Putative choline/ethanolamine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMG9_LEIBR

TriTrypDb:

LbrM.34.1390 , LBRM2903_340020200

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0044237	cellular metabolic process	2	13
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0004305	ethanolamine kinase activity	5	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0004103	choline kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.398
CLV_C14_Caspase3-7	70	74	PF00656	0.699
CLV_NRD_NRD_1	411	413	PF00675	0.304
CLV_NRD_NRD_1	419	421	PF00675	0.304
CLV_NRD_NRD_1	444	446	PF00675	0.302
CLV_PCSK_KEX2_1	390	392	PF00082	0.324
CLV_PCSK_KEX2_1	419	421	PF00082	0.326
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.362
CLV_PCSK_SKI1_1	199	203	PF00082	0.271
CLV_PCSK_SKI1_1	29	33	PF00082	0.565
CLV_PCSK_SKI1_1	295	299	PF00082	0.344
CLV_PCSK_SKI1_1	323	327	PF00082	0.358
CLV_PCSK_SKI1_1	37	41	PF00082	0.613
CLV_PCSK_SKI1_1	385	389	PF00082	0.348
CLV_PCSK_SKI1_1	445	449	PF00082	0.307
CLV_Separin_Metazoa	26	30	PF03568	0.599
DEG_APCC_DBOX_1	587	595	PF00400	0.525
DEG_SCF_FBW7_1	432	437	PF00400	0.501
DOC_AGCK_PIF_2	465	470	PF00069	0.480
DOC_ANK_TNKS_1	492	499	PF00023	0.643
DOC_CKS1_1	307	312	PF01111	0.548
DOC_CKS1_1	45	50	PF01111	0.716
DOC_CYCLIN_RxL_1	151	162	PF00134	0.507
DOC_CYCLIN_RxL_1	352	362	PF00134	0.539
DOC_CYCLIN_yClb5_NLxxxL_5	81	87	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.577
DOC_MAPK_gen_1	356	366	PF00069	0.562
DOC_MAPK_gen_1	390	397	PF00069	0.539
DOC_MAPK_JIP1_4	154	160	PF00069	0.720
DOC_MAPK_MEF2A_6	390	397	PF00069	0.520
DOC_MAPK_MEF2A_6	461	468	PF00069	0.483
DOC_PP1_RVXF_1	459	466	PF00149	0.562
DOC_USP7_MATH_1	252	256	PF00917	0.548
DOC_USP7_MATH_1	280	284	PF00917	0.577
DOC_USP7_MATH_1	327	331	PF00917	0.572
DOC_USP7_MATH_1	434	438	PF00917	0.519
DOC_USP7_MATH_1	629	633	PF00917	0.530
DOC_USP7_UBL2_3	446	450	PF12436	0.511
DOC_USP7_UBL2_3	515	519	PF12436	0.542
DOC_USP7_UBL2_3	94	98	PF12436	0.591
DOC_WW_Pin1_4	141	146	PF00397	0.709
DOC_WW_Pin1_4	229	234	PF00397	0.491
DOC_WW_Pin1_4	259	264	PF00397	0.480
DOC_WW_Pin1_4	306	311	PF00397	0.528
DOC_WW_Pin1_4	430	435	PF00397	0.483
DOC_WW_Pin1_4	44	49	PF00397	0.659
DOC_WW_Pin1_4	581	586	PF00397	0.598
LIG_14-3-3_CanoR_1	154	159	PF00244	0.703
LIG_14-3-3_CanoR_1	370	374	PF00244	0.469
LIG_AP2alpha_2	626	628	PF02296	0.371
LIG_APCC_ABBAyCdc20_2	461	467	PF00400	0.504
LIG_BIR_III_4	73	77	PF00653	0.459
LIG_BRCT_BRCA1_1	439	443	PF00533	0.562
LIG_CtBP_PxDLS_1	48	52	PF00389	0.747
LIG_deltaCOP1_diTrp_1	124	133	PF00928	0.479
LIG_FHA_1	198	204	PF00498	0.405
LIG_FHA_1	254	260	PF00498	0.471
LIG_FHA_1	369	375	PF00498	0.510
LIG_FHA_1	590	596	PF00498	0.425
LIG_FHA_1	78	84	PF00498	0.597
LIG_FHA_2	148	154	PF00498	0.591
LIG_FHA_2	307	313	PF00498	0.531
LIG_FHA_2	481	487	PF00498	0.480
LIG_FHA_2	585	591	PF00498	0.504
