Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMI0_LEIBR

TriTrypDb:

LbrM.34.1500 , LBRM2903_340021300

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HMI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.440
CLV_C14_Caspase3-7	140	144	PF00656	0.404
CLV_C14_Caspase3-7	189	193	PF00656	0.529
CLV_C14_Caspase3-7	388	392	PF00656	0.281
CLV_NRD_NRD_1	403	405	PF00675	0.524
CLV_NRD_NRD_1	54	56	PF00675	0.538
CLV_NRD_NRD_1	96	98	PF00675	0.597
CLV_PCSK_KEX2_1	109	111	PF00082	0.727
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.727
CLV_PCSK_SKI1_1	283	287	PF00082	0.482
CLV_PCSK_SKI1_1	405	409	PF00082	0.524
CLV_PCSK_SKI1_1	55	59	PF00082	0.695
CLV_PCSK_SKI1_1	554	558	PF00082	0.580
DEG_APCC_DBOX_1	493	501	PF00400	0.419
DOC_CKS1_1	265	270	PF01111	0.305
DOC_MAPK_DCC_7	274	284	PF00069	0.314
DOC_MAPK_gen_1	4	13	PF00069	0.672
DOC_MAPK_gen_1	404	412	PF00069	0.371
DOC_MAPK_gen_1	55	61	PF00069	0.345
DOC_MAPK_gen_1	78	88	PF00069	0.348
DOC_MAPK_MEF2A_6	404	412	PF00069	0.383
DOC_MAPK_MEF2A_6	457	466	PF00069	0.364
DOC_MAPK_MEF2A_6	55	63	PF00069	0.345
DOC_PP1_RVXF_1	170	176	PF00149	0.336
DOC_PP2B_LxvP_1	512	515	PF13499	0.409
DOC_SPAK_OSR1_1	344	348	PF12202	0.449
DOC_USP7_MATH_1	2	6	PF00917	0.747
DOC_USP7_MATH_1	229	233	PF00917	0.527
DOC_USP7_MATH_1	378	382	PF00917	0.345
DOC_USP7_MATH_1	385	389	PF00917	0.353
DOC_WW_Pin1_4	181	186	PF00397	0.523
DOC_WW_Pin1_4	264	269	PF00397	0.387
DOC_WW_Pin1_4	337	342	PF00397	0.300
DOC_WW_Pin1_4	383	388	PF00397	0.425
DOC_WW_Pin1_4	458	463	PF00397	0.340
LIG_14-3-3_CanoR_1	262	266	PF00244	0.306
LIG_14-3-3_CanoR_1	283	291	PF00244	0.416
LIG_14-3-3_CanoR_1	37	45	PF00244	0.493
LIG_14-3-3_CanoR_1	494	498	PF00244	0.444
LIG_14-3-3_CanoR_1	540	548	PF00244	0.390
LIG_14-3-3_CanoR_1	554	562	PF00244	0.382
LIG_14-3-3_CanoR_1	6	12	PF00244	0.718
LIG_Actin_WH2_2	129	144	PF00022	0.357
LIG_Actin_WH2_2	43	60	PF00022	0.520
LIG_APCC_ABBAyCdc20_2	153	159	PF00400	0.368
LIG_BRCT_BRCA1_1	9	13	PF00533	0.672
LIG_Clathr_ClatBox_1	133	137	PF01394	0.543
LIG_Clathr_ClatBox_1	532	536	PF01394	0.390
LIG_EH_1	546	550	PF12763	0.310
LIG_FHA_1	145	151	PF00498	0.492
LIG_FHA_1	234	240	PF00498	0.482
LIG_FHA_1	251	257	PF00498	0.326
LIG_FHA_1	362	368	PF00498	0.435
LIG_FHA_1	505	511	PF00498	0.366
LIG_FHA_1	528	534	PF00498	0.380
LIG_FHA_1	540	546	PF00498	0.299
LIG_FHA_1	66	72	PF00498	0.504
LIG_FHA_2	189	195	PF00498	0.499
