OTU domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/OTU-like cysteine protease, putative

Species:

Leishmania braziliensis

UniProt:

A4HMG1_LEIBR

TriTrypDb:

LbrM.34.1310 , LBRM2903_340019400

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	2
GO:0004843	cysteine-type deubiquitinase activity	5	1
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0101005	deubiquitinase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.531
CLV_NRD_NRD_1	101	103	PF00675	0.407
CLV_NRD_NRD_1	156	158	PF00675	0.681
CLV_NRD_NRD_1	579	581	PF00675	0.484
CLV_NRD_NRD_1	613	615	PF00675	0.607
CLV_NRD_NRD_1	9	11	PF00675	0.432
CLV_PCSK_FUR_1	373	377	PF00082	0.388
CLV_PCSK_FUR_1	577	581	PF00082	0.601
CLV_PCSK_KEX2_1	101	103	PF00082	0.407
CLV_PCSK_KEX2_1	156	158	PF00082	0.651
CLV_PCSK_KEX2_1	375	377	PF00082	0.614
CLV_PCSK_KEX2_1	382	384	PF00082	0.501
CLV_PCSK_KEX2_1	576	578	PF00082	0.534
CLV_PCSK_KEX2_1	579	581	PF00082	0.558
CLV_PCSK_KEX2_1	613	615	PF00082	0.607
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.463
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.523
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.576
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.618
CLV_PCSK_PC7_1	371	377	PF00082	0.391
CLV_PCSK_PC7_1	609	615	PF00082	0.541
CLV_PCSK_SKI1_1	107	111	PF00082	0.571
CLV_PCSK_SKI1_1	382	386	PF00082	0.515
CLV_PCSK_SKI1_1	576	580	PF00082	0.572
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DEG_SCF_FBW7_1	620	627	PF00400	0.531
DEG_SPOP_SBC_1	147	151	PF00917	0.652
DEG_SPOP_SBC_1	220	224	PF00917	0.468
DEG_SPOP_SBC_1	228	232	PF00917	0.431
DEG_SPOP_SBC_1	24	28	PF00917	0.761
DOC_CKS1_1	295	300	PF01111	0.466
DOC_MAPK_gen_1	213	220	PF00069	0.620
DOC_MAPK_gen_1	472	480	PF00069	0.562
DOC_MAPK_gen_1	70	79	PF00069	0.435
DOC_MAPK_HePTP_8	69	81	PF00069	0.521
DOC_MAPK_MEF2A_6	472	480	PF00069	0.482
DOC_MAPK_MEF2A_6	72	81	PF00069	0.502
DOC_MIT_MIM_1	381	391	PF04212	0.546
DOC_PP1_RVXF_1	56	62	PF00149	0.561
DOC_PP2B_LxvP_1	647	650	PF13499	0.546
DOC_PP4_FxxP_1	201	204	PF00568	0.579
DOC_PP4_FxxP_1	414	417	PF00568	0.513
DOC_USP7_MATH_1	24	28	PF00917	0.723
DOC_USP7_MATH_1	34	38	PF00917	0.781
DOC_USP7_MATH_1	345	349	PF00917	0.672
DOC_USP7_MATH_1	429	433	PF00917	0.586
DOC_USP7_MATH_1	51	55	PF00917	0.566
DOC_USP7_MATH_1	641	645	PF00917	0.714
DOC_USP7_MATH_1	654	658	PF00917	0.735
DOC_USP7_MATH_1	698	702	PF00917	0.755
DOC_USP7_MATH_2	225	231	PF00917	0.477
