XK-related protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

XK-related protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMI9_LEIBR

TriTrypDb:

LbrM.34.1590 , LBRM2903_340022200

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HMI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.546
CLV_NRD_NRD_1	264	266	PF00675	0.584
CLV_NRD_NRD_1	89	91	PF00675	0.334
CLV_PCSK_KEX2_1	173	175	PF00082	0.544
CLV_PCSK_KEX2_1	264	266	PF00082	0.584
CLV_PCSK_KEX2_1	87	89	PF00082	0.362
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.386
CLV_PCSK_SKI1_1	148	152	PF00082	0.389
DEG_SCF_FBW7_1	195	200	PF00400	0.603
DOC_CKS1_1	247	252	PF01111	0.736
DOC_CKS1_1	255	260	PF01111	0.607
DOC_CKS1_1	39	44	PF01111	0.466
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.304
DOC_MAPK_FxFP_2	152	155	PF00069	0.540
DOC_MAPK_gen_1	87	96	PF00069	0.501
DOC_MAPK_MEF2A_6	278	286	PF00069	0.671
DOC_MAPK_MEF2A_6	51	59	PF00069	0.217
DOC_MAPK_MEF2A_6	89	98	PF00069	0.525
DOC_PP1_RVXF_1	112	119	PF00149	0.398
DOC_PP1_RVXF_1	138	144	PF00149	0.438
DOC_PP1_RVXF_1	146	153	PF00149	0.645
DOC_PP4_FxxP_1	152	155	PF00568	0.666
DOC_PP4_FxxP_1	79	82	PF00568	0.581
DOC_WW_Pin1_4	193	198	PF00397	0.629
DOC_WW_Pin1_4	227	232	PF00397	0.706
DOC_WW_Pin1_4	238	243	PF00397	0.754
DOC_WW_Pin1_4	246	251	PF00397	0.779
DOC_WW_Pin1_4	254	259	PF00397	0.676
DOC_WW_Pin1_4	38	43	PF00397	0.465
LIG_14-3-3_CanoR_1	14	19	PF00244	0.501
LIG_14-3-3_CanoR_1	153	159	PF00244	0.576
LIG_14-3-3_CanoR_1	219	226	PF00244	0.751
LIG_14-3-3_CanoR_1	233	242	PF00244	0.725
LIG_14-3-3_CanoR_1	276	284	PF00244	0.598
LIG_14-3-3_CanoR_1	45	53	PF00244	0.385
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_FHA_1	108	114	PF00498	0.382
LIG_FHA_1	124	130	PF00498	0.254
LIG_FHA_1	14	20	PF00498	0.505
LIG_FHA_1	155	161	PF00498	0.558
LIG_FHA_1	167	173	PF00498	0.579
LIG_FHA_1	194	200	PF00498	0.753
LIG_FHA_1	203	209	PF00498	0.733
LIG_FHA_1	220	226	PF00498	0.756
LIG_FHA_2	255	261	PF00498	0.637
LIG_LIR_Apic_2	236	242	PF02991	0.731
LIG_LIR_Apic_2	244	250	PF02991	0.777
LIG_LIR_Gen_1	133	144	PF02991	0.357
LIG_LIR_Gen_1	223	234	PF02991	0.611
LIG_LIR_Gen_1	28	36	PF02991	0.427
LIG_LIR_Nem_3	133	139	PF02991	0.357
LIG_LIR_Nem_3	223	229	PF02991	0.617
LIG_LIR_Nem_3	28	33	PF02991	0.427
LIG_MAD2	111	119	PF02301	0.469
LIG_PDZ_Class_2	281	286	PF00595	0.743
LIG_Pex14_1	75	79	PF04695	0.559
LIG_Pex14_2	145	149	PF04695	0.489
LIG_Pex14_2	154	158	PF04695	0.497
LIG_Pex14_2	21	25	PF04695	0.357
LIG_REV1ctd_RIR_1	142	152	PF16727	0.347
LIG_SH2_CRK	136	140	PF00017	0.357
LIG_SH2_CRK	226	230	PF00017	0.616
LIG_SH2_CRK	240	244	PF00017	0.636
LIG_SH2_CRK	247	251	PF00017	0.629
LIG_SH2_NCK_1	240	244	PF00017	0.675
