Mismatch repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mismatch repair protein PMS1, putative

Species:

Leishmania braziliensis

UniProt:

A4HMI7_LEIBR

TriTrypDb:

LbrM.34.1570 , LBRM2903_340022000

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032300	mismatch repair complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0032389	MutLalpha complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HMI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006298	mismatch repair	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003690	double-stranded DNA binding	5	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0030983	mismatched DNA binding	6	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140299	small molecule sensor activity	1	10
GO:0140612	DNA damage sensor activity	2	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140664	ATP-dependent DNA damage sensor activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	435	439	PF00656	0.590
CLV_C14_Caspase3-7	509	513	PF00656	0.685
CLV_C14_Caspase3-7	544	548	PF00656	0.512
CLV_C14_Caspase3-7	565	569	PF00656	0.519
CLV_NRD_NRD_1	10	12	PF00675	0.461
CLV_NRD_NRD_1	210	212	PF00675	0.469
CLV_NRD_NRD_1	360	362	PF00675	0.321
CLV_NRD_NRD_1	377	379	PF00675	0.406
CLV_PCSK_KEX2_1	360	362	PF00082	0.299
CLV_PCSK_KEX2_1	377	379	PF00082	0.406
CLV_PCSK_KEX2_1	430	432	PF00082	0.586
CLV_PCSK_KEX2_1	622	624	PF00082	0.540
CLV_PCSK_KEX2_1	798	800	PF00082	0.541
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.299
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.704
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.540
CLV_PCSK_PC1ET2_1	798	800	PF00082	0.541
CLV_PCSK_SKI1_1	183	187	PF00082	0.532
CLV_PCSK_SKI1_1	193	197	PF00082	0.492
CLV_PCSK_SKI1_1	259	263	PF00082	0.506
CLV_PCSK_SKI1_1	27	31	PF00082	0.286
CLV_PCSK_SKI1_1	361	365	PF00082	0.321
CLV_PCSK_SKI1_1	37	41	PF00082	0.231
CLV_PCSK_SKI1_1	377	381	PF00082	0.413
CLV_PCSK_SKI1_1	719	723	PF00082	0.395
CLV_PCSK_SKI1_1	798	802	PF00082	0.505
CLV_Separin_Metazoa	831	835	PF03568	0.381
DEG_APCC_DBOX_1	819	827	PF00400	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DEG_SIAH_1	610	618	PF03145	0.504
DEG_SPOP_SBC_1	461	465	PF00917	0.761
DEG_SPOP_SBC_1	504	508	PF00917	0.694
DOC_AGCK_PIF_1	424	429	PF00069	0.534
DOC_CDC14_PxL_1	311	319	PF14671	0.420
DOC_CKS1_1	238	243	PF01111	0.535
DOC_CKS1_1	415	420	PF01111	0.435
DOC_CKS1_1	791	796	PF01111	0.462
DOC_CYCLIN_RxL_1	359	369	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	699	705	PF00134	0.377
DOC_MAPK_gen_1	360	366	PF00069	0.209
DOC_MAPK_gen_1	783	791	PF00069	0.321
DOC_MAPK_gen_1	798	804	PF00069	0.393
DOC_MAPK_MEF2A_6	37	45	PF00069	0.462
DOC_PP1_RVXF_1	273	279	PF00149	0.321
DOC_PP2B_LxvP_1	699	702	PF13499	0.420
