Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMI6_LEIBR

TriTrypDb:

LbrM.34.1560 , LBRM2903_340021900

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4HMI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.601
CLV_C14_Caspase3-7	535	539	PF00656	0.571
CLV_NRD_NRD_1	123	125	PF00675	0.662
CLV_NRD_NRD_1	142	144	PF00675	0.568
CLV_NRD_NRD_1	165	167	PF00675	0.542
CLV_NRD_NRD_1	206	208	PF00675	0.534
CLV_NRD_NRD_1	298	300	PF00675	0.613
CLV_NRD_NRD_1	331	333	PF00675	0.521
CLV_NRD_NRD_1	337	339	PF00675	0.529
CLV_NRD_NRD_1	429	431	PF00675	0.595
CLV_PCSK_KEX2_1	110	112	PF00082	0.609
CLV_PCSK_KEX2_1	123	125	PF00082	0.554
CLV_PCSK_KEX2_1	167	169	PF00082	0.610
CLV_PCSK_KEX2_1	206	208	PF00082	0.534
CLV_PCSK_KEX2_1	240	242	PF00082	0.476
CLV_PCSK_KEX2_1	298	300	PF00082	0.613
CLV_PCSK_KEX2_1	331	333	PF00082	0.507
CLV_PCSK_KEX2_1	336	338	PF00082	0.508
CLV_PCSK_KEX2_1	532	534	PF00082	0.563
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.609
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.641
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.446
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.563
CLV_PCSK_PC7_1	332	338	PF00082	0.395
CLV_PCSK_SKI1_1	167	171	PF00082	0.533
CLV_PCSK_SKI1_1	175	179	PF00082	0.532
CLV_PCSK_SKI1_1	240	244	PF00082	0.462
CLV_PCSK_SKI1_1	361	365	PF00082	0.543
CLV_PCSK_SKI1_1	402	406	PF00082	0.657
CLV_PCSK_SKI1_1	635	639	PF00082	0.640
CLV_Separin_Metazoa	362	366	PF03568	0.638
DEG_APCC_KENBOX_2	605	609	PF00400	0.617
DEG_Nend_UBRbox_3	1	3	PF02207	0.616
DEG_SPOP_SBC_1	40	44	PF00917	0.670
DOC_CYCLIN_yClb5_NLxxxL_5	395	403	PF00134	0.485
DOC_MAPK_DCC_7	76	85	PF00069	0.748
DOC_MAPK_gen_1	109	117	PF00069	0.542
DOC_MAPK_gen_1	358	366	PF00069	0.647
DOC_MAPK_gen_1	400	407	PF00069	0.623
DOC_MAPK_gen_1	475	484	PF00069	0.561
DOC_MAPK_MEF2A_6	400	407	PF00069	0.650
DOC_MAPK_MEF2A_6	475	484	PF00069	0.593
DOC_MAPK_MEF2A_6	76	85	PF00069	0.755
DOC_MAPK_NFAT4_5	400	408	PF00069	0.649
DOC_PP2B_LxvP_1	70	73	PF13499	0.713
DOC_USP7_MATH_1	215	219	PF00917	0.565
DOC_USP7_MATH_1	40	44	PF00917	0.664
DOC_USP7_MATH_1	455	459	PF00917	0.732
DOC_USP7_MATH_1	497	501	PF00917	0.626
DOC_USP7_MATH_1	54	58	PF00917	0.739
DOC_USP7_MATH_1	74	78	PF00917	0.671
DOC_WW_Pin1_4	50	55	PF00397	0.691
DOC_WW_Pin1_4	59	64	PF00397	0.676
DOC_WW_Pin1_4	76	81	PF00397	0.735
LIG_14-3-3_CanoR_1	562	570	PF00244	0.541
LIG_14-3-3_CanoR_1	572	579	PF00244	0.601
LIG_Actin_WH2_2	144	161	PF00022	0.637
LIG_deltaCOP1_diTrp_1	538	548	PF00928	0.439
LIG_FHA_1	182	188	PF00498	0.473