DOC_USP7_UBL2_3	579	583	PF12436	0.394
DOC_WW_Pin1_4	221	226	PF00397	0.691
DOC_WW_Pin1_4	294	299	PF00397	0.461
DOC_WW_Pin1_4	531	536	PF00397	0.662
DOC_WW_Pin1_4	546	551	PF00397	0.511
DOC_WW_Pin1_4	554	559	PF00397	0.440
DOC_WW_Pin1_4	620	625	PF00397	0.747
DOC_WW_Pin1_4	64	69	PF00397	0.596
DOC_WW_Pin1_4	650	655	PF00397	0.722
DOC_WW_Pin1_4	686	691	PF00397	0.724
DOC_WW_Pin1_4	694	699	PF00397	0.716
LIG_14-3-3_CanoR_1	119	124	PF00244	0.494
LIG_14-3-3_CanoR_1	143	147	PF00244	0.545
LIG_14-3-3_CanoR_1	501	507	PF00244	0.616
LIG_14-3-3_CanoR_1	590	599	PF00244	0.684
LIG_14-3-3_CanoR_1	640	649	PF00244	0.791
LIG_14-3-3_CanoR_1	668	675	PF00244	0.717
LIG_14-3-3_CanoR_1	85	89	PF00244	0.512
LIG_Actin_RPEL_3	112	131	PF02755	0.398
LIG_BRCT_BRCA1_1	702	706	PF00533	0.560
LIG_FHA_1	392	398	PF00498	0.444
LIG_FHA_1	592	598	PF00498	0.694
LIG_FHA_1	64	70	PF00498	0.538
LIG_FHA_1	658	664	PF00498	0.543
LIG_FHA_2	295	301	PF00498	0.462
LIG_FHA_2	365	371	PF00498	0.522
LIG_FHA_2	458	464	PF00498	0.561
LIG_GSK3_LRP6_1	694	699	PF00069	0.679
LIG_LIR_Apic_2	178	183	PF02991	0.498
LIG_LIR_Gen_1	105	115	PF02991	0.530
LIG_LIR_Gen_1	311	322	PF02991	0.455
LIG_LIR_Gen_1	435	446	PF02991	0.499
LIG_LIR_Gen_1	87	96	PF02991	0.500
LIG_LIR_Nem_3	105	111	PF02991	0.531
LIG_LIR_Nem_3	132	138	PF02991	0.633
LIG_LIR_Nem_3	435	441	PF02991	0.475
LIG_LIR_Nem_3	447	451	PF02991	0.367
LIG_LIR_Nem_3	542	547	PF02991	0.453
LIG_LIR_Nem_3	87	91	PF02991	0.449
LIG_MYND_1	665	669	PF01753	0.680
LIG_NRBOX	3	9	PF00104	0.509
LIG_NRBOX	565	571	PF00104	0.560
LIG_PCNA_yPIPBox_3	563	577	PF02747	0.340
LIG_Pex14_1	488	492	PF04695	0.482
LIG_PTB_Apo_2	186	193	PF02174	0.559
LIG_PTB_Apo_2	408	415	PF02174	0.513
LIG_SH2_CRK	438	442	PF00017	0.475
LIG_SH2_CRK	494	498	PF00017	0.389
LIG_SH2_GRB2like	314	317	PF00017	0.446
LIG_SH2_NCK_1	295	299	PF00017	0.558
LIG_SH2_NCK_1	506	510	PF00017	0.526
LIG_SH2_NCK_1	553	557	PF00017	0.430
LIG_SH2_SRC	553	556	PF00017	0.397
LIG_SH2_STAP1	314	318	PF00017	0.449
LIG_SH2_STAP1	438	442	PF00017	0.496
LIG_SH2_STAT5	288	291	PF00017	0.560
LIG_SH2_STAT5	3	6	PF00017	0.565
LIG_SH2_STAT5	366	369	PF00017	0.525
LIG_SH2_STAT5	421	424	PF00017	0.586
LIG_SH2_STAT5	451	454	PF00017	0.495
LIG_SH2_STAT5	537	540	PF00017	0.572
LIG_SH2_STAT5	547	550	PF00017	0.465
LIG_SH2_STAT5	88	91	PF00017	0.455
LIG_SH3_1	600	606	PF00018	0.529
LIG_SH3_1	685	691	PF00018	0.757
LIG_SH3_3	204	210	PF00018	0.552
LIG_SH3_3	600	606	PF00018	0.624
