Peroxin-5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-5

Gene product:

peroxisome targeting signal 1 receptor, putative

Species:

Leishmania braziliensis

UniProt:

A4HMG4_LEIBR

TriTrypDb:

LbrM.34.1340 , LBRM2903_340019700

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HMG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0016560	protein import into peroxisome matrix, docking	5	1

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	1
GO:0005048	signal sequence binding	4	1
GO:0005052	peroxisome matrix targeting signal-1 binding	6	1
GO:0005488	binding	1	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.714
CLV_NRD_NRD_1	502	504	PF00675	0.424
CLV_PCSK_SKI1_1	223	227	PF00082	0.514
DEG_APCC_DBOX_1	599	607	PF00400	0.361
DEG_APCC_DBOX_1	97	105	PF00400	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.603
DOC_PP4_FxxP_1	455	458	PF00568	0.453
DOC_PP4_MxPP_1	276	279	PF00568	0.521
DOC_USP7_MATH_1	118	122	PF00917	0.716
DOC_USP7_MATH_1	170	174	PF00917	0.651
DOC_USP7_MATH_1	269	273	PF00917	0.729
DOC_USP7_MATH_1	419	423	PF00917	0.394
DOC_USP7_MATH_1	437	441	PF00917	0.609
DOC_USP7_MATH_1	456	460	PF00917	0.466
DOC_USP7_MATH_1	476	480	PF00917	0.215
DOC_USP7_MATH_1	573	577	PF00917	0.506
DOC_USP7_MATH_1	591	595	PF00917	0.367
DOC_USP7_MATH_1	97	101	PF00917	0.709
DOC_USP7_UBL2_3	514	518	PF12436	0.356
DOC_WW_Pin1_4	274	279	PF00397	0.717
LIG_14-3-3_CanoR_1	414	420	PF00244	0.294
LIG_14-3-3_CanoR_1	600	604	PF00244	0.380
LIG_BRCT_BRCA1_1	478	482	PF00533	0.485
LIG_deltaCOP1_diTrp_1	50	57	PF00928	0.456
LIG_FHA_1	246	252	PF00498	0.467
LIG_FHA_1	600	606	PF00498	0.392
LIG_FHA_1	615	621	PF00498	0.385
LIG_FHA_2	201	207	PF00498	0.548
LIG_FHA_2	373	379	PF00498	0.374
LIG_FHA_2	464	470	PF00498	0.524
LIG_FHA_2	613	619	PF00498	0.555
LIG_IBAR_NPY_1	327	329	PF08397	0.401
LIG_LIR_Apic_2	452	458	PF02991	0.530
LIG_LIR_Gen_1	186	194	PF02991	0.640
LIG_LIR_Gen_1	253	262	PF02991	0.407
LIG_LIR_Gen_1	304	312	PF02991	0.520
LIG_LIR_Gen_1	366	377	PF02991	0.504
LIG_LIR_Gen_1	432	441	PF02991	0.551
LIG_LIR_Gen_1	479	488	PF02991	0.504
LIG_LIR_Gen_1	594	603	PF02991	0.285
LIG_LIR_Nem_3	138	143	PF02991	0.748
LIG_LIR_Nem_3	186	191	PF02991	0.602
LIG_LIR_Nem_3	210	216	PF02991	0.501
LIG_LIR_Nem_3	264	270	PF02991	0.670
LIG_LIR_Nem_3	366	372	PF02991	0.380
LIG_LIR_Nem_3	432	436	PF02991	0.486
LIG_LIR_Nem_3	479	485	PF02991	0.474
LIG_LIR_Nem_3	594	599	PF02991	0.287
LIG_PCNA_PIPBox_1	461	470	PF02747	0.415
LIG_Pex14_1	184	188	PF04695	0.553
LIG_Pex14_1	301	305	PF04695	0.531
LIG_Pex14_1	53	57	PF04695	0.553
LIG_Pex14_2	623	627	PF04695	0.369
LIG_PTB_Apo_2	427	434	PF02174	0.326
LIG_PTB_Apo_2	540	547	PF02174	0.299
LIG_PTB_Phospho_1	427	433	PF10480	0.321
LIG_PTB_Phospho_1	540	546	PF10480	0.299
LIG_Rb_pABgroove_1	462	470	PF01858	0.282
LIG_SH2_CRK	140	144	PF00017	0.752
LIG_SH2_CRK	188	192	PF00017	0.672
LIG_SH2_GRB2like	557	560	PF00017	0.378
LIG_SH2_NCK_1	188	192	PF00017	0.587
LIG_SH2_NCK_1	563	567	PF00017	0.412
LIG_SH2_SRC	336	339	PF00017	0.287
LIG_SH2_STAP1	433	437	PF00017	0.526
LIG_SH2_STAP1	468	472	PF00017	0.535
LIG_SH2_STAP1	616	620	PF00017	0.392
LIG_SH2_STAT5	250	253	PF00017	0.529
LIG_SH2_STAT5	287	290	PF00017	0.743
LIG_SH2_STAT5	546	549	PF00017	0.318
LIG_SH2_STAT5	616	619	PF00017	0.314
LIG_SH3_3	232	238	PF00018	0.519
LIG_SH3_3	239	245	PF00018	0.545
