Pru domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome complex subunit Rpn13 ubiquitin receptor, putative

Species:

Leishmania braziliensis

UniProt:

A4HMJ8_LEIBR

TriTrypDb:

LbrM.34.1680 , LBRM2903_340023100

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	7
GO:0005634	nucleus	5	14
GO:0005737	cytoplasm	2	15
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	15
GO:0043231	intracellular membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	15
GO:0140535	intracellular protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1905368	peptidase complex	3	7
GO:1905369	endopeptidase complex	4	7
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HMJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008047	enzyme activator activity	3	1
GO:0016504	peptidase activator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0061133	endopeptidase activator activity	5	1
GO:0061134	peptidase regulator activity	3	1
GO:0061135	endopeptidase regulator activity	4	1
GO:0070628	proteasome binding	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.483
CLV_NRD_NRD_1	31	33	PF00675	0.301
CLV_PCSK_KEX2_1	31	33	PF00082	0.299
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.341
CLV_PCSK_SKI1_1	136	140	PF00082	0.572
CLV_PCSK_SKI1_1	147	151	PF00082	0.281
CLV_PCSK_SKI1_1	79	83	PF00082	0.270
DEG_SPOP_SBC_1	154	158	PF00917	0.561
DOC_CDC14_PxL_1	7	15	PF14671	0.305
DOC_CYCLIN_RxL_1	76	84	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.531
DOC_MAPK_gen_1	125	132	PF00069	0.656
DOC_MAPK_gen_1	144	151	PF00069	0.528
DOC_MAPK_gen_1	31	38	PF00069	0.493
DOC_MAPK_gen_1	64	71	PF00069	0.535
DOC_PP1_RVXF_1	77	84	PF00149	0.484
DOC_PP4_FxxP_1	222	225	PF00568	0.561
DOC_PP4_MxPP_1	1	4	PF00568	0.589
DOC_USP7_MATH_1	112	116	PF00917	0.487
DOC_USP7_MATH_1	140	144	PF00917	0.639
DOC_USP7_MATH_1	196	200	PF00917	0.500
DOC_USP7_MATH_1	41	45	PF00917	0.569
DOC_USP7_MATH_1	51	55	PF00917	0.557
DOC_USP7_UBL2_3	101	105	PF12436	0.548
DOC_USP7_UBL2_3	146	150	PF12436	0.571
LIG_14-3-3_CanoR_1	125	131	PF00244	0.708
LIG_14-3-3_CanoR_1	64	70	PF00244	0.530
LIG_EVH1_2	3	7	PF00568	0.562
LIG_FHA_1	127	133	PF00498	0.660
LIG_FHA_1	150	156	PF00498	0.534
LIG_FHA_1	41	47	PF00498	0.507
LIG_FHA_1	75	81	PF00498	0.494
LIG_FHA_2	201	207	PF00498	0.574
LIG_LIR_Apic_2	221	225	PF02991	0.562
LIG_LIR_Nem_3	133	138	PF02991	0.575
LIG_LIR_Nem_3	214	218	PF02991	0.488
LIG_SH2_CRK	215	219	PF00017	0.541
LIG_SH2_STAT5	109	112	PF00017	0.328
LIG_SH2_STAT5	178	181	PF00017	0.544
LIG_SH2_STAT5	35	38	PF00017	0.544
LIG_SH2_STAT5	94	97	PF00017	0.551
LIG_SH3_3	190	196	PF00018	0.511
LIG_WRC_WIRS_1	35	40	PF05994	0.541
MOD_CK1_1	158	164	PF00069	0.527
MOD_CK1_1	166	172	PF00069	0.507
MOD_CK1_1	40	46	PF00069	0.524
MOD_CK1_1	54	60	PF00069	0.523
MOD_CK2_1	200	206	PF00069	0.539
MOD_CK2_1	41	47	PF00069	0.509
MOD_CK2_1	49	55	PF00069	0.473
MOD_GlcNHglycan	106	109	PF01048	0.541
MOD_GlcNHglycan	39	42	PF01048	0.339
MOD_GlcNHglycan	43	46	PF01048	0.322
MOD_GlcNHglycan	55	59	PF01048	0.224
MOD_GSK3_1	138	145	PF00069	0.591
MOD_GSK3_1	149	156	PF00069	0.471
MOD_GSK3_1	158	165	PF00069	0.505
MOD_GSK3_1	196	203	PF00069	0.539
MOD_GSK3_1	37	44	PF00069	0.546
MOD_NEK2_1	155	160	PF00069	0.507
MOD_NEK2_1	218	223	PF00069	0.418
MOD_NEK2_2	34	39	PF00069	0.525
MOD_PIKK_1	188	194	PF00454	0.527
MOD_PIKK_1	196	202	PF00454	0.519
MOD_Plk_4	112	118	PF00069	0.513
MOD_Plk_4	155	161	PF00069	0.520
MOD_Plk_4	166	172	PF00069	0.518
MOD_Plk_4	200	206	PF00069	0.449
MOD_Plk_4	34	40	PF00069	0.488
MOD_Plk_4	67	73	PF00069	0.534
MOD_SUMO_rev_2	100	107	PF00179	0.556
MOD_SUMO_rev_2	133	138	PF00179	0.640
MOD_SUMO_rev_2	143	152	PF00179	0.575
TRG_ENDOCYTIC_2	215	218	PF00928	0.511
TRG_ENDOCYTIC_2	35	38	PF00928	0.561
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T1	Leptomonas seymouri	68%	100%
A0A0S4KJ38	Bodo saltans	35%	99%
A0A1X0P5X9	Trypanosomatidae	28%	89%
A0A1X0P6U7	Trypanosomatidae	40%	100%
A0A3Q8IIY1	Leishmania donovani	88%	100%
A0A3R7K022	Trypanosoma rangeli	31%	93%
A0A422MVV1	Trypanosoma rangeli	39%	100%
A4IB77	Leishmania infantum	88%	100%
C9ZZD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
C9ZZK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
E9AEZ8	Leishmania major	87%	100%
E9B654	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5ATF0	Trypanosoma cruzi	34%	100%