tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMK1_LEIBR

TriTrypDb:

LbrM.34.1710 , LBRM2903_340023400

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.764
CLV_C14_Caspase3-7	253	257	PF00656	0.628
CLV_C14_Caspase3-7	284	288	PF00656	0.389
CLV_NRD_NRD_1	41	43	PF00675	0.432
CLV_NRD_NRD_1	50	52	PF00675	0.342
CLV_PCSK_KEX2_1	2	4	PF00082	0.604
CLV_PCSK_KEX2_1	41	43	PF00082	0.429
CLV_PCSK_KEX2_1	49	51	PF00082	0.353
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.604
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.417
CLV_PCSK_SKI1_1	163	167	PF00082	0.333
CLV_PCSK_SKI1_1	50	54	PF00082	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.653
DOC_CYCLIN_RxL_1	18	29	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	310	313	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.324
DOC_MAPK_gen_1	161	170	PF00069	0.314
DOC_MAPK_gen_1	24	32	PF00069	0.319
DOC_PP1_RVXF_1	139	146	PF00149	0.305
DOC_PP1_RVXF_1	22	29	PF00149	0.449
DOC_PP2B_LxvP_1	309	312	PF13499	0.485
DOC_PP2B_LxvP_1	71	74	PF13499	0.324
DOC_PP4_FxxP_1	28	31	PF00568	0.376
DOC_SPAK_OSR1_1	27	31	PF12202	0.336
DOC_USP7_MATH_1	230	234	PF00917	0.778
DOC_USP7_MATH_1	235	239	PF00917	0.769
DOC_USP7_MATH_1	314	318	PF00917	0.650
DOC_USP7_MATH_2	83	89	PF00917	0.319
DOC_USP7_UBL2_3	209	213	PF12436	0.478
DOC_WW_Pin1_4	217	222	PF00397	0.730
DOC_WW_Pin1_4	241	246	PF00397	0.775
DOC_WW_Pin1_4	96	101	PF00397	0.305
LIG_14-3-3_CanoR_1	169	178	PF00244	0.333
LIG_14-3-3_CanoR_1	27	31	PF00244	0.350
LIG_14-3-3_CanoR_1	282	291	PF00244	0.524
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.305
LIG_FHA_1	117	123	PF00498	0.305
LIG_FHA_2	245	251	PF00498	0.607
LIG_FHA_2	282	288	PF00498	0.499
LIG_FHA_2	302	308	PF00498	0.554
LIG_FHA_2	320	326	PF00498	0.469
LIG_FHA_2	9	15	PF00498	0.349
LIG_LIR_Gen_1	304	314	PF02991	0.470
LIG_LIR_Nem_3	106	110	PF02991	0.295
LIG_LIR_Nem_3	174	180	PF02991	0.278
LIG_LIR_Nem_3	192	198	PF02991	0.220
LIG_LIR_Nem_3	267	273	PF02991	0.346
LIG_LIR_Nem_3	293	299	PF02991	0.465
LIG_LIR_Nem_3	304	309	PF02991	0.419
LIG_LYPXL_yS_3	107	110	PF13949	0.305
LIG_PTB_Apo_2	139	146	PF02174	0.287
LIG_SH2_CRK	140	144	PF00017	0.394
LIG_SH2_CRK	56	60	PF00017	0.305
LIG_SH2_GRB2like	272	275	PF00017	0.359
LIG_SH2_PTP2	276	279	PF00017	0.358
LIG_SH2_PTP2	78	81	PF00017	0.324
LIG_SH2_STAT3	272	275	PF00017	0.348
LIG_SH2_STAT3	299	302	PF00017	0.501
LIG_SH2_STAT5	187	190	PF00017	0.305
LIG_SH2_STAT5	196	199	PF00017	0.305
LIG_SH2_STAT5	201	204	PF00017	0.305
LIG_SH2_STAT5	272	275	PF00017	0.348
LIG_SH2_STAT5	276	279	PF00017	0.358
LIG_SH2_STAT5	283	286	PF00017	0.462
LIG_SH2_STAT5	291	294	PF00017	0.494
LIG_SH2_STAT5	299	302	PF00017	0.378
LIG_SH2_STAT5	54	57	PF00017	0.305
LIG_SH2_STAT5	78	81	PF00017	0.324
