Arginase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Arginase

Gene product:

arginase

Species:

Leishmania braziliensis

UniProt:

A4HMH0_LEIBR

TriTrypDb:

LbrM.34.1400

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMH0

Function

Biological processes
Term	Name	Level	Count
GO:0000050	urea cycle	4	7
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006525	arginine metabolic process	6	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009987	cellular process	1	7
GO:0019627	urea metabolic process	3	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043436	oxoacid metabolic process	4	7
GO:0043603	amide metabolic process	3	7
GO:0043604	amide biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0071941	nitrogen cycle metabolic process	3	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:0006527	arginine catabolic process	5	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006591	ornithine metabolic process	5	1
GO:0006595	polyamine metabolic process	6	1
GO:0006596	polyamine biosynthetic process	7	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009065	glutamine family amino acid catabolic process	6	1
GO:0009308	amine metabolic process	4	1
GO:0009309	amine biosynthetic process	5	1
GO:0016054	organic acid catabolic process	4	1
GO:0019547	arginine catabolic process to ornithine	6	1
GO:0042401	biogenic amine biosynthetic process	6	1
GO:0044248	cellular catabolic process	3	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901606	alpha-amino acid catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004053	arginase activity	5	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0030145	manganese ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.616
CLV_NRD_NRD_1	68	70	PF00675	0.324
CLV_NRD_NRD_1	98	100	PF00675	0.325
CLV_PCSK_KEX2_1	82	84	PF00082	0.405
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.396
CLV_PCSK_SKI1_1	199	203	PF00082	0.324
CLV_PCSK_SKI1_1	326	330	PF00082	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.717
DOC_CDC14_PxL_1	174	182	PF14671	0.405
DOC_CKS1_1	321	326	PF01111	0.631
DOC_MAPK_gen_1	182	191	PF00069	0.524
DOC_MAPK_gen_1	199	207	PF00069	0.524
DOC_MAPK_gen_1	9	18	PF00069	0.460
DOC_MAPK_MEF2A_6	12	20	PF00069	0.390
DOC_PP1_RVXF_1	48	54	PF00149	0.524
DOC_PP2B_LxvP_1	251	254	PF13499	0.524
DOC_USP7_UBL2_3	70	74	PF12436	0.426
DOC_WW_Pin1_4	229	234	PF00397	0.524
DOC_WW_Pin1_4	255	260	PF00397	0.485
DOC_WW_Pin1_4	320	325	PF00397	0.615
LIG_14-3-3_CanoR_1	106	112	PF00244	0.426
LIG_14-3-3_CanoR_1	261	267	PF00244	0.524
LIG_Actin_WH2_2	25	43	PF00022	0.405
LIG_APCC_ABBA_1	126	131	PF00400	0.596
LIG_Clathr_ClatBox_1	162	166	PF01394	0.524
LIG_Clathr_ClatBox_1	282	286	PF01394	0.524
LIG_FHA_1	130	136	PF00498	0.405
LIG_FHA_1	234	240	PF00498	0.524
LIG_FHA_1	89	95	PF00498	0.524
LIG_FHA_2	53	59	PF00498	0.567
LIG_LIR_Gen_1	172	181	PF02991	0.524
LIG_LIR_Gen_1	92	102	PF02991	0.401
LIG_LIR_Nem_3	172	177	PF02991	0.485
LIG_LIR_Nem_3	92	98	PF02991	0.527
LIG_PCNA_yPIPBox_3	50	61	PF02747	0.567
LIG_SH2_CRK	95	99	PF00017	0.596
LIG_SH2_PTP2	188	191	PF00017	0.524
LIG_SH2_SRC	252	255	PF00017	0.524
LIG_SH2_STAT5	188	191	PF00017	0.524
LIG_SH2_STAT5	252	255	PF00017	0.482
LIG_SH2_STAT5	322	325	PF00017	0.571
LIG_SH2_STAT5	38	41	PF00017	0.492
LIG_SH3_3	16	22	PF00018	0.559
LIG_SUMO_SIM_par_1	236	242	PF11976	0.524
LIG_SUMO_SIM_par_1	281	286	PF11976	0.524
LIG_TYR_ITIM	186	191	PF00017	0.524
LIG_UBA3_1	77	85	PF00899	0.405
MOD_CDK_SPK_2	229	234	PF00069	0.596
MOD_CDK_SPK_2	320	325	PF00069	0.574
MOD_CDK_SPxK_1	255	261	PF00069	0.524
MOD_CDK_SPxK_1	320	326	PF00069	0.586
MOD_CDK_SPxxK_3	320	327	PF00069	0.372
MOD_CK1_1	88	94	PF00069	0.405
MOD_CK2_1	262	268	PF00069	0.498
MOD_CK2_1	27	33	PF00069	0.502
MOD_CK2_1	52	58	PF00069	0.567
