Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HMD7_LEIBR

TriTrypDb:

LbrM.34.1070 , LBRM2903_340016700

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A4HMD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD7

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	651	655	PF00656	0.266
CLV_NRD_NRD_1	523	525	PF00675	0.338
CLV_NRD_NRD_1	833	835	PF00675	0.628
CLV_NRD_NRD_1	846	848	PF00675	0.511
CLV_PCSK_KEX2_1	846	848	PF00082	0.556
CLV_PCSK_SKI1_1	396	400	PF00082	0.446
CLV_PCSK_SKI1_1	473	477	PF00082	0.408
CLV_PCSK_SKI1_1	533	537	PF00082	0.305
CLV_PCSK_SKI1_1	555	559	PF00082	0.295
CLV_PCSK_SKI1_1	668	672	PF00082	0.499
CLV_PCSK_SKI1_1	775	779	PF00082	0.602
CLV_PCSK_SKI1_1	84	88	PF00082	0.382
DEG_SPOP_SBC_1	139	143	PF00917	0.380
DEG_SPOP_SBC_1	14	18	PF00917	0.680
DOC_AGCK_PIF_2	124	129	PF00069	0.293
DOC_CYCLIN_RxL_1	393	403	PF00134	0.254
DOC_CYCLIN_RxL_1	470	478	PF00134	0.254
DOC_MAPK_gen_1	244	253	PF00069	0.558
DOC_MAPK_gen_1	348	355	PF00069	0.484
DOC_MAPK_MEF2A_6	587	596	PF00069	0.228
DOC_PP1_RVXF_1	452	458	PF00149	0.496
DOC_PP1_RVXF_1	630	637	PF00149	0.279
DOC_PP4_FxxP_1	43	46	PF00568	0.517
DOC_PP4_FxxP_1	59	62	PF00568	0.495
DOC_SPAK_OSR1_1	67	71	PF12202	0.385
DOC_USP7_MATH_1	322	326	PF00917	0.279
DOC_USP7_MATH_1	6	10	PF00917	0.637
DOC_USP7_MATH_1	750	754	PF00917	0.392
DOC_USP7_UBL2_3	521	525	PF12436	0.372
DOC_WW_Pin1_4	318	323	PF00397	0.279
DOC_WW_Pin1_4	380	385	PF00397	0.189
DOC_WW_Pin1_4	417	422	PF00397	0.232
DOC_WW_Pin1_4	624	629	PF00397	0.268
DOC_WW_Pin1_4	669	674	PF00397	0.307
DOC_WW_Pin1_4	698	703	PF00397	0.344
LIG_14-3-3_CanoR_1	244	250	PF00244	0.502
LIG_14-3-3_CanoR_1	290	294	PF00244	0.531
LIG_14-3-3_CanoR_1	366	371	PF00244	0.453
LIG_14-3-3_CanoR_1	546	551	PF00244	0.507
LIG_14-3-3_CanoR_1	587	595	PF00244	0.266
LIG_14-3-3_CanoR_1	632	637	PF00244	0.250
LIG_14-3-3_CanoR_1	649	653	PF00244	0.294
LIG_14-3-3_CanoR_1	67	73	PF00244	0.584
LIG_14-3-3_CanoR_1	706	712	PF00244	0.313
LIG_14-3-3_CanoR_1	740	744	PF00244	0.375
LIG_14-3-3_CanoR_1	89	94	PF00244	0.279
LIG_AP2alpha_2	104	106	PF02296	0.279
LIG_BRCT_BRCA1_1	120	124	PF00533	0.380
LIG_deltaCOP1_diTrp_1	422	427	PF00928	0.223
LIG_eIF4E_1	450	456	PF01652	0.384
LIG_FHA_1	181	187	PF00498	0.366
LIG_FHA_1	233	239	PF00498	0.276
LIG_FHA_1	33	39	PF00498	0.606
LIG_FHA_1	390	396	PF00498	0.383
LIG_FHA_1	432	438	PF00498	0.427
LIG_FHA_1	566	572	PF00498	0.416
LIG_FHA_1	607	613	PF00498	0.206
LIG_FHA_1	669	675	PF00498	0.313
LIG_FHA_2	16	22	PF00498	0.601
LIG_FHA_2	46	52	PF00498	0.551
LIG_FHA_2	490	496	PF00498	0.277
LIG_FHA_2	538	544	PF00498	0.430
LIG_LIR_Apic_2	385	390	PF02991	0.305
LIG_LIR_Apic_2	803	807	PF02991	0.498
