Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMH6_LEIBR

TriTrypDb:

LbrM.34.1460 , LBRM2903_340020900

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.762
CLV_C14_Caspase3-7	393	397	PF00656	0.563
CLV_NRD_NRD_1	102	104	PF00675	0.599
CLV_NRD_NRD_1	131	133	PF00675	0.810
CLV_NRD_NRD_1	229	231	PF00675	0.600
CLV_NRD_NRD_1	323	325	PF00675	0.584
CLV_NRD_NRD_1	344	346	PF00675	0.661
CLV_NRD_NRD_1	354	356	PF00675	0.640
CLV_NRD_NRD_1	411	413	PF00675	0.582
CLV_NRD_NRD_1	467	469	PF00675	0.527
CLV_NRD_NRD_1	504	506	PF00675	0.696
CLV_PCSK_KEX2_1	131	133	PF00082	0.810
CLV_PCSK_KEX2_1	323	325	PF00082	0.578
CLV_PCSK_KEX2_1	344	346	PF00082	0.624
CLV_PCSK_KEX2_1	353	355	PF00082	0.639
CLV_PCSK_KEX2_1	410	412	PF00082	0.555
CLV_PCSK_KEX2_1	467	469	PF00082	0.527
CLV_PCSK_KEX2_1	503	505	PF00082	0.773
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.608
CLV_PCSK_PC7_1	463	469	PF00082	0.524
CLV_PCSK_SKI1_1	230	234	PF00082	0.683
CLV_PCSK_SKI1_1	344	348	PF00082	0.582
CLV_PCSK_SKI1_1	467	471	PF00082	0.514
DEG_APCC_DBOX_1	466	474	PF00400	0.504
DOC_CKS1_1	362	367	PF01111	0.754
DOC_CKS1_1	372	377	PF01111	0.576
DOC_CKS1_1	624	629	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.651
DOC_MAPK_gen_1	230	238	PF00069	0.709
DOC_MAPK_gen_1	323	331	PF00069	0.587
DOC_MAPK_gen_1	410	419	PF00069	0.524
DOC_MAPK_RevD_3	308	324	PF00069	0.674
DOC_PP2B_LxvP_1	215	218	PF13499	0.660
DOC_PP2B_LxvP_1	329	332	PF13499	0.594
DOC_PP4_MxPP_1	670	673	PF00568	0.569
DOC_USP7_MATH_1	223	227	PF00917	0.485
DOC_USP7_MATH_1	420	424	PF00917	0.328
DOC_USP7_MATH_1	453	457	PF00917	0.565
DOC_USP7_MATH_1	499	503	PF00917	0.725
DOC_USP7_MATH_1	559	563	PF00917	0.565
DOC_USP7_MATH_1	65	69	PF00917	0.572
DOC_WW_Pin1_4	119	124	PF00397	0.735
DOC_WW_Pin1_4	236	241	PF00397	0.622
DOC_WW_Pin1_4	279	284	PF00397	0.688
DOC_WW_Pin1_4	294	299	PF00397	0.415
DOC_WW_Pin1_4	361	366	PF00397	0.801
DOC_WW_Pin1_4	371	376	PF00397	0.580
DOC_WW_Pin1_4	397	402	PF00397	0.707
DOC_WW_Pin1_4	620	625	PF00397	0.752
DOC_WW_Pin1_4	69	74	PF00397	0.758
LIG_14-3-3_CanoR_1	18	24	PF00244	0.451
LIG_14-3-3_CanoR_1	224	232	PF00244	0.674
LIG_14-3-3_CanoR_1	242	249	PF00244	0.467
LIG_14-3-3_CanoR_1	376	382	PF00244	0.597
LIG_14-3-3_CanoR_1	40	48	PF00244	0.517
LIG_14-3-3_CanoR_1	560	566	PF00244	0.534
LIG_14-3-3_CanoR_1	630	637	PF00244	0.611
LIG_14-3-3_CanoR_1	66	73	PF00244	0.803
LIG_AP2alpha_1	7	11	PF02296	0.588
LIG_APCC_ABBAyCdc20_2	410	416	PF00400	0.556
LIG_BIR_II_1	1	5	PF00653	0.359
LIG_BRCT_BRCA1_1	305	309	PF00533	0.583
LIG_Clathr_ClatBox_1	402	406	PF01394	0.648
LIG_deltaCOP1_diTrp_1	545	552	PF00928	0.635
LIG_EH1_1	106	114	PF00400	0.536
LIG_eIF4E_1	671	677	PF01652	0.459
LIG_FHA_1	194	200	PF00498	0.603
LIG_FHA_1	231	237	PF00498	0.653
LIG_FHA_1	326	332	PF00498	0.591
LIG_FHA_1	357	363	PF00498	0.624
LIG_FHA_1	384	390	PF00498	0.768
LIG_FHA_1	442	448	PF00498	0.500
LIG_FHA_1	476	482	PF00498	0.707
