Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HME6_LEIBR

TriTrypDb:

LbrM.34.1160 , LBRM2903_340017800

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HME6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HME6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.445
CLV_NRD_NRD_1	339	341	PF00675	0.529
CLV_NRD_NRD_1	400	402	PF00675	0.524
CLV_NRD_NRD_1	505	507	PF00675	0.497
CLV_NRD_NRD_1	621	623	PF00675	0.465
CLV_NRD_NRD_1	679	681	PF00675	0.538
CLV_NRD_NRD_1	736	738	PF00675	0.616
CLV_NRD_NRD_1	834	836	PF00675	0.529
CLV_NRD_NRD_1	89	91	PF00675	0.489
CLV_PCSK_FUR_1	818	822	PF00082	0.510
CLV_PCSK_KEX2_1	122	124	PF00082	0.440
CLV_PCSK_KEX2_1	15	17	PF00082	0.506
CLV_PCSK_KEX2_1	273	275	PF00082	0.512
CLV_PCSK_KEX2_1	31	33	PF00082	0.378
CLV_PCSK_KEX2_1	316	318	PF00082	0.393
CLV_PCSK_KEX2_1	329	331	PF00082	0.313
CLV_PCSK_KEX2_1	339	341	PF00082	0.436
CLV_PCSK_KEX2_1	679	681	PF00082	0.538
CLV_PCSK_KEX2_1	820	822	PF00082	0.555
CLV_PCSK_KEX2_1	843	845	PF00082	0.502
CLV_PCSK_KEX2_1	89	91	PF00082	0.488
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.440
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.617
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.494
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.373
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.620
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.563
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.515
CLV_PCSK_SKI1_1	15	19	PF00082	0.561
CLV_PCSK_SKI1_1	212	216	PF00082	0.351
CLV_PCSK_SKI1_1	270	274	PF00082	0.503
CLV_PCSK_SKI1_1	330	334	PF00082	0.620
CLV_PCSK_SKI1_1	340	344	PF00082	0.565
CLV_PCSK_SKI1_1	448	452	PF00082	0.505
CLV_PCSK_SKI1_1	489	493	PF00082	0.368
CLV_PCSK_SKI1_1	506	510	PF00082	0.421
CLV_PCSK_SKI1_1	535	539	PF00082	0.532
CLV_PCSK_SKI1_1	598	602	PF00082	0.420
CLV_PCSK_SKI1_1	709	713	PF00082	0.562
CLV_PCSK_SKI1_1	807	811	PF00082	0.392
CLV_PCSK_SKI1_1	836	840	PF00082	0.481
CLV_PCSK_SKI1_1	92	96	PF00082	0.548
DEG_APCC_DBOX_1	315	323	PF00400	0.491
DEG_APCC_DBOX_1	477	485	PF00400	0.452
DEG_APCC_DBOX_1	597	605	PF00400	0.351
DEG_APCC_DBOX_1	621	629	PF00400	0.483
DEG_APCC_DBOX_1	708	716	PF00400	0.465
DEG_APCC_DBOX_1	778	786	PF00400	0.430
DEG_APCC_DBOX_1	799	807	PF00400	0.561
DEG_SPOP_SBC_1	739	743	PF00917	0.487
DOC_CYCLIN_yCln2_LP_2	757	763	PF00134	0.406
DOC_MAPK_gen_1	122	129	PF00069	0.326
DOC_MAPK_gen_1	316	324	PF00069	0.491
DOC_MAPK_gen_1	483	492	PF00069	0.324
DOC_MAPK_gen_1	620	630	PF00069	0.573
DOC_MAPK_gen_1	794	803	PF00069	0.542
DOC_MAPK_gen_1	92	101	PF00069	0.354
DOC_MAPK_MEF2A_6	122	129	PF00069	0.326
DOC_MAPK_MEF2A_6	20	28	PF00069	0.653
DOC_MAPK_MEF2A_6	598	606	PF00069	0.354
DOC_MAPK_MEF2A_6	690	698	PF00069	0.534
DOC_PP1_RVXF_1	413	419	PF00149	0.359
DOC_USP7_MATH_1	528	532	PF00917	0.442
DOC_USP7_MATH_1	567	571	PF00917	0.519
DOC_USP7_MATH_1	739	743	PF00917	0.749
DOC_USP7_MATH_1	771	775	PF00917	0.660
DOC_USP7_MATH_1	790	794	PF00917	0.318
DOC_USP7_MATH_1	842	846	PF00917	0.475
DOC_USP7_UBL2_3	839	843	PF12436	0.415
DOC_WW_Pin1_4	357	362	PF00397	0.643
DOC_WW_Pin1_4	652	657	PF00397	0.681