LIG_SH2_STAT3	164	167	PF00017	0.586
LIG_SH2_STAT5	127	130	PF00017	0.438
LIG_SH2_STAT5	181	184	PF00017	0.685
LIG_SH2_STAT5	54	57	PF00017	0.498
LIG_SH2_STAT5	65	68	PF00017	0.357
LIG_SH3_3	192	198	PF00018	0.676
LIG_SH3_3	36	42	PF00018	0.461
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.454
LIG_SUMO_SIM_par_1	204	209	PF11976	0.595
LIG_TYR_ITIM	52	57	PF00017	0.371
LIG_UBA3_1	105	111	PF00899	0.320
LIG_WRC_WIRS_1	18	23	PF05994	0.438
MOD_CDK_SPK_2	254	259	PF00069	0.641
MOD_CDK_SPxK_1	227	233	PF00069	0.649
MOD_CDK_SPxxK_3	38	45	PF00069	0.397
MOD_CK1_1	13	19	PF00069	0.462
MOD_CK1_1	159	165	PF00069	0.664
MOD_CK1_1	209	215	PF00069	0.753
MOD_CK1_1	241	247	PF00069	0.716
MOD_CK1_1	28	34	PF00069	0.434
MOD_CK1_1	44	50	PF00069	0.268
MOD_CK2_1	254	260	PF00069	0.751
MOD_GlcNHglycan	183	186	PF01048	0.580
MOD_GlcNHglycan	211	214	PF01048	0.505
MOD_GlcNHglycan	251	254	PF01048	0.542
MOD_GlcNHglycan	278	281	PF01048	0.584
MOD_GSK3_1	10	17	PF00069	0.560
MOD_GSK3_1	123	130	PF00069	0.282
MOD_GSK3_1	156	163	PF00069	0.752
MOD_GSK3_1	193	200	PF00069	0.670
MOD_GSK3_1	202	209	PF00069	0.653
MOD_GSK3_1	238	245	PF00069	0.734
MOD_GSK3_1	249	256	PF00069	0.744
MOD_GSK3_1	34	41	PF00069	0.559
MOD_N-GLC_1	179	184	PF02516	0.492
MOD_NEK2_1	123	128	PF00069	0.274
MOD_NEK2_1	134	139	PF00069	0.342
MOD_NEK2_1	225	230	PF00069	0.675
MOD_NEK2_1	25	30	PF00069	0.362
MOD_NEK2_1	55	60	PF00069	0.351
MOD_NEK2_1	67	72	PF00069	0.357
MOD_PIKK_1	163	169	PF00454	0.713
MOD_PKA_2	13	19	PF00069	0.418
MOD_PKA_2	209	215	PF00069	0.724
MOD_PKA_2	218	224	PF00069	0.755
MOD_PKA_2	44	50	PF00069	0.388
MOD_Plk_4	134	140	PF00069	0.273
MOD_Plk_4	14	20	PF00069	0.508
MOD_Plk_4	202	208	PF00069	0.739
MOD_Plk_4	25	31	PF00069	0.339
MOD_Plk_4	34	40	PF00069	0.227
MOD_Plk_4	55	61	PF00069	0.387
MOD_Plk_4	67	73	PF00069	0.357
MOD_ProDKin_1	193	199	PF00069	0.631
MOD_ProDKin_1	227	233	PF00069	0.706
MOD_ProDKin_1	238	244	PF00069	0.754
MOD_ProDKin_1	246	252	PF00069	0.734
MOD_ProDKin_1	254	260	PF00069	0.678
MOD_ProDKin_1	38	44	PF00069	0.462
TRG_ENDOCYTIC_2	136	139	PF00928	0.357
TRG_ENDOCYTIC_2	226	229	PF00928	0.618
TRG_ENDOCYTIC_2	54	57	PF00928	0.357
TRG_ER_diArg_1	172	174	PF00400	0.715
TRG_ER_diArg_1	264	266	PF00400	0.693
TRG_ER_diArg_1	275	278	PF00400	0.605
TRG_ER_diArg_1	88	90	PF00400	0.548
TRG_NLS_MonoCore_2	86	91	PF00514	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T3	Leptomonas seymouri	51%	98%
A0A3Q8IV65	Leishmania donovani	65%	100%
A0A3R7M240	Trypanosoma rangeli	39%	100%
A4IB69	Leishmania infantum	65%	100%
E9AEZ0	Leishmania major	64%	97%
E9B646	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
V5B3X7	Trypanosoma cruzi	41%	100%