Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HMF0_LEIBR

TriTrypDb:

LbrM.34.1200 , LBRM2903_340018400

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HMF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMF0

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0033554	cellular response to stress	3	11
GO:0046902	regulation of mitochondrial membrane permeability	4	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0061024	membrane organization	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090559	regulation of membrane permeability	3	11
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	5	11
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.322
CLV_NRD_NRD_1	53	55	PF00675	0.399
CLV_PCSK_FUR_1	279	283	PF00082	0.464
CLV_PCSK_KEX2_1	190	192	PF00082	0.322
CLV_PCSK_KEX2_1	254	256	PF00082	0.571
CLV_PCSK_KEX2_1	281	283	PF00082	0.441
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.571
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.418
CLV_PCSK_SKI1_1	12	16	PF00082	0.451
CLV_PCSK_SKI1_1	201	205	PF00082	0.503
CLV_PCSK_SKI1_1	251	255	PF00082	0.440
CLV_PCSK_SKI1_1	67	71	PF00082	0.669
DEG_APCC_DBOX_1	73	81	PF00400	0.393
DEG_SCF_FBW7_2	202	209	PF00400	0.560
DOC_CKS1_1	203	208	PF01111	0.493
DOC_MAPK_gen_1	279	288	PF00069	0.397
DOC_MAPK_gen_1	54	60	PF00069	0.431
DOC_MAPK_HePTP_8	222	234	PF00069	0.376
DOC_MAPK_MEF2A_6	225	234	PF00069	0.381
DOC_MAPK_MEF2A_6	279	288	PF00069	0.397
DOC_MAPK_RevD_3	176	191	PF00069	0.436
DOC_PP1_RVXF_1	168	175	PF00149	0.436
DOC_PP4_FxxP_1	75	78	PF00568	0.385
DOC_USP7_MATH_1	132	136	PF00917	0.449
DOC_USP7_MATH_1	158	162	PF00917	0.436
DOC_WW_Pin1_4	202	207	PF00397	0.537
DOC_WW_Pin1_4	305	310	PF00397	0.543
DOC_WW_Pin1_4	83	88	PF00397	0.195
LIG_14-3-3_CanoR_1	184	188	PF00244	0.531
LIG_14-3-3_CanoR_1	201	206	PF00244	0.504
LIG_14-3-3_CanoR_1	214	222	PF00244	0.475
LIG_14-3-3_CanoR_1	231	235	PF00244	0.488
LIG_14-3-3_CanoR_1	63	70	PF00244	0.546
LIG_Actin_WH2_2	129	145	PF00022	0.454
LIG_Actin_WH2_2	38	56	PF00022	0.334
LIG_APCC_ABBA_1	124	129	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	185	189	PF00533	0.436
LIG_EVH1_1	77	81	PF00568	0.375
LIG_EVH1_2	81	85	PF00568	0.447
LIG_FHA_1	105	111	PF00498	0.436
LIG_FHA_1	202	208	PF00498	0.464
LIG_FHA_1	214	220	PF00498	0.408
LIG_FHA_1	84	90	PF00498	0.381
LIG_FHA_2	231	237	PF00498	0.391
LIG_LIR_Apic_2	72	78	PF02991	0.407
LIG_LIR_Gen_1	261	268	PF02991	0.378
LIG_LIR_Gen_1	280	288	PF02991	0.378
LIG_LIR_Nem_3	197	203	PF02991	0.468
LIG_LIR_Nem_3	261	265	PF02991	0.383
LIG_LIR_Nem_3	27	32	PF02991	0.345
LIG_LIR_Nem_3	280	286	PF02991	0.387
LIG_LIR_Nem_3	289	295	PF02991	0.337
LIG_LIR_Nem_3	84	88	PF02991	0.437
LIG_MYND_1	78	82	PF01753	0.452
LIG_PDZ_Class_1	313	318	PF00595	0.471
LIG_Pex14_2	185	189	PF04695	0.449
LIG_Pex14_2	32	36	PF04695	0.344
LIG_PTB_Apo_2	217	224	PF02174	0.363
LIG_PTB_Phospho_1	217	223	PF10480	0.358
LIG_SH2_NCK_1	127	131	PF00017	0.436
LIG_SH2_NCK_1	61	65	PF00017	0.514
LIG_SH2_PTP2	57	60	PF00017	0.445
LIG_SH2_SRC	111	114	PF00017	0.466
LIG_SH2_SRC	127	130	PF00017	0.436
LIG_SH2_SRC	57	60	PF00017	0.432
LIG_SH2_STAP1	127	131	PF00017	0.436
LIG_SH2_STAP1	223	227	PF00017	0.363
LIG_SH2_STAT3	223	226	PF00017	0.377
LIG_SH2_STAT5	163	166	PF00017	0.458
LIG_SH2_STAT5	171	174	PF00017	0.486
LIG_SH2_STAT5	22	25	PF00017	0.358
LIG_SH2_STAT5	29	32	PF00017	0.333
LIG_SH2_STAT5	44	47	PF00017	0.248
LIG_SH2_STAT5	57	60	PF00017	0.420
LIG_SH2_STAT5	61	64	PF00017	0.455
LIG_SH3_3	152	158	PF00018	0.449
LIG_SH3_3	200	206	PF00018	0.554
LIG_SH3_3	25	31	PF00018	0.341
LIG_SH3_3	75	81	PF00018	0.409
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.449
LIG_TRAF2_1	301	304	PF00917	0.491
LIG_TRFH_1	75	79	PF08558	0.386
LIG_UBA3_1	218	225	PF00899	0.402
LIG_WW_2	78	81	PF00397	0.379
MOD_CDK_SPxK_1	202	208	PF00069	0.558
MOD_CK1_1	135	141	PF00069	0.492
MOD_CK1_1	2	8	PF00069	0.588
MOD_CK1_1	305	311	PF00069	0.594
MOD_CK2_1	189	195	PF00069	0.531
MOD_GlcNHglycan	165	168	PF01048	0.240
MOD_GlcNHglycan	240	243	PF01048	0.561
MOD_GSK3_1	189	196	PF00069	0.520
MOD_N-GLC_1	104	109	PF02516	0.236
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	189	194	PF00069	0.476
MOD_NEK2_1	247	252	PF00069	0.546
MOD_NEK2_1	302	307	PF00069	0.464
MOD_NEK2_1	36	41	PF00069	0.330
MOD_NEK2_2	158	163	PF00069	0.436
MOD_PIKK_1	213	219	PF00454	0.410
MOD_PKA_2	183	189	PF00069	0.436
MOD_PKA_2	213	219	PF00069	0.429
MOD_PKA_2	230	236	PF00069	0.490
MOD_PKA_2	62	68	PF00069	0.523
MOD_Plk_1	158	164	PF00069	0.503
MOD_Plk_1	247	253	PF00069	0.490
MOD_Plk_1	260	266	PF00069	0.312
MOD_Plk_1	286	292	PF00069	0.372
MOD_Plk_1	302	308	PF00069	0.486
MOD_Plk_4	302	308	PF00069	0.500
MOD_Plk_4	36	42	PF00069	0.300
MOD_ProDKin_1	202	208	PF00069	0.539
MOD_ProDKin_1	305	311	PF00069	0.553
MOD_ProDKin_1	83	89	PF00069	0.195
TRG_DiLeu_BaEn_2	111	117	PF01217	0.436
TRG_DiLeu_BaEn_3	151	157	PF01217	0.492
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.531
TRG_ENDOCYTIC_2	127	130	PF00928	0.462
TRG_ENDOCYTIC_2	171	174	PF00928	0.470
TRG_ENDOCYTIC_2	29	32	PF00928	0.333
TRG_ENDOCYTIC_2	292	295	PF00928	0.371
TRG_ENDOCYTIC_2	299	302	PF00928	0.336
TRG_ENDOCYTIC_2	57	60	PF00928	0.462
TRG_ER_diArg_1	189	191	PF00400	0.436
TRG_NES_CRM1_1	115	129	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE1	Leptomonas seymouri	85%	99%
A0A0S4IWU2	Bodo saltans	70%	100%
A0A1X0NHW7	Trypanosomatidae	74%	100%
A0A3S7X925	Leishmania donovani	94%	100%
A4IB22	Leishmania infantum	94%	100%
C9ZNL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9B607	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9GNH7	Leishmania major	95%	100%
V5B7T8	Trypanosoma cruzi	73%	90%