Putative cyclophilin 14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 14, putative

Species:

Leishmania braziliensis

UniProt:

A4HMJ2_LEIBR

TriTrypDb:

LbrM.34.1620 , LBRM2903_340022500

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HMJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.503
CLV_NRD_NRD_1	253	255	PF00675	0.455
CLV_NRD_NRD_1	437	439	PF00675	0.677
CLV_PCSK_FUR_1	135	139	PF00082	0.421
CLV_PCSK_KEX2_1	137	139	PF00082	0.423
CLV_PCSK_KEX2_1	253	255	PF00082	0.455
CLV_PCSK_KEX2_1	366	368	PF00082	0.554
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.496
CLV_PCSK_SKI1_1	152	156	PF00082	0.363
CLV_PCSK_SKI1_1	310	314	PF00082	0.455
CLV_PCSK_SKI1_1	62	66	PF00082	0.451
DEG_APCC_DBOX_1	137	145	PF00400	0.612
DEG_APCC_DBOX_1	309	317	PF00400	0.255
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DOC_CYCLIN_RxL_1	134	145	PF00134	0.611
DOC_MAPK_gen_1	135	143	PF00069	0.629
DOC_MAPK_MEF2A_6	135	143	PF00069	0.617
DOC_MAPK_MEF2A_6	152	161	PF00069	0.549
DOC_MAPK_MEF2A_6	180	189	PF00069	0.356
DOC_USP7_MATH_1	26	30	PF00917	0.662
DOC_USP7_MATH_2	300	306	PF00917	0.347
DOC_WW_Pin1_4	321	326	PF00397	0.272
DOC_WW_Pin1_4	38	43	PF00397	0.672
DOC_WW_Pin1_4	90	95	PF00397	0.604
LIG_14-3-3_CanoR_1	138	144	PF00244	0.614
LIG_14-3-3_CanoR_1	152	161	PF00244	0.549
LIG_14-3-3_CanoR_1	20	26	PF00244	0.719
LIG_14-3-3_CanoR_1	310	320	PF00244	0.246
LIG_14-3-3_CanoR_1	34	44	PF00244	0.652
LIG_14-3-3_CanoR_1	408	414	PF00244	0.469
LIG_14-3-3_CanoR_1	48	54	PF00244	0.772
LIG_Actin_WH2_2	201	218	PF00022	0.330
LIG_BRCT_BRCA1_1	323	327	PF00533	0.285
LIG_FHA_1	299	305	PF00498	0.314
LIG_FHA_1	38	44	PF00498	0.721
LIG_FHA_2	111	117	PF00498	0.692
LIG_FHA_2	140	146	PF00498	0.634
LIG_FHA_2	153	159	PF00498	0.547
LIG_LIR_Gen_1	24	33	PF02991	0.564
LIG_LIR_Nem_3	219	225	PF02991	0.280
LIG_LIR_Nem_3	24	30	PF02991	0.561
LIG_PTB_Apo_2	292	299	PF02174	0.207
LIG_PTB_Apo_2	63	70	PF02174	0.589
LIG_PTB_Phospho_1	292	298	PF10480	0.207
LIG_PTB_Phospho_1	63	69	PF10480	0.588
LIG_SH2_CRK	27	31	PF00017	0.566
LIG_SH2_NCK_1	27	31	PF00017	0.566
LIG_SH2_NCK_1	348	352	PF00017	0.347
LIG_SH2_NCK_1	393	397	PF00017	0.404
LIG_SH2_STAP1	172	176	PF00017	0.315
LIG_SH2_STAP1	27	31	PF00017	0.566
LIG_SH2_STAT3	336	339	PF00017	0.255
LIG_SH2_STAT5	192	195	PF00017	0.382
LIG_SH2_STAT5	222	225	PF00017	0.275
LIG_SH2_STAT5	247	250	PF00017	0.255
LIG_SH2_STAT5	298	301	PF00017	0.244
LIG_SH2_STAT5	369	372	PF00017	0.347
LIG_SH2_STAT5	69	72	PF00017	0.597
LIG_SH3_3	144	150	PF00018	0.595
LIG_SH3_3	383	389	PF00018	0.318
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.540
LIG_SUMO_SIM_par_1	139	146	PF11976	0.619
LIG_TYR_ITIM	220	225	PF00017	0.277
