348	352	PF00082	0.210
CLV_PCSK_SKI1_1	370	374	PF00082	0.297
CLV_PCSK_SKI1_1	410	414	PF00082	0.425
CLV_PCSK_SKI1_1	84	88	PF00082	0.369
CLV_PCSK_SKI1_1	92	96	PF00082	0.341
DEG_Nend_UBRbox_3	1	3	PF02207	0.447
DEG_SCF_FBW7_1	440	446	PF00400	0.384
DEG_SPOP_SBC_1	443	447	PF00917	0.387
DOC_CKS1_1	440	445	PF01111	0.380
DOC_CYCLIN_RxL_1	144	157	PF00134	0.523
DOC_CYCLIN_RxL_1	352	365	PF00134	0.509
DOC_CYCLIN_RxL_1	88	97	PF00134	0.445
DOC_PP1_RVXF_1	45	52	PF00149	0.366
DOC_USP7_MATH_1	112	116	PF00917	0.565
DOC_USP7_MATH_1	122	126	PF00917	0.476
DOC_USP7_MATH_1	6	10	PF00917	0.664
DOC_USP7_UBL2_3	300	304	PF12436	0.485
DOC_USP7_UBL2_3	69	73	PF12436	0.512
DOC_USP7_UBL2_3	84	88	PF12436	0.310
DOC_WW_Pin1_4	439	444	PF00397	0.384
LIG_14-3-3_CanoR_1	111	120	PF00244	0.383
LIG_14-3-3_CanoR_1	150	160	PF00244	0.490
LIG_14-3-3_CanoR_1	267	271	PF00244	0.474
LIG_14-3-3_CanoR_1	347	355	PF00244	0.473
LIG_14-3-3_CanoR_1	415	424	PF00244	0.517
LIG_Actin_WH2_2	402	417	PF00022	0.507
LIG_FHA_1	26	32	PF00498	0.410
LIG_FHA_1	267	273	PF00498	0.410
LIG_FHA_1	323	329	PF00498	0.350
LIG_FHA_1	373	379	PF00498	0.438
LIG_FHA_2	102	108	PF00498	0.554
LIG_FHA_2	112	118	PF00498	0.479
LIG_FHA_2	152	158	PF00498	0.492
LIG_FHA_2	216	222	PF00498	0.416
LIG_FHA_2	237	243	PF00498	0.406
LIG_FHA_2	250	256	PF00498	0.406
LIG_FHA_2	304	310	PF00498	0.541
LIG_FHA_2	363	369	PF00498	0.473
LIG_FHA_2	403	409	PF00498	0.475
LIG_FHA_2	416	422	PF00498	0.490
LIG_FHA_2	8	14	PF00498	0.452
LIG_LIR_Gen_1	224	234	PF02991	0.390
LIG_LIR_Nem_3	216	222	PF02991	0.424
LIG_LIR_Nem_3	224	229	PF02991	0.386
LIG_LIR_Nem_3	349	354	PF02991	0.430
LIG_LIR_Nem_3	426	430	PF02991	0.485
LIG_NRBOX	373	379	PF00104	0.416
LIG_NRBOX	408	414	PF00104	0.533
LIG_PDZ_Class_2	449	454	PF00595	0.558
LIG_SH2_CRK	324	328	PF00017	0.547
LIG_SH2_GRB2like	96	99	PF00017	0.505
LIG_SH2_NCK_1	259	263	PF00017	0.509
LIG_SH2_STAP1	178	182	PF00017	0.404
LIG_SH2_STAP1	324	328	PF00017	0.509
LIG_SH2_STAP1	427	431	PF00017	0.380
LIG_SH2_STAP1	96	100	PF00017	0.357
LIG_SH2_STAT3	96	99	PF00017	0.360
LIG_SH2_STAT5	225	228	PF00017	0.528
LIG_SH2_STAT5	289	292	PF00017	0.473
LIG_SH2_STAT5	324	327	PF00017	0.452
LIG_SH2_STAT5	40	43	PF00017	0.370
LIG_SH3_3	11	17	PF00018	0.544
LIG_SH3_3	437	443	PF00018	0.499
LIG_TRAF2_1	115	118	PF00917	0.453
LIG_TRAF2_1	306	309	PF00917	0.484
LIG_TYR_ITIM	176	181	PF00017	0.514
LIG_UBA3_1	341	348	PF00899	0.406
MOD_CK1_1	227	233	PF00069	0.416
MOD_CK1_1	281	287	PF00069	0.365
MOD_CK1_1	9	15	PF00069	0.452
MOD_CK2_1	101	107	PF00069	0.430
MOD_CK2_1	111	117	PF00069	0.387
MOD_CK2_1	162	168	PF00069	0.532
MOD_CK2_1	181	187	PF00069	0.296
MOD_CK2_1	215	221	PF00069	0.416
MOD_CK2_1	249	255	PF00069	0.509
MOD_CK2_1	281	287	PF00069	0.397
MOD_CK2_1	288	294	PF00069	0.377
MOD_CK2_1	303	309	PF00069	0.522
MOD_CK2_1	415	421	PF00069	0.403
MOD_CK2_1	426	432	PF00069	0.500
MOD_CK2_1	52	58	PF00069	0.386
MOD_CK2_1	62	68	PF00069	0.450
MOD_CK2_1	7	13	PF00069	0.453
MOD_GlcNHglycan	348	351	PF01048	0.329