LIG_LIR_Gen_1	121	130	PF02991	0.333
LIG_LIR_Gen_1	206	215	PF02991	0.432
LIG_LIR_Gen_1	235	243	PF02991	0.332
LIG_LIR_Gen_1	422	433	PF02991	0.228
LIG_LIR_Gen_1	619	628	PF02991	0.252
LIG_LIR_Gen_1	686	692	PF02991	0.350
LIG_LIR_Gen_1	710	720	PF02991	0.390
LIG_LIR_Gen_1	761	771	PF02991	0.412
LIG_LIR_Nem_3	104	109	PF02991	0.279
LIG_LIR_Nem_3	121	127	PF02991	0.274
LIG_LIR_Nem_3	131	135	PF02991	0.262
LIG_LIR_Nem_3	141	147	PF02991	0.220
LIG_LIR_Nem_3	206	210	PF02991	0.379
LIG_LIR_Nem_3	235	240	PF02991	0.317
LIG_LIR_Nem_3	321	326	PF02991	0.273
LIG_LIR_Nem_3	385	391	PF02991	0.279
LIG_LIR_Nem_3	422	428	PF02991	0.216
LIG_LIR_Nem_3	52	58	PF02991	0.619
LIG_LIR_Nem_3	619	623	PF02991	0.271
LIG_LIR_Nem_3	635	639	PF02991	0.220
LIG_LIR_Nem_3	686	690	PF02991	0.284
LIG_LIR_Nem_3	710	715	PF02991	0.317
LIG_LIR_Nem_3	761	766	PF02991	0.357
LIG_LIR_Nem_3	768	774	PF02991	0.300
LIG_LYPXL_yS_3	144	147	PF13949	0.310
LIG_MLH1_MIPbox_1	120	124	PF16413	0.380
LIG_NRBOX	331	337	PF00104	0.382
LIG_NRBOX	442	448	PF00104	0.173
LIG_PCNA_PIPBox_1	610	619	PF02747	0.244
LIG_PCNA_yPIPBox_3	603	617	PF02747	0.248
LIG_PCNA_yPIPBox_3	624	637	PF02747	0.165
LIG_Pex14_1	120	124	PF04695	0.279
LIG_Pex14_1	637	641	PF04695	0.268
LIG_Pex14_1	64	68	PF04695	0.477
LIG_Pex14_2	103	107	PF04695	0.258
LIG_Pex14_2	123	127	PF04695	0.215
LIG_Pex14_2	55	59	PF04695	0.625
LIG_PTB_Apo_2	706	713	PF02174	0.317
LIG_PTB_Phospho_1	706	712	PF10480	0.313
LIG_SH2_CRK	178	182	PF00017	0.189
LIG_SH2_CRK	771	775	PF00017	0.290
LIG_SH2_CRK	96	100	PF00017	0.293
LIG_SH2_PTP2	269	272	PF00017	0.351
LIG_SH2_PTP2	687	690	PF00017	0.283
LIG_SH2_SRC	98	101	PF00017	0.312
LIG_SH2_STAP1	301	305	PF00017	0.351
LIG_SH2_STAP1	767	771	PF00017	0.361
LIG_SH2_STAT3	639	642	PF00017	0.268
LIG_SH2_STAT5	237	240	PF00017	0.375
LIG_SH2_STAT5	269	272	PF00017	0.351
LIG_SH2_STAT5	305	308	PF00017	0.435
LIG_SH2_STAT5	387	390	PF00017	0.266
LIG_SH2_STAT5	466	469	PF00017	0.323
LIG_SH2_STAT5	616	619	PF00017	0.280
LIG_SH2_STAT5	620	623	PF00017	0.277
LIG_SH2_STAT5	687	690	PF00017	0.283
LIG_SH2_STAT5	98	101	PF00017	0.345
LIG_SH3_2	62	67	PF14604	0.460
LIG_SH3_3	169	175	PF00018	0.375
LIG_SH3_3	36	42	PF00018	0.569
LIG_SH3_3	378	384	PF00018	0.343
LIG_SH3_3	415	421	PF00018	0.202
LIG_SH3_3	59	65	PF00018	0.480
LIG_SH3_3	714	720	PF00018	0.395
LIG_SH3_3	787	793	PF00018	0.364
LIG_SH3_3	794	800	PF00018	0.380
LIG_SUMO_SIM_anti_2	439	445	PF11976	0.165
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.208
LIG_SUMO_SIM_par_1	439	445	PF11976	0.224
LIG_SUMO_SIM_par_1	472	478	PF11976	0.208
LIG_SxIP_EBH_1	203	216	PF03271	0.349
LIG_TRAF2_1	50	53	PF00917	0.490
LIG_TYR_ITSM	233	240	PF00017	0.316