LIG_FHA_1	631	637	PF00498	0.722
LIG_FHA_1	663	669	PF00498	0.634
LIG_FHA_1	84	90	PF00498	0.470
LIG_FHA_2	288	294	PF00498	0.567
LIG_FHA_2	652	658	PF00498	0.547
LIG_LIR_Gen_1	206	215	PF02991	0.485
LIG_LIR_Gen_1	266	276	PF02991	0.717
LIG_LIR_Gen_1	446	455	PF02991	0.348
LIG_LIR_Gen_1	46	56	PF02991	0.536
LIG_LIR_Gen_1	511	518	PF02991	0.625
LIG_LIR_Gen_1	544	553	PF02991	0.518
LIG_LIR_Gen_1	6	14	PF02991	0.360
LIG_LIR_Nem_3	206	210	PF02991	0.490
LIG_LIR_Nem_3	266	272	PF02991	0.657
LIG_LIR_Nem_3	297	302	PF02991	0.608
LIG_LIR_Nem_3	341	346	PF02991	0.746
LIG_LIR_Nem_3	446	451	PF02991	0.338
LIG_LIR_Nem_3	46	51	PF02991	0.485
LIG_LIR_Nem_3	511	516	PF02991	0.615
LIG_LIR_Nem_3	6	11	PF02991	0.528
LIG_PCNA_PIPBox_1	1	10	PF02747	0.361
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.625
LIG_Pex14_2	7	11	PF04695	0.588
LIG_PTAP_UEV_1	257	262	PF05743	0.642
LIG_RPA_C_Fungi	178	190	PF08784	0.621
LIG_SH2_CRK	343	347	PF00017	0.755
LIG_SH2_STAP1	8	12	PF00017	0.605
LIG_SH2_STAT3	14	17	PF00017	0.387
LIG_SH2_STAT3	566	569	PF00017	0.413
LIG_SH2_STAT5	14	17	PF00017	0.528
LIG_SH2_STAT5	207	210	PF00017	0.427
LIG_SH2_STAT5	533	536	PF00017	0.629
LIG_SH3_2	458	463	PF14604	0.528
LIG_SH3_3	255	261	PF00018	0.666
LIG_SH3_3	414	420	PF00018	0.539
LIG_SH3_3	455	461	PF00018	0.665
LIG_SH3_3	621	627	PF00018	0.811
LIG_SH3_5	123	127	PF00018	0.591
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.612
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.538
LIG_SUMO_SIM_anti_2	570	576	PF11976	0.516
LIG_SUMO_SIM_par_1	648	655	PF11976	0.535
LIG_SUMO_SIM_par_1	82	90	PF11976	0.454
MOD_CDC14_SPxK_1	239	242	PF00782	0.430
MOD_CDC14_SPxK_1	297	300	PF00782	0.607
MOD_CDC14_SPxK_1	72	75	PF00782	0.539
MOD_CDK_SPK_2	371	376	PF00069	0.527
MOD_CDK_SPxK_1	236	242	PF00069	0.432
MOD_CDK_SPxK_1	294	300	PF00069	0.598
MOD_CDK_SPxK_1	69	75	PF00069	0.548
MOD_CDK_SPxxK_3	397	404	PF00069	0.699
MOD_CDK_SPxxK_3	623	630	PF00069	0.618
MOD_CK1_1	108	114	PF00069	0.549
MOD_CK1_1	137	143	PF00069	0.615
MOD_CK1_1	456	462	PF00069	0.682
MOD_CK1_1	497	503	PF00069	0.601
MOD_CK1_1	511	517	PF00069	0.594
MOD_CK1_1	535	541	PF00069	0.707
MOD_CK1_1	554	560	PF00069	0.723
MOD_CK1_1	619	625	PF00069	0.723
MOD_CK1_1	629	635	PF00069	0.750
MOD_CK1_1	68	74	PF00069	0.705
MOD_CK1_1	83	89	PF00069	0.517
MOD_CK2_1	174	180	PF00069	0.474
MOD_CK2_1	287	293	PF00069	0.613
MOD_CK2_1	559	565	PF00069	0.486
MOD_GlcNHglycan	137	140	PF01048	0.793
MOD_GlcNHglycan	146	149	PF01048	0.614
MOD_GlcNHglycan	175	179	PF01048	0.626
MOD_GlcNHglycan	218	221	PF01048	0.621
MOD_GlcNHglycan	258	261	PF01048	0.642
MOD_GlcNHglycan	383	386	PF01048	0.699
MOD_GlcNHglycan	392	396	PF01048	0.689
MOD_GlcNHglycan	499	502	PF01048	0.647
MOD_GlcNHglycan	510	513	PF01048	0.602
MOD_GlcNHglycan	538	541	PF01048	0.647
MOD_GlcNHglycan	556	559	PF01048	0.420
MOD_GlcNHglycan	83	86	PF01048	0.546
MOD_GSK3_1	12	19	PF00069	0.565
MOD_GSK3_1	161	168	PF00069	0.742
