FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania braziliensis

UniProt:

A4HMH2_LEIBR

TriTrypDb:

LbrM.34.1420 , LBRM2903_340020500

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.444
CLV_NRD_NRD_1	296	298	PF00675	0.585
CLV_NRD_NRD_1	380	382	PF00675	0.605
CLV_NRD_NRD_1	385	387	PF00675	0.613
CLV_NRD_NRD_1	405	407	PF00675	0.590
CLV_NRD_NRD_1	444	446	PF00675	0.744
CLV_NRD_NRD_1	477	479	PF00675	0.683
CLV_NRD_NRD_1	572	574	PF00675	0.628
CLV_NRD_NRD_1	586	588	PF00675	0.779
CLV_NRD_NRD_1	78	80	PF00675	0.605
CLV_PCSK_KEX2_1	130	132	PF00082	0.465
CLV_PCSK_KEX2_1	296	298	PF00082	0.585
CLV_PCSK_KEX2_1	350	352	PF00082	0.256
CLV_PCSK_KEX2_1	405	407	PF00082	0.606
CLV_PCSK_KEX2_1	443	445	PF00082	0.749
CLV_PCSK_KEX2_1	477	479	PF00082	0.678
CLV_PCSK_KEX2_1	572	574	PF00082	0.628
CLV_PCSK_KEX2_1	586	588	PF00082	0.779
CLV_PCSK_KEX2_1	78	80	PF00082	0.605
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.256
CLV_PCSK_PC7_1	439	445	PF00082	0.747
CLV_PCSK_SKI1_1	130	134	PF00082	0.448
CLV_PCSK_SKI1_1	162	166	PF00082	0.412
CLV_PCSK_SKI1_1	193	197	PF00082	0.412
CLV_PCSK_SKI1_1	279	283	PF00082	0.514
DEG_APCC_DBOX_1	130	138	PF00400	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.459
DOC_CKS1_1	324	329	PF01111	0.725
DOC_CYCLIN_yCln2_LP_2	16	19	PF00134	0.422
DOC_MAPK_gen_1	130	137	PF00069	0.437
DOC_MAPK_gen_1	391	401	PF00069	0.724
DOC_MAPK_gen_1	572	580	PF00069	0.569
DOC_MAPK_MEF2A_6	130	139	PF00069	0.412
DOC_MAPK_MEF2A_6	246	254	PF00069	0.412
DOC_MAPK_MEF2A_6	572	580	PF00069	0.569
DOC_MAPK_NFAT4_5	573	581	PF00069	0.572
DOC_PP2B_LxvP_1	16	19	PF13499	0.422
DOC_PP4_FxxP_1	259	262	PF00568	0.387
DOC_SPAK_OSR1_1	81	85	PF12202	0.514
DOC_USP7_MATH_1	155	159	PF00917	0.514
DOC_USP7_MATH_1	204	208	PF00917	0.398
DOC_USP7_MATH_1	328	332	PF00917	0.794
DOC_USP7_MATH_1	434	438	PF00917	0.820
DOC_USP7_MATH_1	488	492	PF00917	0.566
DOC_USP7_MATH_1	520	524	PF00917	0.740
DOC_USP7_MATH_1	536	540	PF00917	0.682
DOC_USP7_MATH_1	556	560	PF00917	0.511
DOC_USP7_MATH_1	631	635	PF00917	0.507
DOC_WW_Pin1_4	240	245	PF00397	0.353
DOC_WW_Pin1_4	323	328	PF00397	0.718
DOC_WW_Pin1_4	61	66	PF00397	0.630
LIG_14-3-3_CanoR_1	154	164	PF00244	0.397
LIG_14-3-3_CanoR_1	179	183	PF00244	0.256
LIG_14-3-3_CanoR_1	227	233	PF00244	0.412
LIG_14-3-3_CanoR_1	478	487	PF00244	0.750
LIG_14-3-3_CanoR_1	504	512	PF00244	0.581
LIG_14-3-3_CanoR_1	572	580	PF00244	0.569
LIG_14-3-3_CanoR_1	89	99	PF00244	0.450
LIG_APCC_ABBA_1	198	203	PF00400	0.412
LIG_BRCT_BRCA1_1	507	511	PF00533	0.584
LIG_BRCT_BRCA1_1	529	533	PF00533	0.705
LIG_Clathr_ClatBox_1	134	138	PF01394	0.412
