Iron-sulfur assembly protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HMF6_LEIBR

TriTrypDb:

LbrM.34.1260 , LBRM2903_340019000

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF6

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.568
CLV_C14_Caspase3-7	183	187	PF00656	0.602
CLV_C14_Caspase3-7	98	102	PF00656	0.456
CLV_NRD_NRD_1	213	215	PF00675	0.760
CLV_NRD_NRD_1	50	52	PF00675	0.510
CLV_NRD_NRD_1	7	9	PF00675	0.566
CLV_PCSK_KEX2_1	213	215	PF00082	0.760
CLV_PCSK_KEX2_1	7	9	PF00082	0.563
CLV_PCSK_PC7_1	209	215	PF00082	0.753
CLV_PCSK_PC7_1	3	9	PF00082	0.596
CLV_PCSK_SKI1_1	86	90	PF00082	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_SPOP_SBC_1	173	177	PF00917	0.752
DEG_SPOP_SBC_1	25	29	PF00917	0.486
DOC_USP7_MATH_1	11	15	PF00917	0.673
DOC_USP7_MATH_1	169	173	PF00917	0.687
DOC_USP7_MATH_1	174	178	PF00917	0.721
DOC_USP7_MATH_1	19	23	PF00917	0.692
DOC_USP7_MATH_1	68	72	PF00917	0.435
DOC_WW_Pin1_4	101	106	PF00397	0.590
DOC_WW_Pin1_4	113	118	PF00397	0.551
DOC_WW_Pin1_4	39	44	PF00397	0.490
LIG_14-3-3_CanoR_1	3	7	PF00244	0.543
LIG_14-3-3_CanoR_1	51	58	PF00244	0.592
LIG_14-3-3_CanoR_1	80	84	PF00244	0.301
LIG_DCNL_PONY_1	1	4	PF03556	0.659
LIG_FHA_1	26	32	PF00498	0.665
LIG_FHA_2	28	34	PF00498	0.627
LIG_LIR_Gen_1	143	153	PF02991	0.458
LIG_LIR_Gen_1	202	211	PF02991	0.604
LIG_LIR_Gen_1	61	69	PF02991	0.388
LIG_LIR_Nem_3	143	148	PF02991	0.456
LIG_LIR_Nem_3	61	67	PF02991	0.391
LIG_SH2_STAT5	64	67	PF00017	0.434
LIG_SH2_STAT5	77	80	PF00017	0.404
MOD_CDK_SPK_2	113	118	PF00069	0.551
MOD_CDK_SPK_2	39	44	PF00069	0.509
MOD_CK1_1	14	20	PF00069	0.672
MOD_CK1_1	172	178	PF00069	0.751
MOD_CK1_1	181	187	PF00069	0.638
MOD_CK1_1	202	208	PF00069	0.762
MOD_CK1_1	212	218	PF00069	0.718
MOD_CK1_1	27	33	PF00069	0.458
MOD_CK1_1	82	88	PF00069	0.315
MOD_CK2_1	124	130	PF00069	0.527
MOD_GlcNHglycan	124	127	PF01048	0.549
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.255
MOD_GlcNHglycan	180	183	PF01048	0.691
MOD_GlcNHglycan	194	197	PF01048	0.631
MOD_GlcNHglycan	70	73	PF01048	0.446
MOD_GSK3_1	11	18	PF00069	0.698
MOD_GSK3_1	120	127	PF00069	0.513
MOD_GSK3_1	169	176	PF00069	0.650
MOD_GSK3_1	19	26	PF00069	0.681
MOD_GSK3_1	209	216	PF00069	0.667
MOD_GSK3_1	35	42	PF00069	0.518
MOD_GSK3_1	47	54	PF00069	0.527
MOD_NEK2_1	124	129	PF00069	0.537
MOD_NEK2_1	140	145	PF00069	0.340
MOD_NEK2_1	161	166	PF00069	0.446
MOD_NEK2_1	199	204	PF00069	0.509
MOD_NEK2_1	2	7	PF00069	0.548
MOD_PK_1	37	43	PF00069	0.525
MOD_PKA_1	213	219	PF00069	0.602
MOD_PKA_1	51	57	PF00069	0.524
MOD_PKA_2	169	175	PF00069	0.722
MOD_PKA_2	190	196	PF00069	0.520
MOD_PKA_2	2	8	PF00069	0.549
MOD_PKA_2	212	218	PF00069	0.708
MOD_PKA_2	79	85	PF00069	0.299
MOD_ProDKin_1	101	107	PF00069	0.591
MOD_ProDKin_1	113	119	PF00069	0.545
MOD_ProDKin_1	39	45	PF00069	0.486
MOD_SUMO_rev_2	135	143	PF00179	0.460
MOD_SUMO_rev_2	82	88	PF00179	0.315
TRG_ENDOCYTIC_2	64	67	PF00928	0.434
TRG_ER_diArg_1	6	8	PF00400	0.569
TRG_NLS_MonoExtC_3	165	170	PF00514	0.623
TRG_NLS_MonoExtN_4	166	171	PF00514	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD94	Leptomonas seymouri	64%	98%
A0A0S4JDK9	Bodo saltans	41%	100%
A0A1X0NHC3	Trypanosomatidae	53%	100%
A0A3S7X981	Leishmania donovani	78%	100%
A4IB28	Leishmania infantum	78%	100%
C9ZNM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B613	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q9GRP9	Leishmania major	80%	100%