ANF_receptor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HMJ6_LEIBR

TriTrypDb:

LbrM.34.1660 , LBRM2903_340022900

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HMJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008194	UDP-glycosyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016757	glycosyltransferase activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.452
CLV_NRD_NRD_1	159	161	PF00675	0.629
CLV_NRD_NRD_1	292	294	PF00675	0.516
CLV_NRD_NRD_1	392	394	PF00675	0.506
CLV_PCSK_FUR_1	290	294	PF00082	0.502
CLV_PCSK_KEX2_1	104	106	PF00082	0.465
CLV_PCSK_KEX2_1	159	161	PF00082	0.645
CLV_PCSK_KEX2_1	292	294	PF00082	0.516
CLV_PCSK_KEX2_1	392	394	PF00082	0.514
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.465
CLV_PCSK_SKI1_1	24	28	PF00082	0.485
CLV_PCSK_SKI1_1	69	73	PF00082	0.535
CLV_PCSK_SKI1_1	96	100	PF00082	0.572
DEG_APCC_DBOX_1	95	103	PF00400	0.240
DEG_COP1_1	136	145	PF00400	0.264
DEG_SPOP_SBC_1	135	139	PF00917	0.238
DOC_CKS1_1	76	81	PF01111	0.227
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.220
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.343
DOC_MAPK_DCC_7	103	113	PF00069	0.238
DOC_MAPK_gen_1	387	396	PF00069	0.354
DOC_MAPK_MEF2A_6	104	113	PF00069	0.233
DOC_MAPK_MEF2A_6	123	132	PF00069	0.179
DOC_MAPK_MEF2A_6	316	323	PF00069	0.301
DOC_MAPK_MEF2A_6	7	15	PF00069	0.336
DOC_PP1_RVXF_1	25	31	PF00149	0.235
DOC_PP2B_LxvP_1	128	131	PF13499	0.272
DOC_PP2B_PxIxI_1	201	207	PF00149	0.242
DOC_PP4_FxxP_1	307	310	PF00568	0.271
DOC_USP7_MATH_1	228	232	PF00917	0.296
DOC_USP7_MATH_1	361	365	PF00917	0.324
DOC_USP7_MATH_1	92	96	PF00917	0.264
DOC_USP7_UBL2_3	458	462	PF12436	0.520
DOC_WW_Pin1_4	32	37	PF00397	0.257
DOC_WW_Pin1_4	336	341	PF00397	0.216
DOC_WW_Pin1_4	362	367	PF00397	0.231
DOC_WW_Pin1_4	427	432	PF00397	0.383
DOC_WW_Pin1_4	75	80	PF00397	0.225
LIG_14-3-3_CanoR_1	103	108	PF00244	0.253
LIG_14-3-3_CanoR_1	123	131	PF00244	0.173
LIG_14-3-3_CanoR_1	146	151	PF00244	0.323
LIG_14-3-3_CanoR_1	172	181	PF00244	0.371
LIG_14-3-3_CanoR_1	194	204	PF00244	0.226
LIG_14-3-3_CanoR_1	290	300	PF00244	0.300
LIG_14-3-3_CanoR_1	348	355	PF00244	0.390
LIG_14-3-3_CanoR_1	52	60	PF00244	0.270
LIG_Actin_WH2_2	12	29	PF00022	0.398
LIG_BIR_II_1	1	5	PF00653	0.378
LIG_BRCT_BRCA1_1	146	150	PF00533	0.325
LIG_BRCT_BRCA1_1	440	444	PF00533	0.202
LIG_deltaCOP1_diTrp_1	156	161	PF00928	0.328
LIG_FHA_1	196	202	PF00498	0.232
LIG_FHA_1	3	9	PF00498	0.412
LIG_FHA_1	366	372	PF00498	0.402
LIG_FHA_1	55	61	PF00498	0.370
LIG_FHA_1	76	82	PF00498	0.234
LIG_FHA_2	280	286	PF00498	0.390
LIG_FHA_2	33	39	PF00498	0.241
LIG_GBD_Chelix_1	438	446	PF00786	0.202
LIG_GBD_Chelix_1	9	17	PF00786	0.480
LIG_HP1_1	319	323	PF01393	0.194
LIG_Integrin_RGD_1	221	223	PF01839	0.458
LIG_IRF3_LxIS_1	438	443	PF10401	0.202
LIG_LIR_Apic_2	304	310	PF02991	0.274
LIG_LIR_Gen_1	329	340	PF02991	0.215
LIG_LIR_LC3C_4	5	10	PF02991	0.339
LIG_LIR_Nem_3	147	153	PF02991	0.499
LIG_LIR_Nem_3	156	161	PF02991	0.392
LIG_LIR_Nem_3	230	235	PF02991	0.273
LIG_LIR_Nem_3	329	335	PF02991	0.219
LIG_Pex14_2	307	311	PF04695	0.263
LIG_Pex14_2	459	463	PF04695	0.524
LIG_REV1ctd_RIR_1	217	225	PF16727	0.240
LIG_REV1ctd_RIR_1	449	459	PF16727	0.349
LIG_SH2_CRK	263	267	PF00017	0.385
LIG_SH2_CRK	332	336	PF00017	0.326
LIG_SH2_SRC	238	241	PF00017	0.318
LIG_SH2_STAP1	248	252	PF00017	0.207
LIG_SH2_STAP1	332	336	PF00017	0.200
