Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMI4_LEIBR

TriTrypDb:

LbrM.34.1540 , LBRM2903_340021700

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.652
CLV_C14_Caspase3-7	19	23	PF00656	0.660
CLV_C14_Caspase3-7	365	369	PF00656	0.545
CLV_NRD_NRD_1	233	235	PF00675	0.635
CLV_NRD_NRD_1	299	301	PF00675	0.665
CLV_PCSK_KEX2_1	206	208	PF00082	0.626
CLV_PCSK_KEX2_1	233	235	PF00082	0.635
CLV_PCSK_KEX2_1	247	249	PF00082	0.506
CLV_PCSK_KEX2_1	289	291	PF00082	0.715
CLV_PCSK_KEX2_1	298	300	PF00082	0.657
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.556
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.561
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.585
CLV_PCSK_SKI1_1	116	120	PF00082	0.463
CLV_PCSK_SKI1_1	300	304	PF00082	0.680
DEG_APCC_DBOX_1	115	123	PF00400	0.532
DEG_COP1_1	61	70	PF00400	0.373
DEG_SPOP_SBC_1	302	306	PF00917	0.569
DOC_CKS1_1	209	214	PF01111	0.621
DOC_CKS1_1	311	316	PF01111	0.571
DOC_MAPK_gen_1	247	253	PF00069	0.562
DOC_MAPK_gen_1	298	309	PF00069	0.573
DOC_MAPK_MEF2A_6	35	43	PF00069	0.611
DOC_USP7_MATH_1	107	111	PF00917	0.632
DOC_USP7_MATH_1	178	182	PF00917	0.671
DOC_USP7_MATH_1	190	194	PF00917	0.530
DOC_USP7_MATH_1	261	265	PF00917	0.569
DOC_USP7_MATH_1	302	306	PF00917	0.738
DOC_USP7_MATH_1	338	342	PF00917	0.594
DOC_USP7_MATH_1	55	59	PF00917	0.416
DOC_USP7_MATH_1	93	97	PF00917	0.633
DOC_WW_Pin1_4	208	213	PF00397	0.794
DOC_WW_Pin1_4	274	279	PF00397	0.656
DOC_WW_Pin1_4	290	295	PF00397	0.693
DOC_WW_Pin1_4	307	312	PF00397	0.493
DOC_WW_Pin1_4	323	328	PF00397	0.614
LIG_14-3-3_CanoR_1	184	190	PF00244	0.668
LIG_14-3-3_CanoR_1	233	239	PF00244	0.603
LIG_14-3-3_CanoR_1	268	273	PF00244	0.663
LIG_14-3-3_CanoR_1	290	294	PF00244	0.810
LIG_14-3-3_CanoR_1	300	309	PF00244	0.644
LIG_14-3-3_CanoR_1	8	13	PF00244	0.583
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_4	368	372	PF00653	0.765
LIG_Clathr_ClatBox_1	15	19	PF01394	0.511
LIG_eIF4E_1	10	16	PF01652	0.340
LIG_FHA_1	291	297	PF00498	0.663
LIG_FHA_1	62	68	PF00498	0.632
LIG_FHA_2	126	132	PF00498	0.691
LIG_Integrin_RGD_1	201	203	PF01839	0.530
LIG_LIR_Gen_1	11	21	PF02991	0.608
LIG_LIR_Gen_1	76	83	PF02991	0.324
LIG_LIR_Nem_3	11	16	PF02991	0.588
LIG_LIR_Nem_3	36	41	PF02991	0.427
LIG_LIR_Nem_3	76	80	PF02991	0.573
LIG_LIR_Nem_3	96	102	PF02991	0.407
LIG_NRBOX	153	159	PF00104	0.359
LIG_PDZ_Class_2	429	434	PF00595	0.655
LIG_Pex14_1	200	204	PF04695	0.531
LIG_Pex14_1	297	301	PF04695	0.578
LIG_SH2_CRK	375	379	PF00017	0.566
LIG_SH2_NCK_1	209	213	PF00017	0.719
LIG_SH2_NCK_1	388	392	PF00017	0.588
LIG_SH2_PTP2	148	151	PF00017	0.354
LIG_SH2_PTP2	38	41	PF00017	0.577
LIG_SH2_SRC	38	41	PF00017	0.577
LIG_SH2_STAT5	148	151	PF00017	0.354
LIG_SH2_STAT5	375	378	PF00017	0.559
LIG_SH2_STAT5	38	41	PF00017	0.577
LIG_SH3_1	209	215	PF00018	0.833
LIG_SH3_3	209	215	PF00018	0.833
LIG_SH3_3	308	314	PF00018	0.568