LIG_SH3_3	263	269	PF00018	0.593
LIG_SH3_3	319	325	PF00018	0.448
LIG_SH3_3	425	431	PF00018	0.480
LIG_SH3_3	436	442	PF00018	0.527
LIG_SH3_3	507	513	PF00018	0.514
LIG_SH3_3	96	102	PF00018	0.670
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.397
LIG_TRAF2_1	203	206	PF00917	0.535
LIG_TRAF2_1	335	338	PF00917	0.295
LIG_TYR_ITSM	184	191	PF00017	0.665
MOD_CK1_1	144	150	PF00069	0.623
MOD_CK1_1	274	280	PF00069	0.631
MOD_CK1_1	558	564	PF00069	0.460
MOD_CK2_1	200	206	PF00069	0.554
MOD_CK2_1	283	289	PF00069	0.527
MOD_CK2_1	360	366	PF00069	0.467
MOD_CK2_1	372	378	PF00069	0.309
MOD_CK2_1	612	618	PF00069	0.521
MOD_GlcNHglycan	146	149	PF01048	0.699
MOD_GlcNHglycan	172	175	PF01048	0.619
MOD_GlcNHglycan	26	29	PF01048	0.699
MOD_GlcNHglycan	273	276	PF01048	0.764
MOD_GlcNHglycan	583	586	PF01048	0.564
MOD_GSK3_1	196	203	PF00069	0.524
MOD_GSK3_1	24	31	PF00069	0.765
MOD_GSK3_1	270	277	PF00069	0.708
MOD_GSK3_1	404	411	PF00069	0.478
MOD_GSK3_1	476	483	PF00069	0.528
MOD_GSK3_1	581	588	PF00069	0.528
MOD_N-GLC_1	144	149	PF02516	0.713
MOD_N-GLC_1	316	321	PF02516	0.456
MOD_N-GLC_1	558	563	PF02516	0.458
MOD_NEK2_1	372	377	PF00069	0.373
MOD_NEK2_1	406	411	PF00069	0.382
MOD_NEK2_1	519	524	PF00069	0.299
MOD_NEK2_1	599	604	PF00069	0.384
MOD_NEK2_1	77	82	PF00069	0.543
MOD_NEK2_2	419	424	PF00069	0.414
MOD_PIKK_1	103	109	PF00454	0.739
MOD_PIKK_1	118	124	PF00454	0.682
MOD_PIKK_1	135	141	PF00454	0.718
MOD_PIKK_1	177	183	PF00454	0.673
MOD_PIKK_1	186	192	PF00454	0.669
MOD_PIKK_1	372	378	PF00454	0.378
MOD_PIKK_1	476	482	PF00454	0.532
MOD_PIKK_1	558	564	PF00454	0.460
MOD_PIKK_1	573	579	PF00454	0.412
MOD_PIKK_1	77	83	PF00454	0.687
MOD_PKA_2	413	419	PF00069	0.305
MOD_PKA_2	599	605	PF00069	0.374
MOD_PKA_2	97	103	PF00069	0.497
MOD_Plk_1	144	150	PF00069	0.741
MOD_Plk_1	186	192	PF00069	0.669
MOD_Plk_1	558	564	PF00069	0.460
MOD_Plk_2-3	283	289	PF00069	0.498
MOD_Plk_2-3	463	469	PF00069	0.540
MOD_Plk_4	110	116	PF00069	0.707
MOD_Plk_4	14	20	PF00069	0.720
MOD_Plk_4	159	165	PF00069	0.508
MOD_Plk_4	262	268	PF00069	0.630
MOD_Plk_4	283	289	PF00069	0.595
MOD_Plk_4	449	455	PF00069	0.603
MOD_Plk_4	585	591	PF00069	0.603
MOD_ProDKin_1	274	280	PF00069	0.714
TRG_DiLeu_BaEn_1	230	235	PF01217	0.597
TRG_DiLeu_BaEn_1	32	37	PF01217	0.618
TRG_DiLeu_BaEn_2	211	217	PF01217	0.554
TRG_DiLeu_BaEn_3	337	343	PF01217	0.297
TRG_ENDOCYTIC_2	140	143	PF00928	0.744
TRG_ENDOCYTIC_2	188	191	PF00928	0.605
TRG_ENDOCYTIC_2	214	217	PF00928	0.500
TRG_ENDOCYTIC_2	305	308	PF00928	0.505
TRG_ENDOCYTIC_2	433	436	PF00928	0.381
TRG_ENDOCYTIC_2	557	560	PF00928	0.378
TRG_NES_CRM1_1	618	630	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT5	Leptomonas seymouri	79%	100%
A0A0S4KFV0	Bodo saltans	47%	100%
A0A1X0NH73	Trypanosomatidae	50%	97%
A0A3S7X906	Leishmania donovani	86%	100%
A0A422N9P3	Trypanosoma rangeli	49%	97%
A4IB35	Leishmania infantum	86%	100%
C9ZNN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9AEW5	Leishmania major	85%	100%
E9B621	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O09012	Mus musculus	32%	99%
O70525	Cavia porcellus	31%	99%
O74711	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q1RMV0	Bos taurus	32%	99%
Q2M2R8	Rattus norvegicus	32%	99%
Q5ZMQ9	Gallus gallus	32%	98%
Q920N5	Cricetulus griseus	31%	99%
Q9FMA3	Arabidopsis thaliana	34%	87%
V5B7T1	Trypanosoma cruzi	48%	95%