Integrase core domain containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMF8_LEIBR

TriTrypDb:

LbrM.34.1280 , LBRM2903_340019100

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.669
CLV_C14_Caspase3-7	190	194	PF00656	0.637
CLV_NRD_NRD_1	131	133	PF00675	0.561
CLV_NRD_NRD_1	296	298	PF00675	0.633
CLV_NRD_NRD_1	314	316	PF00675	0.682
CLV_NRD_NRD_1	392	394	PF00675	0.432
CLV_NRD_NRD_1	423	425	PF00675	0.539
CLV_PCSK_KEX2_1	314	316	PF00082	0.557
CLV_PCSK_KEX2_1	394	396	PF00082	0.484
CLV_PCSK_KEX2_1	423	425	PF00082	0.524
CLV_PCSK_KEX2_1	57	59	PF00082	0.505
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.484
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.483
CLV_PCSK_SKI1_1	309	313	PF00082	0.662
CLV_PCSK_SKI1_1	387	391	PF00082	0.469
CLV_PCSK_SKI1_1	395	399	PF00082	0.544
CLV_PCSK_SKI1_1	53	57	PF00082	0.656
DEG_Nend_UBRbox_2	1	3	PF02207	0.458
DEG_SPOP_SBC_1	291	295	PF00917	0.565
DOC_CKS1_1	243	248	PF01111	0.572
DOC_CKS1_1	68	73	PF01111	0.517
DOC_MAPK_DCC_7	58	68	PF00069	0.496
DOC_MAPK_gen_1	57	65	PF00069	0.489
DOC_MAPK_HePTP_8	55	67	PF00069	0.495
DOC_MAPK_MEF2A_6	57	65	PF00069	0.493
DOC_USP7_MATH_1	18	22	PF00917	0.425
DOC_USP7_MATH_1	189	193	PF00917	0.667
DOC_USP7_MATH_1	219	223	PF00917	0.466
DOC_USP7_MATH_1	224	228	PF00917	0.599
DOC_USP7_MATH_1	286	290	PF00917	0.764
DOC_USP7_MATH_1	291	295	PF00917	0.725
DOC_USP7_MATH_1	313	317	PF00917	0.721
DOC_USP7_MATH_1	359	363	PF00917	0.668
DOC_USP7_UBL2_3	387	391	PF12436	0.441
DOC_USP7_UBL2_3	394	398	PF12436	0.495
DOC_USP7_UBL2_3	53	57	PF12436	0.586
DOC_WW_Pin1_4	121	126	PF00397	0.585
DOC_WW_Pin1_4	242	247	PF00397	0.579
DOC_WW_Pin1_4	255	260	PF00397	0.688
DOC_WW_Pin1_4	355	360	PF00397	0.793
DOC_WW_Pin1_4	67	72	PF00397	0.539
LIG_14-3-3_CanoR_1	19	24	PF00244	0.475
LIG_BRCT_BRCA1_1	335	339	PF00533	0.532
LIG_EVH1_2	299	303	PF00568	0.511
LIG_FHA_1	178	184	PF00498	0.490
LIG_FHA_1	243	249	PF00498	0.524
LIG_FHA_1	32	38	PF00498	0.556
LIG_FHA_1	81	87	PF00498	0.548
LIG_FHA_2	150	156	PF00498	0.555
LIG_FHA_2	263	269	PF00498	0.810
LIG_FHA_2	83	89	PF00498	0.676
LIG_LIR_Apic_2	342	347	PF02991	0.522
LIG_LIR_Gen_1	207	217	PF02991	0.449
LIG_LIR_Gen_1	375	381	PF02991	0.487
LIG_LIR_Nem_3	163	169	PF02991	0.550
LIG_LIR_Nem_3	207	213	PF02991	0.444
LIG_LIR_Nem_3	239	244	PF02991	0.597
LIG_LIR_Nem_3	375	380	PF02991	0.496
LIG_MLH1_MIPbox_1	335	339	PF16413	0.509
LIG_Pex14_2	339	343	PF04695	0.523
LIG_SH2_GRB2like	370	373	PF00017	0.451
LIG_SH2_NCK_1	344	348	PF00017	0.521
LIG_SH2_SRC	344	347	PF00017	0.520
LIG_SH2_STAP1	210	214	PF00017	0.501
LIG_SH2_STAP1	370	374	PF00017	0.432
LIG_SH2_STAT5	167	170	PF00017	0.534
LIG_SH2_STAT5	232	235	PF00017	0.513
LIG_SH2_STAT5	242	245	PF00017	0.543
LIG_SH2_STAT5	6	9	PF00017	0.468
LIG_SH3_1	344	350	PF00018	0.518
LIG_SH3_3	116	122	PF00018	0.555
LIG_SH3_3	20	26	PF00018	0.563
LIG_SH3_3	257	263	PF00018	0.731
LIG_SH3_3	344	350	PF00018	0.699
LIG_SH3_3	58	64	PF00018	0.492
LIG_SH3_3	88	94	PF00018	0.644
LIG_SUMO_SIM_par_1	64	70	PF11976	0.508
