DNA polymerase II subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase epsilon subunit B, putative

Species:

Leishmania braziliensis

UniProt:

A4HMK0_LEIBR

TriTrypDb:

LbrM.34.1700 , LBRM2903_340023300

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0008622	epsilon DNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A4HMK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMK0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0033554	cellular response to stress	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.372
CLV_C14_Caspase3-7	446	450	PF00656	0.410
CLV_NRD_NRD_1	134	136	PF00675	0.278
CLV_NRD_NRD_1	240	242	PF00675	0.367
CLV_NRD_NRD_1	41	43	PF00675	0.362
CLV_NRD_NRD_1	423	425	PF00675	0.245
CLV_PCSK_KEX2_1	133	135	PF00082	0.302
CLV_PCSK_KEX2_1	240	242	PF00082	0.358
CLV_PCSK_KEX2_1	41	43	PF00082	0.373
CLV_PCSK_KEX2_1	423	425	PF00082	0.260
CLV_PCSK_SKI1_1	128	132	PF00082	0.255
CLV_PCSK_SKI1_1	241	245	PF00082	0.486
CLV_PCSK_SKI1_1	310	314	PF00082	0.402
CLV_PCSK_SKI1_1	401	405	PF00082	0.256
CLV_PCSK_SKI1_1	42	46	PF00082	0.321
CLV_PCSK_SKI1_1	424	428	PF00082	0.297
CLV_PCSK_SKI1_1	473	477	PF00082	0.294
DEG_APCC_DBOX_1	41	49	PF00400	0.322
DEG_Nend_UBRbox_1	1	4	PF02207	0.532
DEG_SPOP_SBC_1	112	116	PF00917	0.469
DOC_CKS1_1	384	389	PF01111	0.390
DOC_CKS1_1	538	543	PF01111	0.298
DOC_CYCLIN_yClb1_LxF_4	409	414	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	497	503	PF00134	0.338
DOC_MAPK_DCC_7	16	24	PF00069	0.378
DOC_MAPK_gen_1	192	199	PF00069	0.383
DOC_MAPK_gen_1	270	279	PF00069	0.459
DOC_MAPK_HePTP_8	489	501	PF00069	0.309
DOC_MAPK_MEF2A_6	192	199	PF00069	0.370
DOC_MAPK_MEF2A_6	272	280	PF00069	0.449
DOC_MAPK_MEF2A_6	492	501	PF00069	0.282
DOC_PIKK_1	183	191	PF02985	0.382
DOC_PIKK_1	58	65	PF02985	0.413
DOC_PP1_RVXF_1	194	200	PF00149	0.370
DOC_PP1_RVXF_1	308	315	PF00149	0.364
DOC_PP1_RVXF_1	409	415	PF00149	0.268
DOC_PP2B_LxvP_1	497	500	PF13499	0.265
DOC_USP7_MATH_1	217	221	PF00917	0.419
DOC_USP7_MATH_1	371	375	PF00917	0.316
DOC_USP7_MATH_1	84	88	PF00917	0.522
DOC_USP7_UBL2_3	16	20	PF12436	0.386
DOC_USP7_UBL2_3	194	198	PF12436	0.236
DOC_WW_Pin1_4	383	388	PF00397	0.390
DOC_WW_Pin1_4	479	484	PF00397	0.390
DOC_WW_Pin1_4	537	542	PF00397	0.285
LIG_14-3-3_CanoR_1	111	119	PF00244	0.492
LIG_14-3-3_CanoR_1	204	211	PF00244	0.463
LIG_14-3-3_CanoR_1	272	277	PF00244	0.518
LIG_14-3-3_CanoR_1	413	421	PF00244	0.253
LIG_14-3-3_CanoR_1	470	476	PF00244	0.414
LIG_Actin_WH2_2	184	200	PF00022	0.374
LIG_Actin_WH2_2	294	312	PF00022	0.397
LIG_BIR_III_2	449	453	PF00653	0.167
LIG_BIR_III_2	96	100	PF00653	0.237
LIG_eIF4E_1	364	370	PF01652	0.167