LIG_SH3_3	329	335	PF00018	0.637
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.535
LIG_SUMO_SIM_par_1	117	124	PF11976	0.535
MOD_CAAXbox	431	434	PF01239	0.651
MOD_CDK_SPxK_1	328	334	PF00069	0.589
MOD_CDK_SPxxK_3	310	317	PF00069	0.574
MOD_CK1_1	183	189	PF00069	0.667
MOD_CK1_1	292	298	PF00069	0.656
MOD_CK1_1	310	316	PF00069	0.636
MOD_CK1_1	322	328	PF00069	0.554
MOD_CK1_1	407	413	PF00069	0.571
MOD_CK1_1	58	64	PF00069	0.367
MOD_CK2_1	111	117	PF00069	0.523
MOD_CK2_1	127	133	PF00069	0.686
MOD_CK2_1	386	392	PF00069	0.548
MOD_CK2_1	405	411	PF00069	0.774
MOD_GlcNHglycan	109	112	PF01048	0.401
MOD_GlcNHglycan	123	126	PF01048	0.544
MOD_GlcNHglycan	186	189	PF01048	0.743
MOD_GlcNHglycan	234	237	PF01048	0.633
MOD_GlcNHglycan	321	324	PF01048	0.617
MOD_GlcNHglycan	340	343	PF01048	0.747
MOD_GlcNHglycan	364	367	PF01048	0.713
MOD_GlcNHglycan	389	392	PF01048	0.587
MOD_GlcNHglycan	407	410	PF01048	0.602
MOD_GlcNHglycan	57	60	PF01048	0.435
MOD_GlcNHglycan	68	71	PF01048	0.398
MOD_GlcNHglycan	95	98	PF01048	0.626
MOD_GSK3_1	107	114	PF00069	0.469
MOD_GSK3_1	121	128	PF00069	0.692
MOD_GSK3_1	180	187	PF00069	0.585
MOD_GSK3_1	211	218	PF00069	0.580
MOD_GSK3_1	242	249	PF00069	0.758
MOD_GSK3_1	268	275	PF00069	0.717
MOD_GSK3_1	285	292	PF00069	0.571
MOD_GSK3_1	303	310	PF00069	0.740
MOD_GSK3_1	319	326	PF00069	0.572
MOD_GSK3_1	338	345	PF00069	0.526
MOD_GSK3_1	54	61	PF00069	0.379
MOD_LATS_1	182	188	PF00433	0.590
MOD_N-GLC_1	404	409	PF02516	0.541
MOD_NEK2_1	120	125	PF00069	0.517
MOD_NEK2_1	246	251	PF00069	0.563
MOD_NEK2_1	301	306	PF00069	0.635
MOD_NEK2_1	414	419	PF00069	0.784
MOD_NEK2_1	63	68	PF00069	0.628
MOD_NEK2_2	242	247	PF00069	0.596
MOD_PIKK_1	272	278	PF00454	0.832
MOD_PIKK_1	58	64	PF00454	0.355
MOD_PK_1	303	309	PF00069	0.571
MOD_PK_1	8	14	PF00069	0.587
MOD_PKA_1	289	295	PF00069	0.624
MOD_PKA_2	107	113	PF00069	0.404
MOD_PKA_2	178	184	PF00069	0.778
MOD_PKA_2	232	238	PF00069	0.588
MOD_PKA_2	289	295	PF00069	0.655
MOD_PKA_2	34	40	PF00069	0.406
MOD_PKA_2	373	379	PF00069	0.658
MOD_PKA_2	380	386	PF00069	0.680
MOD_PKA_2	405	411	PF00069	0.542
MOD_Plk_1	242	248	PF00069	0.637
MOD_Plk_4	292	298	PF00069	0.622
MOD_Plk_4	34	40	PF00069	0.406
MOD_Plk_4	8	14	PF00069	0.587
MOD_ProDKin_1	208	214	PF00069	0.795
MOD_ProDKin_1	274	280	PF00069	0.657
MOD_ProDKin_1	290	296	PF00069	0.693
MOD_ProDKin_1	307	313	PF00069	0.493
MOD_ProDKin_1	323	329	PF00069	0.613
TRG_ENDOCYTIC_2	10	13	PF00928	0.330
TRG_ENDOCYTIC_2	148	151	PF00928	0.354
TRG_ENDOCYTIC_2	375	378	PF00928	0.559
TRG_ENDOCYTIC_2	38	41	PF00928	0.577
TRG_ENDOCYTIC_2	99	102	PF00928	0.395
TRG_ER_diArg_1	297	300	PF00400	0.671
TRG_NES_CRM1_1	150	163	PF08389	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X927	Leishmania donovani	49%	91%
A4IB64	Leishmania infantum	49%	91%
E9AEY5	Leishmania major	49%	96%
E9B641	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%