LIG_FHA_2	201	207	PF00498	0.526
LIG_FHA_2	241	247	PF00498	0.429
LIG_FHA_2	284	290	PF00498	0.385
LIG_FHA_2	516	522	PF00498	0.463
LIG_HCF-1_HBM_1	483	486	PF13415	0.426
LIG_HP1_1	162	166	PF01393	0.369
LIG_LIR_Apic_2	263	268	PF02991	0.399
LIG_LIR_Apic_2	39	45	PF02991	0.350
LIG_LIR_Gen_1	10	21	PF02991	0.550
LIG_LIR_Gen_1	481	490	PF02991	0.322
LIG_LIR_LC3C_4	20	25	PF02991	0.349
LIG_LIR_Nem_3	10	16	PF02991	0.655
LIG_LIR_Nem_3	100	106	PF02991	0.456
LIG_LIR_Nem_3	289	294	PF02991	0.370
LIG_LIR_Nem_3	391	397	PF02991	0.412
LIG_LIR_Nem_3	440	445	PF02991	0.367
LIG_LIR_Nem_3	481	485	PF02991	0.310
LIG_LYPXL_yS_3	442	445	PF13949	0.481
LIG_MYND_1	511	515	PF01753	0.439
LIG_NRBOX	496	502	PF00104	0.449
LIG_PCNA_yPIPBox_3	78	86	PF02747	0.507
LIG_Pex14_2	308	312	PF04695	0.353
LIG_PTB_Apo_2	222	229	PF02174	0.502
LIG_PTB_Apo_2	300	307	PF02174	0.412
LIG_REV1ctd_RIR_1	257	266	PF16727	0.410
LIG_SH2_CRK	301	305	PF00017	0.409
LIG_SH2_CRK	435	439	PF00017	0.414
LIG_SH2_GRB2like	301	304	PF00017	0.283
LIG_SH2_GRB2like	517	520	PF00017	0.437
LIG_SH2_NCK_1	517	521	PF00017	0.443
LIG_SH2_STAP1	294	298	PF00017	0.338
LIG_SH2_STAT3	397	400	PF00017	0.262
LIG_SH2_STAT5	333	336	PF00017	0.434
LIG_SH2_STAT5	437	440	PF00017	0.349
LIG_SH2_STAT5	470	473	PF00017	0.400
LIG_SH2_STAT5	480	483	PF00017	0.330
LIG_SH2_STAT5	486	489	PF00017	0.318
LIG_SH2_STAT5	517	520	PF00017	0.460
LIG_SH2_STAT5	555	558	PF00017	0.311
LIG_SH3_3	236	242	PF00018	0.458
LIG_SH3_3	335	341	PF00018	0.317
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.383
LIG_SUMO_SIM_par_1	46	52	PF11976	0.402
LIG_SUMO_SIM_par_1	530	536	PF11976	0.330
LIG_TRAF2_1	320	323	PF00917	0.486
LIG_TYR_ITIM	433	438	PF00017	0.405
MOD_CDK_SPxxK_3	337	344	PF00069	0.411
MOD_CK1_1	251	257	PF00069	0.335
MOD_CK1_1	310	316	PF00069	0.329
MOD_CK1_1	5	11	PF00069	0.595
MOD_CK2_1	188	194	PF00069	0.519
MOD_CK2_1	200	206	PF00069	0.414
MOD_CK2_1	240	246	PF00069	0.409
MOD_CK2_1	260	266	PF00069	0.225
MOD_CK2_1	283	289	PF00069	0.363
MOD_CK2_1	317	323	PF00069	0.486
MOD_CK2_1	492	498	PF00069	0.382
MOD_CK2_1	515	521	PF00069	0.438
MOD_GlcNHglycan	19	22	PF01048	0.444
MOD_GlcNHglycan	231	234	PF01048	0.731
MOD_GlcNHglycan	309	312	PF01048	0.510
MOD_GSK3_1	144	151	PF00069	0.440
MOD_GSK3_1	2	9	PF00069	0.705
MOD_GSK3_1	229	236	PF00069	0.499
MOD_GSK3_1	260	267	PF00069	0.322
MOD_GSK3_1	313	320	PF00069	0.352
MOD_GSK3_1	366	373	PF00069	0.420
