LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
methyltransferase domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HMH8_LEIBR
TriTrypDb:
LbrM.34.1480 , LBRM2903_340021100
Length:
412

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

A4HMH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH8

Function

Biological processes
TermNameLevelCount
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 3
GO:0008168 methyltransferase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016741 transferase activity, transferring one-carbon groups 3 3
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 108 110 PF00675 0.491
CLV_PCSK_FUR_1 173 177 PF00082 0.395
CLV_PCSK_KEX2_1 175 177 PF00082 0.409
CLV_PCSK_KEX2_1 276 278 PF00082 0.440
CLV_PCSK_KEX2_1 407 409 PF00082 0.537
CLV_PCSK_KEX2_1 91 93 PF00082 0.425
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.389
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.542
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.537
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.464
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I341 Leptomonas seymouri 76% 100%
A0A0S4J626 Bodo saltans 64% 100%
A0A1X0P6L5 Trypanosomatidae 75% 100%
A0A3Q8IIX0 Leishmania donovani 90% 100%
A0A422NQ76 Trypanosoma rangeli 72% 100%
A4IB48 Leishmania infantum 93% 100%
A4IB58 Leishmania infantum 90% 100%
C9ZZG6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 100%
E9AEX9 Leishmania major 90% 100%
E9B635 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS