LINES_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP82

Species:

Leishmania braziliensis

UniProt:

A4HMI1_LEIBR

TriTrypDb:

LbrM.34.1510 , LBRM2903_340021400

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HMI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.572
CLV_C14_Caspase3-7	143	147	PF00656	0.306
CLV_C14_Caspase3-7	174	178	PF00656	0.391
CLV_C14_Caspase3-7	226	230	PF00656	0.435
CLV_C14_Caspase3-7	385	389	PF00656	0.753
CLV_C14_Caspase3-7	593	597	PF00656	0.434
CLV_C14_Caspase3-7	81	85	PF00656	0.524
CLV_C14_Caspase3-7	9	13	PF00656	0.455
CLV_NRD_NRD_1	184	186	PF00675	0.486
CLV_NRD_NRD_1	414	416	PF00675	0.388
CLV_NRD_NRD_1	589	591	PF00675	0.480
CLV_NRD_NRD_1	667	669	PF00675	0.447
CLV_PCSK_KEX2_1	184	186	PF00082	0.486
CLV_PCSK_KEX2_1	203	205	PF00082	0.481
CLV_PCSK_KEX2_1	282	284	PF00082	0.522
CLV_PCSK_KEX2_1	414	416	PF00082	0.388
CLV_PCSK_KEX2_1	589	591	PF00082	0.480
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.425
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.522
CLV_PCSK_SKI1_1	203	207	PF00082	0.368
CLV_PCSK_SKI1_1	23	27	PF00082	0.475
CLV_PCSK_SKI1_1	231	235	PF00082	0.341
CLV_PCSK_SKI1_1	279	283	PF00082	0.440
CLV_PCSK_SKI1_1	293	297	PF00082	0.254
CLV_PCSK_SKI1_1	32	36	PF00082	0.513
CLV_PCSK_SKI1_1	415	419	PF00082	0.396
CLV_PCSK_SKI1_1	505	509	PF00082	0.464
CLV_PCSK_SKI1_1	590	594	PF00082	0.512
CLV_PCSK_SKI1_1	595	599	PF00082	0.519
DEG_APCC_DBOX_1	414	422	PF00400	0.355
DEG_Nend_UBRbox_3	1	3	PF02207	0.704
DEG_SCF_TRCP1_1	248	253	PF00400	0.465
DOC_CKS1_1	489	494	PF01111	0.242
DOC_MAPK_gen_1	203	210	PF00069	0.432
DOC_MAPK_MEF2A_6	203	210	PF00069	0.432
DOC_MAPK_MEF2A_6	53	61	PF00069	0.431
DOC_PP1_RVXF_1	229	235	PF00149	0.295
DOC_PP1_RVXF_1	666	673	PF00149	0.329
DOC_PP2B_LxvP_1	370	373	PF13499	0.441
DOC_PP2B_LxvP_1	428	431	PF13499	0.393
DOC_PP4_FxxP_1	210	213	PF00568	0.459
DOC_PP4_FxxP_1	489	492	PF00568	0.241
DOC_USP7_MATH_1	141	145	PF00917	0.509
DOC_USP7_MATH_1	171	175	PF00917	0.394
DOC_USP7_MATH_1	308	312	PF00917	0.335
DOC_USP7_MATH_1	371	375	PF00917	0.673
DOC_USP7_MATH_1	645	649	PF00917	0.438
DOC_USP7_MATH_1	687	691	PF00917	0.417
DOC_USP7_MATH_1	733	737	PF00917	0.559
DOC_USP7_MATH_1	762	766	PF00917	0.546
DOC_WW_Pin1_4	472	477	PF00397	0.319
DOC_WW_Pin1_4	488	493	PF00397	0.304
DOC_WW_Pin1_4	650	655	PF00397	0.627
LIG_14-3-3_CanoR_1	204	209	PF00244	0.450
LIG_14-3-3_CanoR_1	293	302	PF00244	0.389
LIG_14-3-3_CanoR_1	314	319	PF00244	0.526
LIG_14-3-3_CanoR_1	344	349	PF00244	0.270
LIG_14-3-3_CanoR_1	463	471	PF00244	0.347
LIG_14-3-3_CanoR_1	499	505	PF00244	0.295
LIG_14-3-3_CanoR_1	639	649	PF00244	0.466
LIG_14-3-3_CanoR_1	656	661	PF00244	0.698
LIG_BRCT_BRCA1_1	21	25	PF00533	0.407
LIG_BRCT_BRCA1_1	700	704	PF00533	0.474
LIG_Clathr_ClatBox_1	157	161	PF01394	0.244
LIG_FHA_1	190	196	PF00498	0.543
LIG_FHA_1	294	300	PF00498	0.438
LIG_FHA_1	393	399	PF00498	0.642
LIG_FHA_1	450	456	PF00498	0.413
LIG_FHA_1	465	471	PF00498	0.396