LIG_FXI_DFP_1	193	197	PF00024	0.596
LIG_LIR_Apic_2	304	310	PF02991	0.556
LIG_LIR_Gen_1	268	276	PF02991	0.563
LIG_LIR_Gen_1	278	289	PF02991	0.564
LIG_LIR_Gen_1	30	39	PF02991	0.550
LIG_LIR_Gen_1	371	381	PF02991	0.562
LIG_LIR_Gen_1	467	478	PF02991	0.546
LIG_LIR_Gen_1	58	69	PF02991	0.636
LIG_LIR_Gen_1	606	616	PF02991	0.410
LIG_LIR_Gen_1	647	655	PF02991	0.357
LIG_LIR_Nem_3	124	129	PF02991	0.505
LIG_LIR_Nem_3	215	220	PF02991	0.577
LIG_LIR_Nem_3	238	244	PF02991	0.472
LIG_LIR_Nem_3	268	273	PF02991	0.481
LIG_LIR_Nem_3	278	284	PF02991	0.481
LIG_LIR_Nem_3	30	36	PF02991	0.542
LIG_LIR_Nem_3	353	358	PF02991	0.505
LIG_LIR_Nem_3	371	376	PF02991	0.557
LIG_LIR_Nem_3	467	473	PF02991	0.493
LIG_LIR_Nem_3	499	505	PF02991	0.526
LIG_LIR_Nem_3	516	521	PF02991	0.369
LIG_LIR_Nem_3	58	64	PF02991	0.455
LIG_LIR_Nem_3	606	611	PF02991	0.367
LIG_LIR_Nem_3	636	640	PF02991	0.368
LIG_LIR_Nem_3	647	651	PF02991	0.357
LIG_LIR_Nem_3	8	14	PF02991	0.634
LIG_NRBOX	383	389	PF00104	0.562
LIG_PCNA_yPIPBox_3	642	652	PF02747	0.483
LIG_Pex14_1	57	61	PF04695	0.460
LIG_Pex14_2	443	447	PF04695	0.562
LIG_Rb_pABgroove_1	127	135	PF01858	0.476
LIG_SH2_CRK	307	311	PF00017	0.397
LIG_SH2_CRK	507	511	PF00017	0.561
LIG_SH2_CRK	61	65	PF00017	0.448
LIG_SH2_NCK_1	307	311	PF00017	0.577
LIG_SH2_NCK_1	470	474	PF00017	0.480
LIG_SH2_NCK_1	61	65	PF00017	0.448
LIG_SH2_PTP2	648	651	PF00017	0.406
LIG_SH2_SRC	33	36	PF00017	0.583
LIG_SH2_STAP1	281	285	PF00017	0.562
LIG_SH2_STAT3	514	517	PF00017	0.583
LIG_SH2_STAT5	313	316	PF00017	0.562
LIG_SH2_STAT5	333	336	PF00017	0.577
LIG_SH2_STAT5	35	38	PF00017	0.588
LIG_SH2_STAT5	470	473	PF00017	0.505
LIG_SH2_STAT5	491	494	PF00017	0.480
LIG_SH2_STAT5	507	510	PF00017	0.483
LIG_SH2_STAT5	533	536	PF00017	0.543
LIG_SH2_STAT5	569	572	PF00017	0.387
LIG_SH2_STAT5	637	640	PF00017	0.405
LIG_SH2_STAT5	648	651	PF00017	0.331
LIG_SH3_2	194	199	PF14604	0.603
LIG_SH3_3	1	7	PF00018	0.546
LIG_SH3_3	191	197	PF00018	0.582
LIG_SH3_3	523	529	PF00018	0.314
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.562
LIG_SUMO_SIM_par_1	46	56	PF11976	0.746
LIG_SUMO_SIM_par_1	66	73	PF11976	0.487
LIG_TRAF2_1	510	513	PF00917	0.556
LIG_UBA3_1	171	179	PF00899	0.598
LIG_UBA3_1	383	390	PF00899	0.562
LIG_WRC_WIRS_1	236	241	PF05994	0.480
LIG_WRC_WIRS_1	281	286	PF05994	0.573
LIG_WRC_WIRS_1	373	378	PF05994	0.558
LIG_WRC_WIRS_1	607	612	PF05994	0.464
LIG_WW_3	26	30	PF00397	0.599
MOD_CDK_SPxxK_3	581	588	PF00069	0.609
MOD_CK1_1	208	214	PF00069	0.562
MOD_CK1_1	368	374	PF00069	0.536
MOD_CK1_1	375	381	PF00069	0.530
MOD_CK1_1	437	443	PF00069	0.552
MOD_CK1_1	50	56	PF00069	0.590
MOD_CK1_1	601	607	PF00069	0.454
MOD_CK2_1	118	124	PF00069	0.422
MOD_CK2_1	147	153	PF00069	0.588
MOD_CK2_1	306	312	PF00069	0.505
MOD_CK2_1	345	351	PF00069	0.480
MOD_CK2_1	480	486	PF00069	0.480
MOD_CK2_1	584	590	PF00069	0.541
MOD_CK2_1	60	66	PF00069	0.607
