Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMD8_LEIBR

TriTrypDb:

LbrM.34.1080 , LBRM2903_340016800

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004792	thiosulfate sulfurtransferase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.674
CLV_NRD_NRD_1	231	233	PF00675	0.459
CLV_NRD_NRD_1	28	30	PF00675	0.555
CLV_NRD_NRD_1	426	428	PF00675	0.579
CLV_NRD_NRD_1	440	442	PF00675	0.559
CLV_NRD_NRD_1	534	536	PF00675	0.701
CLV_NRD_NRD_1	599	601	PF00675	0.790
CLV_NRD_NRD_1	76	78	PF00675	0.738
CLV_PCSK_KEX2_1	231	233	PF00082	0.458
CLV_PCSK_KEX2_1	28	30	PF00082	0.555
CLV_PCSK_KEX2_1	426	428	PF00082	0.579
CLV_PCSK_KEX2_1	440	442	PF00082	0.559
CLV_PCSK_KEX2_1	534	536	PF00082	0.701
CLV_PCSK_KEX2_1	599	601	PF00082	0.790
CLV_PCSK_KEX2_1	76	78	PF00082	0.738
CLV_PCSK_PC7_1	72	78	PF00082	0.534
CLV_PCSK_SKI1_1	232	236	PF00082	0.349
CLV_PCSK_SKI1_1	314	318	PF00082	0.449
CLV_PCSK_SKI1_1	441	445	PF00082	0.628
CLV_PCSK_SKI1_1	559	563	PF00082	0.771
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SPOP_SBC_1	139	143	PF00917	0.785
DEG_SPOP_SBC_1	291	295	PF00917	0.712
DOC_MAPK_gen_1	228	236	PF00069	0.507
DOC_MAPK_gen_1	28	35	PF00069	0.541
DOC_MAPK_gen_1	36	45	PF00069	0.485
DOC_MAPK_gen_1	375	383	PF00069	0.525
DOC_PP2B_LxvP_1	502	505	PF13499	0.642
DOC_PP4_FxxP_1	274	277	PF00568	0.492
DOC_PP4_FxxP_1	373	376	PF00568	0.506
DOC_PP4_MxPP_1	594	597	PF00568	0.569
DOC_USP7_MATH_1	12	16	PF00917	0.716
DOC_USP7_MATH_1	139	143	PF00917	0.767
DOC_USP7_MATH_1	160	164	PF00917	0.739
DOC_USP7_MATH_1	171	175	PF00917	0.672
DOC_USP7_MATH_1	7	11	PF00917	0.740
DOC_USP7_UBL2_3	239	243	PF12436	0.472
DOC_USP7_UBL2_3	493	497	PF12436	0.659
DOC_WW_Pin1_4	102	107	PF00397	0.640
DOC_WW_Pin1_4	162	167	PF00397	0.698
DOC_WW_Pin1_4	360	365	PF00397	0.494
DOC_WW_Pin1_4	474	479	PF00397	0.638
DOC_WW_Pin1_4	583	588	PF00397	0.729
DOC_WW_Pin1_4	589	594	PF00397	0.766
LIG_14-3-3_CanoR_1	121	125	PF00244	0.768
LIG_14-3-3_CanoR_1	20	27	PF00244	0.638
LIG_14-3-3_CanoR_1	440	446	PF00244	0.635
LIG_14-3-3_CanoR_1	559	565	PF00244	0.697
LIG_14-3-3_CanoR_1	77	85	PF00244	0.786
LIG_Actin_WH2_2	106	123	PF00022	0.538
LIG_Actin_WH2_2	217	233	PF00022	0.430
LIG_BRCT_BRCA1_1	140	144	PF00533	0.782
LIG_Dynein_DLC8_1	527	533	PF01221	0.602
LIG_eIF4E_1	388	394	PF01652	0.501
LIG_FHA_1	252	258	PF00498	0.657
LIG_FHA_1	478	484	PF00498	0.618
LIG_FHA_1	497	503	PF00498	0.556
LIG_FHA_1	531	537	PF00498	0.694
LIG_FHA_1	540	546	PF00498	0.647
LIG_FHA_1	80	86	PF00498	0.749
LIG_FHA_2	195	201	PF00498	0.629
LIG_FHA_2	203	209	PF00498	0.657
LIG_FHA_2	235	241	PF00498	0.589
LIG_FHA_2	254	260	PF00498	0.342
