Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMF1_LEIBR

TriTrypDb:

LbrM.34.1210 , LBRM2903_340018500

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.481
CLV_C14_Caspase3-7	214	218	PF00656	0.427
CLV_NRD_NRD_1	117	119	PF00675	0.771
CLV_NRD_NRD_1	194	196	PF00675	0.570
CLV_NRD_NRD_1	203	205	PF00675	0.507
CLV_NRD_NRD_1	246	248	PF00675	0.563
CLV_NRD_NRD_1	98	100	PF00675	0.502
CLV_PCSK_KEX2_1	117	119	PF00082	0.771
CLV_PCSK_KEX2_1	194	196	PF00082	0.584
CLV_PCSK_KEX2_1	212	214	PF00082	0.632
CLV_PCSK_KEX2_1	245	247	PF00082	0.602
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.629
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.632
CLV_PCSK_PC7_1	208	214	PF00082	0.564
CLV_PCSK_PC7_1	242	248	PF00082	0.603
CLV_PCSK_SKI1_1	17	21	PF00082	0.640
CLV_PCSK_SKI1_1	36	40	PF00082	0.347
CLV_Separin_Metazoa	150	154	PF03568	0.377
DEG_SCF_FBW7_2	110	115	PF00400	0.426
DOC_CKS1_1	109	114	PF01111	0.426
DOC_CYCLIN_RxL_1	153	166	PF00134	0.599
DOC_MAPK_MEF2A_6	175	183	PF00069	0.404
DOC_USP7_MATH_1	121	125	PF00917	0.506
DOC_USP7_MATH_1	140	144	PF00917	0.667
DOC_USP7_MATH_1	61	65	PF00917	0.742
DOC_WW_Pin1_4	108	113	PF00397	0.432
DOC_WW_Pin1_4	78	83	PF00397	0.653
LIG_14-3-3_CanoR_1	17	22	PF00244	0.582
LIG_14-3-3_CterR_2	245	248	PF00244	0.539
LIG_Actin_WH2_2	184	202	PF00022	0.573
LIG_FHA_1	11	17	PF00498	0.540
LIG_FHA_1	157	163	PF00498	0.592
LIG_FHA_2	109	115	PF00498	0.636
LIG_FHA_2	54	60	PF00498	0.695
LIG_GBD_Chelix_1	147	155	PF00786	0.387
LIG_LIR_Apic_2	106	112	PF02991	0.644
LIG_MYND_1	82	86	PF01753	0.599
LIG_Pex14_2	103	107	PF04695	0.610
LIG_PTB_Apo_2	26	33	PF02174	0.535
LIG_REV1ctd_RIR_1	30	40	PF16727	0.529
LIG_SH2_STAT5	102	105	PF00017	0.551
LIG_SH2_STAT5	45	48	PF00017	0.525
LIG_SH2_STAT5	94	97	PF00017	0.576
LIG_SH3_1	83	89	PF00018	0.596
LIG_SH3_3	43	49	PF00018	0.445
LIG_SH3_3	79	85	PF00018	0.624
LIG_TRAF2_1	111	114	PF00917	0.623
MOD_CDK_SPK_2	78	83	PF00069	0.674
MOD_CK1_1	186	192	PF00069	0.436
MOD_CK1_1	47	53	PF00069	0.705
MOD_CK2_1	108	114	PF00069	0.613
MOD_CK2_1	20	26	PF00069	0.495
MOD_CK2_1	53	59	PF00069	0.653
MOD_CK2_1	62	68	PF00069	0.696
MOD_GlcNHglycan	123	126	PF01048	0.706
MOD_GlcNHglycan	185	188	PF01048	0.573
MOD_GlcNHglycan	46	49	PF01048	0.582
MOD_GlcNHglycan	53	56	PF01048	0.651
MOD_GlcNHglycan	68	71	PF01048	0.745
MOD_GSK3_1	182	189	PF00069	0.424
MOD_GSK3_1	217	224	PF00069	0.645
MOD_GSK3_1	44	51	PF00069	0.523
MOD_GSK3_1	62	69	PF00069	0.748
MOD_N-GLC_1	121	126	PF02516	0.506
MOD_NEK2_1	199	204	PF00069	0.412
MOD_NEK2_2	10	15	PF00069	0.422
MOD_PIKK_1	140	146	PF00454	0.678
MOD_PIKK_1	199	205	PF00454	0.504
MOD_PKA_2	199	205	PF00069	0.481
MOD_PKA_2	95	101	PF00069	0.613
MOD_Plk_1	156	162	PF00069	0.581
MOD_Plk_4	10	16	PF00069	0.507
MOD_Plk_4	186	192	PF00069	0.720
MOD_ProDKin_1	108	114	PF00069	0.431
MOD_ProDKin_1	78	84	PF00069	0.652
TRG_ENDOCYTIC_2	102	105	PF00928	0.566
TRG_ER_diArg_1	244	247	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V4	Leptomonas seymouri	52%	100%
A0A1X0NIU6	Trypanosomatidae	31%	100%
A0A3R7JUY0	Trypanosoma rangeli	32%	100%
A0A3S7X907	Leishmania donovani	75%	100%
A4IB23	Leishmania infantum	75%	100%
C9ZNL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B608	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q9GN98	Leishmania major	72%	100%