LIG_FHA_1	491	497	PF00498	0.448
LIG_FHA_1	50	56	PF00498	0.633
LIG_FHA_1	579	585	PF00498	0.438
LIG_FHA_1	701	707	PF00498	0.360
LIG_FHA_2	255	261	PF00498	0.588
LIG_FHA_2	267	273	PF00498	0.401
LIG_FHA_2	292	298	PF00498	0.480
LIG_FHA_2	512	518	PF00498	0.417
LIG_FHA_2	591	597	PF00498	0.316
LIG_FHA_2	619	625	PF00498	0.281
LIG_FHA_2	703	709	PF00498	0.467
LIG_LIR_Apic_2	207	213	PF02991	0.458
LIG_LIR_Gen_1	307	316	PF02991	0.344
LIG_LIR_Gen_1	42	50	PF02991	0.667
LIG_LIR_Gen_1	452	462	PF02991	0.421
LIG_LIR_Gen_1	69	79	PF02991	0.369
LIG_LIR_Gen_1	701	711	PF02991	0.415
LIG_LIR_Nem_3	22	28	PF02991	0.344
LIG_LIR_Nem_3	307	312	PF02991	0.452
LIG_LIR_Nem_3	313	319	PF02991	0.468
LIG_LIR_Nem_3	42	48	PF02991	0.670
LIG_LIR_Nem_3	452	457	PF02991	0.420
LIG_LIR_Nem_3	498	504	PF02991	0.354
LIG_LIR_Nem_3	69	74	PF02991	0.368
LIG_LIR_Nem_3	701	707	PF02991	0.418
LIG_LIR_Nem_3	88	94	PF02991	0.347
LIG_PCNA_yPIPBox_3	447	455	PF02747	0.235
LIG_PCNA_yPIPBox_3	570	584	PF02747	0.319
LIG_PDZ_Class_1	775	780	PF00595	0.466
LIG_Pex14_1	118	122	PF04695	0.417
LIG_Pex14_1	71	75	PF04695	0.411
LIG_Pex14_2	508	512	PF04695	0.473
LIG_RPA_C_Fungi	761	773	PF08784	0.474
LIG_SH2_CRK	501	505	PF00017	0.365
LIG_SH2_NCK_1	747	751	PF00017	0.446
LIG_SH2_SRC	547	550	PF00017	0.341
LIG_SH2_STAP1	33	37	PF00017	0.497
LIG_SH2_STAP1	336	340	PF00017	0.518
LIG_SH2_STAP1	547	551	PF00017	0.408
LIG_SH2_STAT5	182	185	PF00017	0.377
LIG_SH2_STAT5	322	325	PF00017	0.512
LIG_SH2_STAT5	454	457	PF00017	0.278
LIG_SH2_STAT5	557	560	PF00017	0.390
LIG_SH2_STAT5	628	631	PF00017	0.458
LIG_SH3_3	651	657	PF00018	0.519
LIG_SH3_3	753	759	PF00018	0.391
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.510
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.324
LIG_SUMO_SIM_par_1	204	209	PF11976	0.434
LIG_SUMO_SIM_par_1	272	278	PF11976	0.336
LIG_SUMO_SIM_par_1	390	399	PF11976	0.653
LIG_SUMO_SIM_par_1	613	618	PF11976	0.588
LIG_SUMO_SIM_par_1	740	746	PF11976	0.477
LIG_SUMO_SIM_par_1	95	102	PF11976	0.252
LIG_TRFH_1	458	462	PF08558	0.258
LIG_UBA3_1	273	282	PF00899	0.466
MOD_CDK_SPxK_1	650	656	PF00069	0.383
MOD_CK1_1	291	297	PF00069	0.473
MOD_CK1_1	399	405	PF00069	0.467
MOD_CK1_1	409	415	PF00069	0.525
MOD_CK1_1	481	487	PF00069	0.244
MOD_CK1_1	513	519	PF00069	0.488
MOD_CK1_1	618	624	PF00069	0.384
MOD_CK1_1	663	669	PF00069	0.518
MOD_CK1_1	69	75	PF00069	0.384
MOD_CK1_1	729	735	PF00069	0.528
MOD_CK2_1	324	330	PF00069	0.592
MOD_CK2_1	434	440	PF00069	0.540
MOD_CK2_1	538	544	PF00069	0.484
MOD_CK2_1	547	553	PF00069	0.461
MOD_CK2_1	618	624	PF00069	0.292
MOD_CK2_1	687	693	PF00069	0.553
MOD_CK2_1	702	708	PF00069	0.355
MOD_CK2_1	96	102	PF00069	0.339
MOD_GlcNHglycan	187	190	PF01048	0.448
MOD_GlcNHglycan	242	245	PF01048	0.675
MOD_GlcNHglycan	246	251	PF01048	0.706
MOD_GlcNHglycan	252	255	PF01048	0.691
MOD_GlcNHglycan	398	401	PF01048	0.666
MOD_GlcNHglycan	408	411	PF01048	0.564
MOD_GlcNHglycan	436	439	PF01048	0.607