MOD_GlcNHglycan	436	439	PF01048	0.520
MOD_GSK3_1	211	218	PF00069	0.447
MOD_GSK3_1	224	231	PF00069	0.376
MOD_GSK3_1	274	281	PF00069	0.471
MOD_GSK3_1	299	306	PF00069	0.492
MOD_GSK3_1	439	446	PF00069	0.586
MOD_N-GLC_1	52	57	PF02516	0.496
MOD_NEK2_1	131	136	PF00069	0.514
MOD_NEK2_1	181	186	PF00069	0.531
MOD_NEK2_1	31	36	PF00069	0.456
MOD_NEK2_1	362	367	PF00069	0.440
MOD_NEK2_1	414	419	PF00069	0.436
MOD_PIKK_1	151	157	PF00454	0.523
MOD_PIKK_1	274	280	PF00454	0.350
MOD_PIKK_1	303	309	PF00454	0.452
MOD_PIKK_1	362	368	PF00454	0.416
MOD_PIKK_1	415	421	PF00454	0.415
MOD_PKA_1	247	253	PF00069	0.406
MOD_PKA_1	266	272	PF00069	0.406
MOD_PKA_2	131	137	PF00069	0.476
MOD_PKA_2	266	272	PF00069	0.509
MOD_PKA_2	322	328	PF00069	0.350
MOD_PKA_2	346	352	PF00069	0.509
MOD_PKA_2	414	420	PF00069	0.490
MOD_PKB_1	247	255	PF00069	0.503
MOD_Plk_1	215	221	PF00069	0.416
MOD_Plk_1	254	260	PF00069	0.350
MOD_Plk_1	402	408	PF00069	0.437
MOD_Plk_2-3	397	403	PF00069	0.454
MOD_Plk_4	426	432	PF00069	0.475
MOD_ProDKin_1	439	445	PF00069	0.380
MOD_SUMO_for_1	105	108	PF00179	0.480
MOD_SUMO_for_1	176	179	PF00179	0.340
MOD_SUMO_for_1	240	243	PF00179	0.406
MOD_SUMO_rev_2	165	174	PF00179	0.397
MOD_SUMO_rev_2	205	214	PF00179	0.304
MOD_SUMO_rev_2	294	302	PF00179	0.475
MOD_SUMO_rev_2	368	375	PF00179	0.505
MOD_SUMO_rev_2	386	395	PF00179	0.340
MOD_SUMO_rev_2	403	412	PF00179	0.509
TRG_DiLeu_BaEn_1	316	321	PF01217	0.489
TRG_ENDOCYTIC_2	178	181	PF00928	0.515
TRG_ENDOCYTIC_2	324	327	PF00928	0.482
TRG_ENDOCYTIC_2	338	341	PF00928	0.411
TRG_ENDOCYTIC_2	40	43	PF00928	0.370
TRG_ER_diArg_1	351	353	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.206
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.206
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.236
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE1	Leptomonas seymouri	81%	94%
A0A0N1HYA1	Leptomonas seymouri	31%	98%
A0A0S4IRB6	Bodo saltans	55%	99%
A0A0S4J2F6	Bodo saltans	27%	100%
A0A1X0P612	Trypanosomatidae	62%	96%
A0A1X0P7Y2	Trypanosomatidae	29%	100%
A0A3S5H7Z1	Leishmania donovani	89%	98%
A0A3S7XAT7	Leishmania donovani	31%	99%
A0A422MVC9	Trypanosoma rangeli	32%	100%
A0A422NNP7	Trypanosoma rangeli	60%	98%
A4HP56	Leishmania braziliensis	30%	99%
A4IB81	Leishmania infantum	88%	98%
A4IDG2	Leishmania infantum	31%	99%
A5D7M3	Bos taurus	34%	95%
C9ZZK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
D0A342	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AF02	Leishmania major	89%	100%
E9ASW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9B658	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
F1QNW4	Danio rerio	33%	96%
O15697	Trypanosoma brucei rhodesiense	29%	100%
O95995	Homo sapiens	34%	95%
Q499U4	Rattus norvegicus	34%	95%
Q4Q1N3	Leishmania major	31%	100%
Q60779	Mus musculus	33%	95%
Q7XJ96	Chlamydomonas reinhardtii	37%	96%
Q8MT08	Drosophila melanogaster	26%	95%
V5ATF4	Trypanosoma cruzi	60%	98%
V5BTX8	Trypanosoma cruzi	31%	93%