Putative mitochondrial processing peptidase, beta subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase, beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HMG0_LEIBR

TriTrypDb:

LbrM.34.1300 , LBRM2903_340019300

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	6
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0004175	endopeptidase activity	4	1
GO:0004222	metalloendopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	432	434	PF00675	0.423
CLV_NRD_NRD_1	461	463	PF00675	0.443
CLV_PCSK_KEX2_1	432	434	PF00082	0.423
CLV_PCSK_SKI1_1	176	180	PF00082	0.369
CLV_PCSK_SKI1_1	198	202	PF00082	0.463
CLV_PCSK_SKI1_1	233	237	PF00082	0.427
CLV_PCSK_SKI1_1	25	29	PF00082	0.584
CLV_PCSK_SKI1_1	316	320	PF00082	0.358
CLV_PCSK_SKI1_1	425	429	PF00082	0.431
CLV_PCSK_SKI1_1	54	58	PF00082	0.415
DEG_APCC_DBOX_1	24	32	PF00400	0.586
DEG_APCC_DBOX_1	432	440	PF00400	0.438
DEG_APCC_KENBOX_2	123	127	PF00400	0.479
DOC_CKS1_1	186	191	PF01111	0.443
DOC_MAPK_MEF2A_6	54	62	PF00069	0.415
DOC_PIKK_1	167	174	PF02985	0.374
DOC_USP7_MATH_1	178	182	PF00917	0.358
DOC_USP7_MATH_1	234	238	PF00917	0.372
DOC_USP7_UBL2_3	244	248	PF12436	0.363
DOC_USP7_UBL2_3	402	406	PF12436	0.441
DOC_WW_Pin1_4	179	184	PF00397	0.384
DOC_WW_Pin1_4	185	190	PF00397	0.394
DOC_WW_Pin1_4	325	330	PF00397	0.358
LIG_14-3-3_CanoR_1	209	214	PF00244	0.443
LIG_14-3-3_CanoR_1	269	274	PF00244	0.358
LIG_14-3-3_CanoR_1	316	322	PF00244	0.358
LIG_14-3-3_CanoR_1	433	443	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	1	5	PF00533	0.602
LIG_BRCT_BRCA1_1	20	24	PF00533	0.558
LIG_Clathr_ClatBox_1	410	414	PF01394	0.475
LIG_deltaCOP1_diTrp_1	479	484	PF00928	0.428
LIG_EH_1	342	346	PF12763	0.374
LIG_FHA_1	270	276	PF00498	0.358
LIG_FHA_1	55	61	PF00498	0.376
LIG_FHA_1	74	80	PF00498	0.250
LIG_FHA_2	227	233	PF00498	0.358
LIG_FHA_2	379	385	PF00498	0.374
LIG_HCF-1_HBM_1	114	117	PF13415	0.328
LIG_LIR_Gen_1	114	122	PF02991	0.397
LIG_LIR_Gen_1	2	12	PF02991	0.604
LIG_LIR_Gen_1	320	329	PF02991	0.358
LIG_LIR_Gen_1	384	393	PF02991	0.359
LIG_LIR_Gen_1	437	445	PF02991	0.471
LIG_LIR_Nem_3	116	122	PF02991	0.395
LIG_LIR_Nem_3	2	8	PF02991	0.590
LIG_LIR_Nem_3	21	27	PF02991	0.536
LIG_LIR_Nem_3	237	242	PF02991	0.377
LIG_LIR_Nem_3	320	324	PF02991	0.358
LIG_LIR_Nem_3	348	352	PF02991	0.481
LIG_LIR_Nem_3	384	388	PF02991	0.359
LIG_LIR_Nem_3	437	443	PF02991	0.449
LIG_LIR_Nem_3	467	471	PF02991	0.385
LIG_PCNA_PIPBox_1	452	461	PF02747	0.421
LIG_PCNA_yPIPBox_3	304	318	PF02747	0.358
LIG_PCNA_yPIPBox_3	452	463	PF02747	0.424
LIG_Pex14_1	266	270	PF04695	0.374
LIG_Pex14_1	484	488	PF04695	0.441
LIG_PTB_Apo_2	264	271	PF02174	0.374
LIG_PTB_Phospho_1	264	270	PF10480	0.374
LIG_Rb_pABgroove_1	434	442	PF01858	0.567
LIG_SH2_CRK	119	123	PF00017	0.415
LIG_SH2_CRK	270	274	PF00017	0.374