LIG_TRAF2_1	157	160	PF00917	0.522
LIG_TRAF2_2	259	264	PF00917	0.624
LIG_UBA3_1	396	405	PF00899	0.405
LIG_UBA3_1	55	62	PF00899	0.483
MOD_CDK_SPK_2	121	126	PF00069	0.579
MOD_CDK_SPxK_1	67	73	PF00069	0.515
MOD_CDK_SPxxK_3	121	128	PF00069	0.560
MOD_CK1_1	124	130	PF00069	0.667
MOD_CK1_1	134	140	PF00069	0.578
MOD_CK1_1	192	198	PF00069	0.608
MOD_CK1_1	21	27	PF00069	0.386
MOD_CK1_1	269	275	PF00069	0.650
MOD_CK1_1	289	295	PF00069	0.588
MOD_CK1_1	305	311	PF00069	0.523
MOD_CK1_1	316	322	PF00069	0.719
MOD_CK1_1	358	364	PF00069	0.592
MOD_CK1_1	365	371	PF00069	0.549
MOD_CK1_1	4	10	PF00069	0.504
MOD_CK2_1	149	155	PF00069	0.557
MOD_CK2_1	219	225	PF00069	0.562
MOD_CK2_1	282	288	PF00069	0.533
MOD_CK2_1	82	88	PF00069	0.671
MOD_GlcNHglycan	133	136	PF01048	0.718
MOD_GlcNHglycan	141	144	PF01048	0.631
MOD_GlcNHglycan	193	197	PF01048	0.631
MOD_GlcNHglycan	200	204	PF01048	0.504
MOD_GlcNHglycan	271	274	PF01048	0.583
MOD_GlcNHglycan	284	287	PF01048	0.639
MOD_GlcNHglycan	304	307	PF01048	0.580
MOD_GlcNHglycan	361	364	PF01048	0.530
MOD_GlcNHglycan	39	42	PF01048	0.753
MOD_GSK3_1	1	8	PF00069	0.670
MOD_GSK3_1	173	180	PF00069	0.483
MOD_GSK3_1	183	190	PF00069	0.642
MOD_GSK3_1	21	28	PF00069	0.456
MOD_GSK3_1	262	269	PF00069	0.770
MOD_GSK3_1	278	285	PF00069	0.645
MOD_GSK3_1	286	293	PF00069	0.618
MOD_GSK3_1	333	340	PF00069	0.619
MOD_GSK3_1	355	362	PF00069	0.627
MOD_GSK3_1	97	104	PF00069	0.768
MOD_N-GLC_1	155	160	PF02516	0.534
MOD_N-GLC_1	248	253	PF02516	0.586
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	37	42	PF00069	0.702
MOD_PIKK_1	155	161	PF00454	0.528
MOD_PIKK_1	177	183	PF00454	0.502
MOD_PIKK_1	187	193	PF00454	0.660
MOD_PIKK_1	248	254	PF00454	0.616
MOD_PIKK_1	25	31	PF00454	0.386
MOD_PIKK_1	6	12	PF00454	0.361
MOD_PIKK_1	80	86	PF00454	0.544
MOD_PK_1	19	25	PF00069	0.468
MOD_PKA_1	314	320	PF00069	0.663
MOD_PKA_2	131	137	PF00069	0.581
MOD_PKA_2	18	24	PF00069	0.468
MOD_PKA_2	313	319	PF00069	0.612
MOD_PKA_2	407	413	PF00069	0.399
MOD_Plk_1	365	371	PF00069	0.566
MOD_Plk_2-3	366	372	PF00069	0.474
MOD_Plk_4	1	7	PF00069	0.501
MOD_Plk_4	173	179	PF00069	0.517
MOD_Plk_4	236	242	PF00069	0.503
MOD_Plk_4	407	413	PF00069	0.399
MOD_ProDKin_1	121	127	PF00069	0.586
MOD_ProDKin_1	242	248	PF00069	0.585
MOD_ProDKin_1	255	261	PF00069	0.688
MOD_ProDKin_1	355	361	PF00069	0.792
MOD_ProDKin_1	67	73	PF00069	0.540
MOD_SUMO_rev_2	127	134	PF00179	0.561
MOD_SUMO_rev_2	379	389	PF00179	0.460
TRG_DiLeu_BaEn_1	376	381	PF01217	0.490
TRG_DiLeu_BaEn_1	392	397	PF01217	0.360
TRG_DiLeu_BaEn_2	384	390	PF01217	0.410
TRG_DiLeu_LyEn_5	392	397	PF01217	0.401
TRG_ENDOCYTIC_2	210	213	PF00928	0.438
TRG_ER_diArg_1	313	315	PF00400	0.538
TRG_ER_diArg_1	393	396	PF00400	0.481
TRG_ER_diArg_1	422	424	PF00400	0.423
TRG_ER_diArg_1	75	78	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V5	Leptomonas seymouri	36%	83%
A0A3Q8IV47	Leishmania donovani	56%	95%
A4IB29	Leishmania infantum	56%	95%
E9AEV9	Leishmania major	54%	100%
E9B615	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	95%