LIG_TYR_ITIM	25	30	PF00017	0.561
LIG_ULM_U2AF65_1	438	443	PF00076	0.482
LIG_WRC_WIRS_1	44	49	PF05994	0.670
MOD_CK2_1	110	116	PF00069	0.700
MOD_CK2_1	139	145	PF00069	0.634
MOD_CK2_1	152	158	PF00069	0.554
MOD_CK2_1	430	436	PF00069	0.380
MOD_GlcNHglycan	313	316	PF01048	0.491
MOD_GlcNHglycan	332	335	PF01048	0.456
MOD_GlcNHglycan	409	412	PF01048	0.689
MOD_GlcNHglycan	49	52	PF01048	0.527
MOD_GlcNHglycan	77	80	PF01048	0.542
MOD_GlcNHglycan	81	84	PF01048	0.573
MOD_GSK3_1	194	201	PF00069	0.319
MOD_GSK3_1	223	230	PF00069	0.391
MOD_GSK3_1	298	305	PF00069	0.316
MOD_GSK3_1	32	39	PF00069	0.717
MOD_GSK3_1	321	328	PF00069	0.265
MOD_GSK3_1	376	383	PF00069	0.361
MOD_GSK3_1	43	50	PF00069	0.721
MOD_GSK3_1	53	60	PF00069	0.776
MOD_GSK3_1	64	71	PF00069	0.663
MOD_GSK3_1	75	82	PF00069	0.741
MOD_N-GLC_1	227	232	PF02516	0.547
MOD_N-GLC_1	325	330	PF02516	0.465
MOD_N-GLC_1	57	62	PF02516	0.463
MOD_NEK2_1	174	179	PF00069	0.352
MOD_NEK2_1	194	199	PF00069	0.253
MOD_NEK2_1	32	37	PF00069	0.695
MOD_NEK2_1	380	385	PF00069	0.373
MOD_NEK2_1	392	397	PF00069	0.350
MOD_NEK2_1	43	48	PF00069	0.704
MOD_NEK2_2	325	330	PF00069	0.187
MOD_PIKK_1	424	430	PF00454	0.528
MOD_PK_1	129	135	PF00069	0.655
MOD_PK_1	216	222	PF00069	0.294
MOD_PKA_1	253	259	PF00069	0.255
MOD_PKA_2	253	259	PF00069	0.248
MOD_PKA_2	407	413	PF00069	0.483
MOD_PKA_2	47	53	PF00069	0.685
MOD_Plk_1	100	106	PF00069	0.803
MOD_Plk_1	325	331	PF00069	0.275
MOD_Plk_4	100	106	PF00069	0.649
MOD_Plk_4	139	145	PF00069	0.614
MOD_Plk_4	216	222	PF00069	0.293
MOD_ProDKin_1	321	327	PF00069	0.272
MOD_ProDKin_1	38	44	PF00069	0.673
MOD_ProDKin_1	90	96	PF00069	0.603
MOD_SUMO_for_1	125	128	PF00179	0.644
MOD_SUMO_rev_2	332	338	PF00179	0.296
MOD_SUMO_rev_2	397	405	PF00179	0.368
MOD_SUMO_rev_2	50	59	PF00179	0.604
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.672
TRG_ENDOCYTIC_2	172	175	PF00928	0.295
TRG_ENDOCYTIC_2	222	225	PF00928	0.275
TRG_ENDOCYTIC_2	27	30	PF00928	0.563
TRG_ENDOCYTIC_2	348	351	PF00928	0.347
TRG_ENDOCYTIC_2	393	396	PF00928	0.373
TRG_ER_diArg_1	135	138	PF00400	0.704
TRG_ER_diArg_1	17	20	PF00400	0.672
TRG_NES_CRM1_1	151	166	PF08389	0.639
TRG_NLS_MonoCore_2	437	442	PF00514	0.474
TRG_NLS_MonoExtN_4	438	443	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ3	Leptomonas seymouri	68%	98%
A0A1X0P6T5	Trypanosomatidae	77%	100%
A0A3S7X941	Leishmania donovani	82%	100%
A0A422NQ98	Trypanosoma rangeli	70%	100%
A4IB72	Leishmania infantum	82%	100%
C9ZZI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AEZ3	Leishmania major	83%	100%
E9B649	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QBH1	Leishmania major	28%	100%
V5BP10	Trypanosoma cruzi	71%	100%