LIG_FHA_1	189	195	PF00498	0.498
LIG_FHA_1	203	209	PF00498	0.505
LIG_FHA_1	380	386	PF00498	0.761
LIG_FHA_1	440	446	PF00498	0.611
LIG_FHA_1	548	554	PF00498	0.550
LIG_FHA_2	17	23	PF00498	0.667
LIG_FHA_2	491	497	PF00498	0.578
LIG_FHA_2	602	608	PF00498	0.579
LIG_LIR_Gen_1	468	476	PF02991	0.556
LIG_LIR_Nem_3	104	108	PF02991	0.577
LIG_LIR_Nem_3	468	473	PF02991	0.637
LIG_PDZ_Class_2	634	639	PF00595	0.595
LIG_RPA_C_Fungi	255	267	PF08784	0.477
LIG_RPA_C_Fungi	494	506	PF08784	0.626
LIG_SH2_GRB2like	272	275	PF00017	0.575
LIG_SH2_PTP2	470	473	PF00017	0.659
LIG_SH2_SRC	12	15	PF00017	0.578
LIG_SH2_STAP1	272	276	PF00017	0.575
LIG_SH2_STAP1	530	534	PF00017	0.577
LIG_SH2_STAT5	105	108	PF00017	0.604
LIG_SH2_STAT5	12	15	PF00017	0.535
LIG_SH2_STAT5	421	424	PF00017	0.578
LIG_SH2_STAT5	470	473	PF00017	0.584
LIG_SH2_STAT5	530	533	PF00017	0.609
LIG_SH3_3	75	81	PF00018	0.700
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.480
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.545
LIG_SUMO_SIM_par_1	599	604	PF11976	0.472
LIG_SUMO_SIM_par_1	614	622	PF11976	0.432
LIG_TRAF2_1	179	182	PF00917	0.599
LIG_TRAF2_1	224	227	PF00917	0.557
LIG_TRAF2_1	289	292	PF00917	0.476
LIG_TRAF2_1	414	417	PF00917	0.596
LIG_TRAF2_1	566	569	PF00917	0.602
LIG_TRAF2_1	619	622	PF00917	0.587
MOD_CDK_SPxK_1	63	69	PF00069	0.536
MOD_CK1_1	218	224	PF00069	0.586
MOD_CK1_1	34	40	PF00069	0.707
MOD_CK1_1	368	374	PF00069	0.637
MOD_CK1_1	528	534	PF00069	0.610
MOD_CK1_1	79	85	PF00069	0.662
MOD_CK1_1	91	97	PF00069	0.557
MOD_CK2_1	12	18	PF00069	0.618
MOD_CK2_1	286	292	PF00069	0.504
MOD_CK2_1	373	379	PF00069	0.646
MOD_CK2_1	490	496	PF00069	0.533
MOD_CK2_1	497	503	PF00069	0.549
MOD_CK2_1	517	523	PF00069	0.287
MOD_CK2_1	572	578	PF00069	0.553
MOD_CK2_1	601	607	PF00069	0.521
MOD_CK2_1	616	622	PF00069	0.587
MOD_DYRK1A_RPxSP_1	76	80	PF00069	0.763
MOD_GlcNHglycan	14	17	PF01048	0.655
MOD_GlcNHglycan	36	39	PF01048	0.593
MOD_GlcNHglycan	367	370	PF01048	0.505
MOD_GlcNHglycan	43	46	PF01048	0.542
MOD_GlcNHglycan	457	460	PF01048	0.763
MOD_GlcNHglycan	519	522	PF01048	0.616
MOD_GlcNHglycan	85	88	PF01048	0.560
MOD_GlcNHglycan	99	102	PF01048	0.654
MOD_GSK3_1	214	221	PF00069	0.523
MOD_GSK3_1	242	249	PF00069	0.501
MOD_GSK3_1	27	34	PF00069	0.711
MOD_GSK3_1	365	372	PF00069	0.627
MOD_GSK3_1	455	462	PF00069	0.690
MOD_GSK3_1	50	57	PF00069	0.742
MOD_GSK3_1	528	535	PF00069	0.575
MOD_GSK3_1	59	66	PF00069	0.735
MOD_GSK3_1	79	86	PF00069	0.609
MOD_GSK3_1	8	15	PF00069	0.634
MOD_GSK3_1	97	104	PF00069	0.615
MOD_N-GLC_1	497	502	PF02516	0.597
