Putative NADH-dependent fumarate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-dependent fumarate reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HME1_LEIBR

TriTrypDb:

LbrM.34.1110 , LBRM2903_340017200

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005815	microtubule organizing center	2	1
GO:0020015	glycosome	7	1
GO:0036064	ciliary basal body	3	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HME1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HME1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0010181	FMN binding	4	10
GO:0016156	fumarate reductase (NADH) activity	5	5
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	6
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	5
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0000104	succinate dehydrogenase activity	4	1
GO:0008177	succinate dehydrogenase (ubiquinone) activity	5	1
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.314
CLV_NRD_NRD_1	153	155	PF00675	0.314
CLV_NRD_NRD_1	229	231	PF00675	0.310
CLV_NRD_NRD_1	44	46	PF00675	0.693
CLV_NRD_NRD_1	482	484	PF00675	0.349
CLV_NRD_NRD_1	62	64	PF00675	0.305
CLV_PCSK_KEX2_1	155	157	PF00082	0.314
CLV_PCSK_KEX2_1	44	46	PF00082	0.559
CLV_PCSK_KEX2_1	482	484	PF00082	0.353
CLV_PCSK_KEX2_1	62	64	PF00082	0.305
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.314
CLV_PCSK_SKI1_1	377	381	PF00082	0.333
CLV_PCSK_SKI1_1	433	437	PF00082	0.349
CLV_PCSK_SKI1_1	66	70	PF00082	0.528
CLV_PCSK_SKI1_1	9	13	PF00082	0.610
CLV_Separin_Metazoa	120	124	PF03568	0.476
DEG_APCC_DBOX_1	183	191	PF00400	0.310
DOC_CKS1_1	450	455	PF01111	0.349
DOC_CYCLIN_yClb1_LxF_4	377	383	PF00134	0.310
DOC_MAPK_gen_1	278	287	PF00069	0.402
DOC_MAPK_MEF2A_6	278	287	PF00069	0.402
DOC_PP4_FxxP_1	139	142	PF00568	0.402
DOC_PP4_FxxP_1	450	453	PF00568	0.349
DOC_USP7_MATH_1	77	81	PF00917	0.668
DOC_USP7_UBL2_3	14	18	PF12436	0.548
DOC_USP7_UBL2_3	373	377	PF12436	0.310
DOC_WW_Pin1_4	164	169	PF00397	0.314
DOC_WW_Pin1_4	449	454	PF00397	0.314
DOC_WW_Pin1_4	462	467	PF00397	0.314
DOC_WW_Pin1_4	476	481	PF00397	0.349
LIG_14-3-3_CanoR_1	184	193	PF00244	0.326
LIG_14-3-3_CanoR_1	198	203	PF00244	0.379
LIG_14-3-3_CanoR_1	340	348	PF00244	0.402
LIG_14-3-3_CanoR_1	44	54	PF00244	0.546
LIG_Actin_WH2_2	54	72	PF00022	0.474
LIG_Clathr_ClatBox_1	287	291	PF01394	0.314
LIG_deltaCOP1_diTrp_1	134	139	PF00928	0.402
LIG_FHA_1	265	271	PF00498	0.470
LIG_FHA_1	296	302	PF00498	0.314
LIG_FHA_1	308	314	PF00498	0.314
LIG_FHA_1	409	415	PF00498	0.456
LIG_FHA_1	450	456	PF00498	0.314
LIG_FHA_1	493	499	PF00498	0.314
LIG_FHA_2	122	128	PF00498	0.402
LIG_FHA_2	411	417	PF00498	0.470
LIG_LIR_Apic_2	137	142	PF02991	0.402
LIG_LIR_Apic_2	310	315	PF02991	0.315
LIG_LIR_Nem_3	416	420	PF02991	0.347
LIG_LRP6_Inhibitor_1	178	184	PF00058	0.476
LIG_PCNA_yPIPBox_3	192	203	PF02747	0.346
LIG_PCNA_yPIPBox_3	503	514	PF02747	0.317
LIG_Pex14_1	135	139	PF04695	0.402
LIG_Pex14_2	29	33	PF04695	0.584
LIG_Pex14_2	375	379	PF04695	0.310
LIG_SH2_CRK	364	368	PF00017	0.402
LIG_SH2_STAT3	218	221	PF00017	0.476
LIG_SH2_STAT3	257	260	PF00017	0.402
LIG_SH2_STAT5	182	185	PF00017	0.402
LIG_SH2_STAT5	312	315	PF00017	0.349
LIG_SH2_STAT5	364	367	PF00017	0.402
LIG_SH2_STAT5	447	450	PF00017	0.314
LIG_SH2_STAT5	457	460	PF00017	0.314
LIG_SH3_1	24	30	PF00018	0.588
LIG_SH3_2	19	24	PF14604	0.586
LIG_SH3_2	27	32	PF14604	0.530
LIG_SH3_3	158	164	PF00018	0.402
LIG_SH3_3	16	22	PF00018	0.646
LIG_SH3_3	24	30	PF00018	0.596
LIG_SH3_3	300	306	PF00018	0.314
LIG_SH3_3	478	484	PF00018	0.358
LIG_UBA3_1	199	206	PF00899	0.476
LIG_WRC_WIRS_1	136	141	PF05994	0.402
MOD_CDK_SPxK_1	476	482	PF00069	0.310
MOD_CDK_SPxxK_3	476	483	PF00069	0.310
MOD_CK1_1	126	132	PF00069	0.314
MOD_CK1_1	263	269	PF00069	0.349
MOD_CK1_1	307	313	PF00069	0.349
MOD_CK1_1	341	347	PF00069	0.314
MOD_CK1_1	357	363	PF00069	0.314
MOD_CK2_1	410	416	PF00069	0.349
MOD_CK2_1	505	511	PF00069	0.314
MOD_GlcNHglycan	110	113	PF01048	0.257
MOD_GlcNHglycan	127	131	PF01048	0.314
MOD_GlcNHglycan	2	5	PF01048	0.530
MOD_GlcNHglycan	223	226	PF01048	0.376
MOD_GlcNHglycan	320	323	PF01048	0.335
MOD_GlcNHglycan	356	359	PF01048	0.450
MOD_GlcNHglycan	466	469	PF01048	0.289
