Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HMD6_LEIBR

TriTrypDb:

LbrM.34.1060 , LBRM2903_340016600

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A4HMD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD6

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.268
CLV_C14_Caspase3-7	806	810	PF00656	0.339
CLV_MEL_PAP_1	524	530	PF00089	0.167
CLV_NRD_NRD_1	498	500	PF00675	0.366
CLV_NRD_NRD_1	681	683	PF00675	0.507
CLV_PCSK_KEX2_1	498	500	PF00082	0.306
CLV_PCSK_KEX2_1	681	683	PF00082	0.551
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.299
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.551
CLV_PCSK_SKI1_1	617	621	PF00082	0.497
CLV_PCSK_SKI1_1	675	679	PF00082	0.465
CLV_PCSK_SKI1_1	752	756	PF00082	0.613
DEG_ODPH_VHL_1	684	695	PF01847	0.348
DEG_SPOP_SBC_1	108	112	PF00917	0.475
DOC_AGCK_PIF_2	93	98	PF00069	0.295
DOC_MAPK_DCC_7	540	549	PF00069	0.162
DOC_MAPK_gen_1	213	222	PF00069	0.360
DOC_MAPK_gen_1	56	64	PF00069	0.217
DOC_MAPK_HePTP_8	512	524	PF00069	0.167
DOC_MAPK_MEF2A_6	515	524	PF00069	0.339
DOC_MAPK_MEF2A_6	540	549	PF00069	0.230
DOC_PP1_RVXF_1	579	586	PF00149	0.281
DOC_PP4_FxxP_1	355	358	PF00568	0.304
DOC_PP4_FxxP_1	43	46	PF00568	0.186
DOC_USP7_MATH_1	167	171	PF00917	0.347
DOC_USP7_MATH_1	291	295	PF00917	0.281
DOC_USP7_MATH_1	436	440	PF00917	0.430
DOC_USP7_MATH_1	671	675	PF00917	0.306
DOC_USP7_MATH_1	686	690	PF00917	0.404
DOC_USP7_MATH_1	8	12	PF00917	0.654
DOC_WW_Pin1_4	287	292	PF00397	0.281
DOC_WW_Pin1_4	573	578	PF00397	0.270
DOC_WW_Pin1_4	6	11	PF00397	0.618
DOC_WW_Pin1_4	618	623	PF00397	0.305
DOC_WW_Pin1_4	649	654	PF00397	0.332
DOC_WW_Pin1_4	710	715	PF00397	0.338
LIG_14-3-3_CanoR_1	213	219	PF00244	0.304
LIG_14-3-3_CanoR_1	259	263	PF00244	0.533
LIG_14-3-3_CanoR_1	324	333	PF00244	0.513
LIG_14-3-3_CanoR_1	581	586	PF00244	0.252
LIG_14-3-3_CanoR_1	598	602	PF00244	0.296
LIG_14-3-3_CanoR_1	657	663	PF00244	0.317
LIG_14-3-3_CanoR_1	800	805	PF00244	0.441
LIG_AP2alpha_2	73	75	PF02296	0.281
LIG_BRCT_BRCA1_1	172	176	PF00533	0.417
LIG_BRCT_BRCA1_1	89	93	PF00533	0.382
LIG_DLG_GKlike_1	800	807	PF00625	0.296
LIG_eIF4E_1	464	470	PF01652	0.408
LIG_eIF4E_1	710	716	PF01652	0.294
LIG_FHA_1	166	172	PF00498	0.314
LIG_FHA_1	20	26	PF00498	0.603
LIG_FHA_1	202	208	PF00498	0.278
LIG_FHA_1	325	331	PF00498	0.377
LIG_FHA_1	410	416	PF00498	0.395
LIG_FHA_1	452	458	PF00498	0.308
LIG_FHA_1	504	510	PF00498	0.421
LIG_FHA_1	618	624	PF00498	0.311
LIG_FHA_1	703	709	PF00498	0.339
LIG_FHA_2	374	380	PF00498	0.292
LIG_FHA_2	574	580	PF00498	0.259
LIG_FHA_2	732	738	PF00498	0.342
LIG_LIR_Apic_2	40	46	PF02991	0.167
