Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMI5_LEIBR

TriTrypDb:

LbrM.34.1550 , LBRM2903_340021800

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.409
CLV_NRD_NRD_1	227	229	PF00675	0.548
CLV_NRD_NRD_1	252	254	PF00675	0.570
CLV_NRD_NRD_1	341	343	PF00675	0.402
CLV_PCSK_KEX2_1	227	229	PF00082	0.548
CLV_PCSK_KEX2_1	252	254	PF00082	0.560
CLV_PCSK_SKI1_1	243	247	PF00082	0.637
CLV_PCSK_SKI1_1	275	279	PF00082	0.524
CLV_PCSK_SKI1_1	72	76	PF00082	0.563
DEG_APCC_DBOX_1	341	349	PF00400	0.375
DEG_SCF_FBW7_1	114	121	PF00400	0.566
DEG_SCF_FBW7_2	291	296	PF00400	0.467
DEG_SPOP_SBC_1	120	124	PF00917	0.557
DEG_SPOP_SBC_1	217	221	PF00917	0.477
DOC_CKS1_1	33	38	PF01111	0.526
DOC_PP4_FxxP_1	143	146	PF00568	0.588
DOC_PP4_FxxP_1	157	160	PF00568	0.548
DOC_USP7_MATH_1	118	122	PF00917	0.730
DOC_USP7_MATH_1	217	221	PF00917	0.669
DOC_USP7_MATH_1	310	314	PF00917	0.562
DOC_USP7_MATH_1	326	330	PF00917	0.523
DOC_WW_Pin1_4	114	119	PF00397	0.597
DOC_WW_Pin1_4	156	161	PF00397	0.721
DOC_WW_Pin1_4	289	294	PF00397	0.467
DOC_WW_Pin1_4	32	37	PF00397	0.527
DOC_WW_Pin1_4	75	80	PF00397	0.719
LIG_14-3-3_CanoR_1	149	154	PF00244	0.666
LIG_14-3-3_CanoR_1	84	89	PF00244	0.585
LIG_Actin_WH2_2	292	308	PF00022	0.678
LIG_APCC_ABBA_1	264	269	PF00400	0.532
LIG_BRCT_BRCA1_1	153	157	PF00533	0.601
LIG_EH1_1	239	247	PF00400	0.639
LIG_FHA_1	35	41	PF00498	0.528
LIG_FHA_1	76	82	PF00498	0.497
LIG_FHA_2	196	202	PF00498	0.507
LIG_FHA_2	323	329	PF00498	0.411
LIG_LIR_Apic_2	141	146	PF02991	0.591
LIG_LIR_Apic_2	154	160	PF02991	0.554
LIG_LIR_Nem_3	262	267	PF02991	0.554
LIG_LIR_Nem_3	279	284	PF02991	0.688
LIG_PDZ_Class_3	350	355	PF00595	0.643
LIG_Pex14_2	264	268	PF04695	0.671
LIG_SH2_SRC	183	186	PF00017	0.483
LIG_SH2_STAP1	47	51	PF00017	0.529
LIG_SH2_STAT3	238	241	PF00017	0.425
LIG_SH2_STAT3	282	285	PF00017	0.694
LIG_SH2_STAT5	165	168	PF00017	0.511
LIG_SH2_STAT5	183	186	PF00017	0.620
LIG_SH2_STAT5	214	217	PF00017	0.529
LIG_SH2_STAT5	238	241	PF00017	0.425
LIG_SH3_3	83	89	PF00018	0.536
LIG_SUMO_SIM_anti_2	37	45	PF11976	0.532
LIG_SUMO_SIM_par_1	110	117	PF11976	0.566
LIG_WRC_WIRS_1	140	145	PF05994	0.493
LIG_WW_1	145	148	PF00397	0.726
MOD_CK1_1	121	127	PF00069	0.556
MOD_CK1_1	151	157	PF00069	0.651
MOD_CK1_1	168	174	PF00069	0.442
MOD_CK1_1	220	226	PF00069	0.557
MOD_CK1_1	28	34	PF00069	0.661
MOD_CK1_1	87	93	PF00069	0.576
MOD_GlcNHglycan	128	131	PF01048	0.675
MOD_GlcNHglycan	133	136	PF01048	0.660
MOD_GlcNHglycan	154	157	PF01048	0.555
MOD_GlcNHglycan	167	170	PF01048	0.481
MOD_GlcNHglycan	27	30	PF01048	0.707
MOD_GlcNHglycan	285	288	PF01048	0.700
MOD_GlcNHglycan	312	315	PF01048	0.684
MOD_GlcNHglycan	98	101	PF01048	0.788
MOD_GSK3_1	112	119	PF00069	0.608
MOD_GSK3_1	148	155	PF00069	0.708
MOD_GSK3_1	216	223	PF00069	0.506
MOD_GSK3_1	24	31	PF00069	0.749
MOD_GSK3_1	283	290	PF00069	0.659
MOD_GSK3_1	322	329	PF00069	0.628
MOD_GSK3_1	96	103	PF00069	0.709
MOD_NEK2_1	131	136	PF00069	0.567
MOD_NEK2_1	216	221	PF00069	0.502
MOD_NEK2_1	23	28	PF00069	0.577
MOD_PIKK_1	220	226	PF00454	0.501
MOD_PK_1	149	155	PF00069	0.551
MOD_PKA_2	148	154	PF00069	0.724
MOD_Plk_1	100	106	PF00069	0.590
MOD_Plk_1	217	223	PF00069	0.474
MOD_Plk_4	11	17	PF00069	0.624
MOD_Plk_4	139	145	PF00069	0.493
MOD_Plk_4	28	34	PF00069	0.633
MOD_Plk_4	326	332	PF00069	0.551
MOD_ProDKin_1	114	120	PF00069	0.595
MOD_ProDKin_1	156	162	PF00069	0.718
MOD_ProDKin_1	289	295	PF00069	0.468
MOD_ProDKin_1	32	38	PF00069	0.526
MOD_ProDKin_1	75	81	PF00069	0.724
TRG_DiLeu_BaEn_1	176	181	PF01217	0.669
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.454
TRG_ENDOCYTIC_2	183	186	PF00928	0.480
TRG_ENDOCYTIC_2	281	284	PF00928	0.698
TRG_ER_diArg_1	1	4	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF7	Leptomonas seymouri	37%	100%
A0A3S7X929	Leishmania donovani	72%	100%
A4IB65	Leishmania infantum	72%	100%
E9AEY6	Leishmania major	72%	100%
E9B642	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%