Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMJ9_LEIBR

TriTrypDb:

LbrM.34.1690 , LBRM2903_340023200

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.595
CLV_PCSK_KEX2_1	205	207	PF00082	0.551
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.636
CLV_PCSK_SKI1_1	171	175	PF00082	0.551
CLV_PCSK_SKI1_1	202	206	PF00082	0.537
CLV_Separin_Metazoa	154	158	PF03568	0.632
DEG_Nend_UBRbox_1	1	4	PF02207	0.530
DOC_USP7_MATH_1	32	36	PF00917	0.617
DOC_USP7_MATH_1	57	61	PF00917	0.514
DOC_USP7_UBL2_3	205	209	PF12436	0.461
DOC_WW_Pin1_4	33	38	PF00397	0.611
DOC_WW_Pin1_4	40	45	PF00397	0.540
LIG_14-3-3_CanoR_1	127	137	PF00244	0.705
LIG_14-3-3_CanoR_1	17	23	PF00244	0.582
LIG_Actin_WH2_2	190	207	PF00022	0.399
LIG_BIR_III_4	81	85	PF00653	0.520
LIG_FHA_1	129	135	PF00498	0.654
LIG_FHA_1	66	72	PF00498	0.457
LIG_FHA_1	83	89	PF00498	0.423
LIG_FHA_2	20	26	PF00498	0.615
LIG_LIR_Nem_3	35	41	PF02991	0.619
LIG_NRBOX	199	205	PF00104	0.572
LIG_PCNA_PIPBox_1	114	123	PF02747	0.609
LIG_PCNA_yPIPBox_3	109	121	PF02747	0.607
LIG_PCNA_yPIPBox_3	168	177	PF02747	0.510
LIG_Pex14_2	48	52	PF04695	0.627
LIG_SH2_NCK_1	18	22	PF00017	0.633
LIG_SH2_STAP1	151	155	PF00017	0.509
LIG_SH2_STAT5	120	123	PF00017	0.582
LIG_SH2_STAT5	137	140	PF00017	0.597
LIG_SH2_STAT5	74	77	PF00017	0.474
LIG_SH2_STAT5	86	89	PF00017	0.490
LIG_SH3_3	38	44	PF00018	0.587
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.630
LIG_TRAF2_1	105	108	PF00917	0.436
LIG_TRAF2_1	112	115	PF00917	0.409
LIG_TRAF2_1	179	182	PF00917	0.572
MOD_CDK_SPxK_1	33	39	PF00069	0.610
MOD_CDK_SPxxK_3	40	47	PF00069	0.556
MOD_CK1_1	19	25	PF00069	0.671
MOD_CK2_1	101	107	PF00069	0.495
MOD_CK2_1	19	25	PF00069	0.614
MOD_GlcNHglycan	103	106	PF01048	0.407
MOD_GlcNHglycan	206	209	PF01048	0.625
MOD_GSK3_1	97	104	PF00069	0.596
MOD_N-GLC_1	189	194	PF02516	0.526
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	204	209	PF00069	0.391
MOD_PIKK_1	97	103	PF00454	0.609
MOD_PKA_2	101	107	PF00069	0.554
MOD_PKA_2	16	22	PF00069	0.622
MOD_Plk_1	189	195	PF00069	0.522
MOD_Plk_4	189	195	PF00069	0.479
MOD_Plk_4	57	63	PF00069	0.483
MOD_Plk_4	82	88	PF00069	0.493
MOD_ProDKin_1	33	39	PF00069	0.610
MOD_ProDKin_1	40	46	PF00069	0.533
MOD_SUMO_rev_2	77	85	PF00179	0.492
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.611
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T0	Leptomonas seymouri	79%	100%
A0A0S4KLR7	Bodo saltans	61%	100%
A0A1X0P7A8	Trypanosomatidae	62%	100%
A0A3Q8IG68	Leishmania donovani	87%	100%
A4IB78	Leishmania infantum	87%	100%
C9ZZK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AEZ9	Leishmania major	87%	100%
E9B655	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%