LIG_FHA_2	291	297	PF00498	0.635
LIG_FHA_2	318	324	PF00498	0.520
LIG_FHA_2	333	339	PF00498	0.436
LIG_FHA_2	361	367	PF00498	0.494
LIG_FHA_2	547	553	PF00498	0.640
LIG_GBD_Chelix_1	494	502	PF00786	0.429
LIG_LIR_Apic_2	200	204	PF02991	0.640
LIG_LIR_Apic_2	370	376	PF02991	0.487
LIG_LIR_Gen_1	325	336	PF02991	0.357
LIG_LIR_Gen_1	355	364	PF02991	0.525
LIG_LIR_Gen_1	458	467	PF02991	0.558
LIG_LIR_Nem_3	325	331	PF02991	0.357
LIG_LIR_Nem_3	340	345	PF02991	0.501
LIG_LIR_Nem_3	355	360	PF02991	0.501
LIG_LIR_Nem_3	400	404	PF02991	0.495
LIG_LIR_Nem_3	458	462	PF02991	0.553
LIG_LIR_Nem_3	490	495	PF02991	0.564
LIG_PCNA_yPIPBox_3	419	429	PF02747	0.531
LIG_Pex14_1	417	421	PF04695	0.576
LIG_SH2_CRK	421	425	PF00017	0.545
LIG_SH2_CRK	492	496	PF00017	0.561
LIG_SH2_SRC	324	327	PF00017	0.456
LIG_SH2_STAT5	385	388	PF00017	0.501
LIG_SH2_STAT5	404	407	PF00017	0.501
LIG_SH2_STAT5	470	473	PF00017	0.695
LIG_SH3_1	590	596	PF00018	0.783
LIG_SH3_3	258	264	PF00018	0.586
LIG_SH3_3	502	508	PF00018	0.635
LIG_SH3_3	590	596	PF00018	0.770
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.492
LIG_SUMO_SIM_par_1	41	48	PF11976	0.499
LIG_SUMO_SIM_par_1	479	485	PF11976	0.566
LIG_TRAF2_1	123	126	PF00917	0.703
LIG_TRAF2_1	310	313	PF00917	0.593
LIG_TRAF2_1	363	366	PF00917	0.598
LIG_TRAF2_1	463	466	PF00917	0.568
LIG_UBA3_1	398	406	PF00899	0.560
LIG_WRC_WIRS_1	442	447	PF05994	0.634
LIG_WW_3	596	600	PF00397	0.825
MOD_CDK_SPxxK_3	583	590	PF00069	0.755
MOD_CDK_SPxxK_3	592	599	PF00069	0.740
MOD_CK1_1	477	483	PF00069	0.487
MOD_CK1_1	522	528	PF00069	0.729
MOD_CK1_1	560	566	PF00069	0.590
MOD_CK1_1	592	598	PF00069	0.823
MOD_CK1_1	68	74	PF00069	0.692
MOD_CK1_1	81	87	PF00069	0.734
MOD_CK2_1	120	126	PF00069	0.536
MOD_CK2_1	194	200	PF00069	0.552
MOD_CK2_1	234	240	PF00069	0.603
MOD_CK2_1	253	259	PF00069	0.380
MOD_CK2_1	290	296	PF00069	0.699
MOD_CK2_1	307	313	PF00069	0.324
MOD_CK2_1	317	323	PF00069	0.440
MOD_CK2_1	332	338	PF00069	0.501
MOD_CK2_1	360	366	PF00069	0.518
MOD_CK2_1	432	438	PF00069	0.590
MOD_CK2_1	44	50	PF00069	0.493
MOD_GlcNHglycan	10	13	PF01048	0.761
MOD_GlcNHglycan	113	116	PF01048	0.575
MOD_GlcNHglycan	191	195	PF01048	0.687
MOD_GlcNHglycan	286	290	PF01048	0.740
MOD_GlcNHglycan	301	304	PF01048	0.439
MOD_GlcNHglycan	434	437	PF01048	0.559
MOD_GlcNHglycan	559	562	PF01048	0.767
MOD_GSK3_1	1	8	PF00069	0.766
MOD_GSK3_1	111	118	PF00069	0.755
MOD_GSK3_1	190	197	PF00069	0.612
MOD_GSK3_1	220	227	PF00069	0.538
MOD_GSK3_1	247	254	PF00069	0.627
MOD_GSK3_1	513	520	PF00069	0.687
MOD_GSK3_1	588	595	PF00069	0.722
MOD_GSK3_1	81	88	PF00069	0.768
MOD_N-GLC_1	257	262	PF02516	0.512
