Putative metacaspase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metacaspase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMH9_LEIBR

TriTrypDb:

LbrM.34.1490 , LBRM2903_340021200

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HMH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0050896	response to stimulus	1	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.145
CLV_NRD_NRD_1	232	234	PF00675	0.289
CLV_NRD_NRD_1	293	295	PF00675	0.321
CLV_NRD_NRD_1	39	41	PF00675	0.468
CLV_PCSK_KEX2_1	232	234	PF00082	0.278
CLV_PCSK_KEX2_1	28	30	PF00082	0.370
CLV_PCSK_KEX2_1	39	41	PF00082	0.386
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.418
CLV_PCSK_SKI1_1	125	129	PF00082	0.324
CLV_PCSK_SKI1_1	63	67	PF00082	0.222
CLV_PCSK_SKI1_1	86	90	PF00082	0.218
DEG_APCC_DBOX_1	85	93	PF00400	0.271
DOC_CDC14_PxL_1	14	22	PF14671	0.279
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.248
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.370
DOC_MAPK_gen_1	28	35	PF00069	0.276
DOC_MAPK_gen_1	294	301	PF00069	0.298
DOC_MAPK_gen_1	61	69	PF00069	0.279
DOC_MAPK_MEF2A_6	28	35	PF00069	0.425
DOC_MAPK_MEF2A_6	61	69	PF00069	0.281
DOC_MAPK_RevD_3	14	29	PF00069	0.446
DOC_PP2B_LxvP_1	185	188	PF13499	0.407
DOC_PP2B_LxvP_1	208	211	PF13499	0.248
DOC_PP2B_LxvP_1	395	398	PF13499	0.532
DOC_PP4_MxPP_1	348	351	PF00568	0.646
DOC_USP7_MATH_1	12	16	PF00917	0.591
DOC_WW_Pin1_4	403	408	PF00397	0.529
LIG_14-3-3_CanoR_1	373	379	PF00244	0.497
LIG_14-3-3_CanoR_1	392	396	PF00244	0.734
LIG_14-3-3_CanoR_1	40	46	PF00244	0.512
LIG_Actin_WH2_2	121	137	PF00022	0.329
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_Clathr_ClatBox_1	165	169	PF01394	0.316
LIG_eIF4E_1	313	319	PF01652	0.401
LIG_FHA_1	129	135	PF00498	0.407
LIG_FHA_1	269	275	PF00498	0.254
LIG_FHA_1	392	398	PF00498	0.761
LIG_FHA_2	250	256	PF00498	0.247
LIG_FHA_2	287	293	PF00498	0.338
LIG_FHA_2	72	78	PF00498	0.250
LIG_LIR_Apic_2	213	217	PF02991	0.407
LIG_LIR_Gen_1	179	190	PF02991	0.308
LIG_LIR_Gen_1	209	219	PF02991	0.248
LIG_LIR_Gen_1	271	280	PF02991	0.258
LIG_LIR_Gen_1	281	287	PF02991	0.237
LIG_LIR_Gen_1	428	434	PF02991	0.439
LIG_LIR_Nem_3	108	114	PF02991	0.325
LIG_LIR_Nem_3	138	144	PF02991	0.222
LIG_LIR_Nem_3	179	185	PF02991	0.304
LIG_LIR_Nem_3	209	215	PF02991	0.227
LIG_LIR_Nem_3	271	275	PF02991	0.243
LIG_LIR_Nem_3	277	283	PF02991	0.222
LIG_LIR_Nem_3	311	316	PF02991	0.399
LIG_LIR_Nem_3	317	322	PF02991	0.360
LIG_LIR_Nem_3	428	432	PF02991	0.721
LIG_NRBOX	282	288	PF00104	0.378
LIG_PCNA_yPIPBox_3	325	339	PF02747	0.262
LIG_Pex14_1	374	378	PF04695	0.608
LIG_SH2_CRK	357	361	PF00017	0.518
LIG_SH2_CRK	51	55	PF00017	0.415
LIG_SH2_GRB2like	236	239	PF00017	0.329
LIG_SH2_GRB2like	282	285	PF00017	0.407
LIG_SH2_NCK_1	357	361	PF00017	0.421
LIG_SH2_NCK_1	405	409	PF00017	0.648
LIG_SH2_PTP2	214	217	PF00017	0.407
LIG_SH2_SRC	282	285	PF00017	0.316
LIG_SH2_SRC	357	360	PF00017	0.610
LIG_SH2_STAP1	161	165	PF00017	0.294
LIG_SH2_STAT5	214	217	PF00017	0.302
LIG_SH2_STAT5	282	285	PF00017	0.316
LIG_SH2_STAT5	427	430	PF00017	0.729
LIG_SH2_STAT5	57	60	PF00017	0.363
LIG_SH2_STAT5	71	74	PF00017	0.262
LIG_SH3_2	47	52	PF14604	0.411
LIG_SH3_3	103	109	PF00018	0.333
LIG_SH3_3	185	191	PF00018	0.357
LIG_SH3_3	24	30	PF00018	0.322
LIG_SH3_3	296	302	PF00018	0.298
LIG_SH3_3	356	362	PF00018	0.636
LIG_SH3_3	395	401	PF00018	0.685
LIG_SH3_3	404	410	PF00018	0.698
LIG_SH3_3	413	419	PF00018	0.650
LIG_SH3_3	44	50	PF00018	0.353
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.459
LIG_TRAF2_1	289	292	PF00917	0.407
LIG_UBA3_1	165	172	PF00899	0.402
LIG_WRPW_2	313	316	PF00400	0.435
LIG_WW_3	29	33	PF00397	0.316
MOD_CK1_1	245	251	PF00069	0.348
MOD_CK1_1	403	409	PF00069	0.667
MOD_CK2_1	286	292	PF00069	0.372
MOD_CK2_1	71	77	PF00069	0.250
MOD_Cter_Amidation	37	40	PF01082	0.391
MOD_GlcNHglycan	144	147	PF01048	0.227
MOD_GlcNHglycan	203	206	PF01048	0.186
MOD_GlcNHglycan	244	247	PF01048	0.226
MOD_GlcNHglycan	249	252	PF01048	0.227
MOD_GSK3_1	112	119	PF00069	0.156
MOD_GSK3_1	245	252	PF00069	0.310
MOD_GSK3_1	264	271	PF00069	0.246
MOD_GSK3_1	274	281	PF00069	0.225
MOD_GSK3_1	320	327	PF00069	0.380
MOD_GSK3_1	93	100	PF00069	0.358
MOD_LATS_1	170	176	PF00433	0.402
MOD_N-GLC_1	172	177	PF02516	0.405
MOD_N-GLC_1	234	239	PF02516	0.265
MOD_N-GLC_1	324	329	PF02516	0.411
MOD_N-GLC_1	69	74	PF02516	0.316
MOD_NEK2_1	128	133	PF00069	0.316
MOD_NEK2_1	142	147	PF00069	0.210
MOD_NEK2_1	268	273	PF00069	0.281
MOD_NEK2_1	274	279	PF00069	0.241
MOD_NEK2_1	304	309	PF00069	0.243
MOD_NEK2_1	390	395	PF00069	0.567