LIG_SH3_3	622	628	PF00018	0.759
LIG_SH3_3	659	665	PF00018	0.729
LIG_SH3_3	680	686	PF00018	0.739
LIG_SH3_3	688	694	PF00018	0.719
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.481
LIG_TRAF2_1	367	370	PF00917	0.583
LIG_TYR_ITIM	551	556	PF00017	0.411
LIG_WRC_WIRS_1	184	189	PF05994	0.524
MOD_CDC14_SPxK_1	67	70	PF00782	0.593
MOD_CDK_SPK_2	624	629	PF00069	0.522
MOD_CDK_SPxK_1	620	626	PF00069	0.532
MOD_CDK_SPxK_1	64	70	PF00069	0.592
MOD_CK1_1	117	123	PF00069	0.547
MOD_CK1_1	175	181	PF00069	0.587
MOD_CK1_1	229	235	PF00069	0.545
MOD_CK1_1	25	31	PF00069	0.650
MOD_CK1_1	271	277	PF00069	0.445
MOD_CK1_1	348	354	PF00069	0.643
MOD_CK1_1	425	431	PF00069	0.480
MOD_CK1_1	432	438	PF00069	0.364
MOD_CK1_1	499	505	PF00069	0.661
MOD_CK1_1	592	598	PF00069	0.726
MOD_CK1_1	618	624	PF00069	0.785
MOD_CK1_1	653	659	PF00069	0.639
MOD_CK1_1	699	705	PF00069	0.685
MOD_CK1_1	87	93	PF00069	0.445
MOD_CK2_1	221	227	PF00069	0.650
MOD_CK2_1	347	353	PF00069	0.626
MOD_CK2_1	364	370	PF00069	0.488
MOD_CK2_1	513	519	PF00069	0.651
MOD_Cter_Amidation	611	614	PF01082	0.542
MOD_GlcNHglycan	17	20	PF01048	0.613
MOD_GlcNHglycan	174	177	PF01048	0.559
MOD_GlcNHglycan	28	31	PF01048	0.731
MOD_GlcNHglycan	328	331	PF01048	0.685
MOD_GlcNHglycan	347	350	PF01048	0.607
MOD_GlcNHglycan	515	518	PF01048	0.598
MOD_GlcNHglycan	53	56	PF01048	0.663
MOD_GlcNHglycan	570	573	PF01048	0.515
MOD_GlcNHglycan	585	588	PF01048	0.557
MOD_GlcNHglycan	591	594	PF01048	0.669
MOD_GlcNHglycan	98	101	PF01048	0.315
MOD_GSK3_1	117	124	PF00069	0.435
MOD_GSK3_1	142	149	PF00069	0.629
MOD_GSK3_1	219	226	PF00069	0.627
MOD_GSK3_1	22	29	PF00069	0.675
MOD_GSK3_1	425	432	PF00069	0.480
MOD_GSK3_1	522	529	PF00069	0.609
MOD_GSK3_1	581	588	PF00069	0.656
MOD_GSK3_1	601	608	PF00069	0.451
MOD_GSK3_1	620	627	PF00069	0.784
MOD_GSK3_1	636	643	PF00069	0.562
MOD_GSK3_1	650	657	PF00069	0.637
MOD_GSK3_1	677	684	PF00069	0.745
MOD_GSK3_1	686	693	PF00069	0.665
MOD_GSK3_1	694	701	PF00069	0.710
MOD_N-GLC_1	188	193	PF02516	0.465
MOD_N-GLC_1	362	367	PF02516	0.560
MOD_N-GLC_1	502	507	PF02516	0.513
MOD_N-GLC_1	63	68	PF02516	0.510
MOD_N-GLC_1	657	662	PF02516	0.759
MOD_N-GLC_1	96	101	PF02516	0.490
MOD_NEK2_1	121	126	PF00069	0.664
MOD_NEK2_1	130	135	PF00069	0.696
MOD_NEK2_1	146	151	PF00069	0.636
MOD_NEK2_1	158	163	PF00069	0.693
MOD_NEK2_1	317	322	PF00069	0.658
MOD_NEK2_1	391	396	PF00069	0.520
MOD_NEK2_1	422	427	PF00069	0.422
MOD_NEK2_1	497	502	PF00069	0.580
MOD_NEK2_1	79	84	PF00069	0.396