LIG_LIR_Apic_2	780	784	PF02991	0.466
LIG_LIR_Gen_1	173	184	PF02991	0.433
LIG_LIR_Gen_1	204	212	PF02991	0.334
LIG_LIR_Gen_1	421	431	PF02991	0.417
LIG_LIR_Gen_1	502	512	PF02991	0.414
LIG_LIR_Gen_1	635	644	PF02991	0.365
LIG_LIR_Gen_1	661	671	PF02991	0.396
LIG_LIR_Gen_1	737	747	PF02991	0.422
LIG_LIR_Gen_1	90	99	PF02991	0.335
LIG_LIR_Nem_3	100	104	PF02991	0.264
LIG_LIR_Nem_3	110	116	PF02991	0.252
LIG_LIR_Nem_3	173	179	PF02991	0.357
LIG_LIR_Nem_3	204	209	PF02991	0.319
LIG_LIR_Nem_3	290	295	PF02991	0.275
LIG_LIR_Nem_3	563	569	PF02991	0.257
LIG_LIR_Nem_3	584	588	PF02991	0.222
LIG_LIR_Nem_3	63	68	PF02991	0.281
LIG_LIR_Nem_3	635	639	PF02991	0.283
LIG_LIR_Nem_3	643	649	PF02991	0.332
LIG_LIR_Nem_3	661	666	PF02991	0.320
LIG_LIR_Nem_3	73	78	PF02991	0.281
LIG_LIR_Nem_3	737	743	PF02991	0.371
LIG_LIR_Nem_3	90	96	PF02991	0.276
LIG_LYPXL_yS_3	113	116	PF13949	0.377
LIG_MLH1_MIPbox_1	89	93	PF16413	0.382
LIG_NRBOX	300	306	PF00104	0.384
LIG_NRBOX	520	526	PF00104	0.326
LIG_PCNA_PIPBox_1	404	413	PF02747	0.167
LIG_Pex14_1	586	590	PF04695	0.270
LIG_Pex14_1	89	93	PF04695	0.281
LIG_Pex14_2	92	96	PF04695	0.217
LIG_PTB_Apo_2	657	664	PF02174	0.320
LIG_PTB_Phospho_1	657	663	PF10480	0.317
LIG_REV1ctd_RIR_1	353	357	PF16727	0.217
LIG_SH2_CRK	428	432	PF00017	0.305
LIG_SH2_CRK	65	69	PF00017	0.295
LIG_SH2_CRK	801	805	PF00017	0.307
LIG_SH2_PTP2	238	241	PF00017	0.353
LIG_SH2_PTP2	636	639	PF00017	0.282
LIG_SH2_SRC	710	713	PF00017	0.303
LIG_SH2_STAP1	270	274	PF00017	0.353
LIG_SH2_STAP1	337	341	PF00017	0.214
LIG_SH2_STAP1	39	43	PF00017	0.256
LIG_SH2_STAP1	420	424	PF00017	0.504
LIG_SH2_STAT3	588	591	PF00017	0.270
LIG_SH2_STAT5	206	209	PF00017	0.377
LIG_SH2_STAT5	238	241	PF00017	0.353
LIG_SH2_STAT5	274	277	PF00017	0.437
LIG_SH2_STAT5	39	42	PF00017	0.279
LIG_SH2_STAT5	420	423	PF00017	0.470
LIG_SH2_STAT5	434	437	PF00017	0.324
LIG_SH2_STAT5	504	507	PF00017	0.500
LIG_SH2_STAT5	569	572	PF00017	0.279
LIG_SH2_STAT5	636	639	PF00017	0.282
LIG_SH2_STAT5	67	70	PF00017	0.347
LIG_SH2_STAT5	744	747	PF00017	0.230
LIG_SH2_STAT5	801	804	PF00017	0.505
LIG_SH3_3	138	144	PF00018	0.377
LIG_SH3_3	665	671	PF00018	0.403
LIG_SH3_3	764	770	PF00018	0.366
LIG_SH3_3	771	777	PF00018	0.370
LIG_SUMO_SIM_anti_2	326	334	PF11976	0.493
LIG_SUMO_SIM_par_1	20	27	PF11976	0.557
LIG_TRAF2_1	482	485	PF00917	0.511
LIG_TYR_ITIM	426	431	PF00017	0.250
LIG_TYR_ITSM	202	209	PF00017	0.318
LIG_UBA3_1	49	56	PF00899	0.290
LIG_UBA3_1	750	755	PF00899	0.312
LIG_WRC_WIRS_1	202	207	PF05994	0.318
LIG_WRC_WIRS_1	415	420	PF05994	0.414
MOD_CDC14_SPxK_1	290	293	PF00782	0.382
MOD_CDK_SPxK_1	287	293	PF00069	0.281
