LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
methyltransferase domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HMH8_LEIBR
TriTrypDb:
LbrM.34.1480 , LBRM2903_340021100
Length:
412

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HMH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH8

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008168 methyltransferase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016741 transferase activity, transferring one-carbon groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.491
CLV_PCSK_FUR_1 173 177 PF00082 0.395
CLV_PCSK_KEX2_1 175 177 PF00082 0.409
CLV_PCSK_KEX2_1 276 278 PF00082 0.440
CLV_PCSK_KEX2_1 407 409 PF00082 0.537
CLV_PCSK_KEX2_1 91 93 PF00082 0.425
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.389
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.542
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.537
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.464
CLV_PCSK_SKI1_1 10 14 PF00082 0.478
CLV_PCSK_SKI1_1 109 113 PF00082 0.391
CLV_PCSK_SKI1_1 176 180 PF00082 0.392
CLV_PCSK_SKI1_1 315 319 PF00082 0.440
DEG_Nend_Nbox_1 1 3 PF02207 0.587
DOC_MAPK_gen_1 276 285 PF00069 0.203
DOC_MAPK_gen_1 315 325 PF00069 0.240
DOC_MAPK_MEF2A_6 318 326 PF00069 0.240
DOC_PP4_FxxP_1 96 99 PF00568 0.630
DOC_USP7_MATH_1 20 24 PF00917 0.538
DOC_USP7_MATH_1 6 10 PF00917 0.631
DOC_USP7_UBL2_3 175 179 PF12436 0.586
DOC_USP7_UBL2_3 272 276 PF12436 0.342
DOC_WW_Pin1_4 328 333 PF00397 0.243
DOC_WW_Pin1_4 355 360 PF00397 0.264
LIG_14-3-3_CanoR_1 264 273 PF00244 0.240
LIG_14-3-3_CanoR_1 277 286 PF00244 0.239
LIG_AP2alpha_1 339 343 PF02296 0.264
LIG_APCC_ABBA_1 283 288 PF00400 0.182
LIG_BRCT_BRCA1_1 49 53 PF00533 0.613
LIG_FHA_1 145 151 PF00498 0.580
LIG_FHA_1 20 26 PF00498 0.637
LIG_FHA_1 380 386 PF00498 0.259
LIG_FHA_1 84 90 PF00498 0.679
LIG_FHA_2 398 404 PF00498 0.368
LIG_LIR_Gen_1 288 298 PF02991 0.240
LIG_LIR_Nem_3 167 171 PF02991 0.598
LIG_LIR_Nem_3 200 204 PF02991 0.456
LIG_LIR_Nem_3 223 227 PF02991 0.250
LIG_LIR_Nem_3 268 273 PF02991 0.241
LIG_LIR_Nem_3 288 294 PF02991 0.150
LIG_LIR_Nem_3 331 336 PF02991 0.241
LIG_LIR_Nem_3 381 386 PF02991 0.258
LIG_LYPXL_SIV_4 332 340 PF13949 0.250
LIG_LYPXL_yS_3 333 336 PF13949 0.264
LIG_LYPXL_yS_3 388 391 PF13949 0.303
LIG_PCNA_yPIPBox_3 355 364 PF02747 0.239
LIG_Pex14_1 158 162 PF04695 0.562
LIG_Pex14_1 338 342 PF04695 0.244
LIG_Pex14_2 201 205 PF04695 0.437
LIG_Pex14_2 339 343 PF04695 0.240
LIG_PTB_Apo_2 373 380 PF02174 0.295
LIG_PTB_Phospho_1 373 379 PF10480 0.299
LIG_REV1ctd_RIR_1 199 207 PF16727 0.451
