Putative NADH-dependent fumarate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-dependent fumarate reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HME0_LEIBR

TriTrypDb:

LbrM.34.1100 , LBRM2903_340017200

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005815	microtubule organizing center	2	1
GO:0020015	glycosome	7	1
GO:0036064	ciliary basal body	3	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HME0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HME0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0010181	FMN binding	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016156	fumarate reductase (NADH) activity	5	4
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	4
GO:0000104	succinate dehydrogenase activity	4	1
GO:0008177	succinate dehydrogenase (ubiquinone) activity	5	1
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.313
CLV_NRD_NRD_1	124	126	PF00675	0.313
CLV_NRD_NRD_1	200	202	PF00675	0.309
CLV_NRD_NRD_1	453	455	PF00675	0.313
CLV_PCSK_KEX2_1	126	128	PF00082	0.313
CLV_PCSK_KEX2_1	453	455	PF00082	0.315
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.313
CLV_PCSK_SKI1_1	348	352	PF00082	0.305
CLV_PCSK_SKI1_1	404	408	PF00082	0.338
CLV_Separin_Metazoa	91	95	PF03568	0.475
DEG_APCC_DBOX_1	154	162	PF00400	0.309
DOC_ANK_TNKS_1	9	16	PF00023	0.269
DOC_CKS1_1	421	426	PF01111	0.338
DOC_CYCLIN_yClb1_LxF_4	348	354	PF00134	0.371
DOC_MAPK_gen_1	249	258	PF00069	0.371
DOC_MAPK_MEF2A_6	249	258	PF00069	0.371
DOC_PP4_FxxP_1	110	113	PF00568	0.419
DOC_PP4_FxxP_1	421	424	PF00568	0.371
DOC_USP7_UBL2_3	344	348	PF12436	0.371
DOC_WW_Pin1_4	135	140	PF00397	0.313
DOC_WW_Pin1_4	420	425	PF00397	0.313
DOC_WW_Pin1_4	433	438	PF00397	0.313
DOC_WW_Pin1_4	447	452	PF00397	0.338
LIG_14-3-3_CanoR_1	155	164	PF00244	0.349
LIG_14-3-3_CanoR_1	169	174	PF00244	0.399
LIG_14-3-3_CanoR_1	311	319	PF00244	0.371
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_Clathr_ClatBox_1	258	262	PF01394	0.313
LIG_deltaCOP1_diTrp_1	105	110	PF00928	0.419
LIG_FHA_1	236	242	PF00498	0.462
LIG_FHA_1	267	273	PF00498	0.313
LIG_FHA_1	279	285	PF00498	0.313
LIG_FHA_1	380	386	PF00498	0.464
LIG_FHA_1	421	427	PF00498	0.313
LIG_FHA_1	464	470	PF00498	0.313
LIG_FHA_1	50	56	PF00498	0.276
LIG_FHA_2	382	388	PF00498	0.416
LIG_FHA_2	93	99	PF00498	0.419
LIG_LIR_Apic_2	108	113	PF02991	0.419
LIG_LIR_Apic_2	281	286	PF02991	0.314
LIG_LIR_Nem_3	387	391	PF02991	0.336
LIG_LRP6_Inhibitor_1	149	155	PF00058	0.475
LIG_PCNA_yPIPBox_3	163	174	PF02747	0.369
LIG_PCNA_yPIPBox_3	474	485	PF02747	0.317
LIG_Pex14_1	106	110	PF04695	0.419
LIG_Pex14_2	346	350	PF04695	0.309
LIG_SH2_CRK	335	339	PF00017	0.371
LIG_SH2_STAT3	189	192	PF00017	0.475
LIG_SH2_STAT3	228	231	PF00017	0.371
LIG_SH2_STAT5	153	156	PF00017	0.419
LIG_SH2_STAT5	283	286	PF00017	0.313
LIG_SH2_STAT5	335	338	PF00017	0.371
LIG_SH2_STAT5	418	421	PF00017	0.313
LIG_SH2_STAT5	428	431	PF00017	0.313
LIG_SH3_3	129	135	PF00018	0.419
LIG_SH3_3	271	277	PF00018	0.313
LIG_SH3_3	449	455	PF00018	0.317
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.391
LIG_SUMO_SIM_par_1	10	16	PF11976	0.391
LIG_SUMO_SIM_par_1	34	39	PF11976	0.303
LIG_UBA3_1	170	177	PF00899	0.475
LIG_WRC_WIRS_1	107	112	PF05994	0.419
MOD_CDK_SPxK_1	447	453	PF00069	0.371
MOD_CDK_SPxxK_3	447	454	PF00069	0.371
MOD_CK1_1	234	240	PF00069	0.360
MOD_CK1_1	278	284	PF00069	0.371
MOD_CK1_1	312	318	PF00069	0.313
MOD_CK1_1	328	334	PF00069	0.313
MOD_CK1_1	97	103	PF00069	0.313
MOD_CK2_1	381	387	PF00069	0.342
MOD_CK2_1	476	482	PF00069	0.313
MOD_GlcNHglycan	15	18	PF01048	0.306
MOD_GlcNHglycan	194	197	PF01048	0.400
MOD_GlcNHglycan	291	294	PF01048	0.328
MOD_GlcNHglycan	327	330	PF01048	0.357
MOD_GlcNHglycan	437	440	PF01048	0.313
MOD_GlcNHglycan	47	50	PF01048	0.276
MOD_GlcNHglycan	52	55	PF01048	0.281
MOD_GlcNHglycan	70	73	PF01048	0.421
MOD_GlcNHglycan	81	84	PF01048	0.250
MOD_GlcNHglycan	98	102	PF01048	0.313
MOD_GSK3_1	169	176	PF00069	0.423
MOD_GSK3_1	188	195	PF00069	0.419