MOD_GSK3_1	236	243	PF00069	0.608
MOD_GSK3_1	356	363	PF00069	0.724
MOD_GSK3_1	377	384	PF00069	0.726
MOD_GSK3_1	475	482	PF00069	0.623
MOD_GSK3_1	532	539	PF00069	0.683
MOD_GSK3_1	594	601	PF00069	0.728
MOD_GSK3_1	616	623	PF00069	0.697
MOD_GSK3_1	625	632	PF00069	0.706
MOD_GSK3_1	64	71	PF00069	0.690
MOD_GSK3_1	652	659	PF00069	0.545
MOD_GSK3_1	79	86	PF00069	0.512
MOD_N-GLC_1	594	599	PF02516	0.629
MOD_N-GLC_1	619	624	PF02516	0.630
MOD_N-GLC_1	638	643	PF02516	0.671
MOD_NEK2_1	105	110	PF00069	0.665
MOD_NEK2_1	12	17	PF00069	0.642
MOD_NEK2_1	143	148	PF00069	0.733
MOD_NEK2_1	193	198	PF00069	0.599
MOD_NEK2_1	302	307	PF00069	0.544
MOD_NEK2_1	474	479	PF00069	0.553
MOD_NEK2_1	508	513	PF00069	0.536
MOD_NEK2_1	593	598	PF00069	0.639
MOD_NEK2_1	64	69	PF00069	0.717
MOD_NEK2_1	80	85	PF00069	0.559
MOD_NEK2_2	65	70	PF00069	0.686
MOD_PIKK_1	12	18	PF00454	0.649
MOD_PIKK_1	193	199	PF00454	0.645
MOD_PIKK_1	565	571	PF00454	0.404
MOD_PK_1	161	167	PF00069	0.688
MOD_PKA_1	230	236	PF00069	0.714
MOD_PKA_1	354	360	PF00069	0.802
MOD_PKA_2	17	23	PF00069	0.511
MOD_PKA_2	223	229	PF00069	0.475
MOD_PKA_2	287	293	PF00069	0.680
MOD_PKA_2	354	360	PF00069	0.790
MOD_PKA_2	39	45	PF00069	0.503
MOD_PKA_2	559	565	PF00069	0.601
MOD_PKA_2	629	635	PF00069	0.621
MOD_PKA_2	65	71	PF00069	0.804
MOD_Plk_1	165	171	PF00069	0.730
MOD_Plk_1	270	276	PF00069	0.557
MOD_Plk_1	420	426	PF00069	0.396
MOD_Plk_4	105	111	PF00069	0.569
MOD_Plk_4	165	171	PF00069	0.711
MOD_Plk_4	303	309	PF00069	0.563
MOD_Plk_4	325	331	PF00069	0.552
MOD_Plk_4	334	340	PF00069	0.558
MOD_Plk_4	420	426	PF00069	0.396
MOD_Plk_4	443	449	PF00069	0.392
MOD_Plk_4	606	612	PF00069	0.604
MOD_ProDKin_1	119	125	PF00069	0.739
MOD_ProDKin_1	236	242	PF00069	0.623
MOD_ProDKin_1	279	285	PF00069	0.685
MOD_ProDKin_1	294	300	PF00069	0.416
MOD_ProDKin_1	361	367	PF00069	0.800
MOD_ProDKin_1	371	377	PF00069	0.578
MOD_ProDKin_1	397	403	PF00069	0.702
MOD_ProDKin_1	620	626	PF00069	0.754
MOD_ProDKin_1	69	75	PF00069	0.759
MOD_SUMO_rev_2	137	146	PF00179	0.547
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.496
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.691
TRG_ENDOCYTIC_2	207	210	PF00928	0.401
TRG_ENDOCYTIC_2	299	302	PF00928	0.595
TRG_ENDOCYTIC_2	343	346	PF00928	0.754
TRG_ENDOCYTIC_2	48	51	PF00928	0.507
TRG_ENDOCYTIC_2	8	11	PF00928	0.528
TRG_ER_diArg_1	183	186	PF00400	0.623
TRG_ER_diArg_1	322	324	PF00400	0.582
TRG_ER_diArg_1	343	345	PF00400	0.692
TRG_ER_diArg_1	353	355	PF00400	0.754
TRG_ER_diArg_1	411	413	PF00400	0.586
TRG_ER_diArg_1	467	469	PF00400	0.527
TRG_ER_diArg_1	503	505	PF00400	0.773
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXS6	Leptomonas seymouri	48%	91%
A0A3Q8IF12	Leishmania donovani	80%	100%
A4IB56	Leishmania infantum	80%	100%
C9ZZG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AEX7	Leishmania major	78%	100%
E9B633	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%