LIG_SH2_CRK	466	470	PF00017	0.390
LIG_SH2_NCK_1	380	384	PF00017	0.374
LIG_SH2_NCK_1	440	444	PF00017	0.464
LIG_SH2_NCK_1	68	72	PF00017	0.479
LIG_SH2_SRC	68	71	PF00017	0.479
LIG_SH2_STAT5	117	120	PF00017	0.443
LIG_SH2_STAT5	238	241	PF00017	0.415
LIG_SH2_STAT5	258	261	PF00017	0.393
LIG_SH2_STAT5	358	361	PF00017	0.374
LIG_SH2_STAT5	380	383	PF00017	0.374
LIG_SH2_STAT5	458	461	PF00017	0.425
LIG_SH2_STAT5	468	471	PF00017	0.379
LIG_SH3_3	183	189	PF00018	0.522
LIG_SUMO_SIM_par_1	217	223	PF11976	0.376
LIG_TRAF2_1	46	49	PF00917	0.393
LIG_TYR_ITIM	268	273	PF00017	0.374
LIG_WRC_WIRS_1	318	323	PF05994	0.358
MOD_CK1_1	327	333	PF00069	0.367
MOD_CK1_1	338	344	PF00069	0.342
MOD_CK1_1	4	10	PF00069	0.590
MOD_CK1_1	416	422	PF00069	0.421
MOD_CK2_1	226	232	PF00069	0.358
MOD_CK2_1	302	308	PF00069	0.358
MOD_CK2_1	378	384	PF00069	0.358
MOD_CK2_1	63	69	PF00069	0.374
MOD_Cter_Amidation	430	433	PF01082	0.445
MOD_Cter_Amidation	460	463	PF01082	0.497
MOD_GlcNHglycan	20	23	PF01048	0.663
MOD_GlcNHglycan	222	225	PF01048	0.403
MOD_GlcNHglycan	414	418	PF01048	0.467
MOD_GlcNHglycan	472	475	PF01048	0.457
MOD_GSK3_1	120	127	PF00069	0.479
MOD_GSK3_1	13	20	PF00069	0.634
MOD_GSK3_1	298	305	PF00069	0.479
MOD_GSK3_1	31	38	PF00069	0.467
MOD_GSK3_1	320	327	PF00069	0.362
MOD_GSK3_1	478	485	PF00069	0.419
MOD_GSK3_1	50	57	PF00069	0.447
MOD_GSK3_1	85	92	PF00069	0.389
MOD_N-GLC_1	34	39	PF02516	0.498
MOD_N-GLC_1	89	94	PF02516	0.393
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	302	307	PF00069	0.358
MOD_NEK2_1	324	329	PF00069	0.374
MOD_NEK2_1	345	350	PF00069	0.479
MOD_NEK2_1	378	383	PF00069	0.358
MOD_NEK2_1	413	418	PF00069	0.467
MOD_NEK2_1	85	90	PF00069	0.393
MOD_PIKK_1	302	308	PF00454	0.365
MOD_PIKK_1	478	484	PF00454	0.439
MOD_PKA_1	198	204	PF00069	0.463
MOD_PKA_2	208	214	PF00069	0.383
MOD_PKB_1	11	19	PF00069	0.641
MOD_Plk_1	113	119	PF00069	0.355
MOD_Plk_1	226	232	PF00069	0.372
MOD_Plk_1	335	341	PF00069	0.443
MOD_Plk_1	34	40	PF00069	0.522
MOD_Plk_4	113	119	PF00069	0.437
MOD_Plk_4	226	232	PF00069	0.473
MOD_Plk_4	234	240	PF00069	0.482
MOD_Plk_4	4	10	PF00069	0.590
MOD_Plk_4	464	470	PF00069	0.388
MOD_ProDKin_1	179	185	PF00069	0.384
MOD_ProDKin_1	325	331	PF00069	0.358
TRG_DiLeu_BaEn_2	80	86	PF01217	0.443
TRG_ENDOCYTIC_2	117	120	PF00928	0.397
TRG_ENDOCYTIC_2	270	273	PF00928	0.374
TRG_ENDOCYTIC_2	349	352	PF00928	0.479
TRG_ENDOCYTIC_2	440	443	PF00928	0.447
TRG_ENDOCYTIC_2	466	469	PF00928	0.388
TRG_ER_diArg_1	11	14	PF00400	0.653
TRG_ER_diArg_1	432	434	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P575	Leptomonas seymouri	28%	99%
A0A0N1PEB5	Leptomonas seymouri	91%	100%
A0A0S4IUJ1	Bodo saltans	32%	95%
A0A0S4KFV6	Bodo saltans	66%	98%
A0A1X0NHX2	Trypanosomatidae	68%	95%
A0A1X0P2L6	Trypanosomatidae	29%	96%