MOD_GSK3_1	209	216	PF00069	0.331
MOD_GSK3_1	230	237	PF00069	0.314
MOD_GSK3_1	422	429	PF00069	0.338
MOD_GSK3_1	440	447	PF00069	0.338
MOD_GSK3_1	45	52	PF00069	0.276
MOD_N-GLC_1	156	161	PF02516	0.451
MOD_N-GLC_1	278	283	PF02516	0.313
MOD_N-GLC_1	379	384	PF02516	0.444
MOD_NEK2_1	289	294	PF00069	0.313
MOD_NEK2_1	92	97	PF00069	0.338
MOD_PIKK_1	115	121	PF00454	0.313
MOD_PIKK_1	188	194	PF00454	0.475
MOD_PIKK_1	312	318	PF00454	0.371
MOD_PKA_2	289	295	PF00069	0.313
MOD_Plk_2-3	440	446	PF00069	0.309
MOD_Plk_4	220	226	PF00069	0.313
MOD_Plk_4	476	482	PF00069	0.313
MOD_ProDKin_1	135	141	PF00069	0.313
MOD_ProDKin_1	420	426	PF00069	0.313
MOD_ProDKin_1	433	439	PF00069	0.313
MOD_ProDKin_1	447	453	PF00069	0.338
MOD_SUMO_rev_2	195	200	PF00179	0.451
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.475
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.553
TRG_ENDOCYTIC_2	335	338	PF00928	0.371
TRG_ENDOCYTIC_2	388	391	PF00928	0.338
TRG_ENDOCYTIC_2	418	421	PF00928	0.355
TRG_ER_diArg_1	452	454	PF00400	0.313
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	73%	85%
A0A0S4IHN0	Bodo saltans	61%	100%
A0A0S4KND3	Bodo saltans	37%	99%
A0A1S3YEG8	Nicotiana tabacum	27%	80%
A0A1X0NPF8	Trypanosomatidae	36%	76%
A0A3S7WPX2	Leishmania donovani	36%	77%
A0A3S7X915	Leishmania donovani	80%	100%
A0A422MX37	Trypanosoma rangeli	66%	78%
A0R4S9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	90%
A4HME1	Leishmania braziliensis	98%	95%
A4HTA6	Leishmania infantum	35%	91%
A4IB13	Leishmania infantum	80%	100%
B2GCE0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	26%	83%
C8WLE3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	30%	85%
C8WLM1	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	25%	92%
D9PU00	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	29%	94%
E9AEU2	Leishmania major	80%	100%
E9AL95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	76%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O06913	Helicobacter pylori (strain ATCC 700392 / 26695)	28%	72%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P00363	Escherichia coli (strain K12)	29%	85%
P08065	Bacillus subtilis (strain 168)	25%	88%
P0C278	Shewanella frigidimarina	36%	90%
P10902	Escherichia coli (strain K12)	25%	95%
P17412	Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)	26%	78%
P20922	Proteus vulgaris	29%	86%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P44894	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	86%
P64175	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	88%
P71864	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	91%
P83223	Shewanella oneidensis (strain MR-1)	32%	86%
P9WN90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	88%
P9WN91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	88%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	36%	86%
Q28ED0	Xenopus tropicalis	24%	77%
Q4QIK9	Leishmania major	35%	100%
Q4UJM1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	86%
Q6PA58	Xenopus laevis	24%	77%
Q7D5C1	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	91%
Q7M827	Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)	26%	84%
Q7ZVF3	Danio rerio	25%	78%
Q801S2	Xenopus laevis	24%	77%
Q8CVD0	Shewanella oneidensis (strain MR-1)	33%	88%
Q8XA23	Escherichia coli O157:H7	25%	95%
Q8XQG4	Ralstonia solanacearum (strain GMI1000)	25%	96%
Q8YXJ6	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	28%	89%
Q92R32	Rhizobium meliloti (strain 1021)	27%	97%
Q97K95	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	27%	100%
Q9HNZ0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	27%	100%
Q9KPA4	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	28%	96%
Q9X8N8	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	28%	89%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	35%	87%
Q9ZMP0	Helicobacter pylori (strain J99 / ATCC 700824)	28%	72%
V3TQ67	Serratia sp. (strain ATCC 39006)	28%	86%