LIG_RPA_C_Fungi 363 375 PF08784 0.327
LIG_SH2_CRK 224 228 PF00017 0.276
LIG_SH2_CRK 263 267 PF00017 0.276
LIG_SH2_STAT3 162 165 PF00017 0.430
LIG_SH2_STAT3 342 345 PF00017 0.335
LIG_SH2_STAT5 168 171 PF00017 0.442
LIG_SH2_STAT5 342 345 PF00017 0.319
LIG_SH2_STAT5 363 366 PF00017 0.290
LIG_SH2_STAT5 384 387 PF00017 0.336
LIG_SH3_3 203 209 PF00018 0.399
LIG_SH3_3 313 319 PF00018 0.290
LIG_SH3_3 329 335 PF00018 0.290
LIG_SH3_3 383 389 PF00018 0.304
LIG_SUMO_SIM_anti_2 8 15 PF11976 0.485
LIG_SUMO_SIM_par_1 320 327 PF11976 0.316
LIG_TYR_ITIM 386 391 PF00017 0.343
LIG_TYR_ITSM 379 386 PF00017 0.316
MOD_CDC14_SPxK_1 358 361 PF00782 0.309
MOD_CDK_SPxK_1 355 361 PF00069 0.309
MOD_CK1_1 33 39 PF00069 0.515
MOD_CK1_1 48 54 PF00069 0.524
MOD_CK1_1 81 87 PF00069 0.660
MOD_CK2_1 364 370 PF00069 0.290
MOD_CK2_1 397 403 PF00069 0.454
MOD_GlcNHglycan 319 322 PF01048 0.290
MOD_GlcNHglycan 83 86 PF01048 0.728
MOD_GSK3_1 29 36 PF00069 0.548
MOD_GSK3_1 39 46 PF00069 0.510
MOD_GSK3_1 47 54 PF00069 0.488
MOD_GSK3_1 80 87 PF00069 0.531
MOD_N-GLC_1 34 39 PF02516 0.513
MOD_N-GLC_1 43 48 PF02516 0.523
MOD_N-GLC_1 70 75 PF02516 0.743
MOD_N-GLC_1 81 86 PF02516 0.568
MOD_NEK2_1 220 225 PF00069 0.326
MOD_NEK2_1 250 255 PF00069 0.290
MOD_NEK2_1 364 369 PF00069 0.306
MOD_NEK2_2 197 202 PF00069 0.407
MOD_NEK2_2 306 311 PF00069 0.360
MOD_PKA_2 29 35 PF00069 0.508
MOD_PKB_1 277 285 PF00069 0.419
MOD_Plk_1 70 76 PF00069 0.651
MOD_Plk_2-3 397 403 PF00069 0.399
MOD_Plk_4 197 203 PF00069 0.344
MOD_Plk_4 20 26 PF00069 0.498
MOD_Plk_4 379 385 PF00069 0.360
MOD_Plk_4 70 76 PF00069 0.611
MOD_ProDKin_1 328 334 PF00069 0.280
MOD_ProDKin_1 355 361 PF00069 0.309
MOD_SUMO_rev_2 366 374 PF00179 0.290
TRG_ENDOCYTIC_2 168 171 PF00928 0.502
TRG_ENDOCYTIC_2 224 227 PF00928 0.276
TRG_ENDOCYTIC_2 333 336 PF00928 0.276
TRG_ENDOCYTIC_2 383 386 PF00928 0.295
TRG_ENDOCYTIC_2 388 391 PF00928 0.360
TRG_NLS_MonoExtC_3 275 281 PF00514 0.419
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 210 214 PF00026 0.282

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I341 Leptomonas seymouri 76% 100%
A0A0S4J626 Bodo saltans 64% 100%
A0A1X0P6L5 Trypanosomatidae 75% 100%
A0A3Q8IIX0 Leishmania donovani 90% 100%
A0A422NQ76 Trypanosoma rangeli 72% 100%
A4IB48 Leishmania infantum 93% 100%
A4IB58 Leishmania infantum 90% 100%
C9ZZG6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 100%
E9AEX9 Leishmania major 90% 100%
E9B635 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5DKE6 Trypanosoma cruzi 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS