Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMH3_LEIBR

TriTrypDb:

LbrM.34.1430 , LBRM2903_340020600

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.575
CLV_C14_Caspase3-7	393	397	PF00656	0.665
CLV_NRD_NRD_1	146	148	PF00675	0.454
CLV_NRD_NRD_1	44	46	PF00675	0.519
CLV_NRD_NRD_1	556	558	PF00675	0.417
CLV_PCSK_KEX2_1	146	148	PF00082	0.457
CLV_PCSK_KEX2_1	44	46	PF00082	0.519
CLV_PCSK_KEX2_1	493	495	PF00082	0.485
CLV_PCSK_KEX2_1	556	558	PF00082	0.417
CLV_PCSK_KEX2_1	70	72	PF00082	0.434
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.402
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.434
CLV_PCSK_SKI1_1	139	143	PF00082	0.504
CLV_PCSK_SKI1_1	254	258	PF00082	0.441
CLV_PCSK_SKI1_1	426	430	PF00082	0.487
CLV_PCSK_SKI1_1	479	483	PF00082	0.400
CLV_PCSK_SKI1_1	526	530	PF00082	0.447
DEG_APCC_DBOX_1	437	445	PF00400	0.558
DEG_SPOP_SBC_1	31	35	PF00917	0.570
DEG_SPOP_SBC_1	508	512	PF00917	0.625
DOC_CDC14_PxL_1	324	332	PF14671	0.592
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.676
DOC_MAPK_DCC_7	254	262	PF00069	0.629
DOC_MAPK_MEF2A_6	254	262	PF00069	0.629
DOC_PP1_RVXF_1	524	531	PF00149	0.627
DOC_PP2B_LxvP_1	105	108	PF13499	0.676
DOC_PP2B_PxIxI_1	257	263	PF00149	0.691
DOC_PP4_FxxP_1	265	268	PF00568	0.669
DOC_PP4_MxPP_1	81	84	PF00568	0.683
DOC_USP7_MATH_1	190	194	PF00917	0.664
DOC_USP7_MATH_1	31	35	PF00917	0.673
DOC_USP7_MATH_1	338	342	PF00917	0.715
DOC_USP7_MATH_1	383	387	PF00917	0.688
DOC_USP7_MATH_1	453	457	PF00917	0.553
DOC_USP7_MATH_1	508	512	PF00917	0.668
DOC_USP7_MATH_1	566	570	PF00917	0.474
DOC_WW_Pin1_4	153	158	PF00397	0.742
DOC_WW_Pin1_4	343	348	PF00397	0.576
DOC_WW_Pin1_4	432	437	PF00397	0.687
DOC_WW_Pin1_4	509	514	PF00397	0.718
DOC_WW_Pin1_4	547	552	PF00397	0.614
DOC_WW_Pin1_4	555	560	PF00397	0.719
LIG_14-3-3_CanoR_1	273	278	PF00244	0.651
LIG_14-3-3_CanoR_1	32	39	PF00244	0.567
LIG_14-3-3_CanoR_1	353	360	PF00244	0.664
LIG_14-3-3_CanoR_1	409	414	PF00244	0.694
LIG_14-3-3_CanoR_1	438	442	PF00244	0.685
LIG_14-3-3_CanoR_1	564	574	PF00244	0.404
LIG_14-3-3_CanoR_1	74	80	PF00244	0.614
LIG_14-3-3_CanoR_1	9	14	PF00244	0.651
LIG_Actin_WH2_2	365	383	PF00022	0.618
LIG_BH_BH3_1	82	98	PF00452	0.663
LIG_BRCT_BRCA1_1	14	18	PF00533	0.689
LIG_BRCT_BRCA1_1	192	196	PF00533	0.660
LIG_BRCT_BRCA1_1	252	256	PF00533	0.703
LIG_BRCT_BRCA1_1	275	279	PF00533	0.679
LIG_BRCT_BRCA1_1	385	389	PF00533	0.662
LIG_EH1_1	99	107	PF00400	0.569
LIG_eIF4E_1	172	178	PF01652	0.658
LIG_FHA_1	173	179	PF00498	0.603
LIG_FHA_1	213	219	PF00498	0.633
LIG_FHA_1	229	235	PF00498	0.754
LIG_FHA_1	347	353	PF00498	0.607
LIG_FHA_2	18	24	PF00498	0.675
LIG_FHA_2	31	37	PF00498	0.666
LIG_FHA_2	313	319	PF00498	0.555
LIG_FHA_2	527	533	PF00498	0.618
LIG_GBD_Chelix_1	93	101	PF00786	0.414
LIG_LIR_Apic_2	263	268	PF02991	0.668
LIG_LIR_Apic_2	568	574	PF02991	0.267
LIG_LIR_Gen_1	15	25	PF02991	0.670
LIG_LIR_Gen_1	321	331	PF02991	0.595
LIG_LIR_Gen_1	358	368	PF02991	0.635
LIG_LIR_Gen_1	455	466	PF02991	0.594
LIG_LIR_Gen_1	521	530	PF02991	0.612
LIG_LIR_Gen_1	585	596	PF02991	0.507
LIG_LIR_Gen_1	61	69	PF02991	0.636
LIG_LIR_Nem_3	15	21	PF02991	0.701
LIG_LIR_Nem_3	253	259	PF02991	0.698
LIG_LIR_Nem_3	321	327	PF02991	0.662
LIG_LIR_Nem_3	329	334	PF02991	0.588
LIG_LIR_Nem_3	358	363	PF02991	0.660
LIG_LIR_Nem_3	367	372	PF02991	0.545
LIG_LIR_Nem_3	40	46	PF02991	0.536
LIG_LIR_Nem_3	407	413	PF02991	0.689
LIG_LIR_Nem_3	455	461	PF02991	0.589
LIG_LIR_Nem_3	521	527	PF02991	0.617
LIG_LIR_Nem_3	529	533	PF02991	0.549
LIG_LIR_Nem_3	544	549	PF02991	0.618
LIG_LIR_Nem_3	568	573	PF02991	0.321
LIG_LIR_Nem_3	61	65	PF02991	0.633
LIG_MLH1_MIPbox_1	275	279	PF16413	0.679
LIG_MLH1_MIPbox_1	385	389	PF16413	0.662
LIG_NRBOX	199	205	PF00104	0.547
LIG_NRBOX	598	604	PF00104	0.217
LIG_PCNA_yPIPBox_3	288	302	PF02747	0.720
LIG_PCNA_yPIPBox_3	353	363	PF02747	0.544
LIG_SH2_CRK	369	373	PF00017	0.574
LIG_SH2_CRK	524	528	PF00017	0.630
LIG_SH2_NCK_1	320	324	PF00017	0.594
LIG_SH2_STAP1	320	324	PF00017	0.594
LIG_SH2_STAP1	369	373	PF00017	0.616
LIG_SH2_STAP1	374	378	PF00017	0.629
LIG_SH3_2	283	288	PF14604	0.738
LIG_SH3_3	249	255	PF00018	0.797
LIG_SH3_3	280	286	PF00018	0.689
LIG_SH3_3	510	516	PF00018	0.716
LIG_SH3_3	591	597	PF00018	0.314
LIG_TRAF2_1	449	452	PF00917	0.600
LIG_TRAF2_2	83	88	PF00917	0.561
LIG_TRFH_1	186	190	PF08558	0.437
LIG_TRFH_1	324	328	PF08558	0.478
LIG_TRFH_1	360	364	PF08558	0.546
LIG_UBA3_1	326	332	PF00899	0.487
LIG_WRC_WIRS_1	527	532	PF05994	0.524
LIG_WRC_WIRS_1	538	543	PF05994	0.469
LIG_WW_1	83	86	PF00397	0.597
MOD_CDC14_SPxK_1	435	438	PF00782	0.453
MOD_CDC14_SPxK_1	554	557	PF00782	0.509
MOD_CDK_SPK_2	551	556	PF00069	0.476
MOD_CDK_SPxK_1	432	438	PF00069	0.462
MOD_CDK_SPxK_1	551	557	PF00069	0.481
MOD_CK1_1	12	18	PF00069	0.567
MOD_CK1_1	162	168	PF00069	0.619
MOD_CK1_1	250	256	PF00069	0.529
MOD_CK1_1	287	293	PF00069	0.692
MOD_CK1_1	310	316	PF00069	0.440
MOD_CK1_1	341	347	PF00069	0.463
MOD_CK1_1	392	398	PF00069	0.632
MOD_CK1_1	412	418	PF00069	0.624
MOD_CK1_1	445	451	PF00069	0.550
MOD_CK1_1	500	506	PF00069	0.514
MOD_CK1_1	565	571	PF00069	0.253
MOD_CK2_1	17	23	PF00069	0.466
MOD_CK2_1	239	245	PF00069	0.689
MOD_CK2_1	312	318	PF00069	0.401
MOD_CK2_1	445	451	PF00069	0.528
MOD_CK2_1	517	523	PF00069	0.469
MOD_CK2_1	586	592	PF00069	0.436
MOD_GlcNHglycan	241	244	PF01048	0.706
MOD_GlcNHglycan	289	292	PF01048	0.730