LIG_FHA_1	159	165	PF00498	0.394
LIG_FHA_1	398	404	PF00498	0.320
LIG_FHA_1	414	420	PF00498	0.202
LIG_FHA_1	470	476	PF00498	0.400
LIG_FHA_1	503	509	PF00498	0.378
LIG_FHA_2	242	248	PF00498	0.341
LIG_FHA_2	464	470	PF00498	0.271
LIG_FHA_2	472	478	PF00498	0.217
LIG_FHA_2	538	544	PF00498	0.298
LIG_LIR_Apic_2	535	541	PF02991	0.293
LIG_LIR_Gen_1	10	19	PF02991	0.284
LIG_LIR_Gen_1	226	235	PF02991	0.314
LIG_LIR_Gen_1	25	34	PF02991	0.353
LIG_LIR_Gen_1	317	327	PF02991	0.352
LIG_LIR_Gen_1	365	373	PF02991	0.341
LIG_LIR_Gen_1	466	476	PF02991	0.258
LIG_LIR_Gen_1	47	54	PF02991	0.307
LIG_LIR_Nem_3	10	14	PF02991	0.325
LIG_LIR_Nem_3	226	230	PF02991	0.288
LIG_LIR_Nem_3	25	30	PF02991	0.355
LIG_LIR_Nem_3	317	323	PF02991	0.325
LIG_LIR_Nem_3	365	370	PF02991	0.341
LIG_LIR_Nem_3	466	471	PF02991	0.258
LIG_LIR_Nem_3	47	52	PF02991	0.328
LIG_LIR_Nem_3	516	522	PF02991	0.356
LIG_LIR_Nem_3	535	539	PF02991	0.188
LIG_PCNA_PIPBox_1	216	225	PF02747	0.302
LIG_PCNA_PIPBox_1	291	300	PF02747	0.390
LIG_PCNA_PIPBox_1	385	394	PF02747	0.273
LIG_PCNA_yPIPBox_3	172	182	PF02747	0.350
LIG_Pex14_1	223	227	PF04695	0.228
LIG_Pex14_1	515	519	PF04695	0.319
LIG_Pex14_2	316	320	PF04695	0.387
LIG_Pex14_2	426	430	PF04695	0.273
LIG_REV1ctd_RIR_1	295	304	PF16727	0.245
LIG_SH2_CRK	519	523	PF00017	0.348
LIG_SH2_NCK_1	539	543	PF00017	0.329
LIG_SH2_STAP1	364	368	PF00017	0.167
LIG_SH2_STAT5	539	542	PF00017	0.281
LIG_SH3_3	154	160	PF00018	0.293
LIG_SH3_3	230	236	PF00018	0.430
LIG_SH3_3	256	262	PF00018	0.491
LIG_SH3_3	353	359	PF00018	0.254
LIG_SH3_3	365	371	PF00018	0.243
LIG_SH3_3	381	387	PF00018	0.239
LIG_SH3_3	497	503	PF00018	0.304
LIG_SH3_3	521	527	PF00018	0.344
LIG_SUMO_SIM_anti_2	155	162	PF11976	0.450
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.304
LIG_SUMO_SIM_par_1	155	162	PF11976	0.248
LIG_SUMO_SIM_par_1	177	185	PF11976	0.503
LIG_SUMO_SIM_par_1	20	25	PF11976	0.373
LIG_SUMO_SIM_par_1	68	75	PF11976	0.464
LIG_SUMO_SIM_par_1	91	96	PF11976	0.274
LIG_TRAF2_1	72	75	PF00917	0.385
LIG_TRFH_1	17	21	PF08558	0.335
LIG_TRFH_1	255	259	PF08558	0.408
LIG_TRFH_1	367	371	PF08558	0.338
LIG_WRC_WIRS_1	224	229	PF05994	0.226
LIG_WRC_WIRS_1	8	13	PF05994	0.486
MOD_CK1_1	114	120	PF00069	0.549
MOD_CK1_1	200	206	PF00069	0.435
MOD_CK1_1	374	380	PF00069	0.434
MOD_CK2_1	159	165	PF00069	0.447
MOD_CK2_1	455	461	PF00069	0.372
MOD_CK2_1	463	469	PF00069	0.295
MOD_CK2_1	481	487	PF00069	0.304
MOD_CK2_1	546	552	PF00069	0.299
MOD_CK2_1	69	75	PF00069	0.460
MOD_GlcNHglycan	161	164	PF01048	0.460
MOD_GlcNHglycan	219	222	PF01048	0.427
MOD_GlcNHglycan	457	460	PF01048	0.372
MOD_GSK3_1	268	275	PF00069	0.314