MOD_GlcNHglycan	99	102	PF01048	0.423
MOD_GSK3_1	198	205	PF00069	0.425
MOD_GSK3_1	217	224	PF00069	0.244
MOD_GSK3_1	238	245	PF00069	0.339
MOD_GSK3_1	259	266	PF00069	0.315
MOD_GSK3_1	451	458	PF00069	0.349
MOD_GSK3_1	469	476	PF00069	0.349
MOD_N-GLC_1	185	190	PF02516	0.441
MOD_N-GLC_1	307	312	PF02516	0.349
MOD_N-GLC_1	408	413	PF02516	0.310
MOD_NEK2_1	121	126	PF00069	0.349
MOD_NEK2_1	318	323	PF00069	0.314
MOD_NEK2_1	36	41	PF00069	0.658
MOD_PIKK_1	144	150	PF00454	0.314
MOD_PIKK_1	217	223	PF00454	0.476
MOD_PIKK_1	341	347	PF00454	0.402
MOD_PKA_2	318	324	PF00069	0.314
MOD_Plk_2-3	469	475	PF00069	0.310
MOD_Plk_4	249	255	PF00069	0.314
MOD_Plk_4	505	511	PF00069	0.314
MOD_ProDKin_1	164	170	PF00069	0.314
MOD_ProDKin_1	449	455	PF00069	0.314
MOD_ProDKin_1	462	468	PF00069	0.314
MOD_ProDKin_1	476	482	PF00069	0.349
MOD_SUMO_rev_2	224	229	PF00179	0.310
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.476
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.564
TRG_ENDOCYTIC_2	364	367	PF00928	0.402
TRG_ENDOCYTIC_2	417	420	PF00928	0.349
TRG_ENDOCYTIC_2	447	450	PF00928	0.375
TRG_ER_diArg_1	24	27	PF00400	0.590
TRG_ER_diArg_1	44	46	PF00400	0.443
TRG_ER_diArg_1	481	483	PF00400	0.349
TRG_ER_diArg_1	61	63	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	72%	90%
A0A0S4IHN0	Bodo saltans	59%	100%
A0A0S4KND3	Bodo saltans	35%	100%
A0A1X0NPF8	Trypanosomatidae	36%	80%
A0A3S7WPX2	Leishmania donovani	35%	81%
A0A3S7X915	Leishmania donovani	79%	100%
A0A422MX37	Trypanosoma rangeli	62%	83%
A0R4S9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	95%
A4HME0	Leishmania braziliensis	98%	100%
A4HTA6	Leishmania infantum	35%	96%
A4IB13	Leishmania infantum	79%	100%
B2GCE0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	27%	88%
C8WLE3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	29%	90%
C8WLM1	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	23%	97%
D9PU00	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	28%	99%
E9AEU2	Leishmania major	76%	100%
E9AL95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	81%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
F8DIF2	Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537)	27%	68%
F9UNH3	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	29%	67%
G4V4G6	Serratia sp. (strain ATCC 39006)	29%	92%
O06913	Helicobacter pylori (strain ATCC 700392 / 26695)	28%	76%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P00363	Escherichia coli (strain K12)	29%	90%
P0AC41	Escherichia coli (strain K12)	31%	92%
P0AC42	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	92%
P0AC43	Escherichia coli O157:H7	31%	92%
P0C278	Shewanella frigidimarina	35%	95%
P20922	Proteus vulgaris	29%	91%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P44894	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	91%
P64175	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	93%
P71864	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	96%
P83223	Shewanella oneidensis (strain MR-1)	32%	91%
P9WN90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	93%
P9WN91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	93%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	35%	91%
Q28ED0	Xenopus tropicalis	24%	82%
Q4QIK9	Leishmania major	34%	100%
Q6PA58	Xenopus laevis	24%	82%
Q7D5C1	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	96%
Q7M827	Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)	27%	89%
Q801S2	Xenopus laevis	24%	82%
Q8CVD0	Shewanella oneidensis (strain MR-1)	32%	93%
Q8DW88	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	68%
Q8XQG4	Ralstonia solanacearum (strain GMI1000)	25%	100%
Q8YXJ6	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	28%	94%
Q8ZQU3	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	92%
Q92R32	Rhizobium meliloti (strain 1021)	27%	100%
Q97K95	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	27%	100%
Q9X8N8	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	28%	94%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	35%	92%
Q9ZMP0	Helicobacter pylori (strain J99 / ATCC 700824)	28%	76%
V3TQ67	Serratia sp. (strain ATCC 39006)	28%	91%