LIG_WRC_WIRS_1	233	238	PF05994	0.316
LIG_WRC_WIRS_1	424	429	PF05994	0.185
LIG_WRC_WIRS_1	829	834	PF05994	0.331
MOD_CDC14_SPxK_1	321	324	PF00782	0.380
MOD_CDK_SPK_2	624	629	PF00069	0.185
MOD_CDK_SPxK_1	318	324	PF00069	0.279
MOD_CK1_1	242	248	PF00069	0.493
MOD_CK1_1	505	511	PF00069	0.492
MOD_CK1_1	527	533	PF00069	0.547
MOD_CK1_1	576	582	PF00069	0.355
MOD_CK1_1	783	789	PF00069	0.334
MOD_CK2_1	15	21	PF00069	0.606
MOD_CK2_1	409	415	PF00069	0.246
MOD_CK2_1	47	53	PF00069	0.517
MOD_CK2_1	489	495	PF00069	0.406
MOD_CK2_1	836	842	PF00069	0.382
MOD_Cter_Amidation	1	4	PF01082	0.528
MOD_GlcNHglycan	115	118	PF01048	0.532
MOD_GlcNHglycan	120	123	PF01048	0.569
MOD_GlcNHglycan	451	454	PF01048	0.293
MOD_GlcNHglycan	460	463	PF01048	0.302
MOD_GlcNHglycan	752	755	PF01048	0.610
MOD_GlcNHglycan	782	785	PF01048	0.568
MOD_GlcNHglycan	8	11	PF01048	0.422
MOD_GSK3_1	118	125	PF00069	0.349
MOD_GSK3_1	289	296	PF00069	0.521
MOD_GSK3_1	306	313	PF00069	0.211
MOD_GSK3_1	318	325	PF00069	0.297
MOD_GSK3_1	465	472	PF00069	0.249
MOD_GSK3_1	498	505	PF00069	0.554
MOD_GSK3_1	573	580	PF00069	0.288
MOD_GSK3_1	602	609	PF00069	0.273
MOD_N-GLC_1	647	652	PF02516	0.466
MOD_N-GLC_1	780	785	PF02516	0.529
MOD_N-GLC_2	169	171	PF02516	0.435
MOD_N-GLC_2	224	226	PF02516	0.479
MOD_NEK2_1	147	152	PF00069	0.279
MOD_NEK2_1	205	210	PF00069	0.362
MOD_NEK2_1	214	219	PF00069	0.355
MOD_NEK2_1	232	237	PF00069	0.213
MOD_NEK2_1	400	405	PF00069	0.276
MOD_NEK2_1	409	414	PF00069	0.249
MOD_NEK2_1	442	447	PF00069	0.296
MOD_NEK2_1	458	463	PF00069	0.324
MOD_NEK2_1	475	480	PF00069	0.205
MOD_NEK2_1	489	494	PF00069	0.389
MOD_NEK2_1	545	550	PF00069	0.384
MOD_NEK2_1	565	570	PF00069	0.381
MOD_NEK2_1	68	73	PF00069	0.409
MOD_NEK2_1	739	744	PF00069	0.325
MOD_NEK2_1	78	83	PF00069	0.305
MOD_NEK2_2	239	244	PF00069	0.316
MOD_PIKK_1	27	33	PF00454	0.762
MOD_PIKK_1	513	519	PF00454	0.461
MOD_PIKK_1	606	612	PF00454	0.192
MOD_PK_1	366	372	PF00069	0.417
MOD_PK_1	89	95	PF00069	0.314
MOD_PKA_1	524	530	PF00069	0.408
MOD_PKA_2	245	251	PF00069	0.515
MOD_PKA_2	289	295	PF00069	0.531
MOD_PKA_2	469	475	PF00069	0.477
MOD_PKA_2	545	551	PF00069	0.464
MOD_PKA_2	586	592	PF00069	0.235
MOD_PKA_2	602	608	PF00069	0.294
MOD_PKA_2	648	654	PF00069	0.268
MOD_PKA_2	739	745	PF00069	0.370
MOD_PKB_1	364	372	PF00069	0.512
MOD_Plk_1	647	653	PF00069	0.277
MOD_Plk_4	128	134	PF00069	0.279
MOD_Plk_4	232	238	PF00069	0.316
MOD_Plk_4	281	287	PF00069	0.423
MOD_Plk_4	293	299	PF00069	0.423
MOD_Plk_4	436	442	PF00069	0.342
MOD_Plk_4	489	495	PF00069	0.339
MOD_Plk_4	580	586	PF00069	0.274
MOD_Plk_4	595	601	PF00069	0.270
MOD_Plk_4	632	638	PF00069	0.276
MOD_Plk_4	676	682	PF00069	0.364
MOD_Plk_4	707	713	PF00069	0.303
