Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMJ0_LEIBR

TriTrypDb:

LbrM.34.1600 , LBRM2903_340022300

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HMJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.720
CLV_NRD_NRD_1	216	218	PF00675	0.770
CLV_NRD_NRD_1	287	289	PF00675	0.550
CLV_NRD_NRD_1	332	334	PF00675	0.566
CLV_PCSK_FUR_1	346	350	PF00082	0.641
CLV_PCSK_KEX2_1	216	218	PF00082	0.770
CLV_PCSK_KEX2_1	286	288	PF00082	0.797
CLV_PCSK_KEX2_1	332	334	PF00082	0.544
CLV_PCSK_KEX2_1	348	350	PF00082	0.451
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.602
CLV_PCSK_SKI1_1	16	20	PF00082	0.529
CLV_PCSK_SKI1_1	27	31	PF00082	0.525
CLV_PCSK_SKI1_1	332	336	PF00082	0.569
CLV_PCSK_SKI1_1	348	352	PF00082	0.427
CLV_PCSK_SKI1_1	85	89	PF00082	0.539
DEG_APCC_DBOX_1	188	196	PF00400	0.561
DEG_APCC_DBOX_1	26	34	PF00400	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_CKS1_1	127	132	PF01111	0.312
DOC_CYCLIN_RxL_1	327	340	PF00134	0.579
DOC_CYCLIN_RxL_1	344	354	PF00134	0.600
DOC_CYCLIN_RxL_1	63	74	PF00134	0.413
DOC_MAPK_gen_1	25	33	PF00069	0.563
DOC_MAPK_MEF2A_6	2	9	PF00069	0.557
DOC_MAPK_MEF2A_6	313	321	PF00069	0.645
DOC_USP7_MATH_1	197	201	PF00917	0.561
DOC_USP7_MATH_1	394	398	PF00917	0.568
DOC_USP7_UBL2_3	344	348	PF12436	0.624
DOC_USP7_UBL2_3	357	361	PF12436	0.528
DOC_WW_Pin1_4	1	6	PF00397	0.606
DOC_WW_Pin1_4	126	131	PF00397	0.473
LIG_14-3-3_CanoR_1	111	115	PF00244	0.476
LIG_14-3-3_CanoR_1	39	43	PF00244	0.661
LIG_Clathr_ClatBox_1	18	22	PF01394	0.475
LIG_CtBP_PxDLS_1	151	155	PF00389	0.310
LIG_eIF4E_1	72	78	PF01652	0.491
LIG_FHA_1	127	133	PF00498	0.535
LIG_FHA_1	142	148	PF00498	0.396
LIG_FHA_1	2	8	PF00498	0.732
LIG_FHA_1	225	231	PF00498	0.617
LIG_FHA_1	316	322	PF00498	0.565
LIG_FHA_1	357	363	PF00498	0.548
LIG_FHA_2	335	341	PF00498	0.368
LIG_FHA_2	77	83	PF00498	0.488
LIG_FHA_2	86	92	PF00498	0.432
LIG_HP1_1	197	201	PF01393	0.577
LIG_LIR_Gen_1	395	406	PF02991	0.572
LIG_LIR_Gen_1	71	78	PF02991	0.462
LIG_LIR_Nem_3	395	401	PF02991	0.569
LIG_LIR_Nem_3	71	75	PF02991	0.454
LIG_NRBOX	330	336	PF00104	0.512
LIG_PTB_Apo_2	66	73	PF02174	0.544
LIG_PTB_Phospho_1	66	72	PF10480	0.475
LIG_SH2_CRK	72	76	PF00017	0.490
LIG_SH2_STAT3	128	131	PF00017	0.314
LIG_SH2_STAT5	128	131	PF00017	0.567
LIG_SUMO_SIM_par_1	149	155	PF11976	0.315
LIG_SUMO_SIM_par_1	28	34	PF11976	0.500
LIG_SUMO_SIM_par_1	88	93	PF11976	0.400
LIG_TYR_ITIM	70	75	PF00017	0.470
MOD_CK1_1	188	194	PF00069	0.534
MOD_CK1_1	299	305	PF00069	0.650
MOD_CK1_1	43	49	PF00069	0.757
MOD_CK1_1	71	77	PF00069	0.453
MOD_CK2_1	216	222	PF00069	0.736
MOD_CK2_1	372	378	PF00069	0.517
MOD_CK2_1	76	82	PF00069	0.515
MOD_Cter_Amidation	214	217	PF01082	0.749