LIG_SH2_STAT5	8	11	PF00017	0.548
LIG_SH3_3	102	108	PF00018	0.312
LIG_SH3_3	118	124	PF00018	0.281
LIG_SH3_3	216	222	PF00018	0.604
LIG_SH3_3	308	314	PF00018	0.470
LIG_SH3_3	77	83	PF00018	0.454
LIG_TYR_ITIM	105	110	PF00017	0.275
LIG_TYR_ITIM	268	273	PF00017	0.281
MOD_CK1_1	125	131	PF00069	0.267
MOD_CK1_1	172	178	PF00069	0.348
MOD_CK1_1	212	218	PF00069	0.632
MOD_CK1_1	233	239	PF00069	0.780
MOD_CK1_1	244	250	PF00069	0.702
MOD_CK1_1	285	291	PF00069	0.460
MOD_CK1_1	317	323	PF00069	0.732
MOD_CK1_1	88	94	PF00069	0.307
MOD_CK1_1	96	102	PF00069	0.304
MOD_CK2_1	244	250	PF00069	0.613
MOD_CK2_1	319	325	PF00069	0.757
MOD_CK2_1	8	14	PF00069	0.579
MOD_GlcNHglycan	214	217	PF01048	0.632
MOD_GlcNHglycan	237	240	PF01048	0.760
MOD_GlcNHglycan	253	256	PF01048	0.604
MOD_GlcNHglycan	296	299	PF01048	0.547
MOD_GSK3_1	146	153	PF00069	0.304
MOD_GSK3_1	183	190	PF00069	0.309
MOD_GSK3_1	230	237	PF00069	0.787
MOD_GSK3_1	241	248	PF00069	0.586
MOD_GSK3_1	281	288	PF00069	0.384
MOD_GSK3_1	85	92	PF00069	0.304
MOD_LATS_1	167	173	PF00433	0.378
MOD_N-GLC_1	245	250	PF02516	0.493
MOD_N-GLC_1	302	307	PF02516	0.566
MOD_N-GLC_1	317	322	PF02516	0.506
MOD_NEK2_1	145	150	PF00069	0.324
MOD_NEK2_1	26	31	PF00069	0.381
MOD_NEK2_1	93	98	PF00069	0.297
MOD_PIKK_1	169	175	PF00454	0.348
MOD_PKA_2	26	32	PF00069	0.326
MOD_PKA_2	281	287	PF00069	0.505
MOD_Plk_1	116	122	PF00069	0.347
MOD_Plk_1	125	131	PF00069	0.348
MOD_Plk_1	146	152	PF00069	0.322
MOD_Plk_1	302	308	PF00069	0.590
MOD_Plk_4	116	122	PF00069	0.304
MOD_Plk_4	172	178	PF00069	0.296
MOD_Plk_4	183	189	PF00069	0.305
MOD_ProDKin_1	217	223	PF00069	0.734
MOD_ProDKin_1	241	247	PF00069	0.773
MOD_ProDKin_1	96	102	PF00069	0.305
TRG_DiLeu_BaEn_1	264	269	PF01217	0.372
TRG_ENDOCYTIC_2	107	110	PF00928	0.305
TRG_ENDOCYTIC_2	140	143	PF00928	0.378
TRG_ENDOCYTIC_2	195	198	PF00928	0.305
TRG_ENDOCYTIC_2	270	273	PF00928	0.324
TRG_ENDOCYTIC_2	276	279	PF00928	0.363
TRG_ENDOCYTIC_2	56	59	PF00928	0.305
TRG_ENDOCYTIC_2	78	81	PF00928	0.324
TRG_ER_diArg_1	33	36	PF00400	0.439
TRG_ER_diArg_1	50	52	PF00400	0.271
TRG_NLS_MonoCore_2	1	6	PF00514	0.695
TRG_NLS_MonoExtN_4	161	167	PF00514	0.333
TRG_NLS_MonoExtN_4	46	53	PF00514	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD7	Leptomonas seymouri	74%	100%
A0A0S4IR26	Bodo saltans	50%	100%
A0A1X0P5T8	Trypanosomatidae	62%	100%
A0A3S7X980	Leishmania donovani	85%	100%
A4IB80	Leishmania infantum	85%	100%
C9ZZK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AF01	Leishmania major	86%	100%
E9B657	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q28I29	Xenopus tropicalis	30%	100%
Q5RCQ0	Pongo abelii	31%	100%
Q8N5C7	Homo sapiens	31%	100%
Q9D8U7	Mus musculus	32%	100%
V5B8W4	Trypanosoma cruzi	60%	100%