LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
thioredoxin, putative
Species:
Leishmania braziliensis
UniProt:
A4HMF5_LEIBR
TriTrypDb:
LbrM.34.1250 , LBRM2903_340018900
Length:
563

Annotations

LeishMANIAdb annotations

Contains a thioredoxin domain. Homologous to ER-associated disulphide isomerases in other Eukaryotes.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 0
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HMF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF5

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0006950 response to stress 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 9
GO:0003824 catalytic activity 1 9
GO:0016853 isomerase activity 2 9
GO:0016860 intramolecular oxidoreductase activity 3 9
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 303 305 PF00082 0.597
CLV_PCSK_KEX2_1 442 444 PF00082 0.504
CLV_PCSK_KEX2_1 561 563 PF00082 0.495
CLV_PCSK_PC1ET2_1 303 305 PF00082 0.590
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.592
CLV_PCSK_PC1ET2_1 561 563 PF00082 0.522
CLV_PCSK_SKI1_1 11 15 PF00082 0.515
CLV_PCSK_SKI1_1 445 449 PF00082 0.512
CLV_PCSK_SKI1_1 76 80 PF00082 0.561
CLV_PCSK_SKI1_1 81 85 PF00082 0.465
CLV_PCSK_SKI1_1 96 100 PF00082 0.381
DEG_APCC_DBOX_1 10 18 PF00400 0.510
DEG_Nend_UBRbox_3 1 3 PF02207 0.434
DEG_SPOP_SBC_1 209 213 PF00917 0.410
DEG_SPOP_SBC_1 323 327 PF00917 0.241
DOC_CKS1_1 461 466 PF01111 0.405
DOC_CYCLIN_yCln2_LP_2 461 467 PF00134 0.284
DOC_MAPK_gen_1 423 430 PF00069 0.347
DOC_MAPK_MEF2A_6 11 20 PF00069 0.504
DOC_MAPK_MEF2A_6 356 363 PF00069 0.382
DOC_MAPK_RevD_3 428 443 PF00069 0.313
DOC_PP1_RVXF_1 406 412 PF00149 0.370
DOC_SPAK_OSR1_1 238 242 PF12202 0.267
DOC_USP7_MATH_1 209 213 PF00917 0.395
DOC_USP7_MATH_1 232 236 PF00917 0.305
DOC_USP7_MATH_1 307 311 PF00917 0.509
DOC_USP7_MATH_1 407 411 PF00917 0.379
DOC_USP7_MATH_1 90 94 PF00917 0.346
DOC_USP7_UBL2_3 261 265 PF12436 0.328
DOC_USP7_UBL2_3 555 559 PF12436 0.681
DOC_WW_Pin1_4 212 217 PF00397 0.416
DOC_WW_Pin1_4 460 465 PF00397 0.388
DOC_WW_Pin1_4 76 81 PF00397 0.377
DOC_WW_Pin1_4 86 91 PF00397 0.281
LIG_14-3-3_CanoR_1 113 122 PF00244 0.296
LIG_14-3-3_CanoR_1 220 225 PF00244 0.328
LIG_14-3-3_CanoR_1 408 414 PF00244 0.285
LIG_APCC_ABBA_1 283 288 PF00400 0.308
LIG_BRCT_BRCA1_1 130 134 PF00533 0.295
LIG_BRCT_BRCA1_1 344 348 PF00533 0.350
LIG_FHA_1 10 16 PF00498 0.501
LIG_FHA_1 116 122 PF00498 0.196
LIG_FHA_1 183 189 PF00498 0.375
LIG_FHA_1 197 203 PF00498 0.456
LIG_FHA_1 21 27 PF00498 0.516
LIG_FHA_1 371 377 PF00498 0.289
LIG_FHA_1 40 46 PF00498 0.389
LIG_FHA_2 144 150 PF00498 0.218
LIG_FHA_2 324 330 PF00498 0.344
LIG_FHA_2 439 445 PF00498 0.375