MOD_Plk_4	739	745	PF00069	0.362
MOD_Plk_4	758	764	PF00069	0.270
MOD_Plk_4	800	806	PF00069	0.403
MOD_ProDKin_1	318	324	PF00069	0.279
MOD_ProDKin_1	380	386	PF00069	0.189
MOD_ProDKin_1	417	423	PF00069	0.232
MOD_ProDKin_1	624	630	PF00069	0.268
MOD_ProDKin_1	669	675	PF00069	0.313
MOD_ProDKin_1	698	704	PF00069	0.340
TRG_DiLeu_BaEn_1	676	681	PF01217	0.322
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.282
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.160
TRG_ENDOCYTIC_2	144	147	PF00928	0.341
TRG_ENDOCYTIC_2	178	181	PF00928	0.189
TRG_ENDOCYTIC_2	237	240	PF00928	0.316
TRG_ENDOCYTIC_2	259	262	PF00928	0.316
TRG_ENDOCYTIC_2	269	272	PF00928	0.316
TRG_ENDOCYTIC_2	301	304	PF00928	0.316
TRG_ENDOCYTIC_2	620	623	PF00928	0.268
TRG_ENDOCYTIC_2	687	690	PF00928	0.283
TRG_ENDOCYTIC_2	712	715	PF00928	0.328
TRG_ENDOCYTIC_2	771	774	PF00928	0.284
TRG_ENDOCYTIC_2	96	99	PF00928	0.293
TRG_ER_diArg_1	243	246	PF00400	0.576
TRG_ER_diArg_1	347	350	PF00400	0.497
TRG_ER_diArg_1	355	358	PF00400	0.467
TRG_ER_diArg_1	363	366	PF00400	0.411
TRG_ER_diArg_1	732	735	PF00400	0.319
TRG_ER_diArg_1	845	847	PF00400	0.365
TRG_NES_CRM1_1	327	342	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.177
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	50%	100%
A0A1X0NFU7	Trypanosomatidae	55%	100%
A0A3Q8IHT0	Leishmania donovani	71%	99%
A0A3Q8II34	Leishmania donovani	55%	100%
A0A3Q8ILY7	Leishmania donovani	71%	100%
A0A3Q8IV37	Leishmania donovani	81%	100%
A0A422MX14	Trypanosoma rangeli	56%	100%
A4HFF9	Leishmania braziliensis	70%	99%
A4HMD5	Leishmania braziliensis	74%	99%
A4HMD6	Leishmania braziliensis	58%	100%
A4IB08	Leishmania infantum	70%	99%
A4IB09	Leishmania infantum	71%	100%
A4IB10	Leishmania infantum	55%	100%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E2RG47	Canis lupus familiaris	29%	100%
E9AET6	Leishmania major	66%	99%
E9AET7	Leishmania major	71%	100%
E9AET8	Leishmania major	55%	100%
E9AET9	Leishmania major	80%	100%
E9AHU4	Leishmania infantum	81%	100%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
E9B5Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
F1PJP5	Canis lupus familiaris	29%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P39007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P46975	Caenorhabditis elegans	31%	100%
P46977	Homo sapiens	29%	100%
P46978	Mus musculus	29%	100%
Q2KJI2	Bos taurus	29%	100%
Q3TDQ1	Mus musculus	29%	100%
Q54NM9	Dictyostelium discoideum	30%	100%
Q5RCE2	Pongo abelii	29%	100%
Q7XQ88	Oryza sativa subsp. japonica	32%	100%
Q8TCJ2	Homo sapiens	29%	100%
Q93ZY3	Arabidopsis thaliana	31%	100%
Q9FX21	Arabidopsis thaliana	30%	100%
V5BDM6	Trypanosoma cruzi	57%	100%