MOD_GlcNHglycan	527	530	PF01048	0.447
MOD_GlcNHglycan	540	543	PF01048	0.455
MOD_GlcNHglycan	607	610	PF01048	0.524
MOD_GlcNHglycan	617	620	PF01048	0.406
MOD_GlcNHglycan	635	638	PF01048	0.381
MOD_GlcNHglycan	68	71	PF01048	0.459
MOD_GlcNHglycan	731	734	PF01048	0.593
MOD_GlcNHglycan	94	97	PF01048	0.433
MOD_GSK3_1	185	192	PF00069	0.499
MOD_GSK3_1	246	253	PF00069	0.551
MOD_GSK3_1	293	300	PF00069	0.380
MOD_GSK3_1	325	332	PF00069	0.480
MOD_GSK3_1	390	397	PF00069	0.609
MOD_GSK3_1	406	413	PF00069	0.615
MOD_GSK3_1	429	436	PF00069	0.412
MOD_GSK3_1	507	514	PF00069	0.348
MOD_GSK3_1	656	663	PF00069	0.647
MOD_GSK3_1	676	683	PF00069	0.423
MOD_GSK3_1	698	705	PF00069	0.482
MOD_GSK3_1	709	716	PF00069	0.470
MOD_GSK3_1	723	730	PF00069	0.570
MOD_GSK3_1	92	99	PF00069	0.333
MOD_N-GLC_1	109	114	PF02516	0.413
MOD_N-GLC_1	240	245	PF02516	0.577
MOD_N-GLC_1	324	329	PF02516	0.450
MOD_N-GLC_1	645	650	PF02516	0.304
MOD_N-GLC_1	85	90	PF02516	0.251
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	152	157	PF00069	0.408
MOD_NEK2_1	206	211	PF00069	0.445
MOD_NEK2_1	235	240	PF00069	0.556
MOD_NEK2_1	266	271	PF00069	0.384
MOD_NEK2_1	343	348	PF00069	0.358
MOD_NEK2_1	507	512	PF00069	0.350
MOD_NEK2_1	605	610	PF00069	0.315
MOD_NEK2_1	664	669	PF00069	0.467
MOD_NEK2_1	713	718	PF00069	0.486
MOD_PIKK_1	329	335	PF00454	0.306
MOD_PIKK_1	558	564	PF00454	0.366
MOD_PK_1	344	350	PF00069	0.271
MOD_PKA_2	343	349	PF00069	0.262
MOD_PKA_2	578	584	PF00069	0.470
MOD_PKA_2	655	661	PF00069	0.592
MOD_Plk_1	109	115	PF00069	0.248
MOD_Plk_1	645	651	PF00069	0.467
MOD_Plk_4	152	158	PF00069	0.450
MOD_Plk_4	171	177	PF00069	0.351
MOD_Plk_4	254	260	PF00069	0.601
MOD_Plk_4	314	320	PF00069	0.516
MOD_Plk_4	429	435	PF00069	0.427
MOD_Plk_4	44	50	PF00069	0.637
MOD_Plk_4	478	484	PF00069	0.371
MOD_Plk_4	709	715	PF00069	0.347
MOD_Plk_4	96	102	PF00069	0.321
MOD_ProDKin_1	472	478	PF00069	0.319
MOD_ProDKin_1	488	494	PF00069	0.300
MOD_ProDKin_1	650	656	PF00069	0.637
MOD_SUMO_for_1	524	527	PF00179	0.467
TRG_DiLeu_BaEn_1	89	94	PF01217	0.377
TRG_DiLeu_BaEn_2	484	490	PF01217	0.245
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.410
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.395
TRG_ENDOCYTIC_2	309	312	PF00928	0.362
TRG_ENDOCYTIC_2	316	319	PF00928	0.374
TRG_ENDOCYTIC_2	336	339	PF00928	0.334
TRG_ENDOCYTIC_2	454	457	PF00928	0.429
TRG_ENDOCYTIC_2	501	504	PF00928	0.345
TRG_ER_diArg_1	183	185	PF00400	0.388
TRG_ER_diArg_1	414	416	PF00400	0.393
TRG_ER_diArg_1	588	590	PF00400	0.463
TRG_NES_CRM1_1	89	102	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P593	Leptomonas seymouri	50%	98%
A0A0S4J4X2	Bodo saltans	25%	100%
A0A3S7X934	Leishmania donovani	79%	100%
A0A422NQA4	Trypanosoma rangeli	29%	100%
A4IB61	Leishmania infantum	79%	100%
C9ZZH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AEY2	Leishmania major	79%	100%
E9B638	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5B3W9	Trypanosoma cruzi	29%	100%