ARMET_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Degradation arginine-rich protein for mis-folding, putative

Species:

Leishmania braziliensis

UniProt:

A4HME3_LEIBR

TriTrypDb:

LbrM.34.1130 , LBRM2903_340017400

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HME3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HME3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.626
CLV_C14_Caspase3-7	184	188	PF00656	0.679
CLV_NRD_NRD_1	129	131	PF00675	0.633
CLV_NRD_NRD_1	99	101	PF00675	0.729
CLV_PCSK_KEX2_1	129	131	PF00082	0.610
CLV_PCSK_KEX2_1	73	75	PF00082	0.606
CLV_PCSK_KEX2_1	98	100	PF00082	0.631
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.606
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.510
CLV_PCSK_SKI1_1	2	6	PF00082	0.605
CLV_PCSK_SKI1_1	28	32	PF00082	0.491
CLV_PCSK_SKI1_1	36	40	PF00082	0.470
DEG_MDM2_SWIB_1	81	88	PF02201	0.559
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DOC_MAPK_gen_1	136	142	PF00069	0.443
DOC_MAPK_MEF2A_6	2	10	PF00069	0.517
DOC_USP7_MATH_1	119	123	PF00917	0.667
DOC_USP7_MATH_1	168	172	PF00917	0.662
DOC_USP7_MATH_1	175	179	PF00917	0.671
DOC_USP7_MATH_1	67	71	PF00917	0.670
DOC_USP7_UBL2_3	29	33	PF12436	0.316
DOC_WW_Pin1_4	135	140	PF00397	0.669
DOC_WW_Pin1_4	166	171	PF00397	0.629
DOC_WW_Pin1_4	63	68	PF00397	0.440
LIG_BIR_III_2	105	109	PF00653	0.445
LIG_BRCT_BRCA1_1	77	81	PF00533	0.579
LIG_EH1_1	3	11	PF00400	0.386
LIG_FHA_1	196	202	PF00498	0.724
LIG_FHA_1	5	11	PF00498	0.383
LIG_FHA_2	159	165	PF00498	0.579
LIG_FHA_2	21	27	PF00498	0.559
LIG_GBD_Chelix_1	9	17	PF00786	0.401
LIG_LIR_Gen_1	107	116	PF02991	0.659
LIG_LIR_Gen_1	53	60	PF02991	0.315
LIG_LIR_Gen_1	83	89	PF02991	0.455
LIG_LIR_Nem_3	107	112	PF02991	0.655
LIG_LIR_Nem_3	144	150	PF02991	0.582
LIG_LIR_Nem_3	83	88	PF02991	0.539
LIG_Pex14_2	81	85	PF04695	0.546
LIG_PTB_Apo_2	204	211	PF02174	0.566
LIG_PTB_Phospho_1	204	210	PF10480	0.567
LIG_Rb_LxCxE_1	45	64	PF01857	0.205
LIG_SH2_CRK	210	214	PF00017	0.472
LIG_SH2_NCK_1	210	214	PF00017	0.692
LIG_SH2_SRC	210	213	PF00017	0.694
LIG_SH2_STAT3	123	126	PF00017	0.697
LIG_SH2_STAT5	123	126	PF00017	0.642
LIG_SH2_STAT5	165	168	PF00017	0.496
LIG_TRAF2_1	89	92	PF00917	0.396
MOD_CK1_1	169	175	PF00069	0.550
MOD_CK1_1	178	184	PF00069	0.566
MOD_CMANNOS	82	85	PF00535	0.524
MOD_Cter_Amidation	127	130	PF01082	0.598
MOD_GlcNHglycan	117	120	PF01048	0.595
MOD_GlcNHglycan	18	21	PF01048	0.652
MOD_GlcNHglycan	189	192	PF01048	0.697
MOD_GlcNHglycan	69	72	PF01048	0.706
MOD_GSK3_1	115	122	PF00069	0.561
MOD_GSK3_1	16	23	PF00069	0.657
MOD_GSK3_1	171	178	PF00069	0.532
MOD_GSK3_1	182	189	PF00069	0.426
MOD_GSK3_1	63	70	PF00069	0.551
MOD_NEK2_1	13	18	PF00069	0.622
MOD_NEK2_1	142	147	PF00069	0.531
MOD_NEK2_1	158	163	PF00069	0.479
MOD_NEK2_1	186	191	PF00069	0.640
MOD_NEK2_1	4	9	PF00069	0.582
MOD_PIKK_1	169	175	PF00454	0.639
MOD_Plk_1	143	149	PF00069	0.435
MOD_Plk_4	119	125	PF00069	0.614
MOD_Plk_4	13	19	PF00069	0.640
MOD_Plk_4	178	184	PF00069	0.630
MOD_ProDKin_1	135	141	PF00069	0.668
MOD_ProDKin_1	166	172	PF00069	0.628
MOD_ProDKin_1	63	69	PF00069	0.447
MOD_SUMO_for_1	89	92	PF00179	0.421
MOD_SUMO_rev_2	24	30	PF00179	0.353
TRG_DiLeu_BaEn_2	50	56	PF01217	0.310
TRG_ENDOCYTIC_2	210	213	PF00928	0.602
TRG_ER_diArg_1	129	131	PF00400	0.717
TRG_NLS_MonoExtC_3	97	103	PF00514	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS8	Leptomonas seymouri	70%	100%
A0A0S4IZ22	Bodo saltans	38%	100%
A0A1X0NHR2	Trypanosomatidae	54%	97%
A0A3S7X8Z2	Leishmania donovani	81%	100%
A0A422N9T4	Trypanosoma rangeli	47%	95%
A4IB15	Leishmania infantum	81%	100%
C9ZNP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9AEU4	Leishmania major	80%	100%
E9B600	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%