LIG_CSL_BTD_1	324	327	PF09270	0.536
LIG_deltaCOP1_diTrp_1	453	461	PF00928	0.723
LIG_EH1_1	232	240	PF00400	0.412
LIG_eIF4E_1	192	198	PF01652	0.412
LIG_FHA_1	124	130	PF00498	0.492
LIG_FHA_1	172	178	PF00498	0.499
LIG_FHA_1	23	29	PF00498	0.411
LIG_FHA_1	235	241	PF00498	0.390
LIG_FHA_1	520	526	PF00498	0.569
LIG_FHA_1	575	581	PF00498	0.580
LIG_FHA_1	62	68	PF00498	0.597
LIG_FHA_1	628	634	PF00498	0.692
LIG_FHA_1	72	78	PF00498	0.496
LIG_FHA_2	101	107	PF00498	0.496
LIG_FHA_2	393	399	PF00498	0.631
LIG_GBD_Chelix_1	135	143	PF00786	0.412
LIG_IBAR_NPY_1	213	215	PF08397	0.412
LIG_Integrin_RGD_1	445	447	PF01839	0.589
LIG_LIR_Gen_1	158	168	PF02991	0.353
LIG_LIR_Gen_1	231	240	PF02991	0.412
LIG_LIR_Gen_1	466	473	PF02991	0.652
LIG_LIR_Gen_1	85	92	PF02991	0.578
LIG_LIR_Nem_3	158	163	PF02991	0.353
LIG_LIR_Nem_3	186	192	PF02991	0.412
LIG_LIR_Nem_3	231	235	PF02991	0.448
LIG_LIR_Nem_3	85	90	PF02991	0.565
LIG_MLH1_MIPbox_1	529	533	PF16413	0.705
LIG_MYND_1	544	548	PF01753	0.833
LIG_NRBOX	27	33	PF00104	0.445
LIG_SH2_GRB2like	469	472	PF00017	0.647
LIG_SH2_PTP2	87	90	PF00017	0.450
LIG_SH2_SRC	44	47	PF00017	0.436
LIG_SH2_STAP1	120	124	PF00017	0.510
LIG_SH2_STAP1	469	473	PF00017	0.645
LIG_SH2_STAT5	30	33	PF00017	0.426
LIG_SH2_STAT5	44	47	PF00017	0.397
LIG_SH2_STAT5	76	79	PF00017	0.598
LIG_SH2_STAT5	87	90	PF00017	0.431
LIG_SH3_2	427	432	PF14604	0.575
LIG_SH3_3	119	125	PF00018	0.519
LIG_SH3_3	149	155	PF00018	0.318
LIG_SH3_3	208	214	PF00018	0.306
LIG_SH3_3	321	327	PF00018	0.718
LIG_SH3_3	424	430	PF00018	0.776
LIG_SH3_3	539	545	PF00018	0.786
LIG_SH3_3	550	556	PF00018	0.700
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.593
LIG_SUMO_SIM_anti_2	574	582	PF11976	0.571
LIG_SUMO_SIM_par_1	133	138	PF11976	0.412
LIG_SUMO_SIM_par_1	168	175	PF11976	0.412
LIG_SUMO_SIM_par_1	236	243	PF11976	0.390
LIG_SUMO_SIM_par_1	280	286	PF11976	0.490
LIG_SUMO_SIM_par_1	574	582	PF11976	0.593
LIG_TRAF2_1	395	398	PF00917	0.627
LIG_TRFH_1	151	155	PF08558	0.412
LIG_UBA3_1	271	279	PF00899	0.514
LIG_WW_1	41	44	PF00397	0.448
LIG_WW_3	40	44	PF00397	0.442
MOD_CDC14_SPxK_1	243	246	PF00782	0.412
MOD_CDK_SPxK_1	240	246	PF00069	0.412
MOD_CDK_SPxxK_3	65	72	PF00069	0.604
MOD_CK1_1	207	213	PF00069	0.256
MOD_CK1_1	231	237	PF00069	0.514
MOD_CK1_1	380	386	PF00069	0.616
MOD_CK1_1	507	513	PF00069	0.826
MOD_CK1_1	527	533	PF00069	0.738
MOD_CK2_1	101	107	PF00069	0.341
MOD_CK2_1	337	343	PF00069	0.736
MOD_CK2_1	392	398	PF00069	0.626
MOD_CK2_1	65	71	PF00069	0.586
MOD_GlcNHglycan	126	129	PF01048	0.474
MOD_GlcNHglycan	174	177	PF01048	0.373
MOD_GlcNHglycan	285	288	PF01048	0.468
MOD_GlcNHglycan	382	385	PF01048	0.720
