RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMG2_LEIBR

TriTrypDb:

LbrM.34.1320 , LBRM2903_340019500

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG2

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0034462	small-subunit processome assembly	7	1
GO:0034470	ncRNA processing	7	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036260	RNA capping	7	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.675
CLV_C14_Caspase3-7	218	222	PF00656	0.519
CLV_C14_Caspase3-7	75	79	PF00656	0.572
CLV_NRD_NRD_1	125	127	PF00675	0.497
CLV_NRD_NRD_1	135	137	PF00675	0.447
CLV_NRD_NRD_1	147	149	PF00675	0.456
CLV_NRD_NRD_1	157	159	PF00675	0.544
CLV_NRD_NRD_1	161	163	PF00675	0.480
CLV_NRD_NRD_1	229	231	PF00675	0.722
CLV_NRD_NRD_1	43	45	PF00675	0.560
CLV_NRD_NRD_1	55	57	PF00675	0.621
CLV_NRD_NRD_1	97	99	PF00675	0.453
CLV_PCSK_FUR_1	158	162	PF00082	0.414
CLV_PCSK_FUR_1	95	99	PF00082	0.527
CLV_PCSK_KEX2_1	124	126	PF00082	0.558
CLV_PCSK_KEX2_1	147	149	PF00082	0.487
CLV_PCSK_KEX2_1	157	159	PF00082	0.549
CLV_PCSK_KEX2_1	160	162	PF00082	0.346
CLV_PCSK_KEX2_1	228	230	PF00082	0.749
CLV_PCSK_KEX2_1	43	45	PF00082	0.560
CLV_PCSK_KEX2_1	55	57	PF00082	0.621
CLV_PCSK_KEX2_1	94	96	PF00082	0.506
CLV_PCSK_KEX2_1	97	99	PF00082	0.449
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.616
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.676
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.749
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.506
CLV_PCSK_PC7_1	157	163	PF00082	0.669
CLV_PCSK_SKI1_1	15	19	PF00082	0.461
CLV_PCSK_SKI1_1	157	161	PF00082	0.648
CLV_PCSK_SKI1_1	200	204	PF00082	0.669
CLV_PCSK_SKI1_1	220	224	PF00082	0.662
CLV_PCSK_SKI1_1	43	47	PF00082	0.558
DOC_MAPK_gen_1	157	168	PF00069	0.427
DOC_MAPK_gen_1	25	34	PF00069	0.556
DOC_MAPK_gen_1	43	50	PF00069	0.292
DOC_MAPK_MEF2A_6	28	36	PF00069	0.499
DOC_MAPK_MEF2A_6	55	64	PF00069	0.634
DOC_PP1_RVXF_1	31	37	PF00149	0.564
DOC_USP7_MATH_1	215	219	PF00917	0.628
DOC_USP7_UBL2_3	224	228	PF12436	0.551
DOC_WW_Pin1_4	206	211	PF00397	0.531
LIG_14-3-3_CanoR_1	167	174	PF00244	0.464
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_Clathr_ClatBox_1	3	7	PF01394	0.449
LIG_deltaCOP1_diTrp_1	68	73	PF00928	0.533
LIG_FHA_1	207	213	PF00498	0.714
LIG_FHA_1	221	227	PF00498	0.592
LIG_LIR_Apic_2	7	12	PF02991	0.539
LIG_LIR_Gen_1	113	121	PF02991	0.512
LIG_LIR_Gen_1	68	76	PF02991	0.511
LIG_LIR_Nem_3	113	117	PF02991	0.496
LIG_LIR_Nem_3	68	73	PF02991	0.500
LIG_Pex14_1	104	108	PF04695	0.375
LIG_Pex14_2	108	112	PF04695	0.492
LIG_SH2_CRK	9	13	PF00017	0.586
LIG_SH2_GRB2like	19	22	PF00017	0.579
LIG_SH2_NCK_1	9	13	PF00017	0.586
LIG_SH2_SRC	9	12	PF00017	0.508
LIG_SH2_STAT5	19	22	PF00017	0.507
LIG_SH3_3	177	183	PF00018	0.737
LIG_SH3_3	54	60	PF00018	0.641
LIG_UBA3_1	61	67	PF00899	0.526
MOD_CDK_SPK_2	206	211	PF00069	0.531
MOD_CK1_1	184	190	PF00069	0.643
MOD_CK1_1	206	212	PF00069	0.684
MOD_CK2_1	113	119	PF00069	0.487
MOD_CK2_1	138	144	PF00069	0.556
MOD_GlcNHglycan	205	208	PF01048	0.719
MOD_GlcNHglycan	213	216	PF01048	0.726
MOD_GlcNHglycan	74	77	PF01048	0.521
MOD_GSK3_1	211	218	PF00069	0.696
MOD_NEK2_1	71	76	PF00069	0.491
MOD_PIKK_1	10	16	PF00454	0.440
MOD_PKA_2	166	172	PF00069	0.454
MOD_PKA_2	181	187	PF00069	0.438
MOD_Plk_1	138	144	PF00069	0.627
MOD_Plk_2-3	110	116	PF00069	0.503
MOD_Plk_2-3	138	144	PF00069	0.375
MOD_Plk_4	113	119	PF00069	0.474
MOD_ProDKin_1	206	212	PF00069	0.532
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.636
TRG_ENDOCYTIC_2	100	103	PF00928	0.504
TRG_ENDOCYTIC_2	146	149	PF00928	0.651
TRG_ENDOCYTIC_2	39	42	PF00928	0.469
TRG_ER_diArg_1	146	148	PF00400	0.581
TRG_ER_diArg_1	161	164	PF00400	0.617
TRG_ER_diArg_1	42	44	PF00400	0.480
TRG_ER_diArg_1	55	57	PF00400	0.616
TRG_ER_diArg_1	95	98	PF00400	0.544
TRG_ER_FFAT_2	68	78	PF00635	0.552
TRG_NLS_Bipartite_1	147	164	PF00514	0.584
TRG_NLS_MonoExtC_3	159	164	PF00514	0.550
TRG_NLS_MonoExtC_3	223	228	PF00514	0.722
TRG_NLS_MonoExtC_3	51	56	PF00514	0.629
TRG_NLS_MonoExtC_3	93	98	PF00514	0.483
TRG_NLS_MonoExtN_4	157	164	PF00514	0.672
TRG_NLS_MonoExtN_4	49	56	PF00514	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KHV3	Bodo saltans	42%	96%
A0A1X0NJ36	Trypanosomatidae	50%	85%
A0A3S7X912	Leishmania donovani	84%	100%
A3LVD5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	67%
A4IB33	Leishmania infantum	84%	100%
E9AEW3	Leishmania major	81%	100%
E9B619	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q148M8	Bos taurus	27%	84%
Q59YL9	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	72%
Q6BSS5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	77%
Q6FWS2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	75%