DOC_USP7_MATH_1	140	144	PF00917	0.455
DOC_USP7_MATH_1	257	261	PF00917	0.506
DOC_USP7_MATH_1	330	334	PF00917	0.420
DOC_USP7_MATH_1	459	463	PF00917	0.763
DOC_USP7_MATH_1	504	508	PF00917	0.694
DOC_USP7_MATH_1	784	788	PF00917	0.321
DOC_USP7_UBL2_3	208	212	PF12436	0.505
DOC_USP7_UBL2_3	645	649	PF12436	0.420
DOC_WW_Pin1_4	237	242	PF00397	0.487
DOC_WW_Pin1_4	354	359	PF00397	0.423
DOC_WW_Pin1_4	414	419	PF00397	0.580
DOC_WW_Pin1_4	455	460	PF00397	0.604
DOC_WW_Pin1_4	496	501	PF00397	0.761
DOC_WW_Pin1_4	692	697	PF00397	0.404
DOC_WW_Pin1_4	78	83	PF00397	0.570
DOC_WW_Pin1_4	790	795	PF00397	0.431
LIG_14-3-3_CanoR_1	165	169	PF00244	0.467
LIG_14-3-3_CanoR_1	259	268	PF00244	0.395
LIG_14-3-3_CanoR_1	275	281	PF00244	0.316
LIG_14-3-3_CanoR_1	297	305	PF00244	0.266
LIG_14-3-3_CanoR_1	416	424	PF00244	0.570
LIG_14-3-3_CanoR_1	523	528	PF00244	0.734
LIG_14-3-3_CanoR_1	576	584	PF00244	0.597
LIG_14-3-3_CanoR_1	625	631	PF00244	0.637
LIG_14-3-3_CanoR_1	834	840	PF00244	0.450
LIG_14-3-3_CanoR_1	87	94	PF00244	0.494
LIG_Actin_WH2_2	570	587	PF00022	0.516
LIG_Actin_WH2_2	60	78	PF00022	0.330
LIG_BIR_III_4	449	453	PF00653	0.502
LIG_BRCT_BRCA1_1	132	136	PF00533	0.521
LIG_BRCT_BRCA1_1	278	282	PF00533	0.423
LIG_eIF4E_1	683	689	PF01652	0.462
LIG_FHA_1	112	118	PF00498	0.513
LIG_FHA_1	147	153	PF00498	0.462
LIG_FHA_1	161	167	PF00498	0.379
LIG_FHA_1	172	178	PF00498	0.405
LIG_FHA_1	187	193	PF00498	0.305
LIG_FHA_1	21	27	PF00498	0.399
LIG_FHA_1	240	246	PF00498	0.404
LIG_FHA_1	324	330	PF00498	0.248
LIG_FHA_1	38	44	PF00498	0.196
LIG_FHA_1	401	407	PF00498	0.572
LIG_FHA_1	410	416	PF00498	0.524
LIG_FHA_1	464	470	PF00498	0.604
LIG_FHA_1	497	503	PF00498	0.729
LIG_FHA_1	541	547	PF00498	0.657
LIG_FHA_1	70	76	PF00498	0.576
LIG_FHA_1	707	713	PF00498	0.209
LIG_FHA_1	768	774	PF00498	0.377
LIG_FHA_1	79	85	PF00498	0.523
LIG_FHA_1	820	826	PF00498	0.484
LIG_FHA_2	487	493	PF00498	0.795
LIG_FHA_2	529	535	PF00498	0.530
LIG_FHA_2	563	569	PF00498	0.520
LIG_FHA_2	595	601	PF00498	0.629
LIG_FHA_2	633	639	PF00498	0.500
LIG_LIR_Apic_2	455	459	PF02991	0.503
LIG_LIR_Apic_2	811	817	PF02991	0.441
LIG_LIR_Gen_1	422	432	PF02991	0.532
LIG_LIR_Nem_3	262	268	PF02991	0.404
LIG_LIR_Nem_3	279	285	PF02991	0.197
LIG_LIR_Nem_3	422	427	PF02991	0.522
LIG_LIR_Nem_3	597	601	PF02991	0.534
LIG_MYND_1	500	504	PF01753	0.797
LIG_MYND_1	538	542	PF01753	0.539
LIG_Pex14_1	278	282	PF04695	0.321
LIG_Pex14_2	657	661	PF04695	0.309
LIG_RPA_C_Fungi	171	183	PF08784	0.331
LIG_SH2_CRK	265	269	PF00017	0.420
LIG_SH2_CRK	741	745	PF00017	0.356
LIG_SH2_CRK	748	752	PF00017	0.331
LIG_SH2_CRK	766	770	PF00017	0.321
LIG_SH2_GRB2like	642	645	PF00017	0.392
LIG_SH2_NCK_1	100	104	PF00017	0.480
LIG_SH2_NCK_1	748	752	PF00017	0.321
LIG_SH2_SRC	168	171	PF00017	0.378
LIG_SH2_STAP1	168	172	PF00017	0.483