MOD_CK1_1	148	154	PF00069	0.254
MOD_CK1_1	169	175	PF00069	0.323
MOD_CK1_1	211	217	PF00069	0.353
MOD_CK1_1	477	483	PF00069	0.504
MOD_CK1_1	760	766	PF00069	0.338
MOD_CK2_1	809	815	PF00069	0.367
MOD_GlcNHglycan	14	17	PF01048	0.485
MOD_GlcNHglycan	151	154	PF01048	0.426
MOD_GlcNHglycan	528	531	PF01048	0.336
MOD_GlcNHglycan	688	691	PF01048	0.592
MOD_GlcNHglycan	725	728	PF01048	0.563
MOD_GlcNHglycan	745	748	PF01048	0.621
MOD_GlcNHglycan	759	762	PF01048	0.574
MOD_GlcNHglycan	84	87	PF01048	0.534
MOD_GlcNHglycan	89	92	PF01048	0.571
MOD_GSK3_1	145	152	PF00069	0.374
MOD_GSK3_1	165	172	PF00069	0.316
MOD_GSK3_1	258	265	PF00069	0.523
MOD_GSK3_1	275	282	PF00069	0.213
MOD_GSK3_1	287	294	PF00069	0.299
MOD_GSK3_1	324	331	PF00069	0.362
MOD_GSK3_1	33	40	PF00069	0.584
MOD_GSK3_1	414	421	PF00069	0.418
MOD_GSK3_1	8	15	PF00069	0.680
MOD_GSK3_1	807	814	PF00069	0.329
MOD_GSK3_1	87	94	PF00069	0.351
MOD_N-GLC_1	596	601	PF02516	0.468
MOD_N-GLC_1	757	762	PF02516	0.536
MOD_N-GLC_2	138	140	PF02516	0.437
MOD_N-GLC_2	193	195	PF02516	0.281
MOD_NEK2_1	116	121	PF00069	0.334
MOD_NEK2_1	149	154	PF00069	0.392
MOD_NEK2_1	166	171	PF00069	0.334
MOD_NEK2_1	183	188	PF00069	0.357
MOD_NEK2_1	201	206	PF00069	0.215
MOD_NEK2_1	414	419	PF00069	0.459
MOD_NEK2_1	526	531	PF00069	0.308
MOD_NEK2_1	716	721	PF00069	0.311
MOD_NEK2_1	807	812	PF00069	0.310
MOD_NEK2_2	208	213	PF00069	0.318
MOD_NEK2_2	28	33	PF00069	0.605
MOD_NEK2_2	34	39	PF00069	0.520
MOD_NEK2_2	436	441	PF00069	0.294
MOD_PIKK_1	312	318	PF00454	0.291
MOD_PIKK_1	434	440	PF00454	0.244
MOD_PIKK_1	702	708	PF00454	0.348
MOD_PK_1	510	516	PF00069	0.383
MOD_PK_1	58	64	PF00069	0.359
MOD_PKA_2	214	220	PF00069	0.317
MOD_PKA_2	258	264	PF00069	0.533
MOD_PKA_2	323	329	PF00069	0.507
MOD_PKA_2	34	40	PF00069	0.429
MOD_PKA_2	526	532	PF00069	0.349
MOD_PKA_2	597	603	PF00069	0.270
MOD_PKA_2	799	805	PF00069	0.330
MOD_Plk_1	384	390	PF00069	0.184
MOD_Plk_1	502	508	PF00069	0.412
MOD_Plk_1	596	602	PF00069	0.279
MOD_Plk_2-3	731	737	PF00069	0.255
MOD_Plk_2-3	809	815	PF00069	0.319
MOD_Plk_4	170	176	PF00069	0.323
MOD_Plk_4	19	25	PF00069	0.661
MOD_Plk_4	201	207	PF00069	0.318
MOD_Plk_4	250	256	PF00069	0.425
MOD_Plk_4	262	268	PF00069	0.425
MOD_Plk_4	328	334	PF00069	0.433
MOD_Plk_4	34	40	PF00069	0.446
MOD_Plk_4	373	379	PF00069	0.366
MOD_Plk_4	385	391	PF00069	0.249
MOD_Plk_4	420	426	PF00069	0.437
MOD_Plk_4	549	555	PF00069	0.269
MOD_Plk_4	581	587	PF00069	0.278
MOD_Plk_4	625	631	PF00069	0.364
MOD_Plk_4	658	664	PF00069	0.305
MOD_Plk_4	716	722	PF00069	0.350
MOD_Plk_4	777	783	PF00069	0.373
MOD_Plk_4	97	103	PF00069	0.281
MOD_ProDKin_1	287	293	PF00069	0.281