MOD_NEK2_1	1	6	PF00069	0.769
MOD_NEK2_1	138	143	PF00069	0.744
MOD_NEK2_1	161	166	PF00069	0.664
MOD_NEK2_1	209	214	PF00069	0.480
MOD_NEK2_1	220	225	PF00069	0.465
MOD_NEK2_1	290	295	PF00069	0.718
MOD_NEK2_1	316	321	PF00069	0.464
MOD_NEK2_1	471	476	PF00069	0.643
MOD_NEK2_1	519	524	PF00069	0.536
MOD_NEK2_1	545	550	PF00069	0.555
MOD_NEK2_1	557	562	PF00069	0.699
MOD_NEK2_1	78	83	PF00069	0.756
MOD_NEK2_1	85	90	PF00069	0.768
MOD_PIKK_1	20	26	PF00454	0.543
MOD_PIKK_1	528	534	PF00454	0.702
MOD_PK_1	307	313	PF00069	0.338
MOD_PKA_1	251	257	PF00069	0.443
MOD_PKA_1	307	313	PF00069	0.338
MOD_PKA_2	120	126	PF00069	0.536
MOD_PKA_2	471	477	PF00069	0.689
MOD_PKA_2	522	528	PF00069	0.532
MOD_PKA_2	78	84	PF00069	0.752
MOD_PKA_2	90	96	PF00069	0.683
MOD_PKB_1	77	85	PF00069	0.662
MOD_Plk_1	139	145	PF00069	0.658
MOD_Plk_1	209	215	PF00069	0.524
MOD_Plk_1	257	263	PF00069	0.395
MOD_Plk_1	337	343	PF00069	0.501
MOD_Plk_1	512	518	PF00069	0.520
MOD_Plk_2-3	140	146	PF00069	0.537
MOD_Plk_2-3	332	338	PF00069	0.501
MOD_Plk_4	171	177	PF00069	0.530
MOD_Plk_4	220	226	PF00069	0.537
MOD_Plk_4	397	403	PF00069	0.510
MOD_Plk_4	477	483	PF00069	0.634
MOD_ProDKin_1	102	108	PF00069	0.641
MOD_ProDKin_1	162	168	PF00069	0.693
MOD_ProDKin_1	360	366	PF00069	0.494
MOD_ProDKin_1	474	480	PF00069	0.639
MOD_ProDKin_1	583	589	PF00069	0.732
MOD_ProDKin_1	592	598	PF00069	0.767
MOD_SUMO_for_1	283	286	PF00179	0.530
MOD_SUMO_for_1	553	556	PF00179	0.605
MOD_SUMO_rev_2	174	181	PF00179	0.500
MOD_SUMO_rev_2	310	316	PF00179	0.540
MOD_SUMO_rev_2	522	531	PF00179	0.526
MOD_SUMO_rev_2	582	592	PF00179	0.793
TRG_DiLeu_BaEn_1	286	291	PF01217	0.516
TRG_DiLeu_BaEn_1	312	317	PF01217	0.539
TRG_DiLeu_BaEn_1	490	495	PF01217	0.411
TRG_DiLeu_BaEn_1	50	55	PF01217	0.494
TRG_DiLeu_BaEn_4	312	318	PF01217	0.595
TRG_ENDOCYTIC_2	404	407	PF00928	0.493
TRG_ENDOCYTIC_2	421	424	PF00928	0.521
TRG_ENDOCYTIC_2	492	495	PF00928	0.565
TRG_ER_diArg_1	19	22	PF00400	0.632
TRG_ER_diArg_1	225	228	PF00400	0.447
TRG_ER_diArg_1	230	232	PF00400	0.464
TRG_ER_diArg_1	27	29	PF00400	0.576
TRG_ER_diArg_1	425	427	PF00400	0.556
TRG_ER_diArg_1	439	441	PF00400	0.567
TRG_ER_diArg_1	534	536	PF00400	0.724
TRG_ER_diArg_1	598	600	PF00400	0.780
TRG_ER_diArg_1	75	77	PF00400	0.750
TRG_NES_CRM1_1	454	466	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U9	Leptomonas seymouri	73%	100%
A0A0S4IZW5	Bodo saltans	46%	100%
A0A1X0NF45	Trypanosomatidae	57%	100%
A0A3Q8IEZ4	Leishmania donovani	77%	99%
A4IB11	Leishmania infantum	77%	99%
E9AEU0	Leishmania major	77%	100%
E9B5Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%