DOC_WW_Pin1_4	665	670	PF00397	0.589
DOC_WW_Pin1_4	756	761	PF00397	0.645
LIG_14-3-3_CanoR_1	16	24	PF00244	0.560
LIG_14-3-3_CanoR_1	173	179	PF00244	0.361
LIG_14-3-3_CanoR_1	32	36	PF00244	0.461
LIG_14-3-3_CanoR_1	386	396	PF00244	0.463
LIG_14-3-3_CanoR_1	4	10	PF00244	0.635
LIG_14-3-3_CanoR_1	466	471	PF00244	0.559
LIG_14-3-3_CanoR_1	499	503	PF00244	0.498
LIG_14-3-3_CanoR_1	679	683	PF00244	0.530
LIG_14-3-3_CanoR_1	719	729	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_CaM_IQ_9	810	825	PF13499	0.559
LIG_Clathr_ClatBox_1	698	702	PF01394	0.475
LIG_eIF4E_1	682	688	PF01652	0.586
LIG_eIF4E_1	693	699	PF01652	0.470
LIG_FHA_1	158	164	PF00498	0.362
LIG_FHA_1	16	22	PF00498	0.532
LIG_FHA_1	219	225	PF00498	0.469
LIG_FHA_1	23	29	PF00498	0.538
LIG_FHA_1	388	394	PF00498	0.566
LIG_FHA_1	493	499	PF00498	0.474
LIG_FHA_1	536	542	PF00498	0.526
LIG_FHA_1	573	579	PF00498	0.497
LIG_FHA_1	703	709	PF00498	0.460
LIG_FHA_1	721	727	PF00498	0.435
LIG_FHA_1	739	745	PF00498	0.603
LIG_FHA_2	239	245	PF00498	0.434
LIG_FHA_2	300	306	PF00498	0.615
LIG_FHA_2	393	399	PF00498	0.508
LIG_FHA_2	538	544	PF00498	0.438
LIG_FHA_2	569	575	PF00498	0.439
LIG_Integrin_RGD_1	249	251	PF01839	0.397
LIG_LIR_Gen_1	159	168	PF02991	0.516
LIG_LIR_Gen_1	834	842	PF02991	0.397
LIG_LIR_Nem_3	159	165	PF02991	0.519
LIG_LIR_Nem_3	834	840	PF02991	0.393
LIG_NRBOX	255	261	PF00104	0.331
LIG_PCNA_yPIPBox_3	401	414	PF02747	0.366
LIG_Rb_LxCxE_1	320	341	PF01857	0.434
LIG_SH2_STAP1	277	281	PF00017	0.548
LIG_SH2_STAP1	632	636	PF00017	0.608
LIG_SH2_STAT3	277	280	PF00017	0.549
LIG_SH2_STAT5	581	584	PF00017	0.522
LIG_SH2_STAT5	693	696	PF00017	0.545
LIG_SUMO_SIM_anti_2	320	328	PF11976	0.568
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.435
LIG_SUMO_SIM_par_1	24	29	PF11976	0.573
LIG_SUMO_SIM_par_1	320	328	PF11976	0.542
LIG_SUMO_SIM_par_1	494	501	PF11976	0.330
LIG_SUMO_SIM_par_1	697	702	PF11976	0.475
LIG_TRAF2_1	422	425	PF00917	0.613
LIG_TRAF2_1	508	511	PF00917	0.599
LIG_TRAF2_1	540	543	PF00917	0.508
LIG_TRAF2_1	728	731	PF00917	0.463
LIG_WRC_WIRS_1	393	398	PF05994	0.508
MOD_CK1_1	298	304	PF00069	0.596
MOD_CK2_1	103	109	PF00069	0.564
MOD_CK2_1	238	244	PF00069	0.433
MOD_CK2_1	299	305	PF00069	0.501
MOD_CK2_1	31	37	PF00069	0.533
MOD_CK2_1	537	543	PF00069	0.475
MOD_CK2_1	568	574	PF00069	0.480
MOD_CK2_1	659	665	PF00069	0.467
MOD_CK2_1	739	745	PF00069	0.613
MOD_CK2_1	766	772	PF00069	0.549
MOD_CK2_1	81	87	PF00069	0.473
MOD_Cter_Amidation	120	123	PF01082	0.322
MOD_Cter_Amidation	399	402	PF01082	0.561
MOD_Cter_Amidation	735	738	PF01082	0.491
MOD_GlcNHglycan	105	108	PF01048	0.615
MOD_GlcNHglycan	119	122	PF01048	0.406
MOD_GlcNHglycan	769	772	PF01048	0.405
MOD_GSK3_1	157	164	PF00069	0.620
MOD_GSK3_1	219	226	PF00069	0.363
MOD_GSK3_1	295	302	PF00069	0.372
MOD_GSK3_1	353	360	PF00069	0.665
MOD_GSK3_1	435	442	PF00069	0.442
MOD_GSK3_1	494	501	PF00069	0.614
MOD_GSK3_1	5	12	PF00069	0.459
MOD_GSK3_1	568	575	PF00069	0.439
MOD_GSK3_1	659	666	PF00069	0.593
MOD_GSK3_1	767	774	PF00069	0.529
MOD_GSK3_1	81	88	PF00069	0.481
MOD_GSK3_1	99	106	PF00069	0.503
MOD_LATS_1	115	121	PF00433	0.316