MOD_PIKK_1	158	164	PF00454	0.660
MOD_PIKK_1	268	274	PF00454	0.476
MOD_PIKK_1	40	46	PF00454	0.531
MOD_PKA_1	101	107	PF00069	0.454
MOD_PKA_1	156	162	PF00069	0.495
MOD_PKA_2	101	107	PF00069	0.454
MOD_PKA_2	142	148	PF00069	0.534
MOD_PKA_2	15	21	PF00069	0.545
MOD_PKA_2	156	162	PF00069	0.470
MOD_PKA_2	214	220	PF00069	0.558
MOD_PKA_2	326	332	PF00069	0.794
MOD_PKA_2	589	595	PF00069	0.529
MOD_PKA_2	641	647	PF00069	0.813
MOD_PKA_2	677	683	PF00069	0.705
MOD_PKA_2	84	90	PF00069	0.477
MOD_PKB_1	638	646	PF00069	0.545
MOD_Plk_1	117	123	PF00069	0.471
MOD_Plk_1	188	194	PF00069	0.472
MOD_Plk_1	362	368	PF00069	0.552
MOD_Plk_1	502	508	PF00069	0.767
MOD_Plk_1	615	621	PF00069	0.752
MOD_Plk_1	657	663	PF00069	0.570
MOD_Plk_2-3	364	370	PF00069	0.511
MOD_Plk_2-3	457	463	PF00069	0.447
MOD_Plk_4	130	136	PF00069	0.602
MOD_Plk_4	142	148	PF00069	0.610
MOD_Plk_4	175	181	PF00069	0.566
MOD_Plk_4	183	189	PF00069	0.505
MOD_Plk_4	539	545	PF00069	0.495
MOD_Plk_4	615	621	PF00069	0.537
MOD_Plk_4	84	90	PF00069	0.504
MOD_ProDKin_1	221	227	PF00069	0.694
MOD_ProDKin_1	294	300	PF00069	0.461
MOD_ProDKin_1	531	537	PF00069	0.658
MOD_ProDKin_1	546	552	PF00069	0.510
MOD_ProDKin_1	554	560	PF00069	0.453
MOD_ProDKin_1	620	626	PF00069	0.749
MOD_ProDKin_1	64	70	PF00069	0.592
MOD_ProDKin_1	650	656	PF00069	0.721
MOD_ProDKin_1	686	692	PF00069	0.725
MOD_ProDKin_1	694	700	PF00069	0.719
MOD_SUMO_rev_2	309	315	PF00179	0.448
MOD_SUMO_rev_2	99	109	PF00179	0.432
TRG_DiLeu_BaEn_2	196	202	PF01217	0.596
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.552
TRG_ENDOCYTIC_2	135	138	PF00928	0.617
TRG_ENDOCYTIC_2	314	317	PF00928	0.602
TRG_ENDOCYTIC_2	438	441	PF00928	0.325
TRG_ENDOCYTIC_2	494	497	PF00928	0.490
TRG_ENDOCYTIC_2	553	556	PF00928	0.319
TRG_ENDOCYTIC_2	88	91	PF00928	0.482
TRG_ER_diArg_1	156	158	PF00400	0.625
TRG_ER_diArg_1	264	267	PF00400	0.314
TRG_ER_diArg_1	613	615	PF00400	0.591
TRG_ER_diArg_1	637	640	PF00400	0.645
TRG_NLS_MonoExtC_3	575	580	PF00514	0.617
TRG_NLS_MonoExtN_4	576	583	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V7	Leptomonas seymouri	57%	100%
A0A1X0NIV4	Trypanosomatidae	33%	90%
A0A3Q8IJ90	Leishmania donovani	69%	100%
A0A3R7MGK1	Trypanosoma rangeli	37%	100%
A4IB32	Leishmania infantum	69%	100%
C9ZNN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	77%
E9AEW2	Leishmania major	68%	100%
E9B618	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
V5BC93	Trypanosoma cruzi	38%	100%