LIG_LIR_Apic_2 287 293 PF02991 0.299
LIG_LIR_Apic_2 51 57 PF02991 0.399
LIG_LIR_Apic_2 69 74 PF02991 0.212
LIG_LIR_Gen_1 117 124 PF02991 0.291
LIG_LIR_Gen_1 162 171 PF02991 0.194
LIG_LIR_Gen_1 329 339 PF02991 0.388
LIG_LIR_Gen_1 345 355 PF02991 0.353
LIG_LIR_Gen_1 410 421 PF02991 0.376
LIG_LIR_Gen_1 514 525 PF02991 0.322
LIG_LIR_Gen_1 533 542 PF02991 0.353
LIG_LIR_LC3C_4 281 285 PF02991 0.377
LIG_LIR_Nem_3 117 122 PF02991 0.383
LIG_LIR_Nem_3 131 136 PF02991 0.256
LIG_LIR_Nem_3 137 142 PF02991 0.255
LIG_LIR_Nem_3 149 155 PF02991 0.186
LIG_LIR_Nem_3 162 167 PF02991 0.195
LIG_LIR_Nem_3 257 262 PF02991 0.306
LIG_LIR_Nem_3 329 334 PF02991 0.369
LIG_LIR_Nem_3 345 351 PF02991 0.348
LIG_LIR_Nem_3 372 378 PF02991 0.399
LIG_LIR_Nem_3 410 416 PF02991 0.351
LIG_LIR_Nem_3 503 508 PF02991 0.352
LIG_LIR_Nem_3 514 520 PF02991 0.336
LIG_LIR_Nem_3 533 537 PF02991 0.299
LIG_MLH1_MIPbox_1 130 134 PF16413 0.295
LIG_MYND_1 70 74 PF01753 0.179
LIG_OCRL_FandH_1 330 342 PF00620 0.371
LIG_PCNA_yPIPBox_3 126 134 PF02747 0.339
LIG_PCNA_yPIPBox_3 480 491 PF02747 0.289
LIG_Pex14_1 422 426 PF04695 0.300
LIG_PTB_Apo_2 174 181 PF02174 0.239
LIG_PTB_Apo_2 233 240 PF02174 0.306
LIG_PTB_Apo_2 62 69 PF02174 0.339
LIG_REV1ctd_RIR_1 444 453 PF16727 0.326
LIG_SH2_CRK 259 263 PF00017 0.348
LIG_SH2_CRK 290 294 PF00017 0.275
LIG_SH2_GRB2like 133 136 PF00017 0.179
LIG_SH2_PTP2 205 208 PF00017 0.321
LIG_SH2_PTP2 375 378 PF00017 0.405
LIG_SH2_PTP2 413 416 PF00017 0.314
LIG_SH2_SRC 205 208 PF00017 0.293
LIG_SH2_SRC 375 378 PF00017 0.228
LIG_SH2_SRC 413 416 PF00017 0.362
LIG_SH2_STAP1 426 430 PF00017 0.390
LIG_SH2_STAP1 517 521 PF00017 0.319
LIG_SH2_STAT3 487 490 PF00017 0.344
LIG_SH2_STAT5 133 136 PF00017 0.276
LIG_SH2_STAT5 144 147 PF00017 0.207
LIG_SH2_STAT5 170 173 PF00017 0.323
LIG_SH2_STAT5 205 208 PF00017 0.285
LIG_SH2_STAT5 358 361 PF00017 0.294
LIG_SH2_STAT5 375 378 PF00017 0.385
LIG_SH2_STAT5 413 416 PF00017 0.362
LIG_SH2_STAT5 501 504 PF00017 0.338
LIG_SH2_STAT5 71 74 PF00017 0.296
LIG_SH3_3 203 209 PF00018 0.301
LIG_SH3_3 538 544 PF00018 0.289
LIG_SUMO_SIM_anti_2 12 18 PF11976 0.519
LIG_SUMO_SIM_anti_2 39 48 PF11976 0.337
LIG_SUMO_SIM_anti_2 412 418 PF11976 0.329
LIG_SUMO_SIM_anti_2 523 528 PF11976 0.417
LIG_SUMO_SIM_anti_2 58 64 PF11976 0.153
LIG_SUMO_SIM_par_1 15 21 PF11976 0.410
LIG_TRAF2_1 399 402 PF00917 0.379
LIG_TYR_ITSM 371 378 PF00017 0.246
LIG_UBA3_1 347 356 PF00899 0.419
LIG_WRC_WIRS_1 531 536 PF05994 0.417
MOD_CDK_SPK_2 76 81 PF00069 0.274
MOD_CDK_SPxK_1 460 466 PF00069 0.400
MOD_CK1_1 196 202 PF00069 0.345
MOD_CK1_1 212 218 PF00069 0.319
MOD_CK1_1 50 56 PF00069 0.374