MOD_GlcNHglycan	384	388	PF01048	0.597
MOD_GlcNHglycan	502	505	PF01048	0.551
MOD_GlcNHglycan	564	567	PF01048	0.583
MOD_GSK3_1	149	156	PF00069	0.680
MOD_GSK3_1	172	179	PF00069	0.521
MOD_GSK3_1	246	253	PF00069	0.791
MOD_GSK3_1	269	276	PF00069	0.639
MOD_GSK3_1	351	358	PF00069	0.507
MOD_GSK3_1	379	386	PF00069	0.665
MOD_GSK3_1	388	395	PF00069	0.620
MOD_GSK3_1	412	419	PF00069	0.644
MOD_GSK3_1	442	449	PF00069	0.593
MOD_GSK3_1	498	505	PF00069	0.523
MOD_GSK3_1	537	544	PF00069	0.498
MOD_GSK3_1	547	554	PF00069	0.638
MOD_GSK3_1	562	569	PF00069	0.575
MOD_GSK3_1	9	16	PF00069	0.580
MOD_N-GLC_1	149	154	PF02516	0.717
MOD_N-GLC_1	237	242	PF02516	0.658
MOD_N-GLC_1	75	80	PF02516	0.516
MOD_NEK2_1	177	182	PF00069	0.522
MOD_NEK2_1	203	208	PF00069	0.522
MOD_NEK2_1	351	356	PF00069	0.557
MOD_NEK2_1	537	542	PF00069	0.457
MOD_NEK2_2	192	197	PF00069	0.433
MOD_NEK2_2	453	458	PF00069	0.424
MOD_PIKK_1	352	358	PF00454	0.566
MOD_PKA_2	25	31	PF00069	0.626
MOD_PKA_2	287	293	PF00069	0.718
MOD_PKA_2	352	358	PF00069	0.533
MOD_PKA_2	437	443	PF00069	0.511
MOD_Plk_1	149	155	PF00069	0.585
MOD_Plk_1	162	168	PF00069	0.588
MOD_Plk_1	246	252	PF00069	0.523
MOD_Plk_1	445	451	PF00069	0.527
MOD_Plk_1	75	81	PF00069	0.567
MOD_Plk_2-3	446	452	PF00069	0.525
MOD_Plk_4	17	23	PF00069	0.578
MOD_Plk_4	177	183	PF00069	0.571
MOD_Plk_4	273	279	PF00069	0.552
MOD_Plk_4	326	332	PF00069	0.551
MOD_Plk_4	338	344	PF00069	0.474
MOD_Plk_4	346	352	PF00069	0.419
MOD_Plk_4	453	459	PF00069	0.507
MOD_Plk_4	537	543	PF00069	0.556
MOD_Plk_4	566	572	PF00069	0.331
MOD_ProDKin_1	153	159	PF00069	0.690
MOD_ProDKin_1	343	349	PF00069	0.454
MOD_ProDKin_1	432	438	PF00069	0.614
MOD_ProDKin_1	509	515	PF00069	0.652
MOD_ProDKin_1	547	553	PF00069	0.516
MOD_ProDKin_1	555	561	PF00069	0.657
MOD_SUMO_rev_2	217	225	PF00179	0.441
MOD_SUMO_rev_2	66	72	PF00179	0.527
TRG_DiLeu_BaEn_2	67	73	PF01217	0.667
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.442
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.217
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.359
TRG_ENDOCYTIC_2	186	189	PF00928	0.552
TRG_ENDOCYTIC_2	369	372	PF00928	0.509
TRG_ENDOCYTIC_2	524	527	PF00928	0.536
TRG_ENDOCYTIC_2	86	89	PF00928	0.563
TRG_ER_diArg_1	145	147	PF00400	0.580
TRG_ER_diArg_1	43	45	PF00400	0.631
TRG_ER_diArg_1	555	557	PF00400	0.515
TRG_NES_CRM1_1	88	103	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N3	Leptomonas seymouri	37%	84%
A0A3S7X910	Leishmania donovani	79%	100%
A4IB53	Leishmania infantum	79%	100%
C9ZZG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AEX4	Leishmania major	80%	100%
E9B630	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	85%