LIG_SH2_STAP1	352	356	PF00017	0.321
LIG_SH2_STAP1	477	481	PF00017	0.642
LIG_SH2_STAP1	685	689	PF00017	0.321
LIG_SH2_STAT5	100	103	PF00017	0.476
LIG_SH2_STAT5	206	209	PF00017	0.572
LIG_SH2_STAT5	456	459	PF00017	0.671
LIG_SH2_STAT5	642	645	PF00017	0.477
LIG_SH3_1	741	747	PF00018	0.462
LIG_SH3_3	223	229	PF00018	0.493
LIG_SH3_3	309	315	PF00018	0.321
LIG_SH3_3	599	605	PF00018	0.707
LIG_SH3_3	611	617	PF00018	0.622
LIG_SH3_3	741	747	PF00018	0.345
LIG_SUMO_SIM_par_1	148	154	PF11976	0.294
LIG_SUMO_SIM_par_1	242	250	PF11976	0.447
LIG_SUMO_SIM_par_1	362	369	PF11976	0.209
LIG_TRAF2_1	379	382	PF00917	0.438
LIG_TRAF2_1	386	389	PF00917	0.491
LIG_TRAF2_1	542	545	PF00917	0.741
LIG_TYR_ITIM	746	751	PF00017	0.321
LIG_TYR_ITIM	764	769	PF00017	0.345
LIG_WRC_WIRS_1	472	477	PF05994	0.646
MOD_CDK_SPK_2	496	501	PF00069	0.547
MOD_CDK_SPxK_1	354	360	PF00069	0.423
MOD_CDK_SPxxK_3	354	361	PF00069	0.423
MOD_CK1_1	156	162	PF00069	0.448
MOD_CK1_1	215	221	PF00069	0.436
MOD_CK1_1	281	287	PF00069	0.377
MOD_CK1_1	420	426	PF00069	0.578
MOD_CK1_1	455	461	PF00069	0.721
MOD_CK1_1	462	468	PF00069	0.653
MOD_CK1_1	505	511	PF00069	0.705
MOD_CK1_1	627	633	PF00069	0.632
MOD_CK1_1	733	739	PF00069	0.417
MOD_CK1_1	779	785	PF00069	0.321
MOD_CK1_1	86	92	PF00069	0.570
MOD_CK2_1	112	118	PF00069	0.739
MOD_CK2_1	172	178	PF00069	0.580
MOD_CK2_1	257	263	PF00069	0.509
MOD_CK2_1	523	529	PF00069	0.657
MOD_CK2_1	594	600	PF00069	0.472
MOD_CK2_1	644	650	PF00069	0.491
MOD_CK2_1	705	711	PF00069	0.462
MOD_GlcNHglycan	103	106	PF01048	0.623
MOD_GlcNHglycan	155	158	PF01048	0.536
MOD_GlcNHglycan	242	245	PF01048	0.446
MOD_GlcNHglycan	253	256	PF01048	0.427
MOD_GlcNHglycan	259	262	PF01048	0.405
MOD_GlcNHglycan	285	288	PF01048	0.373
MOD_GlcNHglycan	293	296	PF01048	0.385
MOD_GlcNHglycan	384	387	PF01048	0.599
MOD_GlcNHglycan	419	422	PF01048	0.571
MOD_GlcNHglycan	486	489	PF01048	0.737
MOD_GlcNHglycan	560	563	PF01048	0.676
MOD_GlcNHglycan	606	609	PF01048	0.745
MOD_GlcNHglycan	751	754	PF01048	0.451
MOD_GSK3_1	112	119	PF00069	0.755
MOD_GSK3_1	126	133	PF00069	0.523
MOD_GSK3_1	156	163	PF00069	0.436
MOD_GSK3_1	17	24	PF00069	0.416
MOD_GSK3_1	212	219	PF00069	0.521
MOD_GSK3_1	240	247	PF00069	0.463
MOD_GSK3_1	251	258	PF00069	0.463
MOD_GSK3_1	283	290	PF00069	0.298
MOD_GSK3_1	455	462	PF00069	0.655
MOD_GSK3_1	502	509	PF00069	0.715
MOD_GSK3_1	528	535	PF00069	0.658
MOD_GSK3_1	536	543	PF00069	0.512
MOD_GSK3_1	558	565	PF00069	0.667
MOD_GSK3_1	701	708	PF00069	0.423
MOD_GSK3_1	78	85	PF00069	0.528
MOD_N-GLC_1	276	281	PF02516	0.356
MOD_N-GLC_1	330	335	PF02516	0.420
MOD_N-GLC_1	346	351	PF02516	0.420
MOD_N-GLC_1	354	359	PF02516	0.414
MOD_N-GLC_2	551	553	PF02516	0.492
MOD_NEK2_1	172	177	PF00069	0.561
MOD_NEK2_1	186	191	PF00069	0.209
MOD_NEK2_1	268	273	PF00069	0.420
