CDGSH iron-sulfur domain-containing protein 3, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-binding zinc finger CDGSH type, putative

Species:

Leishmania braziliensis

UniProt:

A4HMF9_LEIBR

TriTrypDb:

LbrM.34.1290 , LBRM2903_340019200

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1

Expansion

Sequence features

A4HMF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:0106034	protein maturation by [2Fe-2S] cluster transfer	6	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0051536	iron-sulfur cluster binding	3	8
GO:0051537	2 iron, 2 sulfur cluster binding	4	8
GO:0051540	metal cluster binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.486
CLV_PCSK_KEX2_1	21	23	PF00082	0.470
CLV_PCSK_SKI1_1	74	78	PF00082	0.296
CLV_PCSK_SKI1_1	83	87	PF00082	0.184
DEG_Nend_UBRbox_3	1	3	PF02207	0.546
DOC_MAPK_gen_1	18	26	PF00069	0.432
DOC_USP7_UBL2_3	14	18	PF12436	0.493
DOC_USP7_UBL2_3	68	72	PF12436	0.410
DOC_WW_Pin1_4	92	97	PF00397	0.477
LIG_14-3-3_CanoR_1	88	97	PF00244	0.477
LIG_FHA_2	11	17	PF00498	0.521
LIG_LIR_Gen_1	95	105	PF02991	0.465
LIG_LIR_Nem_3	95	100	PF02991	0.465
LIG_SH2_STAT5	84	87	PF00017	0.465
LIG_SH2_STAT5	97	100	PF00017	0.331
LIG_SH3_1	14	20	PF00018	0.528
LIG_SH3_2	17	22	PF14604	0.555
LIG_SH3_3	14	20	PF00018	0.529
LIG_SH3_3	21	27	PF00018	0.352
LIG_UBA3_1	106	115	PF00899	0.454
MOD_CK1_1	10	16	PF00069	0.527
MOD_GSK3_1	43	50	PF00069	0.481
MOD_GSK3_1	74	81	PF00069	0.289
MOD_NEK2_1	106	111	PF00069	0.437
MOD_NEK2_1	7	12	PF00069	0.547
MOD_Plk_1	74	80	PF00069	0.319
MOD_Plk_1	98	104	PF00069	0.423
MOD_ProDKin_1	92	98	PF00069	0.477
MOD_SUMO_rev_2	10	20	PF00179	0.486
MOD_SUMO_rev_2	65	73	PF00179	0.453
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.508
TRG_ENDOCYTIC_2	97	100	PF00928	0.385
TRG_ER_diArg_1	20	22	PF00400	0.516
TRG_ER_diArg_1	3	6	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P697	Leptomonas seymouri	77%	92%
A0A1X0NMK8	Trypanosomatidae	59%	100%
A0A3Q8IF04	Leishmania donovani	93%	100%
A4IB30	Leishmania infantum	93%	100%
B1AR13	Mus musculus	40%	88%
E9AEW0	Leishmania major	92%	100%
E9B616	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P0C7P0	Homo sapiens	43%	94%