MOD_GlcNHglycan	481	484	PF01048	0.694
MOD_GlcNHglycan	507	510	PF01048	0.805
MOD_GlcNHglycan	512	515	PF01048	0.848
MOD_GlcNHglycan	539	542	PF01048	0.741
MOD_GlcNHglycan	558	561	PF01048	0.546
MOD_GlcNHglycan	61	64	PF01048	0.627
MOD_GSK3_1	1	8	PF00069	0.446
MOD_GSK3_1	120	127	PF00069	0.505
MOD_GSK3_1	319	326	PF00069	0.784
MOD_GSK3_1	328	335	PF00069	0.706
MOD_GSK3_1	434	441	PF00069	0.854
MOD_GSK3_1	455	462	PF00069	0.727
MOD_GSK3_1	493	500	PF00069	0.699
MOD_GSK3_1	520	527	PF00069	0.781
MOD_GSK3_1	532	539	PF00069	0.632
MOD_GSK3_1	554	561	PF00069	0.703
MOD_GSK3_1	609	616	PF00069	0.663
MOD_GSK3_1	61	68	PF00069	0.724
MOD_GSK3_1	627	634	PF00069	0.467
MOD_N-GLC_1	155	160	PF02516	0.454
MOD_N-GLC_1	525	530	PF02516	0.561
MOD_N-GLC_1	561	566	PF02516	0.586
MOD_N-GLC_1	627	632	PF02516	0.492
MOD_NEK2_1	1	6	PF00069	0.453
MOD_NEK2_1	163	168	PF00069	0.412
MOD_NEK2_1	196	201	PF00069	0.501
MOD_NEK2_1	283	288	PF00069	0.468
MOD_NEK2_1	487	492	PF00069	0.683
MOD_NEK2_1	50	55	PF00069	0.496
MOD_NEK2_1	532	537	PF00069	0.718
MOD_OFUCOSY	49	54	PF10250	0.460
MOD_PIKK_1	261	267	PF00454	0.256
MOD_PIKK_1	497	503	PF00454	0.576
MOD_PIKK_1	520	526	PF00454	0.821
MOD_PIKK_1	609	615	PF00454	0.797
MOD_PK_1	572	578	PF00069	0.569
MOD_PKA_1	572	578	PF00069	0.569
MOD_PKA_2	1	7	PF00069	0.451
MOD_PKA_2	178	184	PF00069	0.412
MOD_PKA_2	319	325	PF00069	0.699
MOD_PKA_2	380	386	PF00069	0.616
MOD_PKA_2	434	440	PF00069	0.851
MOD_PKA_2	571	577	PF00069	0.659
MOD_PKA_2	71	77	PF00069	0.688
MOD_PKA_2	90	96	PF00069	0.522
MOD_Plk_1	120	126	PF00069	0.503
MOD_Plk_1	525	531	PF00069	0.560
MOD_Plk_1	561	567	PF00069	0.579
MOD_Plk_1	627	633	PF00069	0.746
MOD_Plk_2-3	110	116	PF00069	0.494
MOD_Plk_2-3	337	343	PF00069	0.736
MOD_Plk_4	234	240	PF00069	0.507
MOD_Plk_4	507	513	PF00069	0.583
MOD_Plk_4	527	533	PF00069	0.805
MOD_Plk_4	561	567	PF00069	0.595
MOD_ProDKin_1	240	246	PF00069	0.353
MOD_ProDKin_1	323	329	PF00069	0.719
MOD_ProDKin_1	61	67	PF00069	0.632
MOD_SUMO_rev_2	307	316	PF00179	0.659
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.485
TRG_ENDOCYTIC_2	192	195	PF00928	0.412
TRG_ENDOCYTIC_2	469	472	PF00928	0.647
TRG_ENDOCYTIC_2	87	90	PF00928	0.450
TRG_ER_diArg_1	129	131	PF00400	0.468
TRG_ER_diArg_1	296	298	PF00400	0.645
TRG_ER_diArg_1	443	445	PF00400	0.749
TRG_ER_diArg_1	77	79	PF00400	0.641
TRG_ER_diArg_1	88	91	PF00400	0.389
TRG_NES_CRM1_1	273	285	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	59%	96%
A0A3Q8IM24	Leishmania donovani	78%	100%
A4IB52	Leishmania infantum	78%	100%
E9AEX3	Leishmania major	78%	100%
E9B629	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%