MOD_GlcNHglycan	146	149	PF01048	0.324
MOD_GlcNHglycan	150	153	PF01048	0.324
MOD_GlcNHglycan	23	26	PF01048	0.324
MOD_GlcNHglycan	29	32	PF01048	0.324
MOD_GSK3_1	142	149	PF00069	0.524
MOD_GSK3_1	229	236	PF00069	0.498
MOD_GSK3_1	316	323	PF00069	0.570
MOD_GSK3_1	84	91	PF00069	0.524
MOD_N-GLC_1	14	19	PF02516	0.223
MOD_N-GLC_1	53	58	PF02516	0.205
MOD_NEK2_1	146	151	PF00069	0.524
MOD_NEK2_1	316	321	PF00069	0.404
MOD_NEK2_2	124	129	PF00069	0.596
MOD_NEK2_2	208	213	PF00069	0.524
MOD_NEK2_2	262	267	PF00069	0.524
MOD_PK_1	14	20	PF00069	0.491
MOD_Plk_1	113	119	PF00069	0.524
MOD_Plk_1	14	20	PF00069	0.223
MOD_Plk_1	53	59	PF00069	0.536
MOD_Plk_2-3	244	250	PF00069	0.596
MOD_Plk_4	124	130	PF00069	0.567
MOD_Plk_4	14	20	PF00069	0.491
MOD_Plk_4	157	163	PF00069	0.524
MOD_Plk_4	316	322	PF00069	0.468
MOD_ProDKin_1	229	235	PF00069	0.524
MOD_ProDKin_1	255	261	PF00069	0.485
MOD_ProDKin_1	320	326	PF00069	0.628
MOD_SUMO_rev_2	193	202	PF00179	0.519
MOD_SUMO_rev_2	58	66	PF00179	0.524
TRG_DiLeu_BaEn_1	278	283	PF01217	0.524
TRG_DiLeu_BaEn_1	73	78	PF01217	0.405
TRG_DiLeu_LyEn_5	289	294	PF01217	0.524
TRG_ENDOCYTIC_2	188	191	PF00928	0.524
TRG_ENDOCYTIC_2	95	98	PF00928	0.489
TRG_ER_diLys_1	326	330	PF00400	0.457
TRG_NLS_Bipartite_1	69	86	PF00514	0.596
TRG_NLS_MonoCore_2	81	86	PF00514	0.596
TRG_NLS_MonoExtC_3	324	329	PF00514	0.424
TRG_NLS_MonoExtN_4	324	330	PF00514	0.431
TRG_PTS1	327	330	PF00515	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY5	Leptomonas seymouri	80%	100%
A0A0S4J155	Bodo saltans	38%	90%
A0A3S7X949	Leishmania donovani	89%	100%
A4IB49	Leishmania infantum	89%	100%
C9ZUY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEX1	Leishmania major	89%	100%
E9B627	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O08691	Mus musculus	41%	93%
O08701	Rattus norvegicus	41%	93%
P00812	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	99%
P05089	Homo sapiens	43%	100%
P07824	Rattus norvegicus	40%	100%
P0A2X9	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	30%	100%
P0A2Y0	Brucella suis biovar 1 (strain 1330)	30%	100%
P0A2Y1	Brucella abortus biovar 1 (strain 9-941)	30%	100%
P14012	Agrobacterium fabrum (strain C58 / ATCC 33970)	31%	100%
P30759	Xenopus laevis	40%	100%
P33280	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	92%
P37818	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P39138	Bacillus subtilis (strain 168)	34%	100%
P40906	Coccidioides posadasii (strain C735)	42%	100%
P49900	Lithobates catesbeianus	41%	100%
P53608	Bacillus caldovelox	36%	100%
P60086	Staphylococcus aureus (strain COL)	35%	100%
P60087	Staphylococcus aureus (strain Mu50 / ATCC 700699)	35%	100%
P60088	Staphylococcus aureus (strain N315)	35%	100%
P70999	Bacillus subtilis (strain 168)	27%	100%
P78540	Homo sapiens	40%	93%
Q10066	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q12611	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	100%
Q1E180	Coccidioides immitis (strain RS)	43%	100%
Q2KJ64	Bos taurus	42%	100%
Q4VK78	Oryctolagus cuniculus	39%	93%
Q58DL1	Bos taurus	41%	93%
Q5Z0G1	Nocardia farcinica (strain IFM 10152)	24%	100%
Q61176	Mus musculus	41%	100%
Q6CLS8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	65%	100%
Q6G7E9	Staphylococcus aureus (strain MSSA476)	35%	100%
Q6GER3	Staphylococcus aureus (strain MRSA252)	35%	100%
Q74ZW4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	63%	83%
Q7M0Z3	Brevibacillus brevis	36%	100%
Q7P0S6	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	25%	100%
Q7VRG4	Blochmannia floridanus	22%	100%
Q8NVE3	Staphylococcus aureus (strain MW2)	35%	100%
Q91553	Xenopus laevis	40%	92%
Q91554	Xenopus laevis	40%	92%
Q91555	Xenopus laevis	40%	92%
Q95JC8	Sus scrofa	42%	100%
Q95KM0	Oryctolagus cuniculus	42%	100%
Q9I6K2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%