LIG_SH2_STAP1	434	438	PF00017	0.294
LIG_SH2_STAT5	238	241	PF00017	0.318
LIG_SH2_STAT5	280	283	PF00017	0.292
LIG_SH2_STAT5	312	315	PF00017	0.229
LIG_SH2_STAT5	343	346	PF00017	0.266
LIG_SH3_3	206	212	PF00018	0.275
LIG_SH3_3	73	79	PF00018	0.236
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.240
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.338
LIG_SUMO_SIM_par_1	130	140	PF11976	0.390
LIG_SUMO_SIM_par_1	318	324	PF11976	0.246
LIG_SUMO_SIM_par_1	55	61	PF11976	0.218
LIG_TYR_ITIM	330	335	PF00017	0.201
LIG_UBA3_1	16	24	PF00899	0.380
LIG_UBA3_1	98	104	PF00899	0.270
LIG_WRC_WIRS_1	248	253	PF05994	0.207
MOD_CDK_SPK_2	362	367	PF00069	0.231
MOD_CK1_1	136	142	PF00069	0.401
MOD_CK1_1	144	150	PF00069	0.315
MOD_CK1_1	2	8	PF00069	0.358
MOD_CK1_1	32	38	PF00069	0.285
MOD_CK2_1	279	285	PF00069	0.368
MOD_CK2_1	380	386	PF00069	0.358
MOD_GlcNHglycan	168	171	PF01048	0.594
MOD_GlcNHglycan	174	177	PF01048	0.538
MOD_GlcNHglycan	183	186	PF01048	0.536
MOD_GlcNHglycan	263	266	PF01048	0.580
MOD_GlcNHglycan	282	285	PF01048	0.444
MOD_GlcNHglycan	32	35	PF01048	0.473
MOD_GlcNHglycan	372	375	PF01048	0.549
MOD_GlcNHglycan	435	438	PF01048	0.588
MOD_GlcNHglycan	54	57	PF01048	0.513
MOD_GlcNHglycan	90	93	PF01048	0.598
MOD_GSK3_1	133	140	PF00069	0.384
MOD_GSK3_1	141	148	PF00069	0.453
MOD_GSK3_1	280	287	PF00069	0.374
MOD_GSK3_1	30	37	PF00069	0.311
MOD_GSK3_1	343	350	PF00069	0.382
MOD_GSK3_1	361	368	PF00069	0.227
MOD_GSK3_1	370	377	PF00069	0.326
MOD_GSK3_1	88	95	PF00069	0.357
MOD_N-GLC_1	270	275	PF02516	0.424
MOD_N-GLC_1	379	384	PF02516	0.452
MOD_N-GLC_1	52	57	PF02516	0.435
MOD_N-GLC_2	274	276	PF02516	0.423
MOD_NEK2_1	163	168	PF00069	0.353
MOD_NEK2_1	174	179	PF00069	0.283
MOD_NEK2_1	181	186	PF00069	0.289
MOD_NEK2_1	227	232	PF00069	0.292
MOD_NEK2_1	252	257	PF00069	0.351
MOD_NEK2_1	278	283	PF00069	0.228
MOD_NEK2_1	30	35	PF00069	0.281
MOD_NEK2_1	440	445	PF00069	0.209
MOD_NEK2_1	450	455	PF00069	0.361
MOD_NEK2_2	238	243	PF00069	0.278
MOD_NEK2_2	374	379	PF00069	0.212
MOD_PIKK_1	195	201	PF00454	0.260
MOD_PIKK_1	80	86	PF00454	0.299
MOD_PKA_1	103	109	PF00069	0.245
MOD_PKA_1	292	298	PF00069	0.314
MOD_PKA_2	122	128	PF00069	0.228
MOD_PKA_2	145	151	PF00069	0.366
MOD_PKA_2	291	297	PF00069	0.329
MOD_PKA_2	347	353	PF00069	0.398
MOD_PKB_1	290	298	PF00069	0.388
MOD_Plk_1	253	259	PF00069	0.232
MOD_Plk_1	284	290	PF00069	0.318
MOD_Plk_1	303	309	PF00069	0.229
MOD_Plk_1	379	385	PF00069	0.275
MOD_Plk_1	92	98	PF00069	0.338
MOD_Plk_4	163	169	PF00069	0.341
MOD_Plk_4	174	180	PF00069	0.421
MOD_Plk_4	247	253	PF00069	0.353
MOD_Plk_4	284	290	PF00069	0.410
MOD_Plk_4	374	380	PF00069	0.218
MOD_Plk_4	41	47	PF00069	0.341
MOD_Plk_4	54	60	PF00069	0.303
MOD_ProDKin_1	32	38	PF00069	0.254
MOD_ProDKin_1	336	342	PF00069	0.215
MOD_ProDKin_1	362	368	PF00069	0.231
MOD_ProDKin_1	427	433	PF00069	0.378
MOD_ProDKin_1	75	81	PF00069	0.234
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.321
TRG_ENDOCYTIC_2	248	251	PF00928	0.205
TRG_ENDOCYTIC_2	263	266	PF00928	0.225
TRG_ENDOCYTIC_2	332	335	PF00928	0.201
TRG_ER_diArg_1	102	105	PF00400	0.253
TRG_ER_diArg_1	158	160	PF00400	0.432
TRG_ER_diArg_1	243	246	PF00400	0.239
TRG_ER_diArg_1	291	293	PF00400	0.294
TRG_ER_diArg_1	392	394	PF00400	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB88	Leptomonas seymouri	38%	96%
A0A1X0P5U1	Trypanosomatidae	25%	92%
A0A3S5IRM5	Trypanosoma rangeli	24%	95%