A0A3S7X938	Leishmania donovani	93%	100%
A0A422N9N5	Trypanosoma rangeli	75%	100%
A0A422NGW3	Trypanosoma rangeli	29%	100%
A0A451EJB9	Leishmania donovani	30%	99%
A4HRI8	Leishmania infantum	30%	99%
A4IB31	Leishmania infantum	93%	100%
C9ZNM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
C9ZXM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC56	Leishmania major	30%	100%
E9AEW1	Leishmania major	93%	100%
E9AJF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9B4A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	99%
E9B617	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O04308	Arabidopsis thaliana	24%	98%
O25656	Helicobacter pylori (strain ATCC 700392 / 26695)	22%	100%
O32965	Mycobacterium leprae (strain TN)	27%	100%
O60044	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
O75439	Homo sapiens	32%	100%
O86835	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	100%
O94745	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	98%
P07256	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P0A5S9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	25%	100%
P10507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P11913	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	100%
P11914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P20069	Rattus norvegicus	25%	94%
P22695	Homo sapiens	24%	100%
P23004	Bos taurus	24%	100%
P29677	Solanum tuberosum	26%	97%
P31800	Bos taurus	31%	100%
P31930	Homo sapiens	29%	100%
P32551	Rattus norvegicus	25%	100%
P43264	Euglena gracilis	32%	99%
P55679	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	22%	96%
P97997	Blastocladiella emersonii	25%	100%
P98080	Caenorhabditis elegans	28%	100%
P9WHT4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WHT5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q00302	Blastocladiella emersonii	29%	100%
Q03346	Rattus norvegicus	32%	100%
Q0P5M8	Bos taurus	26%	93%
Q10713	Homo sapiens	24%	93%
Q1RJ61	Rickettsia bellii (strain RML369-C)	22%	100%
Q23295	Caenorhabditis elegans	29%	100%
Q3SZ71	Bos taurus	32%	100%
Q42290	Arabidopsis thaliana	32%	92%
Q4UML9	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	23%	100%
Q4W6B5	Dictyostelium discoideum	29%	100%
Q54F93	Dictyostelium discoideum	20%	100%
Q5R513	Pongo abelii	24%	93%
Q5REK3	Pongo abelii	32%	100%
Q68FY0	Rattus norvegicus	30%	100%
Q6C2E3	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q95XN2	Caenorhabditis elegans	22%	95%
Q9CXT8	Mus musculus	32%	100%
Q9CZ13	Mus musculus	30%	100%
Q9DB77	Mus musculus	24%	100%
Q9DC61	Mus musculus	25%	94%
Q9P7X1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9Y8B5	Lentinula edodes	31%	100%
Q9ZU25	Arabidopsis thaliana	25%	97%
V5BGV2	Trypanosoma cruzi	76%	100%
V5BH27	Trypanosoma cruzi	30%	100%