MOD_N-GLC_1	512	517	PF02516	0.563
MOD_N-GLC_1	63	68	PF02516	0.710
MOD_NEK2_1	147	152	PF00069	0.507
MOD_NEK2_1	158	163	PF00069	0.582
MOD_NEK2_1	208	213	PF00069	0.553
MOD_NEK2_1	31	36	PF00069	0.712
MOD_NEK2_1	41	46	PF00069	0.597
MOD_NEK2_2	215	220	PF00069	0.570
MOD_PIKK_1	547	553	PF00454	0.555
MOD_PIKK_1	590	596	PF00454	0.573
MOD_PK_1	286	292	PF00069	0.550
MOD_PK_1	532	538	PF00069	0.601
MOD_PKA_1	532	538	PF00069	0.601
MOD_PKA_2	147	153	PF00069	0.545
MOD_PKA_2	158	164	PF00069	0.564
MOD_PKA_2	386	392	PF00069	0.764
MOD_PKA_2	394	400	PF00069	0.714
MOD_PKA_2	459	465	PF00069	0.654
MOD_PKA_2	532	538	PF00069	0.601
MOD_PKA_2	561	567	PF00069	0.463
MOD_PKB_1	315	323	PF00069	0.627
MOD_Plk_1	243	249	PF00069	0.479
MOD_Plk_1	286	292	PF00069	0.504
MOD_Plk_1	590	596	PF00069	0.481
MOD_Plk_1	606	612	PF00069	0.490
MOD_Plk_2-3	373	379	PF00069	0.646
MOD_Plk_2-3	580	586	PF00069	0.518
MOD_Plk_2-3	622	628	PF00069	0.582
MOD_Plk_4	101	107	PF00069	0.635
MOD_Plk_4	532	538	PF00069	0.601
MOD_Plk_4	8	14	PF00069	0.537
MOD_Plk_4	88	94	PF00069	0.677
MOD_ProDKin_1	50	56	PF00069	0.692
MOD_ProDKin_1	59	65	PF00069	0.677
MOD_ProDKin_1	76	82	PF00069	0.735
MOD_SUMO_for_1	169	172	PF00179	0.587
MOD_SUMO_for_1	179	182	PF00179	0.582
MOD_SUMO_for_1	573	576	PF00179	0.455
MOD_SUMO_rev_2	161	169	PF00179	0.629
MOD_SUMO_rev_2	232	242	PF00179	0.426
MOD_SUMO_rev_2	287	295	PF00179	0.476
MOD_SUMO_rev_2	342	351	PF00179	0.533
MOD_SUMO_rev_2	520	526	PF00179	0.613
MOD_SUMO_rev_2	575	584	PF00179	0.584
TRG_DiLeu_BaEn_1	300	305	PF01217	0.614
TRG_DiLeu_BaEn_4	328	334	PF01217	0.572
TRG_ENDOCYTIC_2	105	108	PF00928	0.548
TRG_ENDOCYTIC_2	470	473	PF00928	0.587
TRG_ER_diArg_1	122	124	PF00400	0.668
TRG_ER_diArg_1	129	132	PF00400	0.589
TRG_ER_diArg_1	166	169	PF00400	0.543
TRG_ER_diArg_1	192	195	PF00400	0.572
TRG_ER_diArg_1	206	208	PF00400	0.503
TRG_ER_diArg_1	276	279	PF00400	0.481
TRG_ER_diArg_1	297	299	PF00400	0.590
TRG_ER_diArg_1	331	333	PF00400	0.592
TRG_ER_diArg_1	336	338	PF00400	0.624
TRG_NES_CRM1_1	394	406	PF08389	0.662
TRG_NES_CRM1_1	615	630	PF08389	0.544
TRG_NLS_MonoExtC_3	166	172	PF00514	0.619
TRG_NLS_MonoExtN_4	164	171	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z0	Leptomonas seymouri	72%	95%
A0A0S4J233	Bodo saltans	30%	78%
A0A1X0P6M5	Trypanosomatidae	48%	100%
A0A3Q8IHW5	Leishmania donovani	89%	100%
A4IB66	Leishmania infantum	89%	100%
C9ZZH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AEY7	Leishmania major	89%	100%
E9B643	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BTK9	Trypanosoma cruzi	47%	96%