MOD_CMANNOS	605	608	PF00535	0.341
MOD_GlcNHglycan	180	183	PF01048	0.521
MOD_GlcNHglycan	29	32	PF01048	0.521
MOD_GlcNHglycan	317	320	PF01048	0.257
MOD_GlcNHglycan	377	380	PF01048	0.377
MOD_GlcNHglycan	576	579	PF01048	0.495
MOD_GlcNHglycan	632	635	PF01048	0.426
MOD_GSK3_1	144	151	PF00069	0.733
MOD_GSK3_1	178	185	PF00069	0.496
MOD_GSK3_1	302	309	PF00069	0.445
MOD_GSK3_1	346	353	PF00069	0.494
MOD_GSK3_1	365	372	PF00069	0.562
MOD_GSK3_1	43	50	PF00069	0.716
MOD_GSK3_1	430	437	PF00069	0.509
MOD_GSK3_1	53	60	PF00069	0.653
MOD_LATS_1	116	122	PF00433	0.671
MOD_N-GLC_1	118	123	PF02516	0.625
MOD_N-GLC_1	208	213	PF02516	0.197
MOD_N-GLC_1	327	332	PF02516	0.287
MOD_N-GLC_1	335	340	PF02516	0.349
MOD_NEK2_1	302	307	PF00069	0.405
MOD_NEK2_1	334	339	PF00069	0.561
MOD_NEK2_1	350	355	PF00069	0.416
MOD_NEK2_1	395	400	PF00069	0.545
MOD_NEK2_1	480	485	PF00069	0.476
MOD_NEK2_1	531	536	PF00069	0.535
MOD_NEK2_1	595	600	PF00069	0.361
MOD_NEK2_1	603	608	PF00069	0.311
MOD_NEK2_1	87	92	PF00069	0.468
MOD_NEK2_2	35	40	PF00069	0.593
MOD_PIKK_1	165	171	PF00454	0.499
MOD_PIKK_1	302	308	PF00454	0.475
MOD_PIKK_1	335	341	PF00454	0.571
MOD_PIKK_1	41	47	PF00454	0.684
MOD_PKA_2	21	27	PF00069	0.499
MOD_PKA_2	369	375	PF00069	0.444
MOD_PKA_2	492	498	PF00069	0.464
MOD_Plk_1	118	124	PF00069	0.622
MOD_Plk_1	165	171	PF00069	0.531
MOD_Plk_1	350	356	PF00069	0.543
MOD_Plk_1	53	59	PF00069	0.733
MOD_Plk_4	197	203	PF00069	0.418
MOD_Plk_4	261	267	PF00069	0.520
MOD_Plk_4	280	286	PF00069	0.577
MOD_Plk_4	369	375	PF00069	0.495
MOD_ProDKin_1	141	147	PF00069	0.712
MOD_ProDKin_1	229	235	PF00069	0.491
MOD_ProDKin_1	259	265	PF00069	0.480
MOD_ProDKin_1	306	312	PF00069	0.528
MOD_ProDKin_1	430	436	PF00069	0.469
MOD_ProDKin_1	44	50	PF00069	0.658
MOD_ProDKin_1	581	587	PF00069	0.593
TRG_DiLeu_BaEn_1	166	171	PF01217	0.598
TRG_DiLeu_BaEn_1	268	273	PF01217	0.562
TRG_DiLeu_BaEn_1	79	84	PF01217	0.492
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.564
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.415
TRG_ENDOCYTIC_2	281	284	PF00928	0.516
TRG_ENDOCYTIC_2	33	36	PF00928	0.583
TRG_ENDOCYTIC_2	470	473	PF00928	0.491
TRG_ENDOCYTIC_2	475	478	PF00928	0.483
TRG_ENDOCYTIC_2	61	64	PF00928	0.701
TRG_ENDOCYTIC_2	648	651	PF00928	0.359
TRG_ER_diArg_1	228	231	PF00400	0.577
TRG_ER_diArg_1	418	420	PF00400	0.558
TRG_NES_CRM1_1	212	225	PF08389	0.577
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI3	Leptomonas seymouri	68%	99%
A0A0S4JCZ4	Bodo saltans	23%	100%
A0A1X0NH78	Trypanosomatidae	44%	100%
A0A1X0NIW4	Trypanosomatidae	44%	100%
A0A3Q8IPA3	Leishmania donovani	88%	99%
A0A422N9U8	Trypanosoma rangeli	42%	100%
A4IB50	Leishmania infantum	88%	99%
C9ZNP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AEX0	Leishmania major	87%	100%
E9B626	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BC85	Trypanosoma cruzi	46%	100%