Sideroflexin-5

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Sideroflexin-5

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMG8_LEIBR

TriTrypDb:

LbrM.34.1380 , LBRM2903_340020100

Length:

329

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter protein involed in organellar amino acid uptake. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

A4HMG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.372
CLV_NRD_NRD_1	21	23	PF00675	0.384
CLV_PCSK_KEX2_1	218	220	PF00082	0.629
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.610
CLV_PCSK_SKI1_1	185	189	PF00082	0.283
CLV_PCSK_SKI1_1	83	87	PF00082	0.502
CLV_PCSK_SKI1_1	94	98	PF00082	0.461
DEG_APCC_DBOX_1	190	198	PF00400	0.455
DOC_CKS1_1	247	252	PF01111	0.285
DOC_CYCLIN_RxL_1	182	192	PF00134	0.480

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT03	Leptomonas seymouri	73%	100%
A0A0S4IXN4	Bodo saltans	38%	100%
A0A1X0NHY2	Trypanosomatidae	59%	100%
A0A3R7NG75	Trypanosoma rangeli	59%	100%
A0A3S5H7Y9	Leishmania donovani	90%	100%
A4IB40	Leishmania infantum	90%	100%
C9ZNP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AEW9	Leishmania major	89%	100%
E9B625	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9Y7X4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%

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