MOD_ProDKin_1	573	579	PF00069	0.270
MOD_ProDKin_1	6	12	PF00069	0.619
MOD_ProDKin_1	618	624	PF00069	0.311
MOD_ProDKin_1	649	655	PF00069	0.328
MOD_ProDKin_1	710	716	PF00069	0.330
MOD_SUMO_rev_2	21	31	PF00179	0.542
TRG_DiLeu_BaEn_1	328	333	PF01217	0.417
TRG_DiLeu_BaEn_1	625	630	PF01217	0.322
TRG_ENDOCYTIC_2	113	116	PF00928	0.421
TRG_ENDOCYTIC_2	206	209	PF00928	0.318
TRG_ENDOCYTIC_2	228	231	PF00928	0.318
TRG_ENDOCYTIC_2	238	241	PF00928	0.318
TRG_ENDOCYTIC_2	270	273	PF00928	0.318
TRG_ENDOCYTIC_2	337	340	PF00928	0.338
TRG_ENDOCYTIC_2	428	431	PF00928	0.263
TRG_ENDOCYTIC_2	504	507	PF00928	0.417
TRG_ENDOCYTIC_2	569	572	PF00928	0.270
TRG_ENDOCYTIC_2	636	639	PF00928	0.282
TRG_ENDOCYTIC_2	65	68	PF00928	0.295
TRG_ENDOCYTIC_2	663	666	PF00928	0.327
TRG_ENDOCYTIC_2	801	804	PF00928	0.306
TRG_ER_diArg_1	212	215	PF00400	0.378
TRG_ER_diArg_1	317	320	PF00400	0.497
TRG_ER_diArg_1	57	60	PF00400	0.352
TRG_NES_CRM1_1	296	311	PF08389	0.382
TRG_NLS_MonoCore_2	496	501	PF00514	0.362
TRG_NLS_MonoExtC_3	496	502	PF00514	0.425
TRG_NLS_MonoExtN_4	495	501	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	43%	100%
A0A1X0NFU7	Trypanosomatidae	49%	97%
A0A3Q8IHT0	Leishmania donovani	54%	95%
A0A3Q8II34	Leishmania donovani	80%	100%
A0A3Q8ILY7	Leishmania donovani	57%	100%
A0A3Q8IV37	Leishmania donovani	55%	98%
A0A422MX14	Trypanosoma rangeli	49%	99%
A4HFF9	Leishmania braziliensis	57%	100%
A4HMD5	Leishmania braziliensis	59%	100%
A4HMD7	Leishmania braziliensis	58%	96%
A4IB08	Leishmania infantum	53%	95%
A4IB09	Leishmania infantum	57%	100%
A4IB10	Leishmania infantum	80%	100%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E2RG47	Canis lupus familiaris	30%	100%
E9AET6	Leishmania major	54%	100%
E9AET7	Leishmania major	57%	100%
E9AET8	Leishmania major	79%	100%
E9AET9	Leishmania major	55%	100%
E9AHU4	Leishmania infantum	56%	98%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	95%
E9B5Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	97%
F1PJP5	Canis lupus familiaris	27%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
P39007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P46975	Caenorhabditis elegans	31%	100%
P46977	Homo sapiens	28%	100%
P46978	Mus musculus	27%	100%
Q2KJI2	Bos taurus	28%	100%
Q3TDQ1	Mus musculus	30%	100%
Q54NM9	Dictyostelium discoideum	29%	100%
Q5RCE2	Pongo abelii	28%	100%
Q6F2Z1	Oryza sativa subsp. japonica	28%	100%
Q7XQ88	Oryza sativa subsp. japonica	31%	100%
Q8TCJ2	Homo sapiens	31%	100%
Q93ZY3	Arabidopsis thaliana	30%	100%
Q9FX21	Arabidopsis thaliana	28%	100%
V5BDM6	Trypanosoma cruzi	49%	99%