MOD_GSK3_1	492	499	PF00069	0.415
MOD_GSK3_1	515	522	PF00069	0.451
MOD_GSK3_1	539	546	PF00069	0.310
MOD_GSK3_1	550	557	PF00069	0.306
MOD_GSK3_1	67	74	PF00069	0.367
MOD_N-GLC_1	111	116	PF02516	0.722
MOD_N-GLC_1	224	229	PF02516	0.748
MOD_N-GLC_1	233	238	PF02516	0.699
MOD_N-GLC_1	248	253	PF02516	0.704
MOD_N-GLC_1	260	265	PF02516	0.638
MOD_N-GLC_1	304	309	PF02516	0.554
MOD_N-GLC_1	443	448	PF02516	0.644
MOD_NEK2_1	148	153	PF00069	0.446
MOD_NEK2_1	260	265	PF00069	0.345
MOD_NEK2_1	549	554	PF00069	0.329
MOD_NEK2_1	77	82	PF00069	0.410
MOD_PIKK_1	113	119	PF00454	0.413
MOD_PIKK_1	473	479	PF00454	0.303
MOD_PIKK_1	504	510	PF00454	0.432
MOD_PIKK_1	65	71	PF00454	0.527
MOD_PKA_2	261	267	PF00069	0.379
MOD_PKA_2	353	359	PF00069	0.421
MOD_PKA_2	36	42	PF00069	0.522
MOD_PKA_2	493	499	PF00069	0.445
MOD_PKA_2	5	11	PF00069	0.720
MOD_PKA_2	539	545	PF00069	0.360
MOD_Plk_1	224	230	PF00069	0.560
MOD_Plk_1	248	254	PF00069	0.520
MOD_Plk_1	260	266	PF00069	0.440
MOD_Plk_1	304	310	PF00069	0.350
MOD_Plk_1	443	449	PF00069	0.369
MOD_Plk_1	504	510	PF00069	0.451
MOD_Plk_2-3	125	131	PF00069	0.363
MOD_Plk_2-3	49	55	PF00069	0.403
MOD_Plk_4	240	246	PF00069	0.339
MOD_Plk_4	275	281	PF00069	0.415
MOD_Plk_4	329	335	PF00069	0.284
MOD_Plk_4	496	502	PF00069	0.428
MOD_Plk_4	67	73	PF00069	0.400
MOD_Plk_4	7	13	PF00069	0.701
MOD_ProDKin_1	181	187	PF00069	0.522
MOD_ProDKin_1	264	270	PF00069	0.393
MOD_ProDKin_1	337	343	PF00069	0.301
MOD_ProDKin_1	383	389	PF00069	0.422
MOD_ProDKin_1	458	464	PF00069	0.337
MOD_SUMO_for_1	108	111	PF00179	0.526
MOD_SUMO_rev_2	49	57	PF00179	0.509
TRG_DiLeu_BaEn_1	129	134	PF01217	0.528
TRG_DiLeu_BaEn_1	67	72	PF01217	0.530
TRG_DiLeu_BaEn_4	247	253	PF01217	0.488
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.354
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.442
TRG_ENDOCYTIC_2	103	106	PF00928	0.507
TRG_ENDOCYTIC_2	435	438	PF00928	0.376
TRG_ENDOCYTIC_2	442	445	PF00928	0.429
TRG_ENDOCYTIC_2	486	489	PF00928	0.323
TRG_ER_diArg_1	172	175	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ6	Leptomonas seymouri	42%	100%
A0A0S4J8J1	Bodo saltans	27%	100%
A0A1X0P5Y1	Trypanosomatidae	28%	100%
A0A3R7KJC8	Trypanosoma rangeli	30%	100%
A0A3S7X958	Leishmania donovani	71%	99%
A4IB60	Leishmania infantum	72%	99%
E9AEY1	Leishmania major	69%	100%
E9B637	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
V5BJE1	Trypanosoma cruzi	28%	100%