MOD_N-GLC_1	10	15	PF02516	0.531
MOD_N-GLC_1	796	801	PF02516	0.441
MOD_NEK2_1	238	243	PF00069	0.455
MOD_NEK2_1	299	304	PF00069	0.522
MOD_NEK2_1	477	482	PF00069	0.466
MOD_NEK2_1	492	497	PF00069	0.405
MOD_NEK2_1	498	503	PF00069	0.444
MOD_NEK2_1	572	577	PF00069	0.445
MOD_NEK2_1	715	720	PF00069	0.562
MOD_NEK2_1	732	737	PF00069	0.525
MOD_NEK2_1	9	14	PF00069	0.597
MOD_PIKK_1	219	225	PF00454	0.404
MOD_PIKK_1	512	518	PF00454	0.557
MOD_PIKK_1	99	105	PF00454	0.456
MOD_PK_1	31	37	PF00069	0.481
MOD_PKA_1	15	21	PF00069	0.563
MOD_PKA_1	31	37	PF00069	0.533
MOD_PKA_2	15	21	PF00069	0.522
MOD_PKA_2	172	178	PF00069	0.361
MOD_PKA_2	31	37	PF00069	0.421
MOD_PKA_2	400	406	PF00069	0.480
MOD_PKA_2	477	483	PF00069	0.431
MOD_PKA_2	498	504	PF00069	0.510
MOD_PKA_2	651	657	PF00069	0.678
MOD_PKA_2	678	684	PF00069	0.538
MOD_PKA_2	702	708	PF00069	0.461
MOD_PKA_2	715	721	PF00069	0.561
MOD_PKB_1	794	802	PF00069	0.397
MOD_Plk_1	108	114	PF00069	0.456
MOD_Plk_1	528	534	PF00069	0.538
MOD_Plk_1	632	638	PF00069	0.343
MOD_Plk_1	703	709	PF00069	0.555
MOD_Plk_1	739	745	PF00069	0.599
MOD_Plk_1	796	802	PF00069	0.516
MOD_Plk_2-3	22	28	PF00069	0.548
MOD_Plk_2-3	740	746	PF00069	0.485
MOD_Plk_4	157	163	PF00069	0.470
MOD_Plk_4	31	37	PF00069	0.380
MOD_Plk_4	392	398	PF00069	0.609
MOD_Plk_4	466	472	PF00069	0.464
MOD_Plk_4	477	483	PF00069	0.455
MOD_Plk_4	5	11	PF00069	0.537
MOD_Plk_4	557	563	PF00069	0.597
MOD_Plk_4	751	757	PF00069	0.687
MOD_ProDKin_1	357	363	PF00069	0.637
MOD_ProDKin_1	652	658	PF00069	0.681
MOD_ProDKin_1	665	671	PF00069	0.582
MOD_ProDKin_1	756	762	PF00069	0.640
MOD_SUMO_for_1	272	275	PF00179	0.627
MOD_SUMO_rev_2	128	136	PF00179	0.433
MOD_SUMO_rev_2	257	265	PF00179	0.337
MOD_SUMO_rev_2	71	77	PF00179	0.509
TRG_DiLeu_BaEn_1	132	137	PF01217	0.548
TRG_DiLeu_BaEn_1	295	300	PF01217	0.376
TRG_DiLeu_BaEn_1	320	325	PF01217	0.573
TRG_DiLeu_BaEn_1	328	333	PF01217	0.485
TRG_DiLeu_BaEn_1	40	45	PF01217	0.445
TRG_DiLeu_BaEn_1	447	452	PF01217	0.545
TRG_DiLeu_BaEn_1	683	688	PF01217	0.495
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.335
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.327
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.481
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.503
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.587
TRG_ENDOCYTIC_2	693	696	PF00928	0.545
TRG_ER_diArg_1	143	146	PF00400	0.618
TRG_ER_diArg_1	628	631	PF00400	0.449
TRG_ER_diArg_1	678	680	PF00400	0.542
TRG_ER_diArg_1	800	803	PF00400	0.470
TRG_ER_diArg_1	89	92	PF00400	0.513
TRG_NES_CRM1_1	209	223	PF08389	0.479
TRG_NES_CRM1_1	449	461	PF08389	0.489
TRG_NES_CRM1_1	596	610	PF08389	0.487
TRG_NLS_MonoExtN_4	620	626	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	489	494	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX59	Leptomonas seymouri	52%	99%
A0A1X0NHD9	Trypanosomatidae	26%	100%
A0A3R7K5V9	Trypanosoma rangeli	27%	100%
A0A3S5H7Y8	Leishmania donovani	78%	100%
A4IB18	Leishmania infantum	78%	100%
C9ZNP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9AEU7	Leishmania major	78%	100%
E9B603	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%