MOD_GlcNHglycan	144	147	PF01048	0.514
MOD_GlcNHglycan	157	160	PF01048	0.464
MOD_GlcNHglycan	218	221	PF01048	0.704
MOD_GlcNHglycan	267	270	PF01048	0.674
MOD_GlcNHglycan	27	30	PF01048	0.525
MOD_GlcNHglycan	292	297	PF01048	0.733
MOD_GlcNHglycan	32	36	PF01048	0.542
MOD_GlcNHglycan	412	415	PF01048	0.580
MOD_GlcNHglycan	53	56	PF01048	0.677
MOD_GlcNHglycan	59	62	PF01048	0.646
MOD_GSK3_1	101	108	PF00069	0.426
MOD_GSK3_1	21	28	PF00069	0.399
MOD_GSK3_1	292	299	PF00069	0.770
MOD_GSK3_1	37	44	PF00069	0.694
MOD_GSK3_1	401	408	PF00069	0.507
MOD_GSK3_1	51	58	PF00069	0.580
MOD_GSK3_1	76	83	PF00069	0.409
MOD_N-GLC_1	160	165	PF02516	0.536
MOD_N-GLC_1	240	245	PF02516	0.605
MOD_N-GLC_1	68	73	PF02516	0.419
MOD_NEK2_1	11	16	PF00069	0.402
MOD_NEK2_1	142	147	PF00069	0.452
MOD_NEK2_1	174	179	PF00069	0.430
MOD_NEK2_1	21	26	PF00069	0.391
MOD_NEK2_1	240	245	PF00069	0.584
MOD_NEK2_1	253	258	PF00069	0.534
MOD_NEK2_1	303	308	PF00069	0.774
MOD_NEK2_1	334	339	PF00069	0.497
MOD_NEK2_1	387	392	PF00069	0.547
MOD_NEK2_1	405	410	PF00069	0.343
MOD_NEK2_1	412	417	PF00069	0.588
MOD_NEK2_1	42	47	PF00069	0.751
MOD_NEK2_1	57	62	PF00069	0.439
MOD_NEK2_1	68	73	PF00069	0.363
MOD_NEK2_1	90	95	PF00069	0.381
MOD_NEK2_2	197	202	PF00069	0.517
MOD_NEK2_2	80	85	PF00069	0.517
MOD_PIKK_1	224	230	PF00454	0.627
MOD_PIKK_1	243	249	PF00454	0.385
MOD_PIKK_1	304	310	PF00454	0.778
MOD_PIKK_1	95	101	PF00454	0.507
MOD_PKA_1	216	222	PF00069	0.755
MOD_PKA_2	110	116	PF00069	0.545
MOD_PKA_2	188	194	PF00069	0.530
MOD_PKA_2	216	222	PF00069	0.762
MOD_PKA_2	235	241	PF00069	0.591
MOD_PKA_2	38	44	PF00069	0.635
MOD_Plk_1	160	166	PF00069	0.564
MOD_Plk_1	394	400	PF00069	0.501
MOD_Plk_1	68	74	PF00069	0.397
MOD_Plk_2-3	160	166	PF00069	0.531
MOD_Plk_4	105	111	PF00069	0.381
MOD_Plk_4	299	305	PF00069	0.759
MOD_Plk_4	401	407	PF00069	0.491
MOD_Plk_4	85	91	PF00069	0.455
MOD_ProDKin_1	1	7	PF00069	0.600
MOD_ProDKin_1	126	132	PF00069	0.465
MOD_SUMO_rev_2	340	345	PF00179	0.580
MOD_SUMO_rev_2	378	387	PF00179	0.525
TRG_DiLeu_BaEn_1	330	335	PF01217	0.487
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.511
TRG_DiLeu_LyEn_5	330	335	PF01217	0.510
TRG_ENDOCYTIC_2	72	75	PF00928	0.455
TRG_ER_diArg_1	285	288	PF00400	0.793
TRG_ER_diArg_1	331	333	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E0	Leptomonas seymouri	51%	97%
A0A0S4KH47	Bodo saltans	28%	100%
A0A1X0P5U4	Trypanosomatidae	33%	100%
A0A3Q8IF21	Leishmania donovani	83%	95%
A0A422NQ71	Trypanosoma rangeli	37%	100%
A4IB70	Leishmania infantum	81%	100%
C9ZZH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AEZ1	Leishmania major	77%	98%
E9B647	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	84%