MOD_GSK3_1	310	317	PF00069	0.329
MOD_GSK3_1	397	404	PF00069	0.332
MOD_GSK3_1	455	462	PF00069	0.268
MOD_PIKK_1	203	209	PF00454	0.287
MOD_PK_1	272	278	PF00069	0.368
MOD_PKA_1	401	407	PF00069	0.390
MOD_PKA_2	203	209	PF00069	0.364
MOD_PKA_2	469	475	PF00069	0.309
MOD_PKB_1	270	278	PF00069	0.242
MOD_PKB_1	411	419	PF00069	0.245
MOD_PKB_1	443	451	PF00069	0.167
MOD_Plk_1	200	206	PF00069	0.405
MOD_Plk_1	241	247	PF00069	0.364
MOD_Plk_1	268	274	PF00069	0.324
MOD_Plk_1	310	316	PF00069	0.267
MOD_Plk_1	318	324	PF00069	0.249
MOD_Plk_1	328	334	PF00069	0.215
MOD_Plk_1	374	380	PF00069	0.390
MOD_Plk_4	152	158	PF00069	0.451
MOD_Plk_4	223	229	PF00069	0.390
MOD_Plk_4	272	278	PF00069	0.379
MOD_Plk_4	310	316	PF00069	0.279
MOD_Plk_4	432	438	PF00069	0.325
MOD_Plk_4	471	477	PF00069	0.260
MOD_Plk_4	502	508	PF00069	0.321
MOD_Plk_4	532	538	PF00069	0.301
MOD_ProDKin_1	383	389	PF00069	0.390
MOD_ProDKin_1	479	485	PF00069	0.390
MOD_ProDKin_1	537	543	PF00069	0.294
MOD_SUMO_for_1	4	7	PF00179	0.391
MOD_SUMO_rev_2	58	67	PF00179	0.436
MOD_SUMO_rev_2	72	78	PF00179	0.418
TRG_ENDOCYTIC_2	364	367	PF00928	0.167
TRG_ENDOCYTIC_2	519	522	PF00928	0.355
TRG_ER_diArg_1	133	135	PF00400	0.333
TRG_ER_diArg_1	270	273	PF00400	0.536
TRG_ER_diArg_1	40	42	PF00400	0.399
TRG_ER_diArg_1	411	414	PF00400	0.245
TRG_ER_diArg_1	442	445	PF00400	0.167
TRG_NES_CRM1_1	172	185	PF08389	0.215
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D7	Leptomonas seymouri	69%	100%
A0A0S4IQS3	Bodo saltans	38%	100%
A0A1X0P6P7	Trypanosomatidae	45%	100%
A0A3R7LHF8	Trypanosoma rangeli	44%	100%
A0A3S7X944	Leishmania donovani	86%	100%
A4IB79	Leishmania infantum	86%	100%
A7YWS7	Bos taurus	24%	100%
C9ZZK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AF00	Leishmania major	86%	100%
E9B656	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O54956	Mus musculus	24%	100%
O94263	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	93%
P0CN24	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CN25	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P24482	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	80%
P56282	Homo sapiens	24%	100%
Q19196	Caenorhabditis elegans	22%	100%
Q500V9	Arabidopsis thaliana	26%	100%
Q54Y85	Dictyostelium discoideum	24%	82%
Q5ZKQ6	Gallus gallus	23%	100%
Q6BQR8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	83%
Q6CPH8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	78%
Q6FSK8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	77%
Q758V1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	82%
Q9VRQ7	Drosophila melanogaster	24%	100%
V5BHX7	Trypanosoma cruzi	44%	100%