MOD_CK2_1 176 182 PF00069 0.362
MOD_CK2_1 211 217 PF00069 0.391
MOD_CK2_1 243 249 PF00069 0.407
MOD_CK2_1 323 329 PF00069 0.435
MOD_CK2_1 396 402 PF00069 0.471
MOD_GlcNHglycan 167 170 PF01048 0.503
MOD_GlcNHglycan 194 199 PF01048 0.621
MOD_GlcNHglycan 20 23 PF01048 0.645
MOD_GlcNHglycan 296 299 PF01048 0.620
MOD_GlcNHglycan 344 347 PF01048 0.584
MOD_GSK3_1 138 145 PF00069 0.274
MOD_GSK3_1 178 185 PF00069 0.376
MOD_GSK3_1 193 200 PF00069 0.358
MOD_GSK3_1 20 27 PF00069 0.597
MOD_GSK3_1 208 215 PF00069 0.375
MOD_GSK3_1 218 225 PF00069 0.330
MOD_GSK3_1 302 309 PF00069 0.458
MOD_GSK3_1 311 318 PF00069 0.464
MOD_GSK3_1 72 79 PF00069 0.306
MOD_GSK3_1 86 93 PF00069 0.151
MOD_LATS_1 394 400 PF00433 0.287
MOD_N-GLC_1 103 108 PF02516 0.448
MOD_N-GLC_1 176 181 PF02516 0.445
MOD_NEK2_1 103 108 PF00069 0.316
MOD_NEK2_1 142 147 PF00069 0.234
MOD_NEK2_1 165 170 PF00069 0.390
MOD_NEK2_1 20 25 PF00069 0.556
MOD_NEK2_1 322 327 PF00069 0.410
MOD_NEK2_1 421 426 PF00069 0.238
MOD_NEK2_1 47 52 PF00069 0.278
MOD_NEK2_1 511 516 PF00069 0.337
MOD_PIKK_1 157 163 PF00454 0.322
MOD_PIKK_1 243 249 PF00454 0.399
MOD_PK_1 396 402 PF00069 0.284
MOD_PKA_2 407 413 PF00069 0.288
MOD_Plk_1 103 109 PF00069 0.280
MOD_Plk_1 396 402 PF00069 0.411
MOD_Plk_2-3 176 182 PF00069 0.321
MOD_Plk_4 138 144 PF00069 0.258
MOD_Plk_4 56 62 PF00069 0.346
MOD_ProDKin_1 212 218 PF00069 0.419
MOD_ProDKin_1 460 466 PF00069 0.392
MOD_ProDKin_1 76 82 PF00069 0.377
MOD_ProDKin_1 86 92 PF00069 0.281
TRG_DiLeu_BaEn_1 279 284 PF01217 0.227
TRG_DiLeu_BaEn_1 41 46 PF01217 0.404
TRG_DiLeu_BaEn_1 470 475 PF01217 0.377
TRG_ENDOCYTIC_2 133 136 PF00928 0.265
TRG_ENDOCYTIC_2 205 208 PF00928 0.344
TRG_ENDOCYTIC_2 259 262 PF00928 0.309
TRG_ENDOCYTIC_2 358 361 PF00928 0.287
TRG_ENDOCYTIC_2 375 378 PF00928 0.310
TRG_ENDOCYTIC_2 413 416 PF00928 0.314
TRG_ENDOCYTIC_2 505 508 PF00928 0.363
TRG_ENDOCYTIC_2 512 515 PF00928 0.326
TRG_ENDOCYTIC_2 517 520 PF00928 0.324
TRG_ER_diArg_1 422 425 PF00400 0.396
TRG_ER_diLys_1 559 563 PF00400 0.650
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 380 384 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 396 401 PF00026 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYT4 Leptomonas seymouri 66% 100%
A0A0S4KJA1 Bodo saltans 27% 98%
A0A1X0NH48 Trypanosomatidae 37% 100%
A0A3S7X8Z9 Leishmania donovani 84% 100%
A0A422N9H3 Trypanosoma rangeli 37% 100%
A4IB27 Leishmania infantum 83% 100%
C9ZNM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 96%
E9B612 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q9GRP8 Leishmania major 82% 100%
V5ASA4 Trypanosoma cruzi 42% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS