AAA domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania braziliensis

UniProt:

A4HME8_LEIBR

TriTrypDb:

LbrM.34.1180 , LBRM2903_340018200

Length:

361

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HME8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HME8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.586
CLV_C14_Caspase3-7	201	205	PF00656	0.465
CLV_C14_Caspase3-7	211	215	PF00656	0.465
CLV_C14_Caspase3-7	290	294	PF00656	0.520
CLV_MEL_PAP_1	18	24	PF00089	0.642
CLV_NRD_NRD_1	248	250	PF00675	0.293
CLV_NRD_NRD_1	258	260	PF00675	0.236
CLV_NRD_NRD_1	67	69	PF00675	0.431
CLV_PCSK_KEX2_1	248	250	PF00082	0.290
CLV_PCSK_KEX2_1	257	259	PF00082	0.240
CLV_PCSK_KEX2_1	67	69	PF00082	0.458
CLV_PCSK_SKI1_1	109	113	PF00082	0.308
CLV_PCSK_SKI1_1	136	140	PF00082	0.265
CLV_PCSK_SKI1_1	148	152	PF00082	0.265
CLV_PCSK_SKI1_1	222	226	PF00082	0.265
CLV_PCSK_SKI1_1	24	28	PF00082	0.619
CLV_PCSK_SKI1_1	248	252	PF00082	0.348
CLV_PCSK_SKI1_1	56	60	PF00082	0.379
CLV_PCSK_SKI1_1	67	71	PF00082	0.384
DEG_APCC_DBOX_1	23	31	PF00400	0.455
DEG_MDM2_SWIB_1	225	232	PF02201	0.465
DOC_CYCLIN_RxL_1	255	265	PF00134	0.465
DOC_MAPK_gen_1	257	266	PF00069	0.465
DOC_MAPK_gen_1	272	280	PF00069	0.519
DOC_MAPK_gen_1	61	71	PF00069	0.656
DOC_MAPK_MEF2A_6	192	199	PF00069	0.465
DOC_MAPK_MEF2A_6	257	266	PF00069	0.465
DOC_MAPK_MEF2A_6	274	282	PF00069	0.514
DOC_MAPK_NFAT4_5	257	265	PF00069	0.465
DOC_PP2B_LxvP_1	264	267	PF13499	0.507
DOC_SPAK_OSR1_1	249	253	PF12202	0.548
DOC_USP7_UBL2_3	272	276	PF12436	0.607
DOC_WW_Pin1_4	191	196	PF00397	0.482
DOC_WW_Pin1_4	213	218	PF00397	0.509
DOC_WW_Pin1_4	331	336	PF00397	0.570
DOC_WW_Pin1_4	37	42	PF00397	0.323
LIG_14-3-3_CanoR_1	21	27	PF00244	0.462
LIG_14-3-3_CanoR_1	67	72	PF00244	0.623
LIG_14-3-3_CterR_2	356	361	PF00244	0.619
LIG_Actin_WH2_2	19	36	PF00022	0.424
LIG_BIR_III_2	214	218	PF00653	0.482
LIG_DCNL_PONY_1	1	4	PF03556	0.493
LIG_FHA_1	111	117	PF00498	0.597
LIG_FHA_1	166	172	PF00498	0.467
LIG_FHA_1	53	59	PF00498	0.479
LIG_FHA_1	64	70	PF00498	0.599
LIG_FHA_1	85	91	PF00498	0.577
LIG_FHA_1	9	15	PF00498	0.562
LIG_FHA_2	225	231	PF00498	0.465
LIG_FHA_2	249	255	PF00498	0.548
LIG_FHA_2	305	311	PF00498	0.506
LIG_GBD_Chelix_1	151	159	PF00786	0.282
LIG_LIR_Gen_1	162	171	PF02991	0.507
LIG_LIR_Gen_1	96	105	PF02991	0.526
LIG_LIR_Nem_3	162	166	PF02991	0.507
LIG_LIR_Nem_3	227	232	PF02991	0.481
LIG_LIR_Nem_3	40	46	PF02991	0.346
LIG_LIR_Nem_3	96	102	PF02991	0.540
LIG_NRBOX	277	283	PF00104	0.532
LIG_Pex14_2	225	229	PF04695	0.465
LIG_SH2_CRK	141	145	PF00017	0.465
LIG_SH2_PTP2	298	301	PF00017	0.591
LIG_SH2_STAT5	298	301	PF00017	0.521
LIG_SH2_STAT5	306	309	PF00017	0.491
LIG_SH2_STAT5	43	46	PF00017	0.313
LIG_SH2_STAT5	47	50	PF00017	0.293
LIG_SH3_3	263	269	PF00018	0.466
LIG_SUMO_SIM_par_1	87	93	PF11976	0.587
LIG_TYR_ITIM	296	301	PF00017	0.595
LIG_UBA3_1	186	192	PF00899	0.462
MOD_CK1_1	127	133	PF00069	0.634
MOD_CK1_1	17	23	PF00069	0.406
MOD_CK1_1	170	176	PF00069	0.465
MOD_CK1_1	205	211	PF00069	0.514
MOD_CK1_1	309	315	PF00069	0.529
MOD_CK1_1	63	69	PF00069	0.690
MOD_CK2_1	33	39	PF00069	0.370
MOD_GlcNHglycan	126	129	PF01048	0.430
MOD_GlcNHglycan	210	213	PF01048	0.348
MOD_GlcNHglycan	335	338	PF01048	0.522
MOD_GSK3_1	202	209	PF00069	0.533
MOD_GSK3_1	220	227	PF00069	0.394
MOD_GSK3_1	300	307	PF00069	0.514
MOD_GSK3_1	33	40	PF00069	0.513
MOD_GSK3_1	52	59	PF00069	0.361
MOD_GSK3_1	63	70	PF00069	0.661
MOD_N-GLC_1	59	64	PF02516	0.493
MOD_NEK2_1	159	164	PF00069	0.507
MOD_NEK2_1	206	211	PF00069	0.507
MOD_NEK2_1	33	38	PF00069	0.470
MOD_PIKK_1	287	293	PF00454	0.489
MOD_PIKK_1	343	349	PF00454	0.609
MOD_PK_1	276	282	PF00069	0.598
MOD_PKA_1	248	254	PF00069	0.548
MOD_PKA_1	67	73	PF00069	0.627
MOD_PKA_2	248	254	PF00069	0.548
MOD_PKA_2	60	66	PF00069	0.685
MOD_PKA_2	67	73	PF00069	0.629
MOD_Plk_4	146	152	PF00069	0.465
MOD_Plk_4	159	165	PF00069	0.465
MOD_Plk_4	167	173	PF00069	0.449
MOD_Plk_4	202	208	PF00069	0.501
MOD_Plk_4	220	226	PF00069	0.400
MOD_Plk_4	276	282	PF00069	0.557
MOD_Plk_4	9	15	PF00069	0.467
MOD_ProDKin_1	191	197	PF00069	0.482
MOD_ProDKin_1	213	219	PF00069	0.509
MOD_ProDKin_1	331	337	PF00069	0.571
MOD_ProDKin_1	37	43	PF00069	0.323
MOD_SUMO_rev_2	101	111	PF00179	0.517
MOD_SUMO_rev_2	265	273	PF00179	0.605
TRG_DiLeu_BaEn_1	202	207	PF01217	0.465
TRG_ENDOCYTIC_2	298	301	PF00928	0.591
TRG_ENDOCYTIC_2	43	46	PF00928	0.328
TRG_ER_diArg_1	248	250	PF00400	0.486
TRG_ER_diArg_1	256	259	PF00400	0.444
TRG_ER_diArg_1	67	69	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V2	Leptomonas seymouri	83%	100%
A0A0N0P643	Leptomonas seymouri	30%	67%
A0A0N1HRH8	Leptomonas seymouri	34%	66%
A0A0N1IGY9	Leptomonas seymouri	33%	87%
A0A0N1IM81	Leptomonas seymouri	32%	82%
A0A0N1P9H6	Leptomonas seymouri	33%	81%
A0A0S4IPV5	Bodo saltans	34%	82%
A0A0S4IR32	Bodo saltans	38%	68%
A0A0S4IY28	Bodo saltans	33%	100%
A0A0S4JSD8	Bodo saltans	33%	91%
A0A0S4KLG9	Bodo saltans	36%	72%
A0A1X0NHF1	Trypanosomatidae	57%	100%
A0A1X0NMZ3	Trypanosomatidae	32%	83%
A0A1X0NNS1	Trypanosomatidae	31%	87%
A0A1X0P8T7	Trypanosomatidae	35%	91%
A0A3Q8IHU1	Leishmania donovani	94%	100%
A0A3Q8IIF1	Leishmania donovani	35%	67%
A0A3R7KBD2	Trypanosoma rangeli	58%	100%
A0A3R7KPY1	Trypanosoma rangeli	32%	80%
A0A3S7WRY0	Leishmania donovani	33%	88%
A0A3S7WSK7	Leishmania donovani	32%	82%
A0A3S7X163	Leishmania donovani	35%	68%
A0A422NMN6	Trypanosoma rangeli	35%	91%
A0A422NUD9	Trypanosoma rangeli	31%	91%
A0JMA9	Xenopus tropicalis	37%	67%
A4H6T6	Leishmania braziliensis	33%	100%
A4H795	Leishmania braziliensis	32%	83%
A4HG81	Leishmania braziliensis	35%	69%
A4HVN7	Leishmania infantum	32%	82%
A4IAA1	Leishmania infantum	35%	67%
A4IB20	Leishmania infantum	94%	100%
A7I8B8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	34%	83%
A8QFF6	Brugia malayi	39%	80%
A8XV40	Caenorhabditis briggsae	40%	67%
A9RA82	Papio anubis	34%	74%
B0K657	Thermoanaerobacter sp. (strain X514)	33%	71%
B3DRN4	Bifidobacterium longum (strain DJO10A)	33%	69%
B3EX35	Sorex araneus	34%	74%
B4F6J6	Xenopus tropicalis	40%	100%
B4USW8	Otolemur garnettii	34%	74%
B5X3X5	Salmo salar	34%	74%
B6YXR2	Thermococcus onnurineus (strain NA1)	36%	91%
B7GUP3	Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)	33%	69%
B7NZ88	Oryctolagus cuniculus	34%	74%
C3MRF1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	34%	92%
C3MY47	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	34%	92%
C3MZI6	Sulfolobus islandicus (strain M.16.27)	34%	92%
C3N7K8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	34%	92%
C3NFW6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	34%	92%
C4KIR6	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	34%	92%
C5A6P8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	33%	91%
C9ZKZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	81%
C9ZNL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
C9ZQC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	90%
C9ZRM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
D0A259	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
D0A6K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	83%
D1C4U5	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	31%	74%
E9AEU9	Leishmania major	94%	100%
E9AGB0	Leishmania infantum	33%	88%
E9ANU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	88%
E9APD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	82%
E9AZK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	67%
E9B5C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	67%
E9B605	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F2Z6D2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	33%	97%
F6QV99	Bos taurus	41%	100%
O17071	Caenorhabditis elegans	34%	89%
O42931	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	82%
O57940	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	90%
O74445	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	93%
O74894	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
O75449	Homo sapiens	35%	74%
P28737	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P33298	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	84%
P33299	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	77%
P34124	Dictyostelium discoideum	36%	90%
P34808	Caenorhabditis elegans	36%	76%
P35998	Homo sapiens	33%	83%
P36612	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	81%
P40327	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	83%
P41836	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	90%
P43686	Homo sapiens	31%	86%
P46466	Oryza sativa subsp. japonica	29%	81%
P46471	Mus musculus	33%	83%
P46472	Xenopus laevis	34%	83%
P46502	Caenorhabditis elegans	32%	87%
P46507	Manduca sexta	32%	87%
P53549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	83%
P54775	Mus musculus	31%	86%
P54778	Solanum tuberosum	31%	87%
P54815	Caenorhabditis elegans	39%	100%
P62333	Homo sapiens	35%	93%
P62334	Mus musculus	35%	93%
P62335	Ictidomys tridecemlineatus	35%	93%
P78578	Aspergillus niger	33%	85%
P85200	Helianthus annuus	31%	87%
Q01939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	89%
Q09803	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	84%
Q0IIR9	Xenopus tropicalis	33%	73%
Q0W257	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	87%
Q18787	Caenorhabditis elegans	35%	83%
Q1HGK7	Gallus gallus	35%	73%
Q25544	Naegleria fowleri	34%	87%
Q2KIW6	Bos taurus	35%	93%
Q3T030	Bos taurus	31%	86%
Q4Q2K9	Leishmania major	36%	67%
Q4QG45	Leishmania major	32%	82%
Q4QGS2	Leishmania major	33%	88%
Q4R407	Macaca fascicularis	35%	74%
Q4R4R0	Macaca fascicularis	33%	83%
Q4R7L3	Macaca fascicularis	31%	86%
Q503W7	Danio rerio	35%	100%
Q505J9	Rattus norvegicus	41%	100%
Q55BV5	Dictyostelium discoideum	30%	82%
Q58576	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	84%
Q5E9F9	Bos taurus	33%	83%
Q5JHS5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	91%
Q5R8D7	Pongo abelii	34%	83%
Q5RII9	Danio rerio	33%	74%
Q5U3S1	Danio rerio	33%	74%
Q5UT56	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	35%	88%
Q5XIK7	Rattus norvegicus	35%	74%
Q63347	Rattus norvegicus	33%	83%
Q63570	Rattus norvegicus	31%	86%
Q6E0V2	Rattus norvegicus	35%	74%
Q793F9	Rattus norvegicus	35%	83%
Q7ZZ25	Danio rerio	43%	95%
Q86JA1	Dictyostelium discoideum	33%	84%
Q8G3G6	Bifidobacterium longum (strain NCC 2705)	33%	69%
Q8K0T4	Mus musculus	35%	74%
Q8MNV0	Caenorhabditis elegans	37%	71%
Q8NBU5	Homo sapiens	41%	100%
Q8SQI9	Encephalitozoon cuniculi (strain GB-M1)	29%	93%
Q8SQK0	Encephalitozoon cuniculi (strain GB-M1)	34%	92%
Q8SRH0	Encephalitozoon cuniculi (strain GB-M1)	28%	85%
Q8TI88	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	35%	86%
Q8TX03	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	34%	83%
Q8U4H3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	91%
Q8VEJ9	Mus musculus	35%	83%
Q94BQ2	Arabidopsis thaliana	35%	86%
Q975U2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	92%
Q980M1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	34%	92%
Q9BW62	Homo sapiens	34%	74%
Q9C5U3	Arabidopsis thaliana	35%	86%
Q9D5T0	Mus musculus	41%	100%
Q9HNP9	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	34%	88%
Q9HRW6	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	33%	89%
Q9MAK9	Arabidopsis thaliana	34%	90%
Q9P7J5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q9PUL2	Xenopus laevis	33%	74%
Q9SEI3	Arabidopsis thaliana	36%	90%
Q9SEI4	Arabidopsis thaliana	30%	88%
Q9SL67	Arabidopsis thaliana	29%	81%
Q9SZD4	Arabidopsis thaliana	29%	81%
Q9UN37	Homo sapiens	35%	83%
Q9V287	Pyrococcus abyssi (strain GE5 / Orsay)	34%	91%
Q9WV86	Mus musculus	35%	74%
Q9YAC7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	88%
V5BSS5	Trypanosoma cruzi	32%	91%