MOD_NEK2_1	41	46	PF00069	0.463
MOD_NEK2_1	88	93	PF00069	0.242
MOD_NEK2_2	23	28	PF00069	0.409
MOD_PIKK_1	151	157	PF00454	0.202
MOD_PIKK_1	400	406	PF00454	0.750
MOD_PK_1	172	178	PF00069	0.402
MOD_PKA_2	151	157	PF00069	0.356
MOD_PKA_2	193	199	PF00069	0.222
MOD_PKA_2	372	378	PF00069	0.554
MOD_PKA_2	391	397	PF00069	0.538
MOD_Plk_1	324	330	PF00069	0.411
MOD_Plk_4	12	18	PF00069	0.567
MOD_Plk_4	172	178	PF00069	0.366
MOD_Plk_4	203	209	PF00069	0.232
MOD_Plk_4	324	330	PF00069	0.428
MOD_ProDKin_1	403	409	PF00069	0.529
TRG_DiLeu_BaEn_1	101	106	PF01217	0.234
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.371
TRG_ENDOCYTIC_2	282	285	PF00928	0.252
TRG_ENDOCYTIC_2	313	316	PF00928	0.473
TRG_ER_diArg_1	231	233	PF00400	0.328
TRG_ER_diArg_1	39	41	PF00400	0.474
TRG_NLS_MonoExtC_3	293	298	PF00514	0.407
TRG_NLS_MonoExtN_4	294	299	PF00514	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW49	Leptomonas seymouri	51%	95%
A0A0N1P9F5	Leptomonas seymouri	45%	100%
A0A0N1PDW0	Leptomonas seymouri	79%	100%
A0A0S4J2H4	Bodo saltans	54%	95%
A0A1X0NMB0	Trypanosomatidae	50%	100%
A0A1X0NMU0	Trypanosomatidae	51%	100%
A0A1X0P5R0	Trypanosomatidae	63%	100%
A0A3Q8IG58	Leishmania donovani	84%	99%
A0A422N5J3	Trypanosoma rangeli	50%	100%
A0A422NQE5	Trypanosoma rangeli	64%	94%
A1CL82	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	36%	100%
A1CQZ0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	100%
A1D3V4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	37%	100%
A1D611	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	36%	100%
A2QU58	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	99%
A2RB75	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	100%
A3LSY7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	37%	100%
A4IB59	Leishmania infantum	82%	97%
A4QTY2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	35%	100%
A5D9W7	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	38%	100%
A5DZS4	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	38%	97%
A6R7B8	Ajellomyces capsulatus (strain NAm1 / WU24)	37%	100%
A6SDT7	Botryotinia fuckeliana (strain B05.10)	36%	100%
A6ZP43	Saccharomyces cerevisiae (strain YJM789)	36%	100%
A7F075	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	37%	100%
B0XPP3	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	38%	100%
B0Y081	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	36%	100%
C9ZQB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZQB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZZG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	88%
D0A1S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A6D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AEY0	Leishmania major	83%	99%
E9B636	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
O74477	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P0CM58	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	94%
P0CM59	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	94%
Q08601	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q0CQL9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	100%
Q0CTN3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	100%
Q1E0A3	Coccidioides immitis (strain RS)	38%	94%
Q2UCB7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q2UN81	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q2VLK6	Trypanosoma cruzi (strain CL Brener)	47%	100%
Q2VLK8	Trypanosoma cruzi (strain CL Brener)	63%	98%
Q4PEQ5	Ustilago maydis (strain 521 / FGSC 9021)	39%	100%
Q4WJA1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	100%
Q4WYT0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	100%
Q585F3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	48%	100%
Q5ANA8	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	97%
Q6BH13	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	99%
Q6C2Y6	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	94%
Q6CLS0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6FPX9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q75B43	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	96%
Q7S232	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	96%
Q7S4N5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q7XJE6	Arabidopsis thaliana	32%	100%
Q8IEW1	Trypanosoma brucei brucei	55%	87%
Q8J140	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	100%
Q8T8E5	Trypanosoma brucei brucei	40%	100%
Q8T8E6	Trypanosoma brucei brucei	49%	100%
Q8T8E7	Trypanosoma brucei brucei	48%	100%
V5BTK1	Trypanosoma cruzi	62%	98%