MOD_NEK2_1	67	72	PF00069	0.557
MOD_NEK2_1	739	744	PF00069	0.269
MOD_NEK2_1	83	88	PF00069	0.406
MOD_NEK2_2	160	165	PF00069	0.563
MOD_NEK2_2	217	222	PF00069	0.477
MOD_NEK2_2	39	44	PF00069	0.209
MOD_NEK2_2	586	591	PF00069	0.698
MOD_NEK2_2	835	840	PF00069	0.456
MOD_OFUCOSY	590	595	PF10250	0.488
MOD_PIKK_1	112	118	PF00454	0.758
MOD_PIKK_1	323	329	PF00454	0.428
MOD_PIKK_1	330	336	PF00454	0.413
MOD_PIKK_1	422	428	PF00454	0.656
MOD_PK_1	523	529	PF00069	0.642
MOD_PKA_2	164	170	PF00069	0.464
MOD_PKA_2	296	302	PF00069	0.321
MOD_PKA_2	452	458	PF00069	0.658
MOD_PKA_2	575	581	PF00069	0.695
MOD_PKA_2	624	630	PF00069	0.680
MOD_PKA_2	730	736	PF00069	0.461
MOD_PKA_2	785	791	PF00069	0.310
MOD_PKA_2	819	825	PF00069	0.317
MOD_PKA_2	86	92	PF00069	0.520
MOD_PKA_2	98	104	PF00069	0.587
MOD_PKB_1	623	631	PF00069	0.580
MOD_Plk_1	117	123	PF00069	0.513
MOD_Plk_1	20	26	PF00069	0.345
MOD_Plk_1	276	282	PF00069	0.262
MOD_Plk_1	346	352	PF00069	0.414
MOD_Plk_1	572	578	PF00069	0.741
MOD_Plk_2-3	126	132	PF00069	0.485
MOD_Plk_2-3	517	523	PF00069	0.529
MOD_Plk_4	21	27	PF00069	0.321
MOD_Plk_4	452	458	PF00069	0.778
MOD_Plk_4	471	477	PF00069	0.509
MOD_Plk_4	785	791	PF00069	0.321
MOD_ProDKin_1	237	243	PF00069	0.484
MOD_ProDKin_1	354	360	PF00069	0.423
MOD_ProDKin_1	414	420	PF00069	0.581
MOD_ProDKin_1	455	461	PF00069	0.605
MOD_ProDKin_1	496	502	PF00069	0.762
MOD_ProDKin_1	692	698	PF00069	0.404
MOD_ProDKin_1	78	84	PF00069	0.564
MOD_ProDKin_1	790	796	PF00069	0.431
MOD_SUMO_for_1	105	108	PF00179	0.772
MOD_SUMO_rev_2	31	39	PF00179	0.449
MOD_SUMO_rev_2	711	721	PF00179	0.420
MOD_SUMO_rev_2	733	739	PF00179	0.417
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.462
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.547
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.456
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.499
TRG_ENDOCYTIC_2	265	268	PF00928	0.420
TRG_ENDOCYTIC_2	685	688	PF00928	0.308
TRG_ENDOCYTIC_2	748	751	PF00928	0.321
TRG_ENDOCYTIC_2	766	769	PF00928	0.321
TRG_ER_diArg_1	180	183	PF00400	0.572
TRG_ER_diArg_1	201	204	PF00400	0.488
TRG_ER_diArg_1	376	378	PF00400	0.209
TRG_ER_diArg_1	431	434	PF00400	0.515
TRG_NLS_MonoExtC_3	429	435	PF00514	0.701
TRG_NLS_MonoExtN_4	358	364	PF00514	0.377
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	629	634	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H3	Leptomonas seymouri	62%	100%
A0A1X0P5S1	Trypanosomatidae	45%	100%
A0A3Q8IM41	Leishmania donovani	81%	100%
A4IB67	Leishmania infantum	80%	100%
C9ZZH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AEY8	Leishmania major	82%	100%
E9B644	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q12J93	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	23%	100%
V5BJF3	Trypanosoma cruzi	46%	100%