Dynein light chain roadblock

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated roadblock protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HMJ5_LEIBR

TriTrypDb:

LbrM.34.1650 , LBRM2903_340022800

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005868	cytoplasmic dynein complex	4	5
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	5
GO:0030286	dynein complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	5
GO:1902494	catalytic complex	2	5
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HMJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	5
GO:0007018	microtubule-based movement	3	5
GO:0009987	cellular process	1	5

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0045505	dynein intermediate chain binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yClb1_LxF_4	64	70	PF00134	0.314
DOC_MAPK_gen_1	73	81	PF00069	0.314
DOC_MAPK_MEF2A_6	85	92	PF00069	0.314
DOC_USP7_MATH_1	29	33	PF00917	0.314
DOC_WW_Pin1_4	25	30	PF00397	0.367
LIG_14-3-3_CanoR_1	10	17	PF00244	0.276
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_FHA_1	62	68	PF00498	0.314
LIG_FHA_2	31	37	PF00498	0.288
LIG_LIR_Gen_1	5	15	PF02991	0.311
LIG_LIR_Gen_1	84	95	PF02991	0.314
LIG_LIR_Nem_3	5	11	PF02991	0.311
LIG_LIR_Nem_3	66	72	PF02991	0.314
LIG_LIR_Nem_3	84	90	PF02991	0.314
LIG_SH2_STAP1	43	47	PF00017	0.314
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.314
LIG_SUMO_SIM_par_1	19	24	PF11976	0.313
LIG_UBA3_1	46	53	PF00899	0.314
MOD_CDK_SPxK_1	25	31	PF00069	0.367
MOD_CK2_1	29	35	PF00069	0.293
MOD_GSK3_1	25	32	PF00069	0.332
MOD_NEK2_1	46	51	PF00069	0.367
MOD_PIKK_1	9	15	PF00454	0.314
MOD_PKA_2	30	36	PF00069	0.285
MOD_PKA_2	9	15	PF00069	0.314
MOD_Plk_1	34	40	PF00069	0.325
MOD_Plk_1	4	10	PF00069	0.179
MOD_Plk_4	34	40	PF00069	0.319
MOD_ProDKin_1	25	31	PF00069	0.367
TRG_ENDOCYTIC_2	43	46	PF00928	0.314
TRG_ER_diArg_1	70	73	PF00400	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V1	Leptomonas seymouri	43%	87%
A0A0N1HUN3	Leptomonas seymouri	95%	100%
A0A0S4KIT1	Bodo saltans	87%	99%
A0A1X0P773	Trypanosomatidae	49%	84%
A0A3Q8IJB4	Leishmania donovani	96%	82%
A0A3Q8IJQ7	Leishmania donovani	38%	87%
A0A422P0L4	Trypanosoma rangeli	48%	84%
A4H9K8	Leishmania braziliensis	37%	100%
A4HXX4	Leishmania infantum	38%	87%
A4IB75	Leishmania infantum	96%	82%
C9ZMI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	84%
C9ZWI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	84%
C9ZZS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	82%
E9AEZ6	Leishmania major	95%	100%
E9ARN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	87%
P62627	Mus musculus	60%	100%
P62628	Rattus norvegicus	60%	100%
Q32P85	Bos taurus	57%	100%
Q3T140	Bos taurus	60%	100%
Q4QDU1	Leishmania major	38%	100%
Q8TF09	Homo sapiens	57%	100%
Q9DAJ5	Mus musculus	57%	100%
Q9NP97	Homo sapiens	62